Clopidogrel and Low-Dose Aspirin, Alone or Together, Reduce Risk of Colorectal Cancer
The antiplatelet effect of low-dose aspirin, via inhibition of cyclooxygenase-1, might contribute to its ability to reduce risk of colorectal cancer (CRC). Antiplatelet agents with a different mechanism, such as clopidogrel, might have the same effects. We aimed to quantify the effects of low-dose aspirin and clopidogrel on risk of CRC in a Mediterranean population. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Antonio Rodr íguez-Miguel, Luis A. García-Rodríguez, Miguel Gil, Héctor Montoya, Sara Rodríguez-Martín, Francisco J. de Abajo Source Type: research

Patients with Chronic Liver Disease Suggestive of Nonalcoholic Fatty Liver Disease may be at Higher Risk for Drug Induced Liver Injury
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Craig Lammert, Timothy Imler, Evgenia Teal, Naga Chalasani Source Type: research

Effects of Anti-Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases
Helicobacter pylori induces immune tolerance and is associated with a lower risk for immune-mediated disorders, such as autoimmune and inflammatory bowel diseases (IBD). We aimed to determine the effects of treatment for H pylori infection on the incidence of autoimmune disease and IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Kun-Der Lin, Guei-Fen Chiu, Akbar K. Waljee, Stephanie Y. Owyang, Mohamad El-Zaatari, Shrinivas Bishu, Helmut Grasberger, Min Zhang, Deng-Chyang Wu, John Y. Kao Source Type: research

Efficacy of Supervised Pelvic Floor Muscle Training and Biofeedback vs Attention-control Treatment in Adults with Fecal Incontinence
Pelvic floor muscle training (PFMT) in combination with conservative treatment is recommended as first-line treatment for patients with fecal incontinence, although its efficacy is unclear. We investigated whether supervised PFMT in combination wsith conservative treatment is superior to attention-control massage treatment and conservative treatment in adults with fecal incontinence. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Anja Ussing, Inge Dahn, Ulla Due, Michael S ørensen, Janne Petersen, Thomas Bandholm Source Type: research

Health-related Quality of Life in Non-alcoholic Fatty Liver Disease Associates With Hepatic Inflammation
Chronic liver disease has negative effects on health-related quality of life (HRQL). We analyzed data from the European non-alcoholic fatty liver disease (NAFLD) registry to assess the effects of NAFLD on HRQL. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Yvonne Huber, Marie Boyle, Kate Hallsworth, Dina Tiniakos, Beate K. Straub, Christian Labenz, Christian Ruckes, Peter R. Galle, Manuel Romero-G ómez, Quentin M. Anstee, Jörn M. Schattenberg, EPoS Consortium Investigators Source Type: research

Incidence Trends of Gastroenteropancreatic Neuroendocrine Tumors in the United States
Although multiple studies have reported an increasing incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) over the past decades, there are limited national data on recent trends. Using a population-based registry, we evaluated GEP-NET incidence trends in the United States population from 1975 through 2012, based on age, calendar year at diagnosis, and year of birth. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Mi Ri Lee, Cynthia Harris, Kiwoon Joshua Baeg, Anne Aronson, Juan P. Wisnivesky, Michelle Kang Kim Source Type: research

Cost-effectiveness of Hepatocellular Carcinoma Surveillance After a Sustained Virologic Response to Therapy in Patients With HCV Infection and Advanced Fibrosis
Hepatitis C virus (HCV)-related cirrhosis increases risk for hepatocellular carcinoma (HCC). After a sustained virologic response (SVR) to anti-HCV therapy, the risk of HCC is reduced but not eliminated. Recent developments in antiviral therapy have markedly increased rates of SVR. Guidelines recommend indefinite biannual ultrasound surveillance after SVR for patients with advanced fibrosis before treatment. Surveillance for HCC is cost effective before anti-HCV treatment; we investigated whether it remains so after SVR. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Hooman Farhang Zangneh, William WL. Wong, Beate Sander, Chaim M. Bell, Khalid Mumtaz, Matthew Kowgier, Adriaan J. van der Meer, Sean P. Cleary, Harry L.A. Janssen, Kelvin KW. Chan, Jordan J. Feld Source Type: research

Effects of Anti –Helicobacter pylori Therapy on Incidence of Autoimmune Diseases, Including Inflammatory Bowel Diseases
Helicobacter pylori induces immune tolerance and is associated with a lower risk for immune-mediated disorders, such as autoimmune and inflammatory bowel diseases (IBD). We aimed to determine the effects of treatment for H pylori infection on the incidence of autoimmune disease and IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Kun-Der Lin, Guei-Fen Chiu, Akbar K. Waljee, Stephanie Y. Owyang, Mohamad El-Zaatari, Shrinivas Bishu, Helmut Grasberger, Min Zhang, Deng-Chyang Wu, John Y. Kao Source Type: research

Cost Effectiveness of Hepatocellular Carcinoma Surveillance  After a Sustained Virologic Response to Therapy in Patients With Hepatitis C Virus Infection and Advanced Fibrosis
Hepatitis C virus (HCV)-related cirrhosis increases the risk for hepatocellular carcinoma (HCC). After a sustained virologic response (SVR) to anti-HCV therapy, the risk of HCC is reduced but not eliminated. Recent developments in antiviral therapy have increased rates of SVR markedly. Guidelines recommend indefinite biannual ultrasound surveillance after SVR for patients with advanced fibrosis before treatment. Surveillance for HCC is cost effective before anti-HCV treatment; we investigated whether it remains so after SVR. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 20, 2018 Category: Gastroenterology Authors: Hooman Farhang Zangneh, William W.L. Wong, Beate Sander, Chaim M. Bell, Khalid Mumtaz, Matthew Kowgier, Adriaan J. van der Meer, Sean P. Cleary, Harry L.A. Janssen, Kelvin K.W. Chan, Jordan J. Feld Source Type: research

Causal Role of Bile Acids in Irritable Bowel  Syndrome–Constipation
Vijayvargiya et  al1 from the Mayo Clinic have provided the first mass spectrometric analysis of fecal bile acids in constipated women (irritable bowel syndrome with constipation [IBS-C]) and compared their results with similar measurements in healthy control subjects. They concluded that there is a subset of cons tipated patients who have decreased fecal bile acid output and altered fecal bile acid composition. In particular, the proportion of deoxycholic acid, known to be the dominant fecal bile acid in humans, was decreased. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Authors: Alan F. Hofmann Tags: Letter to the Editor Source Type: research

Diverticulitis
Diverticulosis occurs when pockets (diverticula) form in the wall of the large  bowel. Approximately half of people older than age 50 have diverticulosis. When these pockets become infected or swollen, it is called diverticulitis. Diverticulitis often comes about quickly, and it can be painful. Diverticulitis develops in approximately 5% of people with diverticulosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Tags: AGA Patient Education Section Source Type: research

The Risk of Hepatitis B Virus Reactivation in HBsAg-Negative and Anti-HBc-Positive Patients Receiving Tumor Necrosis Factor Antagonists
We have read the study by Pauly et  al1 with great interest. They collected data from 8887 adults treated with anti–tumor necrosis factor (TNF) drugs for autoimmune diseases and examined hepatitis B virus (HBV) reactivation among 4620 patients who had baseline HBV testing. Among 23 hepatitis B surface antigen (HBsAg)-positive pati ents, 9 had HBV reactivations. They reported no reactivation among 178 HBsAg-negative/antibody to hepatitis B core antigen (anti-HBc)–positive patients, and suggested that this group should not receive prophylactic antiviral therapy. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Authors: Resat Ozaras, Nihal Ozaras, Aslihan Demirel Tags: Letter to the Editor Source Type: research

Reply
We thank Ozaras et  al for their thoughtful comments on our article, “The risk of Hepatitis B Reactivation in HBsAg-Negative and Anti-HBc–Positive Patients Receiving Tumor Necrosis Factor Antagonists.” They pointed out that the cohort of hepatitis B surface antigen (HBsAg)-/antibody to hepatitis B core antigen (anti-HBc)+ patients was a heterogeneous group and those who were negative for antibody to hepatitis B surface antigen were at risk of HBV reactivation when they received potent immunosuppressive therapy such as rituximab. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Authors: Mary Patricia Pauley Tags: Letter to the Editor Source Type: research

Reply
We read with great attention the comment made by Tang et  al1 regarding our systematic review and meta-analysis.2 Tang et al1 raised the concern that we could have missed publications by limiting our search strategy to the MEDLINE database and proposed to systematically perform a thorough search by looking into the Cochrane Central Register of Controlle d Trials and EMBASE. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Authors: Jeremy Meyer, Nicolas C. Buchs, Fr édéric Ris Tags: Letter to the Editor Source Type: research

Reply
We thank Dr Hofmann for his interest, kind comments on our work, and for the valuable points for discussion. We also appreciate the difficulty mentioned regarding optimal stool sampling for bile acid (BA) analysis. This would have been even more important if we had observed no significant change in fecal BAs. On the other hand, we actually showed reduced deoxycholic acid (DCA) in stool from patients with constipation-predominant irritable bowel syndrome (IBS-C). Our methods were based on high-performance liquid chromatography with tandem mass spectrometry. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Authors: Michael Camilleri Tags: Letter to the Editor Source Type: research

Issue Highlights
Pancreatic adenocarcinoma is a highly fatal cancer. Although population-level screening is not recommended, the Cancer of the Pancreas Screening Consortium recently suggested periodic abdominal imaging (with endoscopic ultrasound or magnetic resonance imaging) to screen for pancreatic cancer in high-risk individuals with certain genetic disorders. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Authors: Fasiha Kanwal Tags: Issue highlights Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Elsewhere in The AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute brings you the best original research in the field with a unique combination of reviews, editorials, podcasts, video abstracts, and outcomes research —all supporting clinical practice. Articles on education, policy, and practice management highlight issues pertinent to clinicians. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Information for Authors
Clinical Gastroenterology and Hepatology (CGH) publishes clinical articles on all aspects of the digestive system, including the liver and pancreas. The types of articles Clinical Gastroenterology and Hepatology publishes include original papers,  review articles, and special category manuscripts. Manuscripts must be prepared in accordance with the “Uniform Requirements for Manuscripts Submitted to Biomedical Journals” developed by the International Committee of Medical Journal Editors (ICMJE) (http://www.icmje.org). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 18, 2018 Category: Gastroenterology Source Type: research

Development and Validation of a Scoring System That Includes Corrected QT Interval For Risk Analysis of Patients With Cirrhosis and Gastrointestinal Bleeding
The electrocardiographic QT interval is frequently prolonged in patients with cirrhosis. Acute gastrointestinal bleeding further prolongs corrected QT (QTc) in patients with cirrhosis, which has been associated with increased risk of death within 6 weeks. We aimed to confirm these findings and develop a mortality risk index that incorporates QTc. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 15, 2018 Category: Gastroenterology Authors: Maurizio Biselli, Annagiulia Gramenzi, Barbara Lenzi, Marco Dall ’Agata, Monica Loreta Pierro, Giovanni Perricone, Marta Tonon, Luca Bellettato, Gennaro D’Amico, Paolo Angeli, Silvia Boffelli, Maria Elena Bonavita, Marco Domenicali, Paolo Caraceni, Ma Source Type: research

Jaccoud ’s Arthropathy and Jaundice in a Young Woman
A25-year-old woman with an unknown history presented with severe symptomatic anemia. She was pale, ill-appearing, and jaundiced. Physical examination showed swan-neck deformity and reducible subluxations of the fingers with ulnar deviations (Figures A and B). Plain radiographs showed no erosion. Laboratory work-up was significant for the following: total bilirubin, 14 mg/dL; alanine aminotransferase, 75  U/L;aspartate aminotransferase, 187 U/L; alkaline phosphatase, 315 U/L; international normalized ratio, 1.7; and albumin, 2.1 g/dL. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Danny Issa, Bryce Hatfield, Richard K. Sterling Tags: Electronic Image of the Month Source Type: research

Validation of the Hepatocellular Carcinoma Early detection Screening (HES) algorithm in a Cohort of Veterans with Cirrhosis
Early detection of hepatocellular carcinoma (HCC) through surveillance reduces mortality associated with this cancer. Guidelines recommend HCC surveillance every 6 months for patients with cirrhosis, via ultrasonography, with or without measurement of serum level of alpha fetoprotein (AFP). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Nabihah Tayob, Israel Christie, Peter Richardson, Ziding Feng, Donna L. White, Jessica Davila, Douglas A. Corley, Fasiha Kanwal, Hashem B. El-Serag Source Type: research

Pruritus is Common and Under-treated in Patients with Primary Biliary Cholangitis in the United Kingdom
Little is known about the prevalence or treatment of pruritus associated with primary biliary cholangitis (PBC). We analyzed data from patients with PBC recruited from all clinical centers in the United Kingdom (UK) to characterize the prevalence, severity, progression, and treatment of pruritus. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Vinod S. Hegade, George F. Mells, Holly Fisher, Stuart Kendrick, Julia DiBello, Kim Gilchrist, Graeme J. Alexander, Gideon M. Hirschfield, Richard N. Sandford, David E.J. Jones, UK-PBC Consortium Source Type: research

Validation of Diagnostic and Performance Characteristics of the Wireless Motility Capsule in Patients With Suspected Gastroparesis
It is a challenge to make a diagnosis of gastroparesis. There is good agreement in results from wireless motility capsule (WMC) analysis and gastric emptying scintigraphy (GES), but the diagnostic yield of WMC is unclear and the accuracy of this method has not been validated. We compared the performance characteristics of WMC vs GES in assessing gastric emptying in patients with suspected gastroparesis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Allen A. Lee, Satish Rao, Linda A. Nguyen, Baharak Moshiree, Irene Sarosiek, Michael I. Schulman, John M. Wo, Henry P. Parkman, Gregory E. Wilding, Richard W. McCallum, William L. Hasler, Braden Kuo Source Type: research

Prevalence of Germline Mutations in Polyposis and Colorectal Cancer-associated Genes in Patients With Multiple Colorectal Polyps
Guidelines recommend genetic testing of patients with 10 or more cumulative adenomatous polyps. However, little is known about the utility of these tests —especially for older patients. We aimed to determine the prevalence of pathogenic mutations in patients with multiple colorectal polyps, stratified by age. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Peter P. Stanich, Rachel Pearlman, Alice Hinton, Stephanie Gutierrez, Holly LaDuca, Heather Hampel, Kory Jasperson Source Type: research

Jaccoud ’s Arthropathy and Jaundice in a Young Female
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Danny Issa, Bryce Hatfield, Richard K. Sterling Tags: Image of the Month Source Type: research

Metal Biliary Stents in Benign Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Abdul Haseeb, Stuart K. Amateau Source Type: research

Measurement of Observed Eating Behaviors in Patients with Active and Inactive Eosinophilic Esophagitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Ryan Alexander, Jeffrey A. Alexander, Karthik Ravi, Debra Geno, Crystal Tholen, Kristin Mara, David A. Katzka Source Type: research

Pruritus Is Common and Undertreated in Patients With Primary Biliary Cholangitis in the United Kingdom
Little is known about the prevalence or treatment of pruritus associated with primary biliary cholangitis (PBC). We analyzed data from patients with PBC recruited from all clinical centers in the United Kingdom (UK) to characterize the prevalence, severity, progression, and treatment of pruritus. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Vinod S. Hegade, George F. Mells, Holly Fisher, Stuart Kendrick, Julia DiBello, Kim Gilchrist, Graeme J. Alexander, Gideon M. Hirschfield, Richard N. Sandford, David E.J. Jones, UK-PBC Consortium Source Type: research

Prevalence of Germline Mutations in Polyposis and Colorectal Cancer –Associated Genes in Patients With Multiple Colorectal Polyps
Guidelines recommend genetic testing of patients with 10 or more cumulative adenomatous polyps. However, little is known about the utility of these tests —especially for older patients. We aimed to determine the prevalence of pathogenic mutations in patients with multiple colorectal polyps, stratified by age. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 14, 2018 Category: Gastroenterology Authors: Peter P. Stanich, Rachel Pearlman, Alice Hinton, Stephanie Gutierrez, Holly LaDuca, Heather Hampel, Kory Jasperson Source Type: research

A Jejunal Dieulafoy ’s Lesion Mimicking a Gastrointestinal Stromal Tumor
A previously healthy 41-year-old man presented to our hospital with hematochezia and syncope for 3 days. Single-balloon enteroscopy was performed after  an initial negative esophagogastroduodenoscopy and colonoscopy. Single-balloon enteroscopy showed a 10-mm submucosal protruding lesion at the proximal jejunum (Figure A), with a minute mucosal defect (Figure B) suggestive of a gastrointestinal stromal tumor. A resection of the jejunal lesion was performed. Surgical pathology showed a large-caliber, thick-walled, submucosal artery with intraluminal thrombosis formation and fibrin deposition protruding through a&nb...
Source: Clinical Gastroenterology and Hepatology - December 13, 2018 Category: Gastroenterology Authors: Jingrun Zhao, Zhen Sun, Xuedong Zhang Tags: Electronic Image of the Month Source Type: research

Characterization and Identification of Colorectal Cancer in Persons younger than 50 Years
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 10, 2018 Category: Gastroenterology Authors: Williamson B. Strum, C. Richard Boland Source Type: research

FibroScan Detects Cardiovascular Damage in Patients With  NAFLD
Patients with nonalcoholic fatty liver disease (NAFLD), particularly in the presence of nonalcoholic steatohepatitis or fibrosis, are at high cardiac and cerebrovascular risk.1 (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Rosa Lombardi, Salvatore Petta, Giuseppina Pisano, Paola Dongiovanni, Luca Rinaldi, Luigi Elio Adinolfi, Carlo Acierno, Luca Valenti, Roberta Boemi, Federica Spatola, Antonio Crax ì, Silvia Fargion, Anna Ludovica Fracanzani Tags: Research Correspondence Source Type: research

FibroScan detects cardiovascular damage in patients with NAFLD
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Rosa Lombardi, Salvatore Petta, Giuseppina Pisano, Paola Dongiovanni, Luca Rinaldi, Luigi Elio Adinolfi, Carlo Acierno, Luca Valenti, Roberta Boemi, Federica Spatola, Antonio Crax ì, Silvia Fargion, Anna Ludovica Fracanzani Source Type: research

Universal screening for hepatitis C: an important step in virus elimination
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Jagpreet Chhatwal, Norman L. Sussman Source Type: research

Concomitant Use of Aminosalicylates Is Not Associated with Improved Outcomes in Patients with Ulcerative Colitis Escalated to Vedolizumab
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Christopher Ma, Paulo G. Kotze, Abdulelah Almutairdi, Vipul Jairath, Remo Panaccione Source Type: research

Preventive Medicine in Inflammatory Bowel Disease
The prevalence of inflammatory bowel disease (IBD) is increasing worldwide. The therapeutic options available to our patients are also increasing. These therapies offer patients the prospect of clinical and endoscopic remission, as well as improved quality of life. However, the management of IBD has become complex, including identification of specific risks associated with IBD and its therapies. The provider needs to consider forms of primary, secondary and tertiary prevention in his or her management of patients with IBD in order to prevent complications. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Kimberly N. Weaver, Millie D. Long Source Type: research

Outcomes of Pregnancy in Recipients of Liver Transplants
Despite increasing reports of pregnancy in women who received liver transplants, it is not clear how transplantation and immunosuppression affect pregnancy. We collected data from liver transplant recipients who became pregnant on immunosuppression regimens, pregnancy management, graft morbidity, and outcomes of mothers and neonates. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Sivesh K. Kamarajah, Katherine Arntdz, James Bundred, Bridget Gunson, Geoffrey Haydon, Fiona Thompson Source Type: research

Preoperative Endoscopic Retrograde Cholangiopancreatography is not Associated With Increased Pancreatic Cancer Mortality
Endoscopic Retrograde Cholangiopancreatography (ERCP) before surgery for pancreatic cancer has been associated with infectious complications after surgery. Little is known about the effects of preoperative ERCP on survival of patients with pancreatic cancer. We investigated whether ERCP before surgery affects overall survival, after controlling for confounding factors. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Sheila D. Rustgi, Sunil Amin, Anthony Yang, Michelle K. Kim, Satish Nagula, Nikhil A. Kumta, Christopher J. DiMaio, Paolo Boffetta, Aimee L. Lucas Source Type: research

Obesity and Weight Gain Since Early Adulthood are Associated With a Lower Risk of Microscopic Colitis
We examined the association between obesity and risk of microscopic colitis in a prospective cohort study. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Po-Hong Liu, Kristin E. Burke, Ashwin N. Ananthakrishnan, Paul Lochhead, Ola Olen, Jonas F. Ludvigsson, James M. Richter, Andrew T. Chan, Hamed Khalili Source Type: research

Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis
Adenoma detection rate (ADR) is a quality metric for colorectal cancer screening. We performed a systematic review and network meta-analysis to assess the overall and comparative efficacies of different endoscopic techniques in adenoma detection. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Antonio Facciorusso, Konstantinos Triantafyllou, Mohammad Hassan Murad, Larry J. Prokop, Georgios Tziatzios, Nicola Muscatiello, Siddharth Singh Source Type: research

Significant Increase in Risk of Fibrosis or Cirrhosis at Time of HCV Diagnosis for Hispanics With Diabetes and Obesity Compared with Other Ethnic Groups
Advanced liver disease, which includes fibrosis and cirrhosis, has been reported to be more prevalent in Hispanics patients at the time of diagnosis of chronic hepatitis C virus (HCV) infection than non-Hispanic black or non-Hispanic white patients. We performed a propensity score-matched analysis to determine whether metabolic risk factors contribute to this disparity. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Barbara J. Turner, Chen-Pin Wang, Trisha V. Melhado, Raudel Bobadilla, Mamta K. Jain, Amit G. Singal Source Type: research

Radiation-induced enteritis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Cassandra Gandle, Sadhna Dhingra, Suneal Agarwal Tags: Image of the Month Source Type: research

Gastric schwannoma detected by chest radiograph
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 7, 2018 Category: Gastroenterology Authors: Yasuhiko Hamada, Kyosuke Tanaka, Reiko Yamada Tags: Image of the Month Source Type: research

Optimal Risk Prediction in Upper Gastrointestinal Bleeding: A Quest for the Holy Grail
Since the initial description of the Rockall Score (RS) in 1996,1 clinical prediction tools have been used to risk-stratify patients hospitalized with upper gastrointestinal bleeding (UGIB). Because of the demand for a simple, pre-endoscopic, risk-assessment tool to help providers optimize resource allocation, the Glasgow Blatchford Score (GBS) then was derived to assess which patients with UGIB were likely to require hospital-based treatment before performance of an esophagogastroduodenoscopy.2 The GBS subsequently has been validated in numerous studies to accurately predict the need for endoscopic intervention and mortal...
Source: Clinical Gastroenterology and Hepatology - December 3, 2018 Category: Gastroenterology Authors: Neil Sengupta Tags: Editorial Source Type: research

Optimal Risk Prediction in Upper Gastrointestinal Bleeding – A Quest for the Holy Grail
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - December 3, 2018 Category: Gastroenterology Authors: Neil Sengupta Source Type: research

Challenges to Risk Determination for Patients with Upper Gastrointestinal Bleeding
Since the initial description of the Rockall Score (RS) in 1996,1 clinical prediction tools have been used to risk-stratify patients hospitalized with upper gastrointestinal bleeding (UGIB). Because of the demand for a simple, pre-endoscopic, risk-assessment tool to help providers optimize resource allocation, the Glasgow Blatchford Score (GBS) then was derived to assess which patients with UGIB were likely to require hospital-based treatment before performance of an esophagogastroduodenoscopy.2 The GBS subsequently has been validated in numerous studies to accurately predict the need for endoscopic intervention and mortal...
Source: Clinical Gastroenterology and Hepatology - December 3, 2018 Category: Gastroenterology Authors: Neil Sengupta Tags: Editorial Source Type: research