Spontaneous Idiopathic Bilateral Sagittal Band Rupture: A Case Report
CONCLUSION: Upon examination, she was found to have bilateral dislocation of the extensor tendons at the level of the (MCPJ) of the third and fourth digits. Any underlying cause was excluded, and the diagnosis was confirmed with a dynamic ultrasound study.PMID:38560310 | PMC:PMC10976532 | DOI:10.13107/jocr.2024.v14.i03.4302 (Source: Pain Physician)
Source: Pain Physician - April 1, 2024 Category: Anesthesiology Authors: Fatema H Madan Huda Saeed Alsahlawi Batool B Mohamed Sayed Mohamed Hasan Yusuf Omran Hasan Source Type: research
Vitamin B12 Status and Hyperhomocysteinemia in Patients with Rheumatoid Arthritis Treated with Methotrexate and Folic Acid
CONCLUSION: Our data show high plasma homocysteine levels among RA patients treated with methotrexate and folic acid. While plasma vitamin B12 levels were similar between the two groups, high plasma homocysteine is also a sensitive marker of vitamin B12 deficiency. Additional studies should evaluate for the presence of clinical features of vitamin B12 deficiency and hyperhomocysteinemia among RA patients treated with methotrexate and folic acid.PMID:38561045 | DOI:10.1016/j.amjms.2024.03.020 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Aakash V Patel Sarah L Morgan Ralph Green Maria I Danila Tony R Merriman Keith Wanzeck Hamdy Ahmed Angelo L Gaffo Source Type: research
Spontaneous Idiopathic Bilateral Sagittal Band Rupture: A Case Report
CONCLUSION: Upon examination, she was found to have bilateral dislocation of the extensor tendons at the level of the (MCPJ) of the third and fourth digits. Any underlying cause was excluded, and the diagnosis was confirmed with a dynamic ultrasound study.PMID:38560310 | PMC:PMC10976532 | DOI:10.13107/jocr.2024.v14.i03.4302 (Source: Pain Physician)
Source: Pain Physician - April 1, 2024 Category: Anesthesiology Authors: Fatema H Madan Huda Saeed Alsahlawi Batool B Mohamed Sayed Mohamed Hasan Yusuf Omran Hasan Source Type: research
Vitamin B12 Status and Hyperhomocysteinemia in Patients with Rheumatoid Arthritis Treated with Methotrexate and Folic Acid
CONCLUSION: Our data show high plasma homocysteine levels among RA patients treated with methotrexate and folic acid. While plasma vitamin B12 levels were similar between the two groups, high plasma homocysteine is also a sensitive marker of vitamin B12 deficiency. Additional studies should evaluate for the presence of clinical features of vitamin B12 deficiency and hyperhomocysteinemia among RA patients treated with methotrexate and folic acid.PMID:38561045 | DOI:10.1016/j.amjms.2024.03.020 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Aakash V Patel Sarah L Morgan Ralph Green Maria I Danila Tony R Merriman Keith Wanzeck Hamdy Ahmed Angelo L Gaffo Source Type: research
Vitamin B12 Status and Hyperhomocysteinemia in Patients with Rheumatoid Arthritis Treated with Methotrexate and Folic Acid
CONCLUSION: Our data show high plasma homocysteine levels among RA patients treated with methotrexate and folic acid. While plasma vitamin B12 levels were similar between the two groups, high plasma homocysteine is also a sensitive marker of vitamin B12 deficiency. Additional studies should evaluate for the presence of clinical features of vitamin B12 deficiency and hyperhomocysteinemia among RA patients treated with methotrexate and folic acid.PMID:38561045 | DOI:10.1016/j.amjms.2024.03.020 (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - April 1, 2024 Category: General Medicine Authors: Aakash V Patel Sarah L Morgan Ralph Green Maria I Danila Tony R Merriman Keith Wanzeck Hamdy Ahmed Angelo L Gaffo Source Type: research
Laser capture microscopy (LCM) ‐RNAseq for topological mapping of synovial pathology during rheumatoid arthritis
ConclusionLCM-RNAseq confirms reported transcriptional differences between RA and OA synovium and provides evidence supporting a relationship between synovial topology and molecular anomalies in RA. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 1, 2024 Category: Rheumatology Authors: Benjamin Van Espen,
E. Barton Prideaux,
Andrew R. Wilson,
Camilla R.L. Machado,
Sho Sendo,
James Parker,
Gr égory Seumois,
Cristiano Sacchetti,
Anna C. Belongia,
Narayanan B. Perumal,
Pandurangan Vijayanand,
Matthew D. Linnik,
Robert J. Bensc Tags: Brief Report Source Type: research
Genes, Vol. 15, Pages 448: Predictive Role of Cluster Bean (Cyamopsis tetragonoloba) Derived miRNAs in Human and Cattle Health
ishor Gaikwad
MicroRNAs (miRNAs) are small non-coding conserved molecules with lengths varying between 18-25nt. Plants miRNAs are very stable, and probably they might have been transferred across kingdoms via food intake. Such miRNAs are also called exogenous miRNAs, which regulate the gene expression in host organisms. The miRNAs present in the cluster bean, a drought tolerant legume crop having high commercial value, might have also played a regulatory role for the genes involved in nutrients synthesis or disease pathways in animals including humans due to dietary intake of plant parts of cluster beans. However, the ...
Source: Genes - April 1, 2024 Category: Genetics & Stem Cells Authors: Sarika Sahu Atmakuri Ramakrishna Rao Tanmaya Kumar Sahu Jaya Pandey Shivangi Varshney Archna Kumar Kishor Gaikwad Tags: Article Source Type: research
Visual Quantitative Sensory Testing Provides Transdiagnostic Window into Behavioral and Functional Neural Correlates of Nociplastic Pain
Multisensory hypersensitivity to painful and non-painful stimuli, including light, is common among individuals with nociplastic pain. However, as nociplastic pain is often superimposed upon nociceptive and neuropathic pain, we hypothesized that the degree of nociplastic pain would predict the amount of sensory hypersensitivity in many chronic pain states. To assess this hypothesis, the present study investigated associations between evoked visual sensitivity, brain activation patterns, and clinical outcomes in participants with fibromyalgia (FM,n=45) - the prototypical nociplastic pain condition - and osteoarthritis (OA,n=...
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Noah Waller, Chelsea Kaplan, Andrew Schrepf, Eric Ichesco, Richard Harris, Daniel Clauw, Steven Harte Source Type: research
The Feasibility of Acupressure in Rheumatoid Arthritis
Although acupressure can be helpful in many chronic pain and fatigue states this treatment has never been explored in rheumatoid arthritis (RA). In this open label pilot study, we assessed the feasibility of a 6-week acupressure treatment regimen in RA. Baseline characterization included PROMIS 29+2 and Fibromyalgia Survey Questionnaire (FSQ). Participants completed 6 weeks of daily self-applied acupressure treatments. Post-treatment, participants completed PROMIS 29+2, FSQ, tolerability, acupressure sensation, credibility, and patient global impression of change (PGIC) scales. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Meghana Ranabothu, Richard E Harris, Daniel Clauw, Anne E Murphy Source Type: research
Nociplastic Pain Predicts Disease Activity and Hyperalgesia of Rheumatoid Arthritis Patients
Rheumatoid arthritis (RA) affects> 1.3 million people in the United States. RA is a chronic (long-lasting) autoimmune disease that mostly affects joints. Nociplastic pain has been reported in all musculoskeletal pain disorders, including RA. However, it has been mostly associated with fibromyalgia (FM) which is a widespread pain syndrome associated with insomnia, fatigue, cognitive difficulties, and dysfunction. 30 RA were recruited from UF Rheumatology Clinics. Healthy Controls (HC) were recruited from the community by advertising. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Blas Betancourt, Melyssa Godfrey, Khushi Jamwal, Emily Sanz, Roland Staud Source Type: research
A Partial Toll-like Receptor 4 Agonist Attenuates Pain While Maintaining Immunosufficiency
Activation of Toll-like Receptor 4 (TLR4) from infection or tissue damage/stress is a contributing factor to many diseases including chronic pain. Many of these pain conditions are associated with chronically elevated inflammatory cytokine expression or autoimmune dysregulation (e.g., rheumatoid arthritis, Crohn ’s disease). Current treatment includes biologics that target signaling pathways downstream of TLR4. These drugs reduce pain by reducing cytokine detection and function; many target TNF-alpha. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Richard J. Traub, Ohannes Melemedjian, Shelby Hanson, Robert K. Ernst, Alison J. Scott Source Type: research
Exploring Novel Therapeutic Targets in Inflammatory Pain: Insights from the CFA-Induced Paw Pain Model in Mice
In this study, mice were subjected to CFA-induced inflammation in the paw, mimicking aspects of rheumatoid arthritis, and subsequently assessed for behavioral (tactile and thermal allodynia) and biological (edema and inflammation assessment in paw samples) changes. (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: Kendall Walker, Carla Cancio, Oc éane Pélouin, David Babin, Evelyne Sablé, Solène Pédron Source Type: research
The acute phase reactant orosomucoid-2 directly promotes rheumatoid inflammation
In conclusion, the acute phase protein ORM2 can directly increase the production of proinflammatory mediators and promote chronic arthritis in mice, suggesting that ORM2 could be a new therapeutic target for RA.PMID:38556552 | DOI:10.1038/s12276-024-01188-0 (Source: Molecular Medicine)
Source: Molecular Medicine - March 31, 2024 Category: Molecular Biology Authors: Ki-Myo Kim Kang-Gu Lee Saseong Lee Bong-Ki Hong Heejae Yun Yune-Jung Park Seung-Ah Yoo Wan-Uk Kim Source Type: research
Serum netrin-1 levels are high in Rheumatoid arthritis associated interstitial lung disease
CONCLUSIONS: Netrin-1 is elevated in the serum of patients with RA-ILD, especially in the UIP pattern. Netrin-1 may be a potential candidate for predicting the development of RA-ILD that should be investigated in the pathophysiological and therapeutic fields.PMID:38556035 | DOI:10.1016/j.clinbiochem.2024.110760 (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - March 31, 2024 Category: Biochemistry Authors: Ahmet Kor Serdar Can G üven Sel çuk Akan Funda Eren Hatice Ecem Konak Y üksel Maraş Kevser Orhan Salim Ne şelioğlu Şükran Erten Source Type: research
