Effect of Treatment on the Risk of Viral Infections in Inflammatory Bowel Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 1, 2019 Category: Gastroenterology Authors: Philip B. Miner Source Type: research

Neutrophil-to-Lymphocyte Ratio; an Independent Predictor of Mortality or Just a Surrogate Marker of Underlying Complications?
We read with interest the recently published article by Rice et  al1 illustrating the prognostic value of admission neutrophil-to-lymphocyte ratio (NLR) in patients with cirrhosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Stamatis Karakonstantis, Charalampos Lydakis Tags: Letter to the Editor Source Type: research

No Maintenance, No Gain in Long-term Treatment of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is a chronic allergen-induced/immune-mediated disease that has been rapidly increasing in incidence and prevalence and now accounts for substantial health care costs and  utilization.1–3 The chronicity of EoE has been supported by a number of investigations, including a seminal natural history study by Straumann et al4 in which esophageal eosinophilia and dysphagia persisted in EoE patients over a mean follow-up period of more than 7 years without anti-inflammat ory treatment. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Evan S. Dellon Tags: Editorial Source Type: research

Functional Gastrointestinal Symptoms in Inflammatory Bowel Disease: Rising to the Challenge
We read the recent article by Colombel et  al1 with interest. We applaud the authors for drawing attention to the plight of patients with inflammatory bowel disease (IBD) who report ongoing symptoms in the absence of inflammation. Recently, the inflammatory bowel South-Eastern Norway study has highlighted that, even among patients with ulc erative colitis (UC) in deep histological remission, 1 in 3 may report these so-called functional symptoms.2 Whether such symptoms are due to genuine coexisting functional disease3 or not, they have a substantial impact on the quality of life and psychological health of patients. (S...
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: David J. Gracie, Alexander C. Ford Tags: Letter to the Editor Source Type: research

Reply
We appreciate the interest by Karakonstantis et  al in our article showing that NLR associates with mortality in hospitalized patients with cirrhosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Scott W. Biggins, Jennifer Dodge, Kiran Bambha Tags: Letter to the Editor Source Type: research

Reply
We thank Drs Van Kruiningen and Sura for their letter and interest in the topic of granuloma detection in patients with Crohn ’s disease. We agree that our study had an overall lower rate of granuloma detection, but offer the following explanation for this difference with prior literature. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Christopher Johnson, David G. Binion Tags: Letter to the Editor Source Type: research

Reply
We thank Drs Gracie and Ford for their interest in our recent article.1 We appreciate their comments and discussion of the recent data from the Inflammatory Bowel South-Eastern Norway study,2 highlighting both the clinical significance of functional gastrointestinal symptoms in inflammatory bowel disease (IBD) as well as the critical importance of investigating noninflammatory mechanisms in this patient population. Findings further raise the question of whether histologic remission is a sufficient therapeutic target in IBD patients with persistent symptoms. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Jean-Frederic Colombel, Andrea Shin, Peter R. Gibson Tags: Letter to the Editor Source Type: research

Reply
On behalf of our co-authors, we appreciate the interest of Macaluso et  al1 regarding our study, “Low Risk of Pneumonia From Pneumocystis jirovecii Infection in Patients With Inflammatory Bowel Disease Receiving Immune Suppression,”2 and agree with their comment regarding the lack of consensus on which patients should receive primary prophylaxis against Pneumocyst is jirovecii pneumonia (PJP). We also agree with their suggestion that PJP prophylaxis be considered in inflammatory bowel disease (IBD) patients treated with a calcineurin inhibitor and we also believe, as noted in our article, that patients on ...
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Darrell S. Pardi, Thomas G. Cotter, Edward V. Loftus Tags: Letter to the Editor Source Type: research

Clostridium difficile
is a bacterial infection of the intestine that may cause gut symptoms such as: (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Tags: AGA Patient Education Section Source Type: research

Issue Highlights
Although anti-thrombotic agents are a known risk factor for upper gastrointestinal (GI) bleeding, their impact on patient outcomes is unclear. In this issue of Clinical Gastroenterology and Hepatology, Dunne and colleagues1 reported results from a multi-center, multi-national prospective cohort study to assess the effect of anti-thrombotic agents on outcomes in patients with high-risk upper GI bleeding. The authors evaluated 568 patients with acute upper GI bleeding who underwent endoscopy between March 2014 and March 2015, of whom 44% used anti-thrombotic agents. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Amit Singal Tags: Issue highlights Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Source Type: research

Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Source Type: research

Elsewhere in The AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute brings you the best original research in the field with a unique combination of reviews, editorials, podcasts, video abstracts, and outcomes research —all supporting clinical practice. Articles on education, policy, and practice management highlight issues pertinent to clinicians. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Source Type: research

Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Source Type: research

Reply
We appreciate the valuable comments that Abbasi et  al suggest in relation to our article. We divided the cohort into 2 groups in 1:1 randomly and undertook internal validation. In the test cohort, 3.75 KPa of liver stiffness was selected as the optimal cutoff value for prediction of hepatocellular carcinoma (HCC) development as in our original art icle. In the test cohort, the 1-year and 2-year rates of HCC development in patients with liver stiffness ≥3.75 KPa were 5.7% and 11.4%, respectively, whereas they were 1.0% and 2.0%, respectively, in patients with liver stiffness (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Mayu Higuchi, Nobuharu Tamaki, Masayuki Kurosaki, Namiki Izumi Tags: Letter to the Editor Source Type: research

Reply
We thank Dr Thiruvengadam for his interest and comments regarding the Houston Consensus on testing for Helicobacter pylori infection.1 We carefully considered the downsides of H pylori therapy. The increase in antimicrobial resistance worldwide has resulted in a national and international emphasis on antibiotic stewardship to try to curtail current widespread misuse of antibiotics. With regard to pseudomembranous colitis, this infection is a recognized risk associated with both antimicrobial and proton pump inhibitor use. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Hashem B. El-Serag, David Y. Graham Tags: Letter to the Editor Source Type: research

Successful endoscopic removal of a large pancreatic stone in a patient after pancreaticoduodenectomy
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Hiroki Kitamoto, Masashi Fukushima, Tetsuro Inokuma Source Type: research

A pancreatic lymphoepithelial cyst with floating-balls
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Stefano Francesco Crin ò, Armando Gabbrielli, Erminia Manfrin Source Type: research

A conceptual approach to understanding treatment response in eosinophilic esophagitis
While the diagnosis and initial treatment of eosinophilic esophagitis (EoE) are becoming more standardized, there are still major gaps in knowledge related to measuring treatment response. One such question centers on how to measure treatment response and what treatment end-points should be. This impacts not only patient care and engagement in decision-making, but also the field of drug development. In addition, studies so far have use a myriad of treatment end-points including over a dozen histology end-point criteria. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Evan S. Dellon, Sandeep K. Gupta Source Type: research

Sigmoid gallstone ileus
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: M. Dur án, A. Naranjo, J. Briceño Source Type: research

Biliary ascariasis – an unusual case of obstructive jaundice
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Nor Alia Mohd Noor, Si Ning Goh, Chun Hai Tan Source Type: research

Target and whirl signs: volvulus of intussuscepted colon in an infant
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Yoshitomo Yasui, Tsubasa Shironomae, Tsuyoshi Kuwahara Source Type: research

Primary large anorectal melanoma presenting as intermittent rectal bleeding and mimicking a hemorrhoid
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Rohan Mandaliya, Nidhi Malhotra, Brian Bello Source Type: research

Localized Gastrointestinal Amyloidosis Manifesting as an Isolated Colonic Ulcer: A Rare Cause of Hematochezia
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Sherman Picardo, Konstantin Koro, Cynthia H. Seow Source Type: research

Annular Pancreas
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Manol Jovani, Linda S. Lee Source Type: research

A rare cause of pneumatosis intestinalis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Gurpreet Singh Sandhu, Mahesh Parkash, Pankaj Gupta Source Type: research

Reply to Methodological issues on prediction of hepatocellular carcinoma after sustained virological responses
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Mayu Higuchi, Nobuharu Tamaki, Masayuki Kurosaki, Namiki Izumi Source Type: research

Reply to Letter to the Editor regarding the Houston Consensus conference on testing for H. pylori infection in the United States
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Hashem B. El-Serag, David Y. Graham Source Type: research

A Pancreatic Lymphoepithelial Cyst With Floating Balls
An asymptomatic 60-year-old man was referred for the evaluation of a 70-mm pancreatic lesion. Blood tests, including carbohydrate antigen 19-9, were normal. On T2-weighted magnetic resonance images, the lesion appeared slightly hyperintense with inhomogeneous content. Endoscopic ultrasound revealed a cyst with a regular wall and central thickened septum, containing multiple round, echoic, floating balls (Figure  1A), avascular after contrast injection (Figure 1B). Only 10 mL of yellowish-brown and very thick fluid were slowly aspirated through a 19-gauge needle. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Stefano Francesco Crin ò, Armando Gabbrielli, Erminia Manfrin Tags: Image of the Month Source Type: research

Biliary Ascariasis: An Unusual Case of Obstructive Jaundice
A 30-year-old woman presented with fever and abdominal pain for 5 days. Physical examination revealed tenderness in the epigastrium and right hypochondrium. Laboratory tests showed deranged liver function tests with an obstructive picture (bilirubin of 65 μmol/L). Magnetic resonance cholangiopancreatography demonstrated linear hypointense filling defects in the common bile duct, suspicious for biliary ascariasis (Figure 1A and B). Endoscopic retrograde cholangiopancreatography confirmed the diagnosis when worms were discovered within the stomach an d duodenum and in the common bile duct (Figure 1C and D). (Sou...
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Nor Alia Mohd Noor, Goh Si Ning, Tan Chun Hai Tags: Image of the Month Source Type: research

Target and Whirl Signs: Volvulus of Intussuscepted Colon in an  Infant
An 8-month-old boy presented with a 6-day history of intermittent vomiting and watery diarrhea. Physical examination showed moderate dehydration and abdominal distension without palpable masses. He  was positive for fecal adenovirus antigens. He remained lethargic despite hydration with intravenous fluids. Abdominal contrast-enhanced computed tomography revealed the target sign (bowel-within-bowel configuration) (Figure 1A, arrow) and the whirl sign (bowel apparently swirls with its mesenter y) (Figure 1A, arrowhead). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 30, 2019 Category: Gastroenterology Authors: Yoshitomo Yasui, Tsubasa Shironomae, Tsuyoshi Kuwahara Tags: Image of the Month Source Type: research

Prevalence and Risk Factors of Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis
In patients with nonalcoholic fatty liver disease (NAFLD), steatohepatitis (NASH) is a risk factor for development of fibrosis. However, fibrosis has been observed in livers of patients without NASH. We aimed to estimate the prevalence of fibrosis in patients without NASH and risk factors for fibrosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 29, 2019 Category: Gastroenterology Authors: S. Pelusi, A. Cespiati, R. Rametta, G. Pennisi, V. Mannisto, C. Rosso, G. Baselli, P. Dongiovanni, A.L. Fracanzani, S. Badiali, M. Maggioni, A. Craxi, S. Fargion, D. Prati, V. Nobili, E. Bugianesi, S. Romeo, J. Pihlajamaki, S. Petta, L. Valenti Source Type: research

Transnasal Endoscopy in Unsedated Children With Eosinophilic Esophagitis Using Virtual Reality Video Goggles
Evaluation and treatment of children with eosinophilic esophagitis (EoE) requires serial endoscopic, visual, and histologic assessment by sedated esophagogastroduodenoscopy (EGD). Unsedated transnasal endoscopy (TNE) was reported to be successful in a pilot study of children. We evaluated video goggle and virtual reality-based unsedated TNE in children with EoE, collecting data on rates of completion, adverse events, and adequacy of visual and histologic findings. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 29, 2019 Category: Gastroenterology Authors: Nathalie Nguyen, William J. Lavery, Kelley E. Capocelli, Clinton Smith, Emily M. DeBoer, Robin Deterding, Jeremy D. Prager, Kristina Leinwand, Greg E. Kobak, Robert E. Kramer, Calies Menard-Katcher, Glenn T. Furuta, Dan Atkins, David Fleischer, Matthew Gr Source Type: research

Upright Integrated Relaxation Pressure Facilitates Characterization of Esophagogastric Junction Outflow Obstruction
Under the Chicago Classification of esophageal motility disorders, esophagogastric junction outflow obstruction (EGJOO) includes a varied clinical spectrum that results in diagnostic and management difficulties. We aimed to demonstrate that including upright swallows during high-resolution manometry (HRM) helps identify patients with clinically significant EGJOO. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 29, 2019 Category: Gastroenterology Authors: Joseph R. Triggs, Dustin A. Carlson, Claire Beveridge, Anand Jain, Michael Y. Tye, Peter J. Kahrilas, John E. Pandolfino Source Type: research

Machine Learning-based Development and Validation of a Scoring System for Screening High Risk Esophageal Varices
Many patients with cirrhosis who undergo esophagogastroduodenoscopy (EGD) screening for esophageal varices (EVs) are found to have no or only small EVs. Endoscopic screening for EVs is therefore a potentially deferrable procedure that increases patient risk and healthcare cost. We developed and validated a scoring system, based on readily-available data, to identify patients with EVs varices that need treatment. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 29, 2019 Category: Gastroenterology Authors: Tien Dong, Amir Kalani, Elizabeth Aby, Long Le, Kayti Luu, Meg Hauer, Rahul Kamath, Keith Lindor, James Tabibian Source Type: research

Alcohol-related Liver Disease is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide
Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly due to the large burden of advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages of disease development than patients with hepatitis C virus (HCV) infection or other etiologies. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 29, 2019 Category: Gastroenterology Authors: Neil D. Shah, Meritxell Ventura-Cots, Juan G. Abraldes, Mohamed Alboraie, Ahmad Alfadhli, Josepmaria Argemi, Ester Badia-Aranda, Enrique Arus Soler, A. Sidney Barritt, Fernando Bessone, Marina Biryukova, Flair J. Carrilho, Marlen Castellanos Fern ández, Source Type: research

Prevalence and Risk Factors if Significant Fibrosis in Patients With Nonalcoholic Fatty Liver Without Steatohepatitis
In patients with nonalcoholic fatty liver disease (NAFLD), steatohepatitis (NASH) is a risk factor for development of fibrosis. However, fibrosis has been observed in livers of patients without NASH. We aimed to estimate the prevalence of fibrosis in patients without NASH and risk factors for fibrosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 29, 2019 Category: Gastroenterology Authors: S. Pelusi, A. Cespiati, R. Rametta, G. Pennisi, V. Mannisto, C. Rosso, G. Baselli, P. Dongiovanni, A.L. Fracanzani, S. Badiali, M. Maggioni, A. Craxi, S. Fargion, D. Prati, V. Nobili, E. Bugianesi, S. Romeo, J. Pihlajamaki, S. Petta, L. Valenti Source Type: research

Machine Learning-based Development and Validation of a Scoring System for Screening High-Risk Esophageal Varices
Many patients with cirrhosis who undergo esophagogastroduodenoscopy (EGD) screening for esophageal varices (EVs) are found to have no or only small EVs. Endoscopic screening for EVs is therefore a potentially deferrable procedure that increases patient risk and healthcare cost. We developed and validated a scoring system, based on readily-available data, to identify patients with EVs varices that need treatment. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 29, 2019 Category: Gastroenterology Authors: Tien Dong, Amir Kalani, Elizabeth Aby, Long Le, Kayti Luu, Meg Hauer, Rahul Kamath, Keith Lindor, James H. Tabibian Source Type: research

Short Disease Duration Does Not Always Indicate Early Crohn ’s Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 18, 2019 Category: Gastroenterology Authors: Iago Rodr íguez-Lago, Manuel Barreiro-de Acosta Source Type: research

Effects of Medical Cannabis on Use of Opioids and Hospital Visits by Patients With Painful Chronic Pancreatitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 18, 2019 Category: Gastroenterology Authors: Trevor S. Barlowe, Jenna L. Koliani-Pace, Kerrington D. Smith, Stuart R. Gordon, Timothy B. Gardner Source Type: research

A Comment on Anti –Helicobacter pylori Therapy and Autoimmune Diseases
I have read with great interest the retrospective cohort study by Lin et  al1 that was conducted by using the National Health Insurance Research database in Taiwan. The authors reported that patients with Helicobacter pylori treatment had a higher incidence of autoimmune diseases than untreated patients or those with unknown H pylori status. As reported, in this databas e, data on the outcome of H pylori treatment were not available. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 17, 2019 Category: Gastroenterology Authors: Rinaldo Pellicano Tags: Letter to the Editor Source Type: research

A comment on anti-H. pylori therapy and autoimmune diseases
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 17, 2019 Category: Gastroenterology Authors: Rinaldo Pellicano Source Type: research

Association Between Helicobacter pylori Exposure and Decreased Odds of Eosinophilic Esophagitis —a Systematic Review and Meta-analysis
Previous or current infection with Helicobacter pylori (exposure) has been reported to protect against eosinophilic esophagitis (EoE), perhaps due to H pylori-induced immunomodulation. However, findings vary. We performed a systematic review and meta-analysis of comparative studies to more clearly define the association between H pylori exposure and EoE. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 16, 2019 Category: Gastroenterology Authors: Shailja C. Shah, Adam Tepler, Richard M. Peek, Jean-Frederic Colombel, Ikuo Hirano, Neeraj Narula Source Type: research

Cost-effectiveness of Colorectal Cancer Screening Strategies —a Systematic Review
Widespread screening for colorectal cancer (CRC) has reduced its incidence and mortality. Previous studies investigated the economic effects of CRC screening. We performed a systematic review to provide up to date evidence of the cost effectiveness of CRC screening strategies by answering 3 research questions. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 16, 2019 Category: Gastroenterology Authors: Tao Ran, Chih-Yuan Cheng, Benjamin Misselwitz, Hermann Brenner, Jasper Ubels, Michael Schlander Source Type: research

Endocuff Vision Reduces Inspection Time Without Decreasing Lesion Detection in a Randomized Colonoscopy Trial
Mucosal exposure devices improve detection of lesions during colonoscopy and have reduced examination times in uncontrolled studies. We performed a randomized trial of Endocuff Vision vs standard colonoscopy to compare differences in withdrawal time (the primary end point). We proposed that Endocuff Vision would allow complete mucosal inspection in a shorter time without impairing lesion detection. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 16, 2019 Category: Gastroenterology Authors: Douglas K. Rex, James E. Slaven, Jonathan Garcia, Rachel Lahr, Meghan Searight, Seth A. Gross Source Type: research

Minding the Gap Between Clinical Trials and Treatment With the Mediterranean Dietary Pattern for Patients With Nonalcoholic Fatty Liver Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 14, 2019 Category: Gastroenterology Authors: Shira Zelber-Sagi Source Type: research

Exam 2: Patient-Reported Outcomes and Endoscopic Appearance of Ulcerative Colitis: A Systematic Review and Meta-analysis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 11, 2019 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activity Source Type: research

Holding gastroenterologists accountable for colonoscopy through MACRA episode-based cost measure
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 11, 2019 Category: Gastroenterology Authors: Shazia Mehmood Siddique, Shivan J. Mehta Source Type: research

Reply
We appreciate Dr Palmer ’s thoughtful response to our manuscript, which found baseline pain variability to be a significant predictor of the abdominal pain placebo response in irritable bowel syndrome (IBS) with constipation.1,2 We agree with Dr Palmer that regression to the mean is part of the placebo effect, but we wo uld argue that response to placebo is much more complex than measurement artifact or spontaneous improvement of symptoms. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 10, 2019 Category: Gastroenterology Authors: Sarah Ballou Tags: Letter to the Editor Source Type: research