Diagnostic Performance of Vibration Controlled Transient Elastography in Liver Transplant Recipients
Vibration-controlled transient elastography (VCTE) is a non-invasive tool for detecting hepatic steatosis and fibrosis in patients who have not received liver transplants. We aimed to evaluate the diagnostic performance of VCTE in detection of hepatic steatosis and fibrosis in patients who have undergone liver transplantation. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 6, 2020 Category: Gastroenterology Authors: Mohammad Shadab Siddiqui, Michael O. Idowu, Katharine Stromberg, Adam Sima, Emily Lee, Samarth Patel, Sophia Ghaus, Carolyn Driscoll, Richard K. Sterling, Binu John, Chandra Bhati Source Type: research

Management and Outcomes of Bleeding Within 30 Days of Colonic Polypectomy in a Large, Real-life Multicenter Cohort Study
Management of delayed (within 30 days) post-polypectomy bleeding (DPPB) has not been standardized. Patients often undergo colonoscopies that do not provide any benefit. We aimed to identify factors associated with therapeutic intervention and active bleeding after DPPB. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 6, 2020 Category: Gastroenterology Authors: E. Rodr íguez de Santiago, M. Hernández-Tejero, L. Rivero-Sánchez, O. Ortiz, I. García de la Filia-Molina, J.R. Foruny-Olcina, H.M. Marcos Prieto, M. García-Prada, A. González-Cotorruelo, M.A. De Jorge Turrión, A. Jiménez-Jurado, C. Rodríguez-Esc Source Type: research

Factors Associated With Response to Anorectal Biofeedback Therapy in Patients With Fecal Incontinence
Anorectal biofeedback (BF) is commonly used to treat patients with fecal incontinence (FI), but demand usually exceeds availability. It is therefore important to identify patients most likely to respond to BF treatment. We aimed to identify pre-treatment clinical or physiologic factors that might be used to predict completion and success of BF in women with FI. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 3, 2020 Category: Gastroenterology Authors: Yoav Mazor, Gillian Prott, Michael Jones, Anastasia Ejova, John Kellow, Allison Malcolm Source Type: research

Untangling Nonerosive Reflux Disease From Functional Heartburn
Heartburn is a common symptom in clinical practice, but as many as 70% of patients have normal findings from upper endoscopy. Most of these patients have nonerosive reflux disease (NERD) or functional esophageal disorders. NERD is the most common gastroesophageal reflux disease, and functional heartburn is the most common cause for refractory heartburn. In patients with NERD, symptoms arise from gastroesophageal reflux and esophageal hypersensitivity, whereas in patients with functional heartburn, symptoms result from esophageal hypersensitivity. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 1, 2020 Category: Gastroenterology Authors: Dhyanesh Patel, Ronnie Fass, Michael Vaezi Source Type: research

Working Together to Meet the Needs of Patients with Inflammatory Bowel Diseases
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 1, 2020 Category: Gastroenterology Authors: Erica J. Brenner, Michael D. Kappelman Source Type: research

Management of Chronic Abdominal Distension and Bloating
Abdominal bloating and distension are 2 of the most commonly reported gastrointestinal symptoms. Abdominal bloating is characterized by symptoms of trapped gas, abdominal pressure, and fullness. Abdominal distension is defined as a measurable increase in abdominal girth. These symptoms frequently co-exist, although they can occur separately. Defined by Rome IV criteria, functional abdominal bloating and distension commonly coincide with other functional gastrointestinal disorders, such as functional dyspepsia, irritable bowel syndrome, and functional constipation. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 1, 2020 Category: Gastroenterology Authors: Brian E. Lacy, David Cangemi, Maria Vazquez-Roque Source Type: research

Untangling Non-erosive Reflux Disease From Functional Heartburn
Heartburn is a common symptom in clinical practice, but as many as 70% of patients have normal findings from upper endoscopy. Most of these patients have non-erosive reflux disease (NERD) or functional esophageal disorders. NERD is the most common gastroesophageal reflux disease, and functional heartburn is the most common cause for refractory heartburn. In patients with NERD, symptoms arise from gastroesophageal reflux and esophageal hypersensitivity, whereas in patients with functional heartburn, symptoms result from esophageal hypersensitivity. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 1, 2020 Category: Gastroenterology Authors: Dhyanesh Patel, Ronnie Fass, Michael Vaezi Source Type: research

Association Between Endoscopist Annual Procedure Volume and Colonoscopy Quality: Systematic Review and Meta-analysis
In addition to monitoring adverse events (AEs) and post-colonoscopy colorectal cancers (PCCRC), indicators for assessing colonoscopy quality include adenoma detection rate (ADR) and cecal intubation rate (CIR). It is unclear whether there is an association between annual colonoscopy volume and ADR, CIR, AEs, or PCCRC. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Nauzer Forbes, Devon J. Boyne, Matthew S. Mazurek, Robert J. Hilsden, R. Liam Sutherland, Joy Pader, Yibing Ruan, Abdel Aziz Shaheen, Clarence Wong, Mubasiru Lamidi, Diane L. Lorenzetti, Darren R. Brenner, Steven J. Heitman Source Type: research

Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early- vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort
Idiopathic chronic pancreatitis (ICP) is the second most common subtype of CP. In 1994, researchers reported the bimodal age at onset of ICP symptoms: early-onset ICP (EO-ICP; median age, 19.2 years) and late-onset ICP (LO-ICP; median age, 56.2 years). Ages of onset and clinical features of ICP differed from those of alcohol-related CP (ACP). However, variants in PRSS1 had not yet been associated with ICP. We reexamined ages of onset of ICP in a large, North American cohort of patients, and investigated the effects of genetic factors and alcohol use in patients with EO-ICP, LO-ICP, or ACP. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Michele D. Lewis, Jyothsna Talluri, C. Mel Wilcox, Judah N. Abberbock, Gong Tang, Darwin L. Conwell, Peter A. Banks, Gregory A. Cote, Stuart Sherman, Samer Alkaade, Timothy B. Gardner, Michelle A. Anderson, Bimaljit S. Sandhu, Thiruvengadam Muniraj, Chris Source Type: research

Associations Between Mutations in MSH6 and PMS2 and Risk of Surveillance-detected Colorectal Cancer
Lynch syndrome is the most common inherited cause of colorectal cancer (CRC). Contemporary and mutation-specific estimates of CRC-risk in patients undergoing colonoscopy would optimize surveillance strategies. We performed a prospective national cohort study, using data from New Zealand, to assess overall and mutation-specific risk of CRC in patients with Lynch syndrome undergoing surveillance. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Mehul Lamba, Chris Wakeman, Rosy Ebel, Sarah Hamilton, Chris Frampton, Maxene Kiesanowski, Ben Griffiths, John Keating, Susan Parry, Teresa Chalmers-Watson Source Type: research

Antibiotics Do Not Reduce Length of Hospital Stay for Uncomplicated Diverticulitis in a Pragmatic Double-Blind Randomized Trial
Antibiotic treatment is the standard care for patients with uncomplicated acute diverticulitis. However, this practice is based on low-level evidence and has been challenged by findings from 2 randomized trials, which did not include a placebo group. We investigated the non-inferiority of placebo vs antibiotic treatment for the management of uncomplicated acute diverticulitis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Rebekah Jaung, Sherry Nisbet, Martijn Pieter Gosselink, Angelina Di Re, Celia Keane, Anthony Lin, Tony Milne, Bruce Su ’a, Siraj Rajaratnam, Grahame Ctercteko, Li Hsee, David Rowbotham, Andrew Hill, Ian Bissett Source Type: research

Smartphone Application to Reinforce Education Increases High-Quality Preparation for Colorectal Cancer Screening Colonoscopies in a Randomized Trial
Sufficient bowel preparation is crucial for successful screening and surveillance colonoscopy. However, rates of inadequate preparation are still high. We investigated the effects of reinforced patient education using a smartphone application software (APP) for colonoscopy preparation in participants in a CRC screening program. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Benjamin Walter, Rena Frank, Leopold Ludwig, Nektarios Dikopoulos, Martina Mayr, Bruno Neu, Benjamin Mayer, Alexander Hann, Benjamin Meier, Karel Caca, Thomas Seufferlein, Alexander Meining Source Type: research

Colonic Lipomatosis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Adnan Aman Khan, Ahsan Ullah Khan, Justin Thomas Kupec Tags: Image of the Month Source Type: research

What Clues Can We Use From Primary Sclerosing Cholangitis With Inflammatory Bowel Disease Phenotypes?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Andrew J. Muir Tags: Editorial Source Type: research

Will the quality of research remain the same during the COVID-19 pandemic?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Laurent Peyrin-Biroulet Source Type: research

Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early Vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort
Idiopathic chronic pancreatitis (ICP) is the second most common subtype of CP. In 1994, researchers reported the bimodal age at onset of ICP symptoms: early onset ICP (EO-ICP; median age, 19.2 y) and late-onset ICP (LO-ICP; median age, 56.2 y). Ages of onset and clinical features of ICP differed from those of alcohol-related CP (ACP). However, variants in PRSS1 had not yet been associated with ICP. We reexamined ages of onset of ICP in a large, North American cohort of patients, and investigated the effects of genetic factors and alcohol use in patients with EO-ICP, LO-ICP, and ACP. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 30, 2020 Category: Gastroenterology Authors: Michele D. Lewis, Jyothsna Talluri, C. Mel Wilcox, Judah N. Abberbock, Gong Tang, Darwin L. Conwell, Peter A. Banks, Gregory A. Cote, Stuart Sherman, Samer Alkaade, Timothy B. Gardner, Michelle A. Anderson, Bimaljit S. Sandhu, Thiruvengadam Muniraj, Chris Source Type: research

Reply
We read with interest the comments by O ’Connor et al in response to our article. In their cohort, sexual pain was associated with a higher likelihood of reporting somatic symptoms on the Patient Health Questionnaire-12 (PHQ-12). However, sexual pain was not associated with fecal calprotectin as a marker of inflammatory bowel disease ( IBD) activity. The implication of their response is that women who report sexual pain are women who report more symptoms in general, and that vulvovaginal discomfort is not biologically associated with IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Authors: Samsiya Ona, Millie Long, Caroline Mitchell Tags: Letter to the Editor Source Type: research

Acetaminophen in Plasma and Acute Liver Failure
We read the article “Acetaminophen Is Undetectable in Plasma From More Than Half of Patients Believed to Have Acute Liver Failure” with great interest.1 Leventhal et al1 noted that “Acetaminophen was undetectable in serum samples from 227 patients (52%)” and concluded that “Clinicians should not exclude acet aminophen toxicity because of undetectable levels or withhold N-acetylcysteine for patients with ALI or ALF when acetaminophen toxicity is suspected.” We would like to share ideas on the present study. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Authors: Sora Yasri, Viroj Wiwanitkit Tags: Letter to the Editor Source Type: research

Association Between Inflammatory Bowel Disease and Diabetes Mellitus
The association between inflammatory bowel disease and the risk of other comorbidities has been extensively studied.1,2 Recently a cohort study from Denmark conducted by Jess et  al3 published in Clinical Gastroenterology and Hepatology illustrated that people with inflammatory bowel disease were at increased risk of type 2 diabetes mellitus when compared with people without inflammatory bowel disease (incidence ratio, 1.54; 95% confidence interval, 1.49–1.60). These res ults were consistent with another cohort study from South Korea that found a similar association between inflammatory bowel disease and diabete...
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Authors: Shih-Wei Lai, Yu-Hung Kuo, Kuan-Fu Liao Tags: Letter to the Editor Source Type: research

What Patients Need to Know About Living With IBD
This is the fifth in a series of articles on what patients need to know about living with inflammatory bowel disease. The entire series, which will be published bi-monthly in the AGA Patient Education Section of Clinical Gastroenterology and Hepatology, can be found in the AGA GI Patient Center at https://www.gastro.org/practice-guidance/gi-patient-center/topic/inflammatory-bowel-disease-ibd. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Tags: AGA Patient Education Section Source Type: research

Correction
Fricker ZP, Reddy KR. When (and when not) to treat patients with HBV infection. Clin Gastroenterol Hepatol 2019;17:2644 –2647. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Tags: Correction Source Type: research

Correction
What patients need to know about living with IBD. Clin Gastroenterol Hepatol 2020;18:xv. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Tags: Correction Source Type: research

Issue highlights
Lynch syndrome is the most common inherited cause of gastrointestinal cancer. Although current guidelines recommend endoscopic screening for gastric cancer and Helicobacter pylori infection in carriers of germline variants causing Lynch syndrome, there are limited data to support these recommendations. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Authors: Vincent Wong Tags: Issue Highlights Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Source Type: research

Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Source Type: research

Elsewhere in The AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute brings you the best original research in the field with a unique combination of reviews, editorials, podcasts, video abstracts, and outcomes research —all supporting clinical practice. Articles on education, policy, and practice management highlight issues pertinent to clinicians. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Source Type: research

Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Source Type: research

Persistent Diarrhea in Patients With Crohn ’s Disease After Mucosal Healing is Associated With Lower Diversity of the Intestinal Microbiome and Increased Dysbiosis
In patients with inflammatory bowel diseases (IBD), symptoms do not always associate with the severity of endoscopic inflammation and can persist after mucosal healing. We investigated whether symptoms in patients with successfully treated IBD are related to composition of the intestinal microbiome. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 24, 2020 Category: Gastroenterology Authors: Karen Boland, Larbi Bedrani, Williams Turpin, Boyko Kabakchiev, Joanne Stempak, Krzysztof Borowski, Geoffrey Nguyen, A Hillary Steinhart, Michelle I. Smith, Kenneth Croitoru, Mark S. Silverberg Source Type: research

After a Decade of Marketing Gastroenterology Practices, Has  Anything Changed?
The primary objective of medical practice marketing is to differentiate your brand and communicate your unique attributes and benefits to both your patients and potential patients. In this review, we cover basic fundamentals of marketing, suggest some practical strategies for success in gastroenterology, and discuss how to calculate the return on investment of marketing cost. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 23, 2020 Category: Gastroenterology Authors: Reed Blanchard Hogan, Mary Beth Hogan Tags: Practice Management: The Road Ahead Source Type: research

Real-world Gluten Exposure in Patients With Celiac Disease on Gluten-Free Diets, Determined From Gliadin Immunogenic Peptides in Urine and Fecal Samples
It is not clear how often patients who are on gluten-free diets (GFDs) for treatment celiac disease are still exposed to gluten. We studied levels of gluten immunogenic peptides (GIP) in fecal and urine samples, collected over 4 weeks, from patients with celiac disease following a long-term GFD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 23, 2020 Category: Gastroenterology Authors: Juan Pablo Stefanolo, Mart ín Tálamo, Samanta Dodds, María de la Paz Temprano, Ana Florencia Costa, María Laura Moreno, María Inés Pinto-Sánchez, Edgardo Smecuol, Horacio Vázquez, Andrea Gonzalez, Sonia Isabel Niveloni, Eduardo Mauriño, Elena F. Source Type: research

A Decade of GI Marketing … Has anything changed?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 23, 2020 Category: Gastroenterology Authors: Reed B. Hogan, Beth Hogan Tags: Practice Management Source Type: research

Deep Convolutional Neural Network-aided Detection of Portal Hypertension in Patients With Cirrhosis
Non-invasive and accurate methods are needed to identify patients with clinically significant portal hypertension (CSPH). We investigated the ability of deep convolutional neural network (CNN) analysis of computed tomography (CT) or magnetic resonance (MR) to identify patients with CSPH. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 21, 2020 Category: Gastroenterology Authors: Yanna Liu, Zhenyuan Ning, Necati Örmeci, Weimin An, Qian Yu, Kangfu Han, Yifei Huang, Dengxiang Liu, Fuquan Liu, Zhiwei Li, Huiguo Ding, Hongwu Luo, Changzeng Zuo, Changchun Liu, Jitao Wang, Chunqing Zhang, Jiansong Ji, Wenhui Wang, Zhiwei Wang, Weidong Source Type: research

Long-term Efficacy and Tolerability of RPC4046 in an Open-Label Extension Trial of Patients With Eosinophilic Esophagitis
The short-term efficacy of RPC4046, a monoclonal antibody against interleukin-13, has been demonstrated in patients with eosinophilic esophagitis (EoE). We investigated the long-term efficacy and safety of RPC4046 in an open-label, long-term extension (LTE) study in adults with EoE. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 21, 2020 Category: Gastroenterology Authors: Evan S. Dellon, Margaret H. Collins, Marc E. Rothenberg, Yehudith Assouline-Dayan, Larry Evans, Sandeep Gupta, Alain Schoepfer, Alex Straumann, Ekaterina Safroneeva, Cristian Rodriguez, Neil Minton, Steven Y. Hua, Ikuo Hirano Source Type: research

Visualization of Buried Bumper Syndrome With Upper Endoscopy
An 82-year-old woman with small-bowel resection and percutaneous gastrostomy (PEG) tube insertion for mesenteric ischemia 2 months ago was admitted for anemia. Her hemoglobin level was 8 g/dL with no overt gastrointestinal bleeding. Upper endoscopy visualized erosion of the internal gastrostomy bumper through the wall of the gastric body (Figures A and B), consistent with buried bumper syndrome. No other gastric or duodenal ulcers were identified. Computerized tomography located the bumper in the anterior abdominal wall, not entirely within the stomach (Figures C and D). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Michael Makar, Evan Orosz, Anish Vinit Patel Tags: Electronic Image of the Month Source Type: research

▪▪▪
The conclusion by Yang et  al1 that “replacing animal or dairy fats with vegetable fats, or replacing saturated fats with monounsaturated or polyunsaturated fats, was associated with reduced risk of hepatocellular carcinoma (HCC)” deserves robust comment. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Alain Braillon Tags: Letters to the Editor Source Type: research

Lusutrombopag Is Safe and Efficacious for Treatment of Thrombocytopenia in Patients With and Without Hepatocellular Carcinoma
Patients with hepatocellular carcinoma (HCC) secondary to chronic liver disease often require invasive procedures, but frequently have thrombocytopenia. Lusutrombopag is an agonist of the thrombopoietin receptor that activates platelet production. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Naim Alkhouri, Michio Imawari, Namiki Izumi, Yukio Osaki, Toshimitsu Ochiai, Takeshi Kano, Roy Bentley, Franco Trevisani Source Type: research

Minimal Hepatic Encephalopathy and Mild Cognitive Impairment Worsen Quality of Life in Elderly Patients with Cirrhosis
Patients with cirrhosis are growing older. The overlap between minimal hepatic encephalopathy (MHE) and pre-dementia mild cognitive impairment (MCI) could affect quality of life (QOL). We investigated the performance of elderly patients with cirrhosis on tests for MHE and MCI and their effects on QOL. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Jasmohan S. Bajaj, Andres Duarte-Rojo, Jesse J. Xie, Chathur Acharya, James Wade, Carlos Robles, Leroy R. Thacker, Christopher Flud, Andrew Fagan, Mauricio Garcia-Saenz-de-Sicilia, Melanie B. White, Megan Kelly, Vy Nguyen, Edith A. Gavis, Hugo E. Vargas Source Type: research

Palmar xanthomata in a resolving cholestatic liver injury
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Mark R. Pedersen, Robert J. Fontana, William M. Lee Tags: Image of the Month Source Type: research

Methotrexate-associated Lymphoproliferative Disorder of the Small Intestine
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Hisashi Shiga, Izuru Abe, Atsushi Masamune Tags: Image of the Month Source Type: research

Low but Long-lasting Risk of Reversal of Seroconversion in Patients With Rheumatoid Arthritis Receiving Immunosuppressive Therapy
In patients who have resolved hepatitis B virus (HBV) infection, treatment of rheumatoid arthritis (RA) can result in reappearance of hepatitis B surface antigen (HBsAg), called reverse seroconversion. We investigated clinical features and outcomes of reverse seroconversion in patients who received immunosuppressant or biologic therapy for RA. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Ming-Han Chen, Ming-Huang Chen, Chung-Tei Chou, Ming-Chih Hou, Chang-Youh Tsai, Yi-Hsiang Huang Source Type: research

Normal Functional Luminal Imaging Probe Panometry Findings Associate With Lack of Major Esophageal Motility Disorder on High-Resolution Manometry
A normal esophageal response to distension on functional luminal imaging probe (FLIP) panometry during endoscopy might indicate normal esophageal motor function. We aimed to investigate the correlation of normal FLIP panometry findings with esophageal high-resolution manometry (HRM) and outcomes of discrepant patients. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Alexandra J. Baumann, Erica N. Donnan, Joseph R. Triggs, Wenjun Kou, Jacqueline Prescott, Alex Decorrevont, Emily Dorian, Peter J. Kahrilas, John E. Pandolfino, Dustin A. Carlson Source Type: research

Visualization of Buried Bumper Syndrome with Upper Endoscopy.
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Michael Makar, Evan Orosz, Anish Vinit Patel Tags: Image of the Month Source Type: research

Reply to the Editor ’s comment
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Alain Braillon Source Type: research

Don't overlook digestive symptoms in patients with 2019 novel coronavirus disease (COVID-19)
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2020 Category: Gastroenterology Authors: Shihua Luo, Xiaochun Zhang, Haibo Xu Source Type: research

Cumulative Exposure to Infliximab, But Not Trough Concentrations, Correlates With Rate of Infection
Infliximab increases the risk of infection in patients with inflammatory bowel diseases (IBD), but there is controversy over the relationship between drug concentration and infections. We aimed to assess factors associated with infection in infliximab-treated patients, including pharmacokinetic features. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 18, 2020 Category: Gastroenterology Authors: Amandine Landemaine, Antoine Petitcollin, Charl ène Brochard, Céline Miard, Marie Dewitte, Eric Le Balc’h, Thomas Grainville, Eric Bellissant, Laurent Siproudhis, Guillaume Bouguen Source Type: research

Sloughing Mucosa in Esophagitis Dissecans Superficialis
A 29-year-old man with alcohol abuse presented to the emergency department for multiple episodes of hematemesis. He did disclose epigastric pain and gastroesophageal reflux. He was hemodynamically stable with hemoglobin of 12.8 g/dL. An upper endoscopy revealed a striking sloughing of mucosa into sheets and casts in the distal esophagus (Figures A and B), consistent with a diagnosis of esophagitis dissecans superficialis (EDS). He was treated with bowel rest and acid suppression, and his symptoms resolved over 2 days. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 18, 2020 Category: Gastroenterology Authors: Evan Orosz, Anish Vinit Patel Tags: Electronic Image of the Month Source Type: research

Esophageal Angiolipoma: A Tongue-Like Mucosal Mass
A 60-year-old man presented to our hospital for a 6-month history of belching and vomit, occasionally accompanied by a reducible purple “tongue-like” foreign body seen in the oral cavity. Upon presentation, physical examination and laboratory studies were unremarkable. Esophagogastroduodenoscopy revealed a smooth and soft pedunculated mass measuring 10 × 3.5 cm originated about 19–31 cm from the incisors (Figure A). Endoscop ic ultrasonography revealed a mucosal mass with homogeneous hyperechoic echogenicity, without malignant features (Figure B). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 18, 2020 Category: Gastroenterology Authors: Jun Yi, Xiaowei Liu, Fujun Li Tags: Electronic Image of the Month Source Type: research

Reply
We thank Drs Queiroz and Charabaty for their interest in our recent work, and we appreciate their interpretation of our findings in the context of other existing data.1 In their letter, they underscore the value of combined monitoring of serum infliximab and fecal calprotectin (fCal) concentrations to inform precision dosing of infliximab in patients with Crohn ’s disease (CD).2 In addition, they also touch on current day’s uncertainties, including the reversible causality between infliximab concentrations and disease activity, the predictive value of fCal in patients with CD, and the practical implementation o...
Source: Clinical Gastroenterology and Hepatology - March 18, 2020 Category: Gastroenterology Authors: Erwin Dreesen, Geert D ’Haens, David Laharie, Séverine Vermeire Tags: Letters to the Editor Source Type: research

A Key Role for the Small Bowel in Irritable Bowel Syndrome Pathophysiology: Time to Refocus?
This study provides additional evidence for the key role of intestinal barrier dysfunction in IBS. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 18, 2020 Category: Gastroenterology Authors: Zlatan Mujagic, Daisy M.A. E. Jonkers, Ad A.M. Masclee, Daniel Keszthelyi Tags: Letters to the Editor Source Type: research