Hepatic Sinusoidal Obstruction Syndrome Post-Liver Transplantation: A Rare Complication of Tacrolimus
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 24, 2020 Category: Gastroenterology Authors: Chang Li, Hanyu Ma, Canhui Sun Tags: Image of the Month Source Type: research

Persistently elevated liver enzymes due to Schistosoma mansoni
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 24, 2020 Category: Gastroenterology Authors: Nizar H. Senussi, Vignan Manne Tags: Image of the Month Source Type: research

Spontaneous Regression of Mismatch Repair-Deficient Colon Cancer: A Case Series
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 24, 2020 Category: Gastroenterology Authors: Takuya Yokota, Yutaka Saito, Hiroyuki Takamaru, Shigeki Sekine, Takeshi Nakajima, Masayoshi Yamada, Taku Sakamoto, Hirokazu Taniguchi, Ryoji Kushima, Shunsuke Tsukamoto, Dai Shida, Yukihide Kanemitsu, Takahisa Matsuda Source Type: research

Unusual presentation of a Crohn ’s disease patient: not your typical flare
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 24, 2020 Category: Gastroenterology Authors: Aymen Almuhaidb, Sina Rahimpour, Chien-Huan Chen Tags: Image of the Month Source Type: research

An International Multicentre Comparison of IBD Related Disability and Validation of the IBDDI
The IBD disability index (IBDDI) has been shown to be valid and reliable. We compared the distributional and predictive properties of the IBDDI, when collected from five populations of people living with IBD – from Winnipeg, Chicago, Toronto, Hong Kong, and Jerusalem. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 24, 2020 Category: Gastroenterology Authors: Leigh Anne Shafer, M. Anthony Sofia, David T. Rubin, A Hillary Steinhart, Siew C. Ng, Liran Reches, Eran Israeli, Charles N. Bernstein Source Type: research

Per-Oral Endoscopic Myotomy for Esophagogastric Junction Outflow Obstruction: A Multicenter Pilot Study
Esophagogastric junction outflow obstruction (EGJOO) is a rare but increasingly recognized diagnosis as described by The Chicago Classification of Esophageal Motility Disorders version 3.0 (version 3.0).1 On high-resolution manometry (HRM), EGJOO is characterized by increased integrated relaxation pressure (IRP) of the lower esophageal sphincter (LES), yet with some preserved esophageal peristalsis.2 –4 Little consensus exists on the preferred therapeutic approach.3 Although conceptually per-oral endoscopic myotomy (POEM) should address the measurable dysfunction in the LES, few data exist to support this.5 Thus, we ...
Source: Clinical Gastroenterology and Hepatology - August 21, 2020 Category: Gastroenterology Authors: Chelsea C. Jacobs, Yaseen Perbtani, Dennis Yang, Mohammad A. Al-Haddad, Ite Obaitan, Mohamed Othman, Shawn Groth, Amrita Sethi, Emil Agarunov, Alessandro Repici, Roberta Maselli, Alessia Galtieri, Jacob Moremen, Haley N. Jenkins, Jason B. Samarasena, Kenn Tags: Research Correspondence Source Type: research

Socioeconomic Factors Associated With Liver-related Mortality From 1985 to 2015 in 36 Developed Countries
There is increasing disparity in liver-related mortality worldwide. Although there are many biologic and lifestyle risk factors for liver-related mortality, the effects of inequalities in social and economic determinants of health have received little attention. We investigated changes in liver-related mortality from 1985 through 2015 in 36 countries, using 4 international health and economic databases, and searched for socioeconomic factors that might influence these trends. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 21, 2020 Category: Gastroenterology Authors: Wenhao Li, Polychronis Kemos, Justin D. Salciccioli, Dominic C. Marshall, Joseph Shalhoub, William Alazawi Source Type: research

Per-oral Endoscopic Myotomy (POEM) for Esophagogastric Junction Outflow Obstruction (EGJOO): A Multicenter Pilot Study
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 21, 2020 Category: Gastroenterology Authors: Chelsea C. Jacobs, Yaseen Perbtani, Dennis Yang, Mohammad A. Al-Haddad, Ite Obaitan, Mohamed Othman, Shawn Groth, Amrita Sethi, Emil Agarunov, Alessandro Repici, Roberta Maselli, Alessia Galtieri, Jacob Moremen, Haley N. Jenkins, Jason B. Samarasena, Kenn Source Type: research

Opioid use among patients with inflammatory bowel disease: A systematic review and meta-analysis
Despite reported adverse effects of opioids in patients with inflammatory bowel disease (IBD), the burden of opioid use in this population appears to be high. We performed a systematic review and meta-analysis of prior studies to determine the prevalence of opioid use among patients with IBD as well as risk factors and outcomes associated with opioid use in this population. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2020 Category: Gastroenterology Authors: Blake Niccum, Oluwatoba Moninuola, Kaia Miller, Hamed Khalili Source Type: research

No Association Between DAA Treatment for HCV Infection and Herpes Zoster Infection in Analysis of Data From 37 Clinical Trials
Recent case series and retrospective studies have raised concerns that patients who receive direct-acting antiviral treatment for hepatitis C virus (HCV) infection are at increased risk of developing varicella-zoster virus infection (VZV reactivation). We investigated the relationship between DAA treatment and VZV reactivation by analyzing pooled participant-level data from 37 clinical trials of DAA agents. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2020 Category: Gastroenterology Authors: Maximilian D. Rohde, LaRee Tracy, Takashi E. Komatsu, Samer S. El-Kamary, Wendy Carter Source Type: research

The role of resilience in irritable bowel syndrome, other chronic gastrointestinal conditions and the general population
Resilience is the ability to adapt positively to stress and adversity. It is a potential therapeutic target as it is reduced in irritable bowel syndrome (IBS) compared to healthy controls and associated with worse symptom severity and poorer quality of life. The aim of this study was to examine if these findings are generalizable by comparing resilience between IBS versus the general population and other chronic gastrointestinal (GI) conditions. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2020 Category: Gastroenterology Authors: Colleen H. Parker, Bruce D. Naliboff, Wendy Shih, Angela P. Presson, Lisa Kilpatrick, Arpana Gupta, Cathy Liu, Laurie A. Keefer, Jenny S. Sauk, Robert Hirten, Bruce E. Sands, Lin Chang Source Type: research

Incomplete Response of Gastroesophageal Reflux Symptoms Poorly Predicts Erosive Esophagitis or Barrett ’s Esophagus
Many patients with symptoms of gastroesophageal reflux disease (GERD) not responding to proton pump inhibitor (PPI) undergo upper endoscopy. We hypothesized that incomplete response to PPI is not associated with findings of esophageal pathology on endoscopy, and that psychological distress is inversely associated with pathology. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2020 Category: Gastroenterology Authors: Joel H. Rubenstein, Li Jiang, Jacob E. Kurlander, Joan Chen, Valbona Metko, Maryam Khodadost, Kimberly Nofz, Trivellore Raghunathan Source Type: research

Depression and anxiety are common among patients with cirrhosis
Depression and anxiety can have negative effects on patients and are important to treat. There have been few studies of their prevalence among patients with cirrhosis. We aimed to characterize the prevalence and risk factors for depression and anxiety in a large multi-center cohort of patients with cirrhosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2020 Category: Gastroenterology Authors: Ruben Hernaez, Jennifer R. Kramer, Aisha Khan, Jessica Phillips, Katharine McCallister, Kassie Chaffin, Adriana Portela Hernandez, Hannah Fullington, Cynthia Ortiz, James-Michael Blackwell, Adam Loewen, Yan Liu, Jasmin A. Tiro, Simon C. Lee, Amit G. Singa Source Type: research

Randomized Controlled Trial of Over-the-Scope Clip as Initial Treatment of Severe Non-Variceal Upper Gastrointestinal Bleeding
No prior randomized controlled trial (RCT) has reported patient outcomes of large over-the-scope clip (OTSC) compared to standard hemostasis as initial endoscopic treatment of severe NVUGIB. This was our study aim. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2020 Category: Gastroenterology Authors: D.M. Jensen, Kovacs TOG, Ghassemi KA, Kaneshiro M, Gornbein J Source Type: research

Results of Compliant Participation in Five Rounds of Fecal Immunochemical Test Screening for Colorectal Cancer
We investigated the magnitude and temporal patterns of the decreasing trend in main performance measures of fecal immunochemical test (FIT) screening for colorectal cancer (CRC) observed in second and subsequent rounds. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 19, 2020 Category: Gastroenterology Authors: Flavia Baldacchini, Lauro Bucchi, Orietta Giuliani, Silvia Mancini, Alessandra Ravaioli, Rosa Vattiato, Paolo Giorgi Rossi, Cinzia Campari, Debora Canuti, Enza Di Felice, Francesca Mezzetti, Priscilla Sassoli de Bianchi, Stefano Ferretti, Fabio Falcini, E Source Type: research

Porcelain Gallbladder
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 19, 2020 Category: Gastroenterology Authors: Hiroki Matsuura, Hiroshi Matsushita, Ryota Imamura Tags: Image of the Month Source Type: research

Lymphangiomatosis of the colon
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 19, 2020 Category: Gastroenterology Authors: Zlatan Mujagic, Ad A.M. Masclee, Daniel Keszthelyi Tags: Image of the Month Source Type: research

Results of Compliant Participation in 5 Rounds of Fecal Immunochemical Test Screening for Colorectal Cancer
We investigated the magnitude and temporal patterns of the decreasing trend in main performance measures of fecal immunochemical test (FIT) screening for colorectal cancer (CRC) being observed in second and subsequent rounds. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 19, 2020 Category: Gastroenterology Authors: Flavia Baldacchini, Lauro Bucchi, Orietta Giuliani, Silvia Mancini, Alessandra Ravaioli, Rosa Vattiato, Paolo Giorgi Rossi, Cinzia Campari, Debora Canuti, Enza Di Felice, Francesca Mezzetti, Priscilla Sassoli de Bianchi, Stefano Ferretti, Fabio Falcini, E Source Type: research

A gastric submucosal polypoid lesion with whitish protuberance
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 19, 2020 Category: Gastroenterology Authors: Shin Kashima, Mikihiro Fujiya, Takuma Goto Tags: Image of the Month Source Type: research

Gluten-free Diet Reduces Symptoms, Particularly Diarrhea, in Patients With Irritable Bowel Syndrome and Anti-gliadin IgG
Many patients with irritable bowel syndrome (IBS) perceive that their symptoms are triggered by wheat-containing foods. We assessed symptoms and gastrointestinal transit before and after a gluten-free diet (GFD) in unselected patients with IBS and investigated biomarkers associated with symptoms. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 19, 2020 Category: Gastroenterology Authors: Mar ía Inés Pinto-Sanchez, Andrea Nardelli, Rajka Borojevic, Giada De Palma, Natalia Causada Calo, Justin McCarville, Alberto Caminero, Daniel Basra, Alexa Mordhorst, Ekatherina Ignatova, Suzanne Hansen, Melanie Uhde, Gary L. Norman, Joseph A. Murray, E Source Type: research

Crohn ’s Disease
Crohn ’s disease is a type of inflammatory bowel disease that causes inflammation (pain and swelling) in the gastrointestinal tract (GI), also called the digestive system. Crohn’s disease can be found in people of any age but often occurs between ages 13 and 30. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 18, 2020 Category: Gastroenterology Tags: AGA Patient Education Section Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 18, 2020 Category: Gastroenterology Source Type: research

Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 18, 2020 Category: Gastroenterology Source Type: research

Elsewhere in the AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 18, 2020 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute brings you the best original research in the field with a unique combination of reviews, editorials, podcasts, video abstracts, and outcomes research —all supporting clinical practice. Articles on education, policy, and practice management highlight issues pertinent to clinicians. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 18, 2020 Category: Gastroenterology Source Type: research

Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 18, 2020 Category: Gastroenterology Source Type: research

Inflammatory Bowel Disease Patients With Coronavirus Disease 2019: The Picture Is Taking Shape
We read with interest the systematic review on inflammatory bowel disease (IBD) patients with coronavirus disease 2019 (COVID-19) published by D ’Amico et al.1 The authors provided a comprehensive and up-to-date picture on the epidemiologic and clinical characteristics of IBD patients affected by COVID-19. We would like to elaborate on some points covered in their review. In particular, D’Amico et al1 reported a cumulative prevalence o f COVID-19 among IBD patients of 0.4%. This prevalence rate appears to be comparable with that found in the general population. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 17, 2020 Category: Gastroenterology Authors: Alfredo Papa, Loris Riccardo Lopetuso, Antonio Tursi Tags: Letter to the Editor Source Type: research

IBD patients with COVID-19: the picture is taking shape.
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 17, 2020 Category: Gastroenterology Authors: Alfredo PAPA, Loris Riccardo Lopetuso, Antonio Tursi Source Type: research

STAT6 Variants Associate With Relapse of Eosinophilic Esophagitis in Patients Receiving Long-Term Proton Pump Inhibitor Therapy
Variants in STAT6 associate with a poor initial response, based on histologic features, to proton pump inhibitor (PPI) therapy in pediatric patients with eosinophilic esophagitis (EoE). We investigated whether these genetic variants associate with a poor long-term response in children with EoE who initially responded to PPI therapy. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 13, 2020 Category: Gastroenterology Authors: Edward B. Mougey, Vivian Nguyen, Carolina Guti érrez-Junquera, Sonia Fernández-Fernández, Maria Luz Cilleruelo, Ana Rayo, Belén Borrell, Enriqueta Román, Carmen González-Lois, Montserrat Chao, Hadeel Al-Atrash, James P. Franciosi Source Type: research

The Risk of Extraintestinal Cancer in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Population-Based Cohort Studies
Patients with Crohn ’s disease (CD) and ulcerative colitis (UC) are at increased risk of developing intestinal cancer. However, less is known about the risk of extraintestinal cancers (EICs). The aim of this study was to conduct a systematic review and meta-analysis of population-based cohorts assessing the risk of E ICs in inflammatory bowel disease (IBD) patients. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: Bobby Lo, Mirabella Zhao, Ida Vind, Johan Burisch Source Type: research

Normalization of Fecal Calprotectin Within 12 Months of Diagnosis is Associated with Reduced Risk of Disease Progression in Patients with Crohn ’s Disease
The level of fecal calprotectin (FC) correlates with endoscopic evidence of inflammation in Crohn ’s disease (CD). A treat-to-target algorithm for patients with CD, that incorporates FC, outperforms a treatment strategy based on symptoms alone in induction of mucosal healing at 12 months. We investigated whether normalization of FC within 12 months of diagnosis of CD is associated with a reduc tion in disease progression. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: N. Plevris, J. Fulforth, M. Lyons, S.I. Siakavellas, P.W. Jenkinson, C.S. Chuah, Laura Lucaciu, R.J. Pattenden, I.D. Arnott, G.R. Jones, C.W. Lees Source Type: research

Progression of Stage 2 and 3 Acute Kidney Injury in Patients with Decompensated Cirrhosis and Ascites
Progression of stage 2 and 3 AKI in cirrhosis has not been adequately characterized. Patients with higher stages of AKI are believed to have worse outcomes. We assessed outcomes and factors associated with stages 2 and 3 AKI in patients with cirrhosis in the North American Consortium for the Study of End-stage Liver Disease (NACSELD) cohort. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: Florence Wong, K Rajender Reddy, Puneeta Tandon, Jacqueline G. O ’Leary, Guadalupe Garcia-Tsao, Hugo E. Vargas, Jennifer C. Lai, Scott W. Biggins, Benedict Maliakkal, Michael Fallon, Ram Subramanian, Paul Thuluvath, Patrick S. Kamath, Leroy Thacker, Jas Source Type: research

Effects of Metformin Exposure on Survival in a Large National Cohort of Patients with Diabetes and Cirrhosis
Type II diabetes mellitus worsens the prognosis of cirrhosis. Multiple medications including metformin and statins are often co-administered to manage patients with diabetes. The aim of this study was to assess the impact of metformin exposure on mortality, hepatic decompensation, and hepatocellular carcinoma in individuals with diabetes and cirrhosis, controlling for multiple concomitant exposures. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: David E. Kaplan, Marina Serper, Binu V. John, Kristen M. Tessiatore, Renata Lerer, Rajni Mehta, Rena Fox, Ayse Aytaman, Michelle Baytarian, Kristel Hunt, Jeffrey Albrecht, Tamar H. Taddei, VOCAL Study Group Source Type: research

EFFeCtiveness AND SAFETY OF High versus low dose swallowed TopICal STEROIDs for Maintenance Treatment of Eosinophilic Esophagitis: A Multi-Center Observational Study
Data evaluating efficacy of different doses of swallowed topical corticosteroids (STC) in the long-term management of eosinophilic esophagitis (EoE) are lacking. We assessed long-term effectiveness and safety of different STC doses for adults with EoE after achievement of histological remission. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: Thomas Greuter, Anne Godat, Amit Ringel, Hector Samuel Almonte, Daniel Schupack, Gabriela Mendoza, Talaya McCright-Gill, Evan S. Dellon, Ikuo Hirano, Jeffrey Alexander, Mirna Chehade, Ekaterina Safroneeva, Christian Bussmann, Luc Biedermann, Philipp Schre Source Type: research

Variation in Provider Connectedness Associates with Outcomes of Inflammatory Bowel Diseases in an Analysis of Data from a National Health System
Inflammatory bowel diseases (IBD) often require multidisciplinary care with tight coordination among providers. Provider connectedness, a measure of the relationship among providers, is an important aspect of care coordination that has been linked to higher quality care. We aimed to assess variation in provider connectedness among medical centers, and to understand the association between this established measure of care coordination and outcomes of patients with IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: Shirley Cohen-Mekelburg, Xianshi Yu, Deena Costa, Timothy P. Hofer, Sarah Krein, John Hollingsworth, Wyndy Wiitala, Sameer Saini, Ji Zhu, Akbar Waljee Source Type: research

Guaiac fecal occult blood tests and mortality: A 30-year follow-up of two pooled trials
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: Emma C. Robbins, Amanda J. Cross Source Type: research

The risk of extra-intestinal cancer in inflammatory bowel disease: a systematic review and meta-analysis of population-based cohort studies
Patients with Crohn ’s disease (CD) and ulcerative colitis (UC) are at increased risk of developing intestinal cancer. However, less is known about the risk of extra-intestinal cancers (EICs). The aim of this study was to conduct a systematic review and meta-analysis of population-based cohorts assessing the risk of EICs in inflammatory bowel disease (IBD) patients. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: Bobby Lo, Mirabella Zhao, Ida Vind, Johan Burisch Source Type: research

Diagnostic Accuracy of Fecal Calprotectin Concentration in Evaluating Therapeutic Outcomes of Patients With Ulcerative Colitis
Histologic features of inflammation (histologic inflammation) are associated with clinical relapse in patients with ulcerative colitis (UC). Concentration of fecal calprotectin (FC) can be used to identify patients with mucosal inflammation. We aimed to assess the accuracy of FC measurements in identifying patients with histologic inflammation and to develop a model to predict outcomes of therapy. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 12, 2020 Category: Gastroenterology Authors: Toer W. Stevens, Krisztina Gecse, Jerrold R. Turner, Gert de Hertogh, David T. Rubin, Geert R. D ’Haens Source Type: research

Close observation of the lateral walls of the oropharynx during esophagogastroduodenoscopy
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Kenta Hamada, Hiroyuki Sakae, Hiroyuki Okada Tags: Image of the Month Source Type: research

Frailty is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases
Old age must be considered in weighing the risks of complications vs benefits of treatment for patients with inflammatory bowel diseases (IBD). We conducted a nationally representative cohort study to estimate the independent effects of frailty on burden, costs, and causes for hospitalization in patients with IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Alexander S. Qian, Nghia H. Nguyen, Jessica Elia, Lucila Ohno-Machado, William J. Sandborn, Siddharth Singh Source Type: research

Associations Between Reproductive and Hormone-related Factors and Risk of Nonalcoholic Fatty Liver Disease in a Multiethnic Population
We examined the associations of these factors and exogenous hormone use with NAFLD risk in African American, Japanese American, Latino, Native Hawaiian, and white women. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Jun Wang, Anna H. Wu, Frank Z. Stanczyk, Jacqueline Porcel, Mazen Noureddin, Norah A. Terrault, Lynne R. Wilkens, Veronica Wendy Setiawan Source Type: research

Mast Cell and Eosinophil Counts in Gastric and Duodenal Biopsies From Patients With and Without Eosinophilic Gastroenteritis
Mast cells are believed to contribute to development of eosinophilic gastrointestinal disorders (EGIDs). We quantified mast cells and eosinophils in biopsies from patients with EGIDs and without known esophageal or gastrointestinal disease to investigate associations between these cell types and EGID and its features. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Craig C. Reed, Robert M. Genta, Bradford A. Youngblood, Joshua B. Wechsler, Evan S. Dellon Source Type: research

Active margins, Plexitis, and Granulomas Increase Post-operative Crohn ’s Recurrence: Systematic Review and Meta-analysis
Rates of post-operative Crohn ’s disease (CD) recurrence remain high, although the ability to predict this risk of recurrence remains limited. As such, we aimed to determine the association of histological features at time of resection with post-operative recurrence. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Parul Tandon, Gurpreet Malhi, Daniyal Abdali, Elahn Pogue, John K. Marshall, Anthony de Buck van Overstraeten, Robert Riddell, Neeraj Narula Source Type: research

Genetic Variants Associated With Increased Plasma Levels of Triglycerides, via Effects on the Lipoprotein Lipase Pathway, Increase Risk of Acute Pancreatitis
Almost one third of adults in the West have increased plasma levels of triglycerides. Even mild to moderate hypertriglyceridemia (2 –10 mmol/L or 177–886 mg/dL) is associated with an increased risk of acute pancreatitis. However, it is not clear whether hypertriglyceridemia is a cause or result of acute pancreatitis. Lipoprotein lipase degrades plasma triglycerides. Variants in LPL, APOA5, APOC3, ANGPTL3, and ANGPTL4, which regulate the lipoprotein lipase pathway, result in increased or reduced plasma triglyceride levels. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Signe E.J. Hansen, Christian M. Madsen, Anette Varbo, Anne Tybj ærg-Hansen, Børge G. Nordestgaard Source Type: research

Prevalence of Fatty Liver Disease and Fibrosis detected by Fibroscan in Adults in the United States, 2017-2018
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Donghee Kim, George Cholankeril, Rohit Loomba, Aijaz Ahmed Source Type: research

Psychiatric disorders in patients with a diagnosis of celiac disease during childhood from 1973 to 2016
Few studies have explored the link between childhood celiac disease and long-term psychiatric comorbidities. We performed a population-based cohort study of associations between childhood celiac disease and psychiatric disorders and investigated whether risk persists into adulthood. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Benjamin Lebwohl, Linnea Hagg ård, Louise Emilsson, Jonas Söderling, Bjorn Roelstraete, Agnieszka Butwicka, Peter HR. Green, Jonas F. Ludvigsson Source Type: research

Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn ’s Disease
Ustekinumab is a monoclonal antibody against interleukin 12 and interleukin 23 that has been approved by the Food and Drug Administration for treatment of Crohn ’s disease (CD). We sought to identify the ideal position for ustekinumab in treatment algorithms for CD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 11, 2020 Category: Gastroenterology Authors: Frank I. Scott, Amneet K. Hans, Mark E. Gerich, Blair Fennimore, Ronac Mamtani, Ravy K. Vajravelu, James D. Lewis Source Type: research

Clinical outcomes of COVID-19 patients with chronic hepatitis B virus infection still need to be explored
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 10, 2020 Category: Gastroenterology Authors: Xiu-He Lv, Jin-Lin Yang, Kai Deng Source Type: research

Colonoscopy-related mortality in a fecal immunochemical test-based colorectal cancer screening program
Many countries have introduced colorectal cancer (CRC) screening programs with fecal immunochemical tests (FITs), and follow-up colonoscopies for individuals with a positive FIT result. In order to make an informed decision to participate, individuals must be informed about the benefits and harms of FIT-based screening and subsequent colonoscopy. Colonoscopy-related fatal complications in FIT-based screening are understudied. We aimed to estimate the colonoscopy-related mortality in a national FIT-based CRC screening program. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 7, 2020 Category: Gastroenterology Authors: A.I. Kooyker, E. Toes-Zoutendijk, A.W.J. Opstal-van Winden, M. Buskermolen, A.J. van Vuuren, E.J. Kuipers, F.J. van Kemenade, C. Ramakers, E. Dekker, I.D. Nagtegaal, H.J. de Koning, M.C.W. Spaander, I. Lansdorp-Vogelaar, M.E. van Leerdam Source Type: research

Accuracy of Ultrasound for Evaluation of Colorectal Segments in Patients With Inflammatory Bowel Diseases: a Systematic Review and Meta-analysis
The accuracy of ultrasound for evaluation of individual colorectal segments in patients with inflammatory bowel diseases (IBD) has not been evaluated in a systematic review. We evaluated the diagnostic accuracy of ultrasound in different colorectal segments of patients with IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 7, 2020 Category: Gastroenterology Authors: Shintaro Sagami, Taku Kobayashi, Yusuke Miyatani, Shinji Okabayashi, Hajime Yamazaki, Toshihiko Takada, Kenji Kinoshita, Mariangela Allocca, Reiko Kunisaki, Pradeep Kakkadasam Ramaswamy, Manabu Shiraki, Toshifumi Hibi, Yuki Kataoka Source Type: research