Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Elsewhere in The AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute brings you the best original research in the field with a unique combination of reviews, editorials, podcasts, video abstracts, and outcomes research —all supporting clinical practice. Articles on education, policy, and practice management highlight issues pertinent to clinicians. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Information for Authors
Clinical Gastroenterology and Hepatology (CGH) publishes clinical articles on all aspects of the digestive system, including the liver and pancreas. The types of articles Clinical Gastroenterology and Hepatology publishes include original papers,  review articles, and special category manuscripts. Manuscripts must be prepared in accordance with the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” developed by the International Committee of Medical Journal Editors (ICMJE) (http://www.icmje.org). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Development and Validation of a Scoring System That Includes Corrected QT Interval For Risk Analysis of Patients With Cirrhosis and Gastrointestinal Bleeding
The electrocardiographic QT interval is frequently prolonged in patients with cirrhosis. Acute gastrointestinal bleeding further prolongs corrected QT (QTc) in patients with cirrhosis, which has been associated with increased risk of death within 6 weeks. We aimed to confirm these findings and develop a mortality risk index that incorporates QTc. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 15, 2018 Category: Gastroenterology Authors: Maurizio Biselli, Annagiulia Gramenzi, Barbara Lenzi, Marco Dall ’Agata, Monica Loreta Pierro, Giovanni Perricone, Marta Tonon, Luca Bellettato, Gennaro D’Amico, Paolo Angeli, Silvia Boffelli, Maria Elena Bonavita, Marco Domenicali, Paolo Caraceni, Ma Source Type: research

Jaccoud ’s Arthropathy and Jaundice in a Young Woman
A25-year-old woman with an unknown history presented with severe symptomatic anemia. She was pale, ill-appearing, and jaundiced. Physical examination showed swan-neck deformity and reducible subluxations of the fingers with ulnar deviations (Figures A and B). Plain radiographs showed no erosion. Laboratory work-up was significant for the following: total bilirubin, 14 mg/dL; alanine aminotransferase, 75  U/L;aspartate aminotransferase, 187 U/L; alkaline phosphatase, 315 U/L; international normalized ratio, 1.7; and albumin, 2.1 g/dL. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Danny Issa, Bryce Hatfield, Richard K. Sterling Tags: Electronic Image of the Month Source Type: research

Validation of the Hepatocellular Carcinoma Early detection Screening (HES) algorithm in a Cohort of Veterans with Cirrhosis
Early detection of hepatocellular carcinoma (HCC) through surveillance reduces mortality associated with this cancer. Guidelines recommend HCC surveillance every 6 months for patients with cirrhosis, via ultrasonography, with or without measurement of serum level of alpha fetoprotein (AFP). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Nabihah Tayob, Israel Christie, Peter Richardson, Ziding Feng, Donna L. White, Jessica Davila, Douglas A. Corley, Fasiha Kanwal, Hashem B. El-Serag Source Type: research

Pruritus is Common and Under-treated in Patients with Primary Biliary Cholangitis in the United Kingdom
Little is known about the prevalence or treatment of pruritus associated with primary biliary cholangitis (PBC). We analyzed data from patients with PBC recruited from all clinical centers in the United Kingdom (UK) to characterize the prevalence, severity, progression, and treatment of pruritus. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Vinod S. Hegade, George F. Mells, Holly Fisher, Stuart Kendrick, Julia DiBello, Kim Gilchrist, Graeme J. Alexander, Gideon M. Hirschfield, Richard N. Sandford, David E.J. Jones, UK-PBC Consortium Source Type: research

Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis
It is a challenge to make a diagnosis of gastroparesis. There is good agreement in results from wireless motility capsule (WMC) analysis and gastric emptying scintigraphy (GES), but the diagnostic yield of WMC is unclear and the accuracy of this method has not been validated. We compared the performance characteristics of WMC vs GES in assessing gastric emptying in patients with suspected gastroparesis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Allen A. Lee, Satish Rao, Linda A. Nguyen, Baharak Moshiree, Irene Sarosiek, Michael I. Schulman, John M. Wo, Henry P. Parkman, Gregory E. Wilding, Richard W. McCallum, William L. Hasler, Braden Kuo Source Type: research

Prevalence of Germline Mutations in Polyposis and Colorectal Cancer-associated Genes in Patients With Multiple Colorectal Polyps
Guidelines recommend genetic testing of patients with 10 or more cumulative adenomatous polyps. However, little is known about the utility of these tests —especially for older patients. We aimed to determine the prevalence of pathogenic mutations in patients with multiple colorectal polyps, stratified by age. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Peter P. Stanich, Rachel Pearlman, Alice Hinton, Stephanie Gutierrez, Holly LaDuca, Heather Hampel, Kory Jasperson Source Type: research

Jaccoud ’s Arthropathy and Jaundice in a Young Female
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Danny Issa, Bryce Hatfield, Richard K. Sterling Tags: Image of the Month Source Type: research

Metal Biliary Stents in Benign Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Abdul Haseeb, Stuart K. Amateau Source Type: research

Measurement of Observed Eating Behaviors in Patients with Active and Inactive Eosinophilic Esophagitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Ryan Alexander, Jeffrey A. Alexander, Karthik Ravi, Debra Geno, Crystal Tholen, Kristin Mara, David A. Katzka Source Type: research

Pruritus Is Common and Undertreated in Patients With Primary Biliary Cholangitis in the United Kingdom
Little is known about the prevalence or treatment of pruritus associated with primary biliary cholangitis (PBC). We analyzed data from patients with PBC recruited from all clinical centers in the United Kingdom (UK) to characterize the prevalence, severity, progression, and treatment of pruritus. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Vinod S. Hegade, George F. Mells, Holly Fisher, Stuart Kendrick, Julia DiBello, Kim Gilchrist, Graeme J. Alexander, Gideon M. Hirschfield, Richard N. Sandford, David E.J. Jones, UK-PBC Consortium Source Type: research

Prevalence of Germline Mutations in Polyposis and Colorectal Cancer –Associated Genes in Patients With Multiple Colorectal Polyps
Guidelines recommend genetic testing of patients with 10 or more cumulative adenomatous polyps. However, little is known about the utility of these tests —especially for older patients. We aimed to determine the prevalence of pathogenic mutations in patients with multiple colorectal polyps, stratified by age. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Peter P. Stanich, Rachel Pearlman, Alice Hinton, Stephanie Gutierrez, Holly LaDuca, Heather Hampel, Kory Jasperson Source Type: research

A Jejunal Dieulafoy ’s Lesion Mimicking a Gastrointestinal Stromal Tumor
A previously healthy 41-year-old man presented to our hospital with hematochezia and syncope for 3 days. Single-balloon enteroscopy was performed after  an initial negative esophagogastroduodenoscopy and colonoscopy. Single-balloon enteroscopy showed a 10-mm submucosal protruding lesion at the proximal jejunum (Figure A), with a minute mucosal defect (Figure B) suggestive of a gastrointestinal stromal tumor. A resection of the jejunal lesion was performed. Surgical pathology showed a large-caliber, thick-walled, submucosal artery with intraluminal thrombosis formation and fibrin deposition protruding through a&nb...
Source: Clinical Gastroenterology and Hepatology - December 13, 2018 Category: Gastroenterology Authors: Jingrun Zhao, Zhen Sun, Xuedong Zhang Tags: Electronic Image of the Month Source Type: research

Characterization and Identification of Colorectal Cancer in Persons younger than 50 Years
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 10, 2018 Category: Gastroenterology Authors: Williamson B. Strum, C. Richard Boland Source Type: research

FibroScan Detects Cardiovascular Damage in Patients With  NAFLD
Patients with nonalcoholic fatty liver disease (NAFLD), particularly in the presence of nonalcoholic steatohepatitis or fibrosis, are at high cardiac and cerebrovascular risk.1 (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Rosa Lombardi, Salvatore Petta, Giuseppina Pisano, Paola Dongiovanni, Luca Rinaldi, Luigi Elio Adinolfi, Carlo Acierno, Luca Valenti, Roberta Boemi, Federica Spatola, Antonio Crax ì, Silvia Fargion, Anna Ludovica Fracanzani Tags: Research Correspondence Source Type: research

FibroScan detects cardiovascular damage in patients with NAFLD
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Rosa Lombardi, Salvatore Petta, Giuseppina Pisano, Paola Dongiovanni, Luca Rinaldi, Luigi Elio Adinolfi, Carlo Acierno, Luca Valenti, Roberta Boemi, Federica Spatola, Antonio Crax ì, Silvia Fargion, Anna Ludovica Fracanzani Source Type: research

Universal screening for hepatitis C: an important step in virus elimination
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Jagpreet Chhatwal, Norman L. Sussman Source Type: research

Concomitant Use of Aminosalicylates Is Not Associated with Improved Outcomes in Patients with Ulcerative Colitis Escalated to Vedolizumab
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Christopher Ma, Paulo G. Kotze, Abdulelah Almutairdi, Vipul Jairath, Remo Panaccione Source Type: research

Preventive Medicine in Inflammatory Bowel Disease
The prevalence of inflammatory bowel disease (IBD) is increasing worldwide. The therapeutic options available to our patients are also increasing. These therapies offer patients the prospect of clinical and endoscopic remission, as well as improved quality of life. However, the management of IBD has become complex, including identification of specific risks associated with IBD and its therapies. The provider needs to consider forms of primary, secondary and tertiary prevention in his or her management of patients with IBD in order to prevent complications. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Kimberly N. Weaver, Millie D. Long Source Type: research

Outcomes of Pregnancy in Recipients of Liver Transplants
Despite increasing reports of pregnancy in women who received liver transplants, it is not clear how transplantation and immunosuppression affect pregnancy. We collected data from liver transplant recipients who became pregnant on immunosuppression regimens, pregnancy management, graft morbidity, and outcomes of mothers and neonates. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Sivesh K. Kamarajah, Katherine Arntdz, James Bundred, Bridget Gunson, Geoffrey Haydon, Fiona Thompson Source Type: research

Preoperative Endoscopic Retrograde Cholangiopancreatography is not Associated With Increased Pancreatic Cancer Mortality
Endoscopic Retrograde Cholangiopancreatography (ERCP) before surgery for pancreatic cancer has been associated with infectious complications after surgery. Little is known about the effects of preoperative ERCP on survival of patients with pancreatic cancer. We investigated whether ERCP before surgery affects overall survival, after controlling for confounding factors. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Sheila D. Rustgi, Sunil Amin, Anthony Yang, Michelle K. Kim, Satish Nagula, Nikhil A. Kumta, Christopher J. DiMaio, Paolo Boffetta, Aimee L. Lucas Source Type: research

Obesity and Weight Gain Since Early Adulthood are Associated With a Lower Risk of Microscopic Colitis
We examined the association between obesity and risk of microscopic colitis in a prospective cohort study. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Po-Hong Liu, Kristin E. Burke, Ashwin N. Ananthakrishnan, Paul Lochhead, Ola Olen, Jonas F. Ludvigsson, James M. Richter, Andrew T. Chan, Hamed Khalili Source Type: research

Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis
Adenoma detection rate (ADR) is a quality metric for colorectal cancer screening. We performed a systematic review and network meta-analysis to assess the overall and comparative efficacies of different endoscopic techniques in adenoma detection. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Antonio Facciorusso, Konstantinos Triantafyllou, Mohammad Hassan Murad, Larry J. Prokop, Georgios Tziatzios, Nicola Muscatiello, Siddharth Singh Source Type: research

Significant Increase in Risk of Fibrosis or Cirrhosis at Time of HCV Diagnosis for Hispanics With Diabetes and Obesity Compared with Other Ethnic Groups
Advanced liver disease, which includes fibrosis and cirrhosis, has been reported to be more prevalent in Hispanics patients at the time of diagnosis of chronic hepatitis C virus (HCV) infection than non-Hispanic black or non-Hispanic white patients. We performed a propensity score-matched analysis to determine whether metabolic risk factors contribute to this disparity. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Barbara J. Turner, Chen-Pin Wang, Trisha V. Melhado, Raudel Bobadilla, Mamta K. Jain, Amit G. Singal Source Type: research

Radiation-induced enteritis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Cassandra Gandle, Sadhna Dhingra, Suneal Agarwal Tags: Image of the Month Source Type: research

Gastric schwannoma detected by chest radiograph
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Yasuhiko Hamada, Kyosuke Tanaka, Reiko Yamada Tags: Image of the Month Source Type: research

Optimal Risk Prediction in Upper Gastrointestinal Bleeding: A Quest for the Holy Grail
Since the initial description of the Rockall Score (RS) in 1996,1 clinical prediction tools have been used to risk-stratify patients hospitalized with upper gastrointestinal bleeding (UGIB). Because of the demand for a simple, pre-endoscopic, risk-assessment tool to help providers optimize resource allocation, the Glasgow Blatchford Score (GBS) then was derived to assess which patients with UGIB were likely to require hospital-based treatment before performance of an esophagogastroduodenoscopy.2 The GBS subsequently has been validated in numerous studies to accurately predict the need for endoscopic intervention and mortal...
Source: Clinical Gastroenterology and Hepatology - December 3, 2018 Category: Gastroenterology Authors: Neil Sengupta Tags: Editorial Source Type: research

Optimal Risk Prediction in Upper Gastrointestinal Bleeding – A Quest for the Holy Grail
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 3, 2018 Category: Gastroenterology Authors: Neil Sengupta Source Type: research

Challenges to Risk Determination for Patients with Upper Gastrointestinal Bleeding
Since the initial description of the Rockall Score (RS) in 1996,1 clinical prediction tools have been used to risk-stratify patients hospitalized with upper gastrointestinal bleeding (UGIB). Because of the demand for a simple, pre-endoscopic, risk-assessment tool to help providers optimize resource allocation, the Glasgow Blatchford Score (GBS) then was derived to assess which patients with UGIB were likely to require hospital-based treatment before performance of an esophagogastroduodenoscopy.2 The GBS subsequently has been validated in numerous studies to accurately predict the need for endoscopic intervention and mortal...
Source: Clinical Gastroenterology and Hepatology - December 3, 2018 Category: Gastroenterology Authors: Neil Sengupta Tags: Editorial Source Type: research

Low Literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples
The fecal immunochemical test (FIT) is an alternative to colonoscopy and can increase overall screening for colorectal cancer (CRC). However, little is known about the frequency of and reasons for mishandled FIT samples. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Andrew Wang, Carly Rachocki, Jean A. Shapiro, Rachel B. Issaka, Ma Somsouk Source Type: research

Stents vs Surgery for Patients With Malignant Gastric Outlet Obstruction: Matching the Right Patient to the Right Procedure
Malignant gastric outlet obstruction (MGOO) typically is defined as mechanical blockage of the stomach or proximal small bowel as a result of tumor.1 MGOO commonly is encountered in patients with advanced gastrointestinal cancers, most commonly pancreatic cancer.1,2 MGOO is intensely unpleasant for patients (who already are compromised by their preexisting malignancy), often manifesting with symptoms such as nausea, intractable vomiting, dehydration, abdominal pain, and protein-calorie malnutrition,3,4 MGOO is seen most commonly in patients with advanced and unresectable disease. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Douglas G. Adler Tags: Editorial Source Type: research

Efficacy of Endoscopic Dilation of gastroduodenal Crohn ’s disease strictures: A Systematic Review and Meta-analysis of Individual Patient Data
Little is know about the effects of endoscopic balloon dilation (EBD) for strictures of the upper gastrointestinal (UGI) tract in patients with Crohn ’s disease (CD). We performed a pooled analysis of the efficacy and safety of EBD for UGI CD-associated strictures. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Dominik Bettenworth, Marcus M. M ücke, Rocio Lopez, Amandeep Singh, Weiming Zhu, Feilong Guo, Toshiyuki Matsui, Theodore W. James, Hans Herfarth, Martin Goetz, Ren Mao, Satya Kurada, Jochen Hampe, Katja Matthes, John Gásdal Karstensen, Piero V. Valli, M Source Type: research

Stents versus Surgery for Patients with Malignant Gastric Outlet Obstruction: Matching the Right Patient to the Right Procedure
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Douglas G. Adler Source Type: research

Low-literacy Level Instructions and Reminder Calls Improve Patient Handling of Fecal Immunochemical Test Samples
The fecal immunochemical test (FIT) is an alternative to colonoscopy and can increase overall screening for colorectal cancer (CRC). However, little is known about the frequency of and reasons for mishandled FIT samples. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Andrew Wang, Carly Rachocki, Jean A. Shapiro, Rachel B. Issaka, Ma Somsouk Source Type: research

Patients Prescribed Direct-acting Oral Anticoagulants Have Low Risk of Post-Polypectomy Complications
Use of direct-acting oral anticoagulants (DOACs) is increasing, but little is known about the associated risks in patients undergoing colonoscopy with polypectomy. We aimed to determine the risk of post-polypectomy complications in patients prescribed DOACs. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Jessica X. Yu, Melissa Oliver, Jody Lin, Matthew Chang, Berkeley N. Limketkai, Roy Soetikno, Jay Bhattacharya, Tonya Kaltenbach Source Type: research

Should Patients With Malignant Gastric Outlet Obstruction Receive  Stents or Surgery?
Malignant gastric outlet obstruction (MGOO) typically is defined as mechanical blockage of the stomach or proximal small bowel as a result of tumor.1 MGOO commonly is encountered in patients with advanced gastrointestinal cancers, most commonly pancreatic cancer.1,2 MGOO is intensely unpleasant for patients (who already are compromised by their preexisting malignancy), often manifesting with symptoms such as nausea, intractable vomiting, dehydration, abdominal pain, and protein-calorie malnutrition,3,4 MGOO is seen most commonly in patients with advanced and unresectable disease. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Douglas G. Adler Tags: Editorial Source Type: research

Should Patients With Malignant Gastric Outlet Obstruction Receive Stents or Surgery?
Malignant gastric outlet obstruction (MGOO) typically is defined as mechanical blockage of the stomach or proximal small bowel as a result of tumor.1 MGOO commonly is encountered in patients with advanced gastrointestinal cancers, most commonly pancreatic cancer.1,2 MGOO is intensely unpleasant for patients (who already are compromised by their preexisting malignancy), often manifesting with symptoms such as nausea, intractable vomiting, dehydration, abdominal pain, and protein-calorie malnutrition,3,4 MGOO is seen most commonly in patients with advanced and unresectable disease. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Douglas G. Adler Tags: Editorial Source Type: research

Patients Prescribed Direct-Acting Oral Anticoagulants Have Low Risk of Postpolypectomy Complications
Use of direct-acting oral anticoagulants (DOACs) is increasing, but little is known about the associated risks in patients undergoing colonoscopy with polypectomy. We aimed to determine the risk of post-polypectomy complications in patients prescribed DOACs. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 29, 2018 Category: Gastroenterology Authors: Jessica X. Yu, Melissa Oliver, Jody Lin, Matthew Chang, Berkeley N. Limketkai, Roy Soetikno, Jay Bhattacharya, Tonya Kaltenbach Source Type: research

Prediction of Hepatocellular Carcinoma After Sustained  Virological Responses Using Magnetic Resonance Elastography
Direct acting antivirals (DAAs) have made it possible for most patients to achieve sustained virologic responses (SVR).1 However, some patients developed hepatocellular carcinoma (HCC) even after the eradication of hepatitis C virus2; therefore, it is clinically important to identify patients with a high risk of HCC development after SVR. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: Mayu Higuchi, Nobuharu Tamaki, Masayuki Kurosaki, Keiya Watakabe, Leona Osawa, Wan Wang, Mao Okada, Takao Shimizu, Kenta Takaura, Hitomi Takada, Shun Kaneko, Yutaka Yasui, Kaoru Tsuchiya, Hiroyuki Nakanishi, Jun Itakura, Yuka Takahashi, Namiki Izumi Tags: Research Correspondence Source Type: research

Appendiceal Mucocele: Unexpected Finding in Colonoscopy
A 42-year-old man was admitted because of abdominal pain and constipation, which had persisted for 1 year. Total colonoscopy showed a 2.5-cm subepithelial lesion in the cecum involving the appendicular orifice. After bite-on-bite biopsy, drainage of mucinous and viscous fluid was observed (Figure A), which was aspirated with complete disappearance of the lesion (Figure B). Abdominal computed tomography only revealed a slight thickening of the appendix without lymph node and distant metastasis. The patient underwent appendectomy, and surgical pathology identified an enlarged appendix filled with mucus extending until the mu...
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: Marta Patita, Gon çalo Nunes, Vítor Fernandes Tags: Electronic Image of the Month Source Type: research

Clinical Features at Baseline Cannot Predict Symptom Response to Placebo in Patients With Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disease characterized by ≥15 eosinophils per high-power field (eos/hpf) and esophageal dysfunction.1 One confounder in the assessment of drug efficacy in clinical trials for EoE2 and other gastrointestinal diseases3,4 has been the symptomatic response to placebo. In placebo-controlled, randomized trials of EoE therapies, placebo response rates as high as 78% have been reported.2 To mitigate placebo effect, a phase 2, randomized, double-blind, placebo-controlled trial of budesonide oral suspension (BOS) was designed with a single-blind, placebo run-in to attemp...
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: Ikuo Hirano, Evan S. Dellon, Margaret H. Collins, James Williams, Lan Lan, David A. Katzka Tags: Research Correspondence Source Type: research

Duodenal and Rectal Eosinophilia Are New Biomarkers of Nonceliac Gluten Sensitivity
Going gluten free is thought by many in the community to be the “healthy“ option. Indeed, the gluten-free diet industry represents a $6 billion (in US$) global business.1 There continues to be heightened coverage in the mainstream and social media about gluten and health. It therefore is not surprising that in population-based studies, 7% to 15% of individua ls report symptoms related to wheat ingestion in the absence of celiac disease.2 Of those reporting symptoms related to gluten, approximately 1 in 6 have this suspicion confirmed by double-blind placebo-controlled (DBPC) wheat challenge, referred to as nonc...
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: M. Ellionore J ärbrink-Sehgal, Nicholas J. Talley Tags: Editorial Source Type: research

Duodenal and rectal eosinophilia are new biomarkers of non-celiac gluten sensitivity
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: M. Ellionore J ärbrink-Sehgal, Nicholas J. Talley Source Type: research

Appendiceal Mucocele – Unexpected Finding in Colonoscopy
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: Marta Patita, Gon çalo Nunes, Vítor Fernandes Tags: Image of the Month Source Type: research

Metastatic lung cancer presenting with jejunal intussusception and gastrointestinal bleeding
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 28, 2018 Category: Gastroenterology Authors: Niki Jackson, Thomas Lidner, N. Jewel Samadder Tags: Image of the Month Source Type: research