Modelling Treatment Sequences in Immunology: Optimizing Patient Outcomes
CONCLUSIONS: Prescribing more efficacious treatments earlier provides a greater opportunity to improve patient outcomes and minimizes treatment failures.PMID:38554238 | DOI:10.1007/s12325-023-02766-w (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Rose J Hart Fareen Hassan Sarah Alulis Karl W Patterson Jennifer Norma Barthelmes Jennifer H Boer Dawn Lee Source Type: research
Predictors of serious infections in rheumatoid arthritis-a prospective Brazilian cohort
CONCLUSION: The use of corticosteroids at moderate doses increased the risk of serious infection in RA patients. Reduced functionality assessed by the HAQ and comorbidities were other important factors associated with serious infection in this cohort.PMID:38553751 | DOI:10.1186/s42358-024-00363-1 (Source: Adv Data)
Source: Adv Data - March 30, 2024 Category: Epidemiology Authors: Ana Luisa Bagno de Almeida Maria Fernanda B Resende Guimar ães Maria Raquel da Costa Pinto Leticia Rocha Pereira Ana Paula Monteiro Gomides Reis Karina Rossi Bonfiglioli Paulo Louzada-Junior Rina Dalva Neubarth Giorgi Gl áucio Ricardo Werner de Castro S Source Type: research
Impact of age and cardiovascular risk factors on the incidence of adverse events in patients with rheumatoid arthritis treated with Janus Kinase inhibitors: data from a real-life multicentric cohort
AbstractInhibiting Janus Kinases (JAK) is a crucial therapeutic strategy in rheumatoid arthritis (RA). However, the use of JAK inhibitors has recently raised serious safety concerns. The study aims to evaluate the safety profile of JAKi in patients with RA and identify potential risk factors (RFs) for adverse events (AEs). Data of RA patients treated with JAKi in three Italian centers from January 2017 to December 2022 were retrospectively analyzed. 182 subjects (F:117, 64.3%) underwent 193 treatment courses. 78.6% had at least one RF, including age ≥ 65 years, obesity, smoking habit, hypertension, dyslipidemia, hy...
Source: Clinical and Experimental Medicine - March 30, 2024 Category: Research Source Type: research
Retracted: Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
Biomed Res Int. 2024 Mar 20;2024:9823071. doi: 10.1155/2024/9823071. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2021/2486617.].PMID:38550190 | PMC:PMC10973261 | DOI:10.1155/2024/9823071 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Effect of high disease activity on spinal sagittal malalignment in patients with rheumatoid arthritis
CONCLUSIONS: Spinal sagittal alignment deteriorates over time in patients with RA. High disease activity in RA exacerbates spinal deformity.PMID:38552241 | DOI:10.3171/2024.1.SPINE231199 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - March 29, 2024 Category: Neurosurgery Authors: Shintaro Honda Koichi Murata Shunsuke Fujibayashi Bungo Otsuki Takayoshi Shimizu Takayuki Fujii Yaichiro Okuzu Toshiyuki Kawai Yutaka Kuroda Akira Onishi Kosaku Murakami Hideo Onizawa Masao Tanaka Akio Morinobu Shuichi Matsuda Source Type: research
Retracted: Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum
Biomed Res Int. 2024 Mar 20;2024:9823071. doi: 10.1155/2024/9823071. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2021/2486617.].PMID:38550190 | PMC:PMC10973261 | DOI:10.1155/2024/9823071 (Source: Biomed Res)
Source: Biomed Res - March 29, 2024 Category: Research Authors: BioMed Research International Source Type: research
Wogonin inhibits the migration and invasion of fibroblast-like synoviocytes by targeting PI3K/AKT/NF- κB pathway in rheumatoid arthritis
CONCLUSION: Wogonin effectively inhibits migration, invasion and pro-inflammatory cytokine production of RA fibroblast-like synoviocytes through the PI3K/AKT/NF-κB pathway, and thus wogonin, as a natural flavonoid, has great potential for treating RA.PMID:38552763 | DOI:10.1016/j.abb.2024.109965 (Source: Archives of Biochemistry and Biophysics)
Source: Archives of Biochemistry and Biophysics - March 29, 2024 Category: Biochemistry Authors: Haixin Yang Cuizhen Liu Xiujuan Lin Xing Li Shan Zeng Zhaohui Gong Qiang Xu Detang Li Nan Li Source Type: research
Effect of high disease activity on spinal sagittal malalignment in patients with rheumatoid arthritis
CONCLUSIONS: Spinal sagittal alignment deteriorates over time in patients with RA. High disease activity in RA exacerbates spinal deformity.PMID:38552241 | DOI:10.3171/2024.1.SPINE231199 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - March 29, 2024 Category: Neurosurgery Authors: Shintaro Honda Koichi Murata Shunsuke Fujibayashi Bungo Otsuki Takayoshi Shimizu Takayuki Fujii Yaichiro Okuzu Toshiyuki Kawai Yutaka Kuroda Akira Onishi Kosaku Murakami Hideo Onizawa Masao Tanaka Akio Morinobu Shuichi Matsuda Source Type: research
Effect of high disease activity on spinal sagittal malalignment in patients with rheumatoid arthritis
CONCLUSIONS: Spinal sagittal alignment deteriorates over time in patients with RA. High disease activity in RA exacerbates spinal deformity.PMID:38552241 | DOI:10.3171/2024.1.SPINE231199 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - March 29, 2024 Category: Neurosurgery Authors: Shintaro Honda Koichi Murata Shunsuke Fujibayashi Bungo Otsuki Takayoshi Shimizu Takayuki Fujii Yaichiro Okuzu Toshiyuki Kawai Yutaka Kuroda Akira Onishi Kosaku Murakami Hideo Onizawa Masao Tanaka Akio Morinobu Shuichi Matsuda Source Type: research
Effect of high disease activity on spinal sagittal malalignment in patients with rheumatoid arthritis
CONCLUSIONS: Spinal sagittal alignment deteriorates over time in patients with RA. High disease activity in RA exacerbates spinal deformity.PMID:38552241 | DOI:10.3171/2024.1.SPINE231199 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - March 29, 2024 Category: Neurosurgery Authors: Shintaro Honda Koichi Murata Shunsuke Fujibayashi Bungo Otsuki Takayoshi Shimizu Takayuki Fujii Yaichiro Okuzu Toshiyuki Kawai Yutaka Kuroda Akira Onishi Kosaku Murakami Hideo Onizawa Masao Tanaka Akio Morinobu Shuichi Matsuda Source Type: research
Effect of high disease activity on spinal sagittal malalignment in patients with rheumatoid arthritis
CONCLUSIONS: Spinal sagittal alignment deteriorates over time in patients with RA. High disease activity in RA exacerbates spinal deformity.PMID:38552241 | DOI:10.3171/2024.1.SPINE231199 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - March 29, 2024 Category: Neurosurgery Authors: Shintaro Honda Koichi Murata Shunsuke Fujibayashi Bungo Otsuki Takayoshi Shimizu Takayuki Fujii Yaichiro Okuzu Toshiyuki Kawai Yutaka Kuroda Akira Onishi Kosaku Murakami Hideo Onizawa Masao Tanaka Akio Morinobu Shuichi Matsuda Source Type: research
Effect of high disease activity on spinal sagittal malalignment in patients with rheumatoid arthritis
CONCLUSIONS: Spinal sagittal alignment deteriorates over time in patients with RA. High disease activity in RA exacerbates spinal deformity.PMID:38552241 | DOI:10.3171/2024.1.SPINE231199 (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - March 29, 2024 Category: Neurosurgery Authors: Shintaro Honda Koichi Murata Shunsuke Fujibayashi Bungo Otsuki Takayoshi Shimizu Takayuki Fujii Yaichiro Okuzu Toshiyuki Kawai Yutaka Kuroda Akira Onishi Kosaku Murakami Hideo Onizawa Masao Tanaka Akio Morinobu Shuichi Matsuda Source Type: research
Exploring the Mechanism of Acupuncture's Influence on the Protease Activity and Free Radical Damage in Synovial Fluid of Rheumatoid Arthritis Rats Induced by Type II Collagen from the Release of Active Oxygen
Appl Biochem Biotechnol. 2024 Mar 28. doi: 10.1007/s12010-024-04932-4. Online ahead of print.ABSTRACTAcupuncture was studied to investigate the mechanism of its effect on protease vitality and free radical damage in Type I CIA rats induced by type II collagen. The study divided rats into a control group (injected with physiological saline, n = 10), a model group (injected with type II collagen, n = 10), and an intervention group (injected with type II collagen + acupuncture ST36 and GB39, 3 times a week, for a total of 4 weeks, n = 10) based on the different injected drugs. Then, various indicators of the mice were experim...
Source: Applied Biochemistry and Biotechnology - March 28, 2024 Category: Biochemistry Authors: Kaiying Cui Dezhong Bi Fuyan Wang Pengfei Hou Jinxing Guo Zhanwang Xu Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: J Cell Mol Med - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
KLF transcription factors in bone diseases
J Cell Mol Med. 2024 Apr;28(8):e18278. doi: 10.1111/jcmm.18278.ABSTRACTKrüppel-like factors (KLFs) are crucial in the development of bone disease. They are a family of zinc finger transcription factors that are unusual in containing three highly conserved zinc finger structural domains interacting with DNA. It has been discovered that it engages in various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, and is crucial for the development of human tissues. In recent years, the role of KLFs in bone physiology and pathology has received adequate attention. In addition to regul...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Haixia Wang Juanjuan Han Gorbachev Dmitrii Ke Ning Xin-An Zhang Source Type: research
