Reply
We appreciate the thoughtful response by Peng et  al to our study showing clinical predictors and outcomes of alanine aminotransferase (ALT) flares in patients with chronic hepatitis B.1 (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Mayur Brahmania, Harry L.A. Janssen Tags: Letter to the Editor Source Type: research

Value of VAV3 Methylation in Stool DNA Might Be Restricted to Non –Thiopurine-Treated Inflammatory Bowel Disease Patients
Fecal testing in general and fecal immunochemical testing for hemoglobin in particular have become important screening modalities for the prevention and early detection of sporadic colorectal cancer (CRC). Constant improvements in feces-based screening methodology now have resulted in satisfactory sensitivity and specificity, even in population-wide approaches.1 However, the use of fecal immunochemical testing is less suitable for specific patient populations at risk for CRC, especially in patients with inflammatory bowel disease (IBD), who often display colonic luminal bleeding resulting from ulceration. (Source: Clinical...
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Suk Yee Lam, Jun Yu, Maikel. P. Peppelenbosch Tags: Letter to the Editor Source Type: research

Learning Curve for Endoscopic Submucosal Dissection With an Untutored, Prevalence-Based Approach in the United States
Endoscopic submucosal dissection (ESD) is widely used in Asia to resect early-stage gastrointestinal neoplasms, but use of ESD in Western countries is limited. We collected data on the learning curve for ESD at a high-volume referral center in the United States to guide development of training programs in the Americas and Europe. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Xiaocen Zhang, Erin K. Ly, Sagarika Nithyanand, Rani J. Modayil, Dmitriy O. Khodorskiy, Sivaram Neppala, Sriya Bhumi, Matthew DeMaria, Jessica L. Widmer, David M. Friedel, James H. Grendell, Stavros N. Stavropoulos Source Type: research

Optimal Timing of Total Gastrectomy to Prevent Diffuse Gastric Cancer in Individuals with Pathogenic Variants in CDH1
Carriers of pathogenic variants in CDH1 have a high risk of hereditary diffuse gastric cancer (HDGC). Guidelines recommend prophylactic total gastrectomy (PTG) at age 20 –30 years, although there is controversy over the optimal age. We developed a simulation model to analyze the effects of PTG at different ages on quality-adjusted life-years (QALYs), cancer mortality, and life expectancy. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Monika Laszkowska, Elisabeth Silver, Beth Schrope, Fay Kastrinos, Timothy C. Wang, Chin Hur Source Type: research

Endoscopic Ultrasound-Guided Confocal Laser Endomicroscopy Increases Accuracy of Differentiation of Pancreatic Cystic Lesions
Imaging patterns from endoscopic ultrasound (EUS)-guided needle-based confocal laser endomicroscopy (nCLE) have been associated with specific pancreatic cystic lesions (PCLs). We compared the accuracy of EUS with nCLE in differentiating mucinous from non-mucinous PCLs with that of measurement of carcinoembryonic antigen (CEA) and cytology analysis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Somashekar G. Krishna, Phil A. Hart, Ahmad Malli, Andrew Kruger, Sean T. McCarthy, Samer El-Dika, Jon P. Walker, Mary E. Dillhoff, Andrei Manilchuk, Carl R. Schmidt, Timothy M. Pawlik, Kyle Porter, Christina A. Arnold, Zobeida Cruz-Monserrate, Darwin L. C Source Type: research

Increasing Mortality Among Patients With Diabetes and Chronic Liver Disease From 2007 Through 2017
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Donghee Kim, George Cholankeril, Sun H. Kim, Fahim Abbasi, Joshua W. Knowles, Aijaz Ahmed Source Type: research

Clinical and Pathological Characterization of Lynch-Like Syndrome
Lynch syndrome is characterized by DNA mismatch repair (MMR) deficiency. Some patients with suspected Lynch syndrome have DNA MMR deficiencies but no detectable mutations in genes that encode MMR proteins —this is called Lynch-like syndrome (LLS). There is no consensus on management of patients with LLS. We collected data from a large series of patients with LLS to identify clinical and pathology features. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Maria Dolores Pic ó, Adela Castillejo, Óscar Murcia, Mar Giner-Calabuig, Miren Alustiza, Ariadna Sánchez, Leticia Moreira, María Pellise, Antoni Castells, Marta Carrillo-Palau, Teresa Ramon y Cajal, Alexandra Gisbert-Beamud, Gemma Llort, Carmen Yagüe Source Type: research

Increased Prevalence of Celiac Disease in School-age Children in Italy
Celiac disease is one of the most common diseases worldwide, with an apparent trend of increasing prevalence. We investigated the prevalence of celiac disease in children in Italy in 2015 –2016 and compared that with data from 25 years ago. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Simona Gatti, Elena Lionetti, Linda Balanzoni, Anil K. Verma, Tiziana Galeazzi, Rosaria Gesuita, Novella Scattolo, Mauro Cinquetti, Alessio Fasano, Carlo Catassi, Celiac Screening Team, Roberta Annibali, Giada Del Baldo, Elisa Franceschini, Alessandra Pal Source Type: research

Trichuris trichiura in the colon
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Shunsuke Yamamoto, Antonios Kalepouris Tags: Image of the Month Source Type: research

Reply: Pancreatic fiducial markers placement: time is on my side
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Jorge D. Machicado, Jason Klapman, Sachin Wani Source Type: research

Monitoring a combination of calprotectin and infliximab identifies patients with mucosal healing of Crohn ’s disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Cong Dai, Min Jiang, Ming-jun Sun Source Type: research

An Abdominal mass in a Patient with Neurofibromatosis Type 1
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Savan Kabaria, Hae Yoon Grace Choung, Sushil Ahlawat Source Type: research

Reply to: Understanding more about hepatitis flare in chronic hepatitis B patients
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Mayur Brahmania, Harry L.A. Janssen Source Type: research

Value of VAV3 methylation in stool DNA might be restricted to non-thiopurine treated inflammatory bowel disease patients
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 17, 2019 Category: Gastroenterology Authors: Suk Yee Lam, Jun Yu, Maikel. P. Peppelenbosch Source Type: research

Reply
We appreciate the thoughtful comments from Dr. Lai and agree that “vaccination for herpes zoster is the best way to prevent this disease and its consequences (such as postherpetic neuralgia).” Dr Lai calculated the number needed to treat (NNT) on the basis of the reciprocal of the difference in herpes zoster incidence rates between the vaccinated and unvaccina ted groups. However, the NNT estimate generated from this approach may be difficult to interpret for several reasons. Because this NNT is computed from the incidence rate of events, its inverse does not represent persons but rather person-time. (Source: C...
Source: Clinical Gastroenterology and Hepatology - June 13, 2019 Category: Gastroenterology Authors: Nabeel Khan, Dawei Xie, Yu-Xiao Yang Tags: Letter to the Editor Source Type: research

Response to letter to editor: Herpes zoster vaccine in older adults with Inflammatory Bowel Disease Running head: Herpes zoster and Inflammatory Bowel Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 13, 2019 Category: Gastroenterology Authors: Nabeel Khan, Dawei Xie, Yu-Xiao Yang Source Type: research

Racial Disparities and Trends in Pancreatic Cancer Incidence and Mortality in the United States
Pancreatic cancer is one of the few cancers in the United States that is increasing in incidence. Little is known about racial disparities in incidence and mortality. We characterized racial disparities in pancreatic cancer incidence and mortality in different locations, time periods, age groups, and disease stages. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 13, 2019 Category: Gastroenterology Authors: Anna Tavakkoli, Amit G. Singal, Akbar K. Waljee, B. Joseph Elmunzer, Sandi L. Pruitt, Thomas McKey, Joel H. Rubenstein, James M. Scheiman, Caitlin C. Murphy Source Type: research

Efficacy of Tumor Necrosis Factor Antagonist Treatment in Patients With Refractory Ulcerative Proctitis
It is a challenge to manage patients with ulcerative proctitis, UP) refractory to standard therapy. We investigated the effectiveness of tumor necrosis factor, TNF) antagonists in a large cohort of patients with refractory UP. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 13, 2019 Category: Gastroenterology Authors: Guillaume Pineton de Chambrun, Aur élien Amiot, Guillaume Bouguen, Stéphanie Viennot, Romain Altwegg, Edouard Louis, Michael Collins, Mathurin Fumery, Florian Poullenot, Laura Armengol, Anthony Buisson, Vered Abitbol, David Laharie, Philippe Seksik, St Source Type: research

Genetic and Inflammatory Biomarkers Classify Small Intestine Inflammation in Asymptomatic First-degree Relatives of Patients With Crohn ’s Disease
Relatives of individuals with Crohn's disease (CD) carry CD-associated genetic variants and are often exposed to environmental factors that increase their risk for this disease. We aimed to estimate the utility of genotype, smoking status, family history, and other biomarkers can be used to calculate risk in asymptomatic first-degree relatives of patients with CD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 13, 2019 Category: Gastroenterology Authors: Kirstin M. Taylor, Ken B. Hanscombe, Natalie J. Prescott, Raquel Iniesta, Matthew Traylor, Nicola S. Taylor, Steven Fong, Nicholas Powell, Peter M. Irving, Simon H. Anderson, Christopher G. Mathew, Cathryn M. Lewis, Jeremy D. Sanderson Source Type: research

Statin therapy and mortality of hepatocellular carcinoma
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 13, 2019 Category: Gastroenterology Authors: Shih-Wei Lai Source Type: research

Risk of Development of More-advanced Lesions in Patients With Inflammatory Bowel Diseases and Dysplasia
Patients with inflammatory bowel diseases (IBD) have increased risks of dysplasia and colitis-associated cancer (CAC). We evaluated the risk of development of high-grade dysplasia (HGD) or CAC after diagnosis of dysplasia using data from a national cohort of patients with IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 13, 2019 Category: Gastroenterology Authors: Anneline Cremer, Pieter Demetter, Martine De Vos, Jean-Fran çois Rahier, Filip Baert, Tom Moreels, Elisabeth Macken, Edouard Louis, Liesbeth Ferdinande, Caroline Fervaille, Franceska Dedeurwaerdere, Noela Bletard, Ann Driessen, Gert De Hertogh, Séverine Source Type: research

Development and Validation of Hepamet Fibrosis Scoring System A Simple, Noninvasive Test to Identify Patients With Nonalcoholic Fatty Liver Disease With Advanced Fibrosis
Fibrosis affects prognoses for patients with nonalcoholic fatty liver disease (NAFLD). Several non-invasive scoring systems have aimed to identify patients at risk for advanced fibrosis, but inconclusive results and variations in features of patients (diabetes, obesity and older age) reduce their diagnostic accuracy. We sought to develop a scoring system based on serum markers to identify patients with NAFLD at risk for advanced fibrosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 10, 2019 Category: Gastroenterology Authors: Javier Ampuero, Raluca Pais, Roc ío Aller, Rocío Gallego-Durán, Javier Crespo, Carmelo García-Monzón, Jerome Boursier, Eduardo Vilar, Salvatore Petta, Zheng Ming-Hua, Desamparados Escudero, Jose Luis Calleja, Patricia Aspichueta, Moisés Diago, Jose Source Type: research

Risk of Major Gastrointestinal Bleeding With New vs Conventional Oral Anticoagulants: A Systematic Review and Meta-analysis
There is controversy over whether use of non-vitamin K antagonist oral anticoagulants (NOACs) associates with increased risk of major gastrointestinal bleeding (GIB) compared with conventional therapies (such as vitamin K antagonists or anti-platelet agents). We performed a systematic review and meta-analysis of data from randomized controlled trials and high-quality real-world studies. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 10, 2019 Category: Gastroenterology Authors: Zhi-Chun Gu, An-Hua Wei, Chi Zhang, Xin-Hua Wang, Le Zhang, Long Shen, Zheng Li, Mang-Mang Pan, Xiao-Yan Liu, Jun Pu, Hou-Wen Lin Source Type: research

Development and Validation of Hepamet Fibrosis Scoring System —a Simple, Non-invasive Test to Identify Patients With Nonalcoholic Fatty liver Disease With Advanced Fibrosis
Fibrosis affects prognoses for patients with nonalcoholic fatty liver disease (NAFLD). Several non-invasive scoring systems have aimed to identify patients at risk for advanced fibrosis, but inconclusive results and variations in features of patients (diabetes, obesity and older age) reduce their diagnostic accuracy. We sought to develop a scoring system based on serum markers to identify patients with NAFLD at risk for advanced fibrosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 10, 2019 Category: Gastroenterology Authors: Javier Ampuero, Raluca Pais, Roc ío Aller, Rocío Gallego-Durán, Javier Crespo, Carmelo García-Monzón, Jerome Boursier, Eduardo Vilar, Salvatore Petta, Zheng Ming-Hua, Desamparados Escudero, Jose Luis Calleja, Patricia Aspichueta, Moisés Diago, Jose Source Type: research

Cold Snare Polypectomy: Techniques and Applications
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 10, 2019 Category: Gastroenterology Authors: Rajesh N. Keswani Source Type: research

Understanding more about hepatitis flare in chronic hepatitis B patients
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 10, 2019 Category: Gastroenterology Authors: Chien-Wei Peng, Wen-Juei Jeng Source Type: research

Risk of Major Gastrointestinal Bleeding With New vs Conventional Oral Anticoagulants —a Systematic Review and Meta-analysis
There is controversy over whether use of non-vitamin K antagonist oral anticoagulants (NOACs) associates with increased risk of major gastrointestinal bleeding (GIB) compared with conventional therapies (such as vitamin K antagonists or anti-platelet agents). We performed a systematic review and meta-analysis of data from randomized controlled trials and high-quality real-world studies. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 10, 2019 Category: Gastroenterology Authors: Zhi-Chun Gu, An-Hua Wei, Chi Zhang, Xin-Hua Wang, Le Zhang, Long Shen, Zheng Li, Mang-Mang Pan, Xiao-Yan Liu, Jun Pu, Hou-Wen Lin Source Type: research

Potential Benefits of Switching Liver Transplant Recipients to Tenofovir Alafenamide Prophylaxis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 10, 2019 Category: Gastroenterology Authors: Pimsiri Sripongpun, Ajitha Mannalithara, Paul Y. Kwo, W. Ray Kim Source Type: research

Cutaneous and orbital metastases of intrahepatic cholangiocellular carcinoma
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 10, 2019 Category: Gastroenterology Authors: Ken Kawabe, Kazunori Urabe, Seiya Momosaki Tags: Image of the Month Source Type: research

Manuscript submission for: Clinical Gastroenterology & Hepatology: Predicting Functional Status After Transplantation in Patients with Acute on Chronic Liver Failure
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 7, 2019 Category: Gastroenterology Authors: Beverley Kok, Andres Duarte-Rojo, Puneeta Tandon Source Type: research

Aiming for the Vessel in Investigation of Perivascular Space to Stage Gastrointestinal Malignancies
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 7, 2019 Category: Gastroenterology Authors: Michael B. McCabe, Vanessa M. Shami Source Type: research

Lowering Portal Pressure Improves Outcomes of Patients With Cirrhosis, With or Without Ascites: A Meta-Analysis
In unselected patients with cirrhosis, those with reductions in hepatic venous pressure gradient (HVPG) to below a defined threshold (responders) have a reduced risk of variceal hemorrhage (VH) and death. We performed a meta-analysis to compare this effect in patients with vs without ascites. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 5, 2019 Category: Gastroenterology Authors: L. Turco, C. Villanueva, V. La Mura, J.C. Garc ía-Pagán, T. Reiberger, J. Genescà, R.J. Groszmann, B.C. Sharma, C. Merkel, C. Bureau, E. Alvarado, J.G. Abraldes, A. Albillos, R. Bañares, M. Peck-Radosavljevic, S. Augustin, S. Sarin, J. Bosch, G. Garc Source Type: research

Utility of Endoscopic Submucosal Dissection in T1b Esophageal Cancer
Among esophageal neoplasms, the 2 most common cancers by cell type are squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). Whereas ESCC is the most common type of cancer worldwide,1 EAC is more prevalent than ESCC in the Western world, especially in North America.2 (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Authors: Mohamed O. Othman, Jeffrey H. Lee, Kenneth Wang Tags: Clinical Practice Update: Expert Review Source Type: research

Rate, Risk Factors, and Outcomes of Nonadherence in Pediatric Patients With Celiac Disease: A Systematic Review
The only treatment for celiac disease is strict adherence to a gluten-free diet (GFD). We performed a systematic review to investigate the rate of adherence to a GFD in children with celiac disease, risk factors that affect adherence, and outcomes of non-adherence. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Authors: Anna Myl éus, Norelle R. Reilly, Peter H.R. Green Source Type: research

The Utility of Endoscopic Submucosal Dissection (ESD) in T1b Esophageal Cancer
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Authors: Mohamed O. Othman, Jeffrey H. Lee, Kenneth Wang Source Type: research

Rate, Risk Factors and Outcomes of Non-adherence in Pediatric Patients with Celiac Disease: a Systematic Review
The only treatment for celiac disease is strict adherence to a gluten-free diet (GFD). We performed a systematic review to investigate the rate of adherence to a GFD in children with celiac disease, risk factors that affect adherence, and outcomes of non-adherence. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Authors: Anna Myl éus, Norelle R. Reilly, Peter H.R. Green Source Type: research

Gaps in Viral Hepatitis Awareness in the United States in a Population-based Study
The benefits of highly effective therapies for chronic hepatitis B virus (HBV) or HCV infection can only be realized if infected individuals are identified and linked to care. We sought to identify gaps in awareness of diagnosis of HBV or HCV infection in a population-based sample of adults living in the United States (US). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 4, 2019 Category: Gastroenterology Authors: Kali Zhou, Norah A. Terrault Source Type: research

A System to Determine Risk of Osteoporosis in Patients With Autoimmune Hepatitis
Osteoporosis is a feared complication of autoimmune hepatitis (AIH), but bone disease has not been well studied in these patients. We aimed to identify specific risk factors for osteoporosis in patients with AIH and to develop a scoring system that could be used to identify patients with increased risk of osteoporosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 1, 2019 Category: Gastroenterology Authors: Tobias Schmidt, Constantin Schmidt, Andre Strahl, Haider Mussawy, Tim Rolvien, Nico M. Jandl, Christian Casar, Ralf Oheim, Thorsten Schinke, Ansgar W. Lohse, Michael Amling, Christoph Schramm, Florian Barvencik Source Type: research

Mean Nocturnal Baseline Impedance Correlates with Symptom Outcome When Acid Exposure Time is Inconclusive on Esophageal Reflux Monitoring
Abnormal acid exposure time (AET) associates with good outcomes of symptoms from anti-reflux therapy. Low esophageal mean nocturnal baseline impedance (MNBI) is an additional marker of reflux disease. We aimed to evaluate the value of MNBI when analysis of AET produces borderline or inconclusive results. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 1, 2019 Category: Gastroenterology Authors: Arvind Rengarajan, Edoardo Savarino, Marco Della Coletta, Matteo Ghisa, Amit Patel, C. Prakash Gyawali Source Type: research

Bowel Preparation Agent –Associated Esophageal and Gastric Complication
A 66-year-old man was referred for gastrointestinal bleeding after a negative upper endoscopy. He underwent a colonoscopy with bowel preparation using sodium picosulfate/magnesium citrate (SPMC). The patient reported having chest discomfort after taking the first dose of SPMC. The colonoscopy suggested small-bowel bleeding and an enteroscopy was performed. Mucosal necrosis of the middle to lower esophagus (Figure A) and linear erythema in the proximal stomach (Figure B and Video 1) was found during enteroscopy. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 30, 2019 Category: Gastroenterology Authors: Yu-Chun Hsu, Yang-Yuan Chen, Hsu-Heng Yen Tags: Electronic Image of the Month Source Type: research

Increasing Incidence and Mortality of Gastric Cancer in Immigrant Populations from High to Low Regions of Incidence - a Systematic Review and Meta-Analysis
Gastric cancer is the leading cause of infection-related cancer death and the third-leading cause of cancer death worldwide. The effect of immigration on gastric cancer risk is not well-defined but might be helpful for screening or surveillance endeavors. We performed a systematic review and meta-analysis to define the risk of gastric cancer in immigrants from high-incidence regions to low-incidence regions (Western Europe, Australia, Brazil, Canada, Israel, and the United States). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 30, 2019 Category: Gastroenterology Authors: Baldeep S. Pabla, Shailja C. Shah, Juan E. Corral, Douglas R. Morgan Source Type: research

Bowel preparation agent associated esophageal and gastric complication
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 30, 2019 Category: Gastroenterology Authors: Yu-Chun Hsu, Yang-Yuan Chen, Hsu-Heng Yen Tags: Image of the Month Source Type: research

Epidemiological, Clinical, and Psychological Characteristics of Individuals with Self-reported Irritable Bowel Syndrome Based on the Rome IV vs Rome III Criteria
Few studies have examined the effects of applying the Rome IV criteria for irritable bowel syndrome (IBS) vs the previous standard, the Rome III criteria. We conducted a cross-sectional survey of individuals who self-identify as having IBS to examine this issue. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 30, 2019 Category: Gastroenterology Authors: Christopher J. Black, Yan Yiannakou, Lesley A. Houghton, Alexander C. Ford Source Type: research

Oropharyngeal Findings at Upper Endoscopy
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 30, 2019 Category: Gastroenterology Authors: Hala Fatima Source Type: research

HBV: When (not) to Treat
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 30, 2019 Category: Gastroenterology Authors: Zachary P. Fricker, K. Rajender Reddy Source Type: research

Fecal Incontinence Diagnosed by the Rome IV Criteria in the United States, Canada, and the United Kingdom
An internet survey of 6,300 United States, Canadian, and British subjects found fecal incontinence in 16.1%, but only 3.3% met Rome IV criteria. Excluded subjects had impaired quality of life. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 30, 2019 Category: Gastroenterology Authors: William E. Whitehead, Magnus Simren, Jan Busby-Whitehead, Steve Heymen, Miranda A.L. van Tilburg, Ami D. Sperber, Olafur Palsson Source Type: research

High Consumption of Sweetened Beverages Might Increase the Risk of Inflammatory Bowel Diseases
This study found no association between consumption of sweet ened beverages and later risk of CD or UC. However, this was inconsistent with a previous meta-analysis that reported a positive association between consumption of soft drinks and UC risk (relative risk [RR], 1.69; 95% confidence interval [CI], 1.24–2.30). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 29, 2019 Category: Gastroenterology Authors: Xue-Ying Yang, Peng-Fei Chen, Jian-Hua He Tags: Letter to the Editor Source Type: research

Reply
We appreciate the comments by Yang et  al1 on our manuscript entitled “Sweetened beverage consumption and risk of Crohn’s disease and ulcerative colitis.”2 Yang et al conducted an updated meta-analysis of prior studies and demonstrated a positive association between sweetened beverage consumption and risk of Crohn’s disease an d ulcerative colitis. However, we note several limitations of their analysis. First, as noted by the authors, the majority of prior studies were retrospective case-control in design. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 29, 2019 Category: Gastroenterology Authors: Hamed Khalili Tags: Letter to the Editor Source Type: research

Methodological Issues on Prediction of Hepatocellular Carcinoma After Sustained Virologic Responses
We read with great interest the study by Higuchi et  al.1 One of the aims of the study was to examine whether magnetic resonance elastography (MRE) was useful for predicting the development of hepatocellular carcinoma (HCC) after sustained virologic responses (SVRs).1 (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 29, 2019 Category: Gastroenterology Authors: Masoumeh Abbasi, Mehdi Naderi Tags: Letter to the Editor Source Type: research

Endoscopic Retrograde Cholangiopancreatography
Endoscopic retrograde cholangiopancreatography (ERCP) is a procedure that uses endoscopy, x-ray, and dye to view the biliary tract and pancreatic ducts. Endoscopic refers to a tool called an endoscope; retrograde refers to the direction (backward) the endoscope injects a liquid for x-rays; cholangio refers to the bile duct system; and pancreatography refers to the pancreas. The process of taking these x-rays is known as cholangiopancreatography. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - May 29, 2019 Category: Gastroenterology Tags: AGA Patient Education Section Source Type: research