Screening for fibrosis promotes life-style changes. A prospective cohort study in 4,796 individuals
Early detection of liver fibrosis is believed to promote lifestyle changes. We evaluated self-reported changes in alcohol intake, diet, exercise, and weight after participating in a screening study for liver fibrosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2023 Category: Gastroenterology Authors: Maria Kjaergaard, Katrine Prier Lindvig, Katrine Holtz Thorhauge, Stine Johansen, Johanne Kragh Hansen, Peter Andersen, Camilla Dalby Hansen, Helle Lindholm Schnefeld, Katrine Tholstrup Bech, Nikolaj Torp, Mads Israelsen, S önke Detlefsen, Isabel Grauper Source Type: research

Per- and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2023 Category: Gastroenterology Authors: Manasi Agrawal, Vishal Midya, Amith Maroli, Jared Magee, Lauren Petrick, Jean-Frederic Colombel, PREDICTS collaborators Tags: Research Letter Source Type: research

The Evolving Role of Artificial Intelligence in Gastrointestinal Histopathology: An Update
We describe several current needs within the world of gastrointestinal histopathology, and outline, using currently studied models, how AI can potentially address them. We also highlight pitfalls as AI makes inroads into clinical practice. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 26, 2023 Category: Gastroenterology Authors: D. Chamil Codipilly, Shahriar Faghani, Catherine Hagan, Jason Lewis, Bradley J. Erickson, Prasad G. Iyer Tags: Narrative Reviews Source Type: research

Fecal Urgency in Ulcerative Colitis: Impact on Quality of Life and Psychological Well-being in Active and Inactive Disease States
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 25, 2023 Category: Gastroenterology Authors: Gaurav B. Nigam, Jimmy K. Limdi, Sebastian Bate, Shaheen Hamdy, Dipesh H. Vasant Tags: Research Letter Source Type: research

Liver-Related Events in NASH (MASH): From Subgroup Stratification to Individual Risk Prediction
A new nomenclature for nonalcoholic fatty liver disease has been proposed recently as the result of a modified Delphi process led by 3 large pan-national liver associations (EASL, AASLD, ALEH).1 The term nonalcoholic fatty liver disease has been replaced with metabolic dysfunction-associated steatotic liver disease (MASLD), comprised in the overarching term steatotic liver disease (SLD). The term MASLD identifies the association of SLD with at least 1 of the 5 cardiometabolic risk factors, formerly identified as basic features of the metabolic syndrome. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 24, 2023 Category: Gastroenterology Authors: Massimo Pinzani Tags: Editorial Source Type: research

Liver related events in nash (mash): from subgroup stratification to individual risk prediction
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 24, 2023 Category: Gastroenterology Authors: Massimo Pinzani Tags: Editorial Source Type: research

Age, BMI, and Type 2 Diabetes Modify the Relationship Between PNPLA3 and Advanced Fibrosis in Children and Adults With NAFLD
PNPLA3 G-allele is an important determinant of disease severity in nonalcoholic fatty liver disease (NAFLD). Here, we investigated the effect of age, body mass index (BMI), and type 2 diabetes mellitus (T2DM) on the relationship between PNPLA3 G-allele and advanced fibrosis in adults and children with histologically characterized NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 23, 2023 Category: Gastroenterology Authors: Chaowapong Jarasvaraparn, Eduardo Vilar-Gomez, Katherine P. Yates, Laura A. Wilson, Brent Neuschwander-Tetri, Rohit Loomba, Oscar Cummings, Miriam Vos, Stavra Xanthakos, Jeffrey Schwimmer, Jean P. Molleston, Arun Sanyal, James Tonascia, Naga Chalasani Source Type: research

Eosinophilic esophagitis: seeing only the tip of the iceberg
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 23, 2023 Category: Gastroenterology Authors: Christina M. Ray, Gilaad G. Kaplan, Christopher Ma Tags: Letter to the Editor Source Type: research

Age, BMI, and type2 diabetes modify the relationship between PNPLA3 and advanced fibrosis in children and adults with NAFLD
PNPLA3 G-allele is an important determinant of disease severity in NAFLD. Here, we investigated the effect of age, BMI, and type 2 diabetes mellitus (T2DM) on the relationship between PNPLA3 G-allele and advanced fibrosis in adults and children with histologically characterized NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 23, 2023 Category: Gastroenterology Authors: Chaowapong Jarasvaraparn, Eduardo Vilar-Gomez, Katherine P. Yates, Laura A. Wilson, Brent Neuschwander-Tetri, Rohit Loomba, Oscar Cummings, Miriam Vos, Stavra Xanthakos, Jeffrey Schwimmer, Jean P. Molleston, Arun Sanyal, James Tonascia, Naga Chalasani Source Type: research

Bile acid diarrhea in microscopic colitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 22, 2023 Category: Gastroenterology Authors: Lars Kristian Munck, Signe Wildt, Christian Borup Tags: Letter to the Editor Source Type: research

Tofacitinib is effective in treating refractory immune checkpoint inhibitor hepatitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 22, 2023 Category: Gastroenterology Authors: Mike Wang, Kerry Reynolds, Kamaneh Montazeri, Esperance A. Schaefer, Ryan J. Sullivan, Michael Dougan Tags: Research Letter Source Type: research

Impostor Phenomenon and Microaggressions in Gastroenterology: Exposing the Tip of the Iceberg
Diversity in the health care workforce plays an important role in reducing health disparities, promotes innovative research to address health access and outcomes of marginalized communities, and has been linked to better patient outcomes.1 Nevertheless, women and underrepresented minorities (URM), including individuals from certain racial or ethnic backgrounds, religious groups, sexual orientations, and those with disabilities, to name a few, remain disproportionately underrepresented in gastroenterology. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2023 Category: Gastroenterology Authors: Natalie Farha, Anuradha Bhama, Anthony Tizzano, Sofya Asfaw, Michelle Kang Kim, Carol A. Burke Tags: Diversity, Equity, and Inclusion in GI Source Type: research

Blue Notes
Helicobacter pylori (HP) infection is highly prevalent worldwide, and positivity rates depend strongly on the population under study. However, there are few contemporary data describing HP epidemiology in the racially and ethnically diverse population of the United States. This retrospective study included over 900,000 individuals that had undergone HP testing between 1998 and 2018 in the Veterans Health Administration system. HP testing included serology, fecal H. pylori antigen or urea breath test, rapid urease test, CLO test, and histology evaluation, and the approach was validated against medical records. (Source: Clin...
Source: Clinical Gastroenterology and Hepatology - December 20, 2023 Category: Gastroenterology Authors: Charles J. Kahi Tags: Blue Notes Source Type: research

Exam 1: Withdrawal of Immunomodulators or TNF Antagonists in Patients With Inflammatory Bowel Diseases in Remission on Combination Therapy: A Systematic Review and Meta-analysis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2023 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

Front Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2023 Category: Gastroenterology Source Type: research