Table of Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 21, 2024 Category: Gastroenterology Source Type: research

Elsewhere in the AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 21, 2024 Category: Gastroenterology Source Type: research

Front Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 21, 2024 Category: Gastroenterology Source Type: research

AGA Clinical Practice Update on High-Quality Upper Endoscopy: Expert Review
The purpose of this Clinical Practice Update (CPU) Expert Review is to provide clinicians with guidance on best practices for performing a high-quality upper endoscopic exam. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 21, 2024 Category: Gastroenterology Authors: Satish Nagula, Sravanthi Parasa, Loren Laine, Shailja C. Shah Tags: Clinical Practice Update Source Type: research

DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms
Cytologic and histopathologic diagnosis of nonductal pancreatic neoplasms can be challenging in daily clinical practice, whereas it is crucial for therapy and prognosis. The cancer methylome is successfully used as a diagnostic tool in other cancer entities. Here, we investigate if methylation profiling can improve the diagnostic work-up of pancreatic neoplasms. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 19, 2024 Category: Gastroenterology Authors: Anna Vera D. Verschuur, Wenzel M. Hackeng, Florine Westerbeke, Jamal K. Benhamida, Olca Basturk, Pier Selenica, G. Mihaela Raicu, I. Quintus Molenaar, Hjalmar C. van Santvoort, Lois A. Daamen, David S. Klimstra, Shinichi Yachida, Claudio Luchini, Aatur D. Source Type: research

Global Epidemiology of Gallstones in the 21st Century: A  Systematic Review and Meta-Analysis
Gallstones are common and associated with substantial health and economic burden. We aimed to comprehensively evaluate the prevalence and incidence of gallstones in the 21st century. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 19, 2024 Category: Gastroenterology Authors: Xin Wang, Wenqian Yu, Guoheng Jiang, Hongyu Li, Shiyi Li, Linjun Xie, Xuan Bai, Ping Cui, Qi Chen, YanMei Lou, Li Zou, SuLian Li, ZhongFang Zhou, Chi Zhang, Peng Sun, Mao Min Tags: Systematic Reviews and Meta-analyses Source Type: research

Global Epidemiology of Gallstones in the 21st Century: A Systematic Review and Meta-analysis
Gallstones is common and associated with substantial health and economic burden. We aimed to comprehensively evaluate the prevalence and incidence of gallstones in the 21st century. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 19, 2024 Category: Gastroenterology Authors: Xin Wang, Wenqian Yu, Guoheng Jiang, Hongyu Li, Shiyi Li, Linjun Xie, Xuan Bai, Ping Cui, Qi Chen, YanMei Lou, Li Zou, SuLian Li, ZhongFang Zhou, Chi Zhang, Peng Sun, Mao Min Tags: Systematic Reviews and Meta-analyses Source Type: research

DNA methylation profiling enables accurate classification of non-ductal primary pancreatic neoplasms
Cytological and histopathological diagnosis of non-ductal pancreatic neoplasms can be challenging in daily clinical practice while it is crucial for therapy and prognosis. The cancer methylome is successfully used as a diagnostic tool in other cancer entities. Here, we investigate if methylation profiling can improve the diagnostic work-up of pancreatic neoplasms. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 19, 2024 Category: Gastroenterology Authors: Anna Vera D. Verschuur, Wenzel M. Hackeng, Florine Westerbeke, Jamal K. Benhamida, Olca Basturk, Pier Selenica, G. Mihaela Raicu, I. Quintus Molenaar, Hjalmar C. van Santvoort, Lois A. Daamen, David S. Klimstra, Shinichi Yachida, Claudio Luchini, Aatur D. Source Type: research

Chronic Viral Hepatitis B and C Outweigh MASLD in the Associated Risk of Cirrhosis and HCC
The impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on the development of cirrhosis and hepatocellular carcinoma (HCC) by chronic hepatitis B (CHB) or C infection and antiviral treatment statuses is not well known. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 16, 2024 Category: Gastroenterology Authors: Mei-Hsuan Lee, Yi-Ting Chen, Yu-Han Huang, Sheng-Nan Lu, Tsai-Hsuan Yang, Jee-Fu Huang, Szu-Ching Yin, Ming-Lun Yeh, Chung-Feng Huang, Chia-Yen Dai, Wan-Long Chuang, Ming-Lung Yu, Hwai-I Yang, Hsuan-Yu Chen, Chien-Jen Chen Source Type: research

Long-Term Effectiveness and Durability of COVID-19 Vaccination among Patients with Inflammatory Bowel Disease
COVID-19 vaccination prevents severe disease in most patients with IBD, but immunosuppressive medications can blunt serologic response. We followed adults with IBD for>1-year post-COVID-19 vaccination to describe factors associated with SARS-CoV-2 infection after vaccination, evaluate for a protective SARS-CoV-2 antibody level, characterize SARS-CoV-2 antibody persistence, and identify factors associated with humoral immune response durability. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 16, 2024 Category: Gastroenterology Authors: Erica J. Brenner, Kimberly N. Weaver, Xian Zhang, Arthur J. Kastl, Jennifer A. Strople, Jeremy Adler, Marla C. Dubinsky, Athos Bousvaros, Runa Watkins, Xiangfeng Dai, Wenli Chen, Raymond K. Cross, Peter D.R. Higgins, Ryan C. Ungaro, Meenakshi Bewtra, Eman Source Type: research

Biliary Neuroendocrine Tumor
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 16, 2024 Category: Gastroenterology Authors: Neil Khoury, Qian Wu, Murali Dharan Tags: Images and Videos Source Type: research

Prescribing of Proton Pump Inhibitors for Prevention of Upper Gastrointestinal Bleeding in US Outpatient Visits
Antisecretory medications, primarily proton pump inhibitors (PPIs), have proven effective in reducing upper gastrointestinal toxicities, including upper gastrointestinal bleeding (UGIB), associated with nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin, which are among the most commonly used medications in the United States.1 Accordingly, professional guidance recommends PPIs for patients at high risk for UGIB.2 –4 However, little is known about trends in use of antisecretory medications for gastrointestinal prophylaxis (“gastroprotection”). Herein, we examined contemporary use and prescribing of antisecretor...
Source: Clinical Gastroenterology and Hepatology - February 15, 2024 Category: Gastroenterology Authors: Jacob E. Kurlander, John N. Mafi, Michael J. Racz, Geoffrey D. Barnes, Sameer D. Saini, Patrick D. Meek, Gastrointestinal Bleeding Working Group Tags: Research Letters Source Type: research

Dysphagia and Regurgitated Mass
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 15, 2024 Category: Gastroenterology Authors: Maunoo Lee, Saha Sadeghi, Ronald A. Mathiasen Tags: Images and Videos Source Type: research

Association between celiac disease and irritable bowel syndrome: a nationwide cohort study
To determine the risk of irritable bowel syndrome (IBS) diagnosis in patients with celiac disease (CD) compared to general population comparators. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 15, 2024 Category: Gastroenterology Authors: Karl M årild, Jonas Söderling, Benjamin Lebwohl, Peter HR. Green, Hans Törnblom, Magnus Simrén, Kyle Staller, Ola Olén, Jonas F. Ludvigsson Source Type: research

Heartburn Relief is the Major Unmet Need for Drug Development in Gastroesophageal Reflux Disease: Threshold Value Analysis
Heartburn symptoms contribute to healthcare-seeking among patients with gastroesophageal reflux disease (GERD). Despite clinical guidance, management is often dictated by insurance restrictions. Several potassium-competitive acid blockers (PCAB) are under development as a new class of therapy. We performed economic analyses to align GERD drug development with the needs of gastroenterologists, insurers and patients in a value-based environment. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 15, 2024 Category: Gastroenterology Authors: Eric D. Shah, Michael A. Curley, Amit Patel, Wai-Kit Lo, Walter W. Chan Source Type: research