The “Unknown Unknowns” of Gastrointestinal Endoscopy
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 24, 2022 Category: Gastroenterology Authors: Amnon Sonnenberg, Gennadiy Bakis Source Type: research

Re: Over-The-Scope Clip in the Management of Nonvariceal UGI Bleeding
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 24, 2022 Category: Gastroenterology Authors: Jacqueline N. Chu, Joseph C. Yarze Source Type: research

Cross-sectional imaging may serve a greater purpose in postoperative Crohn ’s disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 24, 2022 Category: Gastroenterology Authors: Suprabhat Giri Source Type: research

Performance of noninvasive tests of fibrosis among Asians, Hispanic and non-Hispanic Whites in the STELLAR trials
This study evaluated the performance of noninvasive tests among White and Asian patients in the STELLAR trials (NCT03053050 and NCT03053063), which evaluated selonsertib in patients with advanced (F3-F4) fibrosis due to nonalcoholic steatohepatitis (NASH). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 21, 2022 Category: Gastroenterology Authors: Vincent Wai-Sun Wong, Won Young Tak, George Boon Bee Goh, Pin-Nan Cheng, Eric J. Lawitz, Zobair M. Younossi, Raj Vuppalanchi, Ziad Younes, Naim Alkhouri, Lulu Wang, Jialuo Liu, Kathryn Kersey, Robert P. Myers, Stephen A. Harrison, Zachary Goodman, Michael Source Type: research

Humoral response to 2-dose BNT162b2 mRNA COVID-19 vaccination in liver transplant recipients.
In the context of the Italian SARS-CoV-2 vaccination program, liver transplant (LT) recipients were prioritized for vaccine administration, although the lower response to vaccines is a well known problem in this population. We aimed to evaluate immunogenicity of BNT162b2 mRNA vaccine in LT recipients and healthy controls and to identify factors associated with negative response to vaccine. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 19, 2022 Category: Gastroenterology Authors: Maria Guarino, Ilaria Esposito, Giuseppe Portella, Valentina Cossiga, Ilaria Loperto, Raffaella Tortora, Michele Cennamo, Mario Capasso, Daniela Terracciano, Alfonso Galeota Lanza, Sarah Di Somma, Francesco Paolo Picciotto, Filomena Morisco, UniNa Collabo Source Type: research

Risk of infections with ustekinumab and tofacitinib compared to tumor necrosis factor α antagonists in inflammatory bowel diseases
The comparative safety of therapies is important to inform relative positioning within the therapeutic algorithm. Tumor necrosis factor α antagonists (anti-TNF) are associated with an increased risk of infections. Whether there is a similar increase with ustekinumab (UST) or tofacitinib has not been established. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 19, 2022 Category: Gastroenterology Authors: David Cheng, Bharati Kochar, Tianxi Cai, Ashwin N. Ananthakrishnan Source Type: research

Exam 2: Risk of Serious Infections With Vedolizumab Versus Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 18, 2022 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

Clinical Outcomes in Biopsy-Proven Nonalcoholic Fatty Liver Disease Patients: A Multicenter Registry-Based Cohort Study
There are no detailed reports of clinical outcomes in Asian patients with nonalcoholic fatty liver disease (NAFLD) who undergo liver biopsy. We aimed to investigate the clinical outcomes of a large cohort of Asian patients with biopsy-proven NAFLD and evaluate the specific effects of nonalcoholic steatohepatitis (NASH) and fibrosis stage. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 17, 2022 Category: Gastroenterology Authors: Hideki Fujii, Michihiro Iwaki, Hideki Hayashi, Hidenori Toyoda, Satoshi Oeda, Hideyuki Hyogo, Miwa Kawanaka, Asahiro Morishita, Kensuke Munekage, Kazuhito Kawata, Sakura Yamamura, Koji Sawada, Tatsuji Maeshiro, Hiroshi Tobita, Yuichi Yoshida, Masafumi Nai Source Type: research

A low FODMAP diet reduces symptoms in treated celiac patients with ongoing symptoms – a randomized controlled trial
Gluten-free diet usually leads to mucosal remission in celiac disease, but persistent symptoms are common. Low FODMAP diet is an established treatment for irritable bowel syndrome (IBS). We have assessed the efficacy of a moderately low FODMAP diet on persistent symptoms in treated celiac patients. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 17, 2022 Category: Gastroenterology Authors: Frida van Megen, Gry I. Skodje, Simon Lergenmuller, Stephanie Z ühlke, Lars Aabakken, Marit B. Veierød, Christine Henriksen, Knut E.A. Lundin Source Type: research

MAFLD and pregnancy – What are the consequences?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 16, 2022 Category: Gastroenterology Authors: Akiko Nakanishi, Linda Henry, Mindie H. Nguyen Source Type: research

Exam 1: Risk of Serious Infections With Vedolizumab Versus Tumor Necrosis Factor Antagonists in Patients With Inflammatory Bowel Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

Issue Highlights
Although colonoscopy with polypectomy has been shown to reduce the overall incidence and mortality from colorectal cancer (CRC), the impact on proximal colon cancers has been harder to demonstrate. Retroflexion in the right colon (RC) and re-examining the RC with a second forward view (SFV) have been shown to increase RC ADR but studies have been limited to a single site, raising the question of generalizability. Tang et  al.1 conducted an international multicenter randomized trial evaluating SFV vs standard withdrawal colonoscopy (SWC) on RC ADR. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Authors: Jane Onken Tags: Issue Highlights Source Type: research

Exam 1: Magnitude and Time-Trend Analysis of Postendoscopy Esophageal Adenocarcinoma: A Systematic Review and Meta-analysis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Source Type: research

Table of Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Source Type: research

Elsewhere in the AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute brings you the best original research in the field with a unique combination of reviews, editorials, podcasts, video abstracts, and outcomes research —all supporting clinical practice. Articles on education, policy, and practice management highlight issues pertinent to clinicians. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Source Type: research

Prostate Cancer Masquerading as Colon Adenocarcinoma
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 13, 2022 Category: Gastroenterology Authors: Preet Patel, Cheng Huang, Erik C. von Rosenvinge Tags: Image of the Month Source Type: research

Induction efficacy of upadacitinib in therapy-refractory crohn ’s disease - a retrospective case series
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 12, 2022 Category: Gastroenterology Authors: Pokryszka Jagoda, Reinisch Sieglinde, Primas Christian, Novacek Gottfried, Reinisch Walter Source Type: research

Dibothriocephalus nihonkaiensis incidentally detected at colonoscopy
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 12, 2022 Category: Gastroenterology Authors: Kimitoshi Kubo, Mototsugu Kato, Yasuhiko Sako Tags: Image of the Month Source Type: research

Some issues considered for clip closure after endoscopic resection of large serrated polyps
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 12, 2022 Category: Gastroenterology Authors: Qing Lu, Xiu-He Lv, Jin-Lin Yang Source Type: research

Spleen size does not correlate with histological stage of liver disease in people with non-alcoholic fatty liver disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 12, 2022 Category: Gastroenterology Authors: Tessa M. Cacciottolo, Anupa Kumar, Edmund M. Godfrey, Susan E. Davies, Michael Allison Source Type: research

Reply to “Body-mass index and PNPLA3 genetic variant modify the association of alcohol consumption with liver fat content”
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 12, 2022 Category: Gastroenterology Authors: Antonio De Vincentis, Federica Tavaglione, Stefano Romeo, Umberto Vespasiani-Gentilucci Source Type: research

What Faculty and Fellows Should Know About Milestones 2.0
This article highlights new features of the gastroenterology (GI) and hepatology milestones and provides action items for programs from a faculty and a fellow perspective. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 11, 2022 Category: Gastroenterology Authors: Lauren L. Donnangelo, Brijen Shah Tags: Educator and Trainee Perspectives Source Type: research

Risk Factors for Incident Inflammatory Bowel Disease According to Disease Phenotype
We examined whether relationships between known risk factors for Crohn ’s disease (CD) and ulcerative colitis (UC) differ according to disease phenotype, defined by Montreal classification, at the time of diagnosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 11, 2022 Category: Gastroenterology Authors: Emily W. Lopes, Paul Lochhead, Kristin E. Burke, James M. Richter, Ashwin N. Ananthakrishnan, Andrew T. Chan, Hamed Khalili Source Type: research

Fenofibrate Mitigates Hypertriglyceridemia in Nonalcoholic Steatohepatitis Patients Treated With Cilofexor/Firsocostat
Patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH) are at high risk of morbidity and mortality. We previously found that a combination of the farnesoid X receptor agonist cilofexor (CILO) and the acetyl-CoA carboxylase (ACC) inhibitor firsocostat (FIR) improved liver histology and biomarkers in NASH with advanced fibrosis but was associated with hypertriglyceridemia. We evaluated the safety and efficacy of icosapent ethyl (Vascepa ®) and fenofibrate to mitigate triglyceride elevations in NASH patients treated with CILO and FIR. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 6, 2022 Category: Gastroenterology Authors: Eric J. Lawitz, Bal Raj Bhandari, Peter J. Ruane, Anita Kohli, Eliza Harting, Dora Ding, Jen-Chieh Chuang, Ryan S. Huss, Chuhan Chung, Robert P. Myers, Rohit Loomba Source Type: research

Association of physical activity with risk of liver fibrosis, sarcopenia, and cardiovascular disease in NAFLD
This study investigated the association of physical activity with risk of liver fibrosis, sarcopenia, and cardiovascular disease (CVD) in NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 5, 2022 Category: Gastroenterology Authors: Ho Soo Chun, Minjong Lee, Hye Ah Lee, Seo Yeong Oh, Hyo Jeong Baek, Jae Won Moon, Yeon Jeong Kim, Jinha Lee, Hyoeun Kim, Hwi Young Kim, Kwon Yoo, Tae Hun Kim, Seung Up Kim Source Type: research

Antibody Response Six Months after SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 5, 2022 Category: Gastroenterology Authors: Sarah Frey, Reezwana Chowdhury, Caoilfhionn M. Connolly, William A. Werbel, Dorry L. Segev, Alyssa M. Parian, IBD Group, Evangelos Tsipotis, Sharon Dudley-Brown, Mark Lazarev, Joanna M. Melia, Brindusa Truta, Huimin Yu, Florin M. Selaru Source Type: research

Severe Bleeding Gastric Barotrauma Unmasking Collagenous Gastritis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 5, 2022 Category: Gastroenterology Authors: Kenneth Leung, Irene Thung, Muhammad Bader Hammami Tags: Image of the Month Source Type: research

QuickStroop, a Shortened Version of EncephalApp, Detects Covert Hepatic Encephalopathy with Similar Accuracy within One Minute
Covert Hepatic Encephalopathy (CHE) is associated with poor outcomes but is often not diagnosed due to the time requirement. Psychometric hepatic encephalopathy (PHES) is the gold standard against which EncephalApp Stroop has been validated. However, EncephalApp (5 runs each in “Off” and “On” state) can take up to 10 minutes. Aim: Define the smallest number of EncephalApp runs needed for comparable accuracy to as the total EncephalApp using CHE on PHES as gold standard. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 5, 2022 Category: Gastroenterology Authors: Chathur Acharya, Jawaid Shaw, Nikki Duong, Andrew Fagan, Sara McGeorge, James B. Wade, Leroy R. Thacker, Jasmohan S. Bajaj Source Type: research

Can a Defecation Posture Modifying Device Correct an Abnormal Balloon Expulsion Test in Chronically Constipated Patients?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 5, 2022 Category: Gastroenterology Authors: Eden Koo, William D. Chey, Gabrielle Ezell, Jason R. Baker, Moira Armstrong, Borko Nojkov Source Type: research

Prevalence and Implications of Frailty in Older Adults with Incident Inflammatory Bowel Diseases: a Nationwide Cohort Study
We aimed to compare the risk of frailty in older adults with incident inflammatory bowel disease (IBD) and matched non-IBD comparators and assess the association between frailty and future hospitalizations and mortality. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 5, 2022 Category: Gastroenterology Authors: Bharati Kochar, Juulia Jylh ävä, Jonas Söderling, Christine S. Ritchie, the SWIBREG study group, Jonas F. Ludvigsson, Hamed Khalili, Ola Olén Source Type: research

Advanced Imaging Within the Bile Duct During Endoscopic Retrograde Cholangiopancreatography
Despite innovation in bile duct imaging over the past 2 decades, indeterminate biliary strictures remain a diagnostic challenge. The prototypical case is a patient who presents with a bile duct stricture, usually symptomatic, but no discrete mass is identified on cross-sectional imaging. The differential diagnosis includes cholangiocarcinoma; other malignancies; and fibroinflammatory causes, such as primary sclerosing cholangitis and autoimmune cholangiopathy. How has recent innovation changed the approach to these patients? (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 4, 2022 Category: Gastroenterology Authors: Kaveh Sharzehi, Gregory A. Cote Tags: Here and Now: Clinical Practice Source Type: research

High-Definition Colonoscopy Compared With Cuff- and Cap-Assisted Colonoscopy: Results From a Multicenter, Prospective, Randomized Controlled Trial
Mucosal exposure devices including distal attachments such as the cuff and cap have shown variable results in improving adenoma detection rates (ADRs) compared with high-definition white light colonoscopy (HDWLE). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 31, 2021 Category: Gastroenterology Authors: Madhav Desai, Douglas K. Rex, Matthew E. Bohm, Perica Davitkov, John M. DeWitt, Monika Fischer, Gregory Faulx, Ryan Heath, Timothy D. Imler, Toyia N. James-Stevenson, Charles J. Kahi, William R. Kessler, Divyanshoo R. Kohli, Lee McHenry, Tarun Rai, Nichol Source Type: research

High-definition colonoscopy compared to cuff- and cap-assisted colonoscopy: Results from a multi-center, prospective, randomized controlled trial
Mucosal exposure devices including distal attachments such as the cuff and cap have shown variable results in improving adenoma detection rates (ADR) compared to high-definition white light colonoscopy (HDWLE). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 31, 2021 Category: Gastroenterology Authors: Madhav Desai, Douglas K. Rex, Matthew E. Bohm, Perica Davitkov, John M. DeWitt, Monika Fischer, Gregory Faulx, Ryan Heath, Timothy D. Imler, Toyia N. James-Stevenson, Charles J. Kahi, William R. Kessler, Divyanshoo R. Kohli, Lee McHenry, Tarun Rai, Nichol Source Type: research

A prospective cohort study of novel markers of hepatitis B virus replication in human immunodeficiency virus coinfection
The contribution of the novel biomarkers, HBV RNA and HBcrAg, to characterization of HBV-HIV coinfection is unclear. We evaluated the longitudinal dynamics of HBV RNA and HBcrAg and their association with classical HBV serum biomarkers and liver histology and viral staining. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 28, 2021 Category: Gastroenterology Authors: Raymond T. Chung, Wendy C. King, Marc G. Ghany, Mauricio Lisker-Melman, Amanda S. Hinerman, Mandana Khalili, Mark Sulkowski, Mamta K. Jain, Eun-Young K. Choi, Michael A. Nalesnik, Atul K. Bhan, Gavin Cloherty, David K. Wong, Richard K. Sterling, HBV-HIV C Source Type: research

Low accuracy of FIB-4 and NAFLD fibrosis scores for screening for liver fibrosis in the population
Fibrosis-4 (FIB-4) and the NAFLD fibrosis score (NFS) are the two most popular non-invasive blood-based serum tests proposed for widespread fibrosis screening. We therefore aimed to describe the accuracy of FIB-4 and NFS to detect elevated liver stiffness as an indicator of hepatic fibrosis in low-prevalence populations. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 28, 2021 Category: Gastroenterology Authors: Isabel Graupera, Maja Thiele, Miquel Serra-Burriel, Lloren ç Caballeria, Dominique Roulot, Grace Lai-Hung Wong, Núria Fabrellas, Indra Neil Guha, Anita Arslanow, Carmen Expósito, Rosario Hernández, Guruprasad Padur Aithal, Peter R. Galle, Guillem Pera Source Type: research

Reply
I would like to reply to the letter to the editor sent by Phan and colleagues regarding our article in Clinical Gastroenterology and Hepatology.1 First, I thank Dr Phan and colleagues for their interest in our research field. The authors raise some concerns on the article addressed in the following. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Benjamin Walter Tags: Letter to the Editor Source Type: research

Reply
We would like to thank Dr Mohta and colleagues for their interest in our study and for their comments. As we showed in our work, our cohort of patients with advanced nonalcoholic fatty liver disease (NAFLD) developed clinical decompensation at lower hepatic venous pressure gradient (HVPG) values as compared with a cohort of patients with hepatitis C virus –related chronic liver disease. We hypothesized that this may be a consequence of an underestimation of the actual portal pressure as assessed by the HVPG measurement,1 although we agree with the authors that the causes underlying this observation may be multifactor...
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Octavi Bassegoda, Pol Olivas, Isabel Graupera, Virginia Hern ández-Gea Tags: Letter to the Editor Source Type: research

Novel diagnostic autoantibodies against Endothelial Protein C Receptor in patients with ulcerative colitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Yoichi Kakuta, Tsuyoshi Shirai, Dermot P.B. McGovern, Jonathan Braun, Hiroshi Fujii, Atsushi Masamune Source Type: research

Clip closure does not reduce risk of bleeding after resection of large serrated polyps: results from a randomized trial
Serrated polyps are important colorectal cancer precursors and are most commonly located in the proximal colon where post-polypectomy bleeding rates are higher. There is limited clinical trial evidence to guide best practices for resection of large serrated polyps (LSPs). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Seth D. Crockett, Mouen Khashab, Douglas K. Rex, Ian S. Grimm, Matthew T. Moyer, Amit Rastogi, Todd A. Mackenzie, Heiko Pohl, Large Polyp Study Group Consortium Source Type: research

Reply on Letter to the editor Digital health interventions for colorectal polyp detection: are we ready for prime time?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Benjamin Walter Source Type: research

Reply to “Decompensation in patients with non-alcoholic steatohepatitis: A multi-hit hypothesis”
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Octavi Bassegoda, Pol Olivas, Isabel Graupera, Virginia Hern ández-Gea Source Type: research

Look for a physical health status surrogate in hepatocellular carcinoma: Have we found the Holy Grail?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 27, 2021 Category: Gastroenterology Authors: Teh-Ia Huo, Shu-Yein Ho, Chia-Yang Hsu Source Type: research

Upadacitinib Was Efficacious and Well-tolerated Over 30 Months in Patients With Crohn ’s Disease in the CELEST Extension Study
The long-term efficacy and safety of upadacitinib was evaluated in an open-label extension (OLE) of a phase II, double-blind, randomized trial of patients with Crohn ’s disease. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Geert D ’Haens, Julian Panés, Edouard Louis, Ana Lacerda, Qian Zhou, John Liu, Edward V. Loftus Source Type: research

Deep Remission in Crohn ’s Disease: Optional or Quintessential
We read with great interest the recently published article by Laharie et  al,1 reporting the long-term follow-up data of patients with Crohn’s disease (CD) from the TAILORIX trial, having sustained corticosteroid-free remission on infliximab. The authors reported that around 47% of the patients had sustained corticosteroid-free clinical remission at the time of inclus ion. There was no difference concerning anal surgery, major abdominal surgery, CD-related hospitalization, or the need for a new systemic CD treatment between patients who achieved remission and those who did not. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Suprabhat Giri, Sumaswi A, Vaneet Jearth Tags: Letters to the Editor Source Type: research

Upadacitinib Was Efficacious and Well Tolerated Over 30 Months in Patients with Crohn ’s Disease in the CELEST Extension Study
The long-term efficacy and safety of upadacitinib was evaluated in an open-label extension (OLE) of a phase 2, double-blind, randomized trial of patients with Crohn ’s disease (CD). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Geert D ’Haens, Julian Panés, Edouard Louis, Ana Lacerda, Qian Zhou, John Liu, Edward V. Loftus Source Type: research

Deep remission in Crohn ’s disease – optional or quintessential.
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: Suprabhat Giri, Sumaswi A, Vaneet Jearth Source Type: research

Impact of SARS-CoV-2 pandemic on vascular liver diseases
Vascular liver diseases (VLD) are represented mainly by portosinusoidal vascular disease (PSVD), non-cirrhotic splanchnic vein thrombosis (SVT) and Budd Chiari syndrome (BCS). It is unknown whether patients with VLD constitute a high-risk population for complications and greater COVID-19-related mortality from SARS-CoV-2 infection. Our objective was to assess the prevalence and severity of SARS-CoV-2 infection among patients with VLD, as well as to assess its impact on hepatic decompensation and survival. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2021 Category: Gastroenterology Authors: A. Baiges, E. Cerda, C. Amicone, L. T éllez, E. Alvarado-Tapias, A. Puente, J.I. Fortea, E. Llop, F. Rocha, L. Orts, O. Ros-Fargas, P. Vizcarra, K. Zekrini, Y. Ould Amara, G. Touati, N. Jimenez, M.J. Serrano, A. Falgà, M. Magaz, P. Olivas, F. Betancourt Source Type: research