Reply
We thank the authors for their interest in our prospective study of aspirin use in patients with biopsy-proven nonalcoholic fatty liver disease (NAFLD).1 The authors highlight that in addition to aspirin, weight loss is a central component of cardiovascular risk reduction, and this in turn can directly influence NAFLD histology. To that end, we would like to emphasize 3 important aspects of our study population and design. First, (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 25, 2019 Category: Gastroenterology Authors: Tracey G. Simon, Kathleen E. Corey Tags: Letter to the Editor Source Type: research

Clinically Significant Fibrosis is Associated With Longitudinal Increases in Fibrosis-4 and NAFLD Fibrosis Scores
We examined longitudinal changes in the NFS and the FIB-4 score in patients with NAFLD, with and without clinically significant fibrosis (CSF). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 25, 2019 Category: Gastroenterology Authors: Preya Janubhai Patel, Johnson Chieh-yu Cheng, Xuan Banh, Lucy Gracen, Daniel Radford-Smith, Fabrina Hossain, Leigh Ula Horsfall, Kelly Lee Hayward, Suzanne Williams, Tracey Johnson, Nigel Neil Brown, Nivene Saad, Katherine Anne Stuart, Anthony William Rus Source Type: research

Factors Associated With Adherence to Helicobacter pylori Testing During Hospitalization for Bleeding Peptic Ulcer Disease
Guidelines recommend testing patients with peptic ulcer disease for Helicobacter pylori infection. We sought to identify factors associated with adherence to testing for H pylori in patients hospitalized for bleeding ulcers and to evaluate whether performing these tests affect risk for rebleeding. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 25, 2019 Category: Gastroenterology Authors: Kenneth W. Hung, Rita M. Knotts, Adam S. Faye, Adam R. Pont, Benjamin Lebwohl, Julian A. Abrams, Daniel E. Freedberg Source Type: research

Supplementary Anal Imaging by Magnetic Resonance Enterography in Patients with Crohn ’s Disease Not Suspected of Having Perianal Fistulas
Few data are available to guide the use of anal imaging for patients with Crohn ’s disease (CD) who are not suspected of having perianal fistulas. We aimed to evaluate the role of anal imaging supplementary to magnetic resonance enterography (MRE) in these patients. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 25, 2019 Category: Gastroenterology Authors: Pyeong Hwa Kim, Seong Ho Park, Kiok Jin, Byong Duk Ye, Yong Sik Yoon, Jong Seok Lee, Hyun Jin Kim, Ah Young Kim, Chang Sik Yu, Suk-Kyun Yang Source Type: research

Patterns of Cannabis Use In Patients With Cyclic Vomiting Syndrome
Some patients with cyclic vomiting syndrome (CVS) use cannabis to relieve stress and for its antiemetic properties. However, chronic cannabis use has been associated paradoxically with cannabinoid hyperemesis syndrome (CHS) and some patients with CVS are thought to have CHS. We sought to characterize patterns of cannabis use by patients with CVS and identify those who could be reclassified as having CHS. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 25, 2019 Category: Gastroenterology Authors: Thangam Venkatesan, Cecilia J. Hillard, Lisa E. Rein, Anjishnu Banerjee, Krista Lisdahl Source Type: research

Addressing HBV Linkage and Retention to Care Requires Comprehensive Assessment of Patient, Provider, and System Factors
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 25, 2019 Category: Gastroenterology Authors: Robert J. Wong Source Type: research

Reply: Daily aspirin use associated with reduced risk for fibrosis progression in patients with nonalcoholic fatty liver disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 25, 2019 Category: Gastroenterology Authors: Tracey G. Simon, Kathleen E. Corey Source Type: research

Reply
We thank Pansart et  al1 for their interest in our recent article.2 We agree that consistency in preanalytical methodology, including choice of extraction kit and method for aliquoting fecal samples, is important to ensure consistency of calprotectin results within a study. With regards to our own study, all feca l calprotectins were measured in a single laboratory, the Biochemistry Department at the Western General Hospital. The laboratory used an enzyme-linked immunosorbent assay from Calpro AS, Lysaker, Norway. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 24, 2019 Category: Gastroenterology Authors: Nicholas A. Kennedy, Charlie W. Lees Tags: Letter to the Editor Source Type: research

Preanalytical heterogeneity in Fecal Calprotectin measurement needs to be considered for tight control: author ’s reply
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 24, 2019 Category: Gastroenterology Authors: Nicholas A. Kennedy, Charlie W. Lees Source Type: research

Measurements of Duodenal Mucosal Integrity are Altered in Celiac Disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 24, 2019 Category: Gastroenterology Authors: Dawn W. Adams, Dhyanesh Patel, Lauren Evers, James C. Slaughter, Tina Higginbotham, Michael Vaezi Source Type: research

Metachronous Advanced Neoplasia on Surveillance Colonoscopy in Young versus Older Onset Colorectal Cancer Patients
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 24, 2019 Category: Gastroenterology Authors: Jamie Tjaden, Charles Muller, Gina Wideroff, Karen Ma, Jinendra Satiya, Daniel Sussman, Eugene Yen, Sonia S. Kupfer, Joshua Melson Source Type: research

Optimizing outcomes of single-operator cholangioscopy-guided biopsies: results of a randomized trial
Although single-operator cholangioscopy is considered to be the most sensitive method for tissue acquisition in patients with indeterminate bile duct strictures (IBDS), methods are needed to optimize the specimen collection and processing techniques. We aimed to determine the optimal method for specimen processing and identify the number of biopsies required to establish a definitive diagnosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 24, 2019 Category: Gastroenterology Authors: Ji Young Bang, Udayakumar Navaneethan, Muhammad Hasan, Bryce Sutton, Robert Hawes, Shyam Varadarajulu Source Type: research

Rate of Reoperation Decreased Significantly After Year 2002 in Patients with Crohn's Disease
We examined time trends and risk factors for reoperation in patients with CD who underwent intestinal surgery, focusing on the effects of post-operative medical treatments. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 20, 2019 Category: Gastroenterology Authors: Takahide Shinagawa, Keisuke Hata, Hiroki Ikeuchi, Kouhei Fukushima, Kitaro Futami, Akira Sugita, Motoi Uchino, Kazuhiro Watanabe, Daijiro Higashi, Hideaki Kimura, Toshimitsu Araki, Tsunekazu Mizushima, Michio Itabashi, Takeshi Ueda, Kazutaka Koganei, Koji Source Type: research

Seroprevalence of H. pylori infection in a national cohort of veterans with non-cardia gastric adenocarcinoma
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 20, 2019 Category: Gastroenterology Authors: Shria Kumar, David C. Metz, David E. Kaplan, David S. Goldberg Source Type: research

Small intestine diverticula in polycystic kidney disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 20, 2019 Category: Gastroenterology Authors: Mahmoud Bayoumi, Diana Snyder, Marcelo F. Vela Tags: Image of the Month Source Type: research

Acute Venous Thromboembolism Risk Highest Within 60 Days After Discharge From the Hospital in Patients With Inflammatory Bowel Diseases
Patients with inflammatory bowel diseases (IBD) have a high risk of venous thromboembolism (VTE). We assess the timing and risk factors associated with readmission to the hospital for VTE among patients with IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 20, 2019 Category: Gastroenterology Authors: Adam S. Faye, Timothy Wen, Ashwin N. Ananthakrishnan, Simon Lichtiger, Gilaad G. Kaplan, Alexander M. Friedman, Garrett Lawlor, Jason D. Wright, Frank J. Attenello, William J. Mack, Benjamin Lebwohl Source Type: research

Diffuse esophageal infiltration by relapsed light chain multiple myeloma
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 20, 2019 Category: Gastroenterology Authors: Rub én Sánchez-Aldehuelo, Diego Burgos-Santamaría, Ana Ferrer Gómez Tags: Image of the Month Source Type: research

Idiopathic Myointimal Hyperplasia of the Mesenteric Veins of the Colon
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 20, 2019 Category: Gastroenterology Authors: Kenechukwu Chudy-Onwugaje, Osman Ali, Mfoniso Umoren Tags: Image of the Month Source Type: research

Exam 1: Management Algorithm for Interrupting Mother to Child Transmission of Hepatitis B Virus
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 18, 2019 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activity Source Type: research

Lifetime Economic Burden of Crohn ’s Disease and Ulcerative Colitis by Age at Diagnosis
Understanding the burden of Crohn ’s disease (CD) and ulcerative colitis (UC) is important for measuring treatment value. We estimated lifetime healthcare costs incurred by patients with CD or UC by age at diagnosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 18, 2019 Category: Gastroenterology Authors: Gary R. Lichtenstein, Ahva Shahabi, Seth A. Seabury, Darius N. Lakdawalla, Oliver D íaz Espinosa, Sarah Green, Michelle Brauer, Robert N. Baldassano Source Type: research

Predictors of Retention in Care Among a Cohort of Chronically HBV Infected Patients: What Are We Missing?
We have read with interest the article entitled “Low Rates of Linkage and Retention Into Care Among Patients With Chronic HBV Infection” by Tang et al1 recently published in Clinical Gastroenterology and Hepatology. Tang et al found a 62.3% rate of linkage to care (LtC) and a 44% rate of retention in care (RiC) in a cohort of chronically he patitis B virus (HBV) infected patients. The authors identified male sex and Asian ethnicity as predictors of RiC, defined as attending at least 2 follow-up visits after the first LtC. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: Laura Magnasco, Livia Di Nino, Laura Ambra Nicolini Tags: Letter to the Editor Source Type: research

Global Prevalence of Colorectal Neoplasia: a Systematic Review and Meta-analysis
We examined the prevalence of any type of adenomas, advanced adenomas (AAD), and CRC according to age, sex, ethnicity, geographical regions, and anatomic location (proximal vs distal). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: Martin CS. Wong, Junjie Huang, Jason LW. Huang, Tiffany WY. Pang, Peter Choi, Jingxuan Wang, Jason I. Chiang, Johnny Yu Jiang Source Type: research

Methylated DNA in Pancreatic Juice Distinguishes Patients With Pancreatic Cancer From Controls
Precursors of pancreatic cancer arise in the ductal epithelium; markers exfoliated into pancreatic juice might be used to detect high-grade dysplasia (HGD) and cancer. Specific methylated DNA sequences in pancreatic tissue have been associated with adenocarcinoma. We analyzed these methylated DNA markers (MDMs) in pancreatic juice samples from patients with pancreatic ductal adenocarcinomas (PDACs) or intraductal papillary mucinous neoplasms (IPMNs) with HGD (cases), and assessed their ability to discriminate these patients from individuals without dysplasia or with IPMNs with low-grade dysplasia (IPMN-LGD) (controls). (So...
Source: Clinical Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: Shounak Majumder, Massimo Raimondo, William R. Taylor, Tracy C. Yab, Calise K. Berger, Brian A. Dukek, Xiaoming Cao, Patrick H. Foote, Chung Wah Wu, Mary E. Devens, Douglas W. Mahoney, Thomas C. Smyrk, Rahul Pannala, Suresh T. Chari, Santhi Swaroop Vege, Source Type: research

Durability of Spontaneous and Treatment-related Loss of Hepatitis B s Antigen
Clearance of hepatitis B surface antigen (HBsAg) from serum is the most desirable endpoint and a proposed definition of functional cure for hepatitis B virus (HBV) infection. However, little is known about the long-term durability of HBsAg loss, and there is controversy over whether the development of antibodies against HBsAg (anti-HBs) is required for maintenance. We aimed to assess the durability of spontaneous or treatment-related (interferon or nucleos(t)ide analogue [NA]) loss of HBsAg. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: Ahmad Samer Alawad, Sungyoung Auh, Daniel Suarez, Marc G. Ghany Source Type: research

Effects of Psychology and Extra-Gastrointestinal Symptoms on Healthcare Use by Subjects With and Without Irritable Bowel Syndrome
There is controversy about whether psychological factors (anxiety and depression) increase seeking of healthcare by patients with irritable bowel syndrome (IBS). We investigated whether psychological factors increase healthcare seeking by patients with IBS and the effects of extra-GI symptoms. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: David T. McNaughton, Anna Andreasson, Brj ánn Ljótsson, Alissa P. Beath, Julia M. Hush, Nicholas J. Talley, Gunnar Ljunggren, Peter T. Schmidt, Lars Agréus, Michael P. Jones Source Type: research

All That Glitters is Not Gold in Vedolizumab Therapy for Patients With Inflammatory Bowel Diseases and Primary Sclerosing Cholangitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: Giulia Roda, Ana Lleo, Silvio Danese, Alessio Aghemo Source Type: research

Predictors of retention in care among a cohort of chronically HBV infected patients. What are we missing?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 16, 2019 Category: Gastroenterology Authors: L. Magnasco, L. Di Nino, L.A. Nicolini Source Type: research

Clinical Factors Associated With Gastric Cancer in Individuals with Lynch Syndrome
Lynch syndrome is the most common inherited cause of gastrointestinal cancer and increases risk for a variety of malignancies, including gastric cancer. We aimed to identify clinical factors associated with gastric cancer in carriers of germline variants causing Lynch syndrome. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 15, 2019 Category: Gastroenterology Authors: Jaihwan Kim, Danielle Braun, Chinedu Ukaegbu, Tara G. Dhingra, Fay Kastrinos, Giovanni Parmigiani, Sapna Syngal, Matthew B. Yurgelun Source Type: research

Long-term Liver-related Outcomes of Patients with Chronic Liver Diseases in Australia
Chronic liver disease is a major health burden that produces significant liver-related morbidity and mortality. We aimed to evaluate liver-related outcomes of patients with different causes of chronic liver disease in Australia. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 15, 2019 Category: Gastroenterology Authors: Yi Huang, John Joseph, W Bastiaan de Boer, Wendy Cheng, Leon A. Adams, Gerry MacQuillan, George Garas, Spiro Raftopoulos, Gary P. Jeffrey Source Type: research

What Patients Need to Know About Living With IBD
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 15, 2019 Category: Gastroenterology Authors: Lucia V. Allen Source Type: research

Phenotypes of Gastroesophageal Reflux Disease: Where Rome, Lyon, and Montreal Meet
Gastroesophageal reflux disease (GERD) is now one of the most common diagnoses made in a gastroenterology practice. From a conventional pathophysiological perspective GERD is conceptualized as incompetence of the antireflux barrier at the esophagogastric junction; the more severe that incompetence, the worse the disease. However, it is increasingly clear that many presentations of GERD represent distinct phenotypes with unique predisposing cofactors and pathophysiology outside of this paradigm. Three major consensus initiatives have grappled with this dilemma (the Montreal Consensus, The Rome Foundation, and the Lyon Conse...
Source: Clinical Gastroenterology and Hepatology - July 15, 2019 Category: Gastroenterology Authors: David A. Katzka, John E. Pandolfino, Peter J. Kahrilas Source Type: research

AGA Clinical Practice Update on Surveillance for Hepatobiliary Cancers in Patients With Primary Sclerosing Cholangitis: Expert Review
The purpose of this clinical practice update is to define key principles in the surveillance of hepatobiliary cancers including cholangiocarcinoma, gallbladder adenocarcinoma, and hepatocellular carcinoma in patients with primary sclerosing cholangitis (PSC). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 12, 2019 Category: Gastroenterology Authors: Christopher L. Bowlus, Joseph K. Lim, Keith D. Lindor Source Type: research

Outcomes of Long-term Treatment of Chronic HBV Infection With Entecavir or Other Agents From a Randomized Trial in 24 Countries
Treatment of chronic hepatitis B virus (HBV) infection with entecavir suppresses virus replication and reduces disease progression, but could require life-long therapy. To investigate clinical outcome events and safety associated with long-term treatment with entecavir, we followed patients treated with entecavir or another standard of care HBV nucleos(t)ide analogue for up to 10 years. We assessed long-term outcomes and relationships with virologic response. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 12, 2019 Category: Gastroenterology Authors: Jin-Lin Hou, Wei Zhao, Changhyeong Lee, Hie-Won Hann, Cheng-Yuan Peng, Tawesak Tanwandee, Viacheslav Morozov, Hartwig Klinker, Jose D. Sollano, Adrian Streinu-Cercel, Hugo Cheinquer, Qing Xie, Yu-Ming Wang, Lai Wei, Ji-Dong Jia, Guozhong Gong, Kwang-Hyub Source Type: research

AGA Institute Clinical Practice Update: Surveillance for Hepatobiliary Cancers in Patients with Primary Sclerosing Cholangitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 12, 2019 Category: Gastroenterology Authors: Christopher L. Bowlus, Joseph K. Lim, Keith D. Lindor Source Type: research

Hormone Therapy for Cancer is a Risk Factor for Relapse of Inflammatory Bowel Diseases
Exposure to hormone contraception has been associated with an increased risk of relapse of inflammatory bowel diseases (IBD). Little is known about the effects of cancer therapies, specifically hormone therapies, on the course of IBD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 11, 2019 Category: Gastroenterology Authors: Jordan E. Axelrad, Ahmad Bazarbashi, James Zhou, Daniel Casta ñeda, Amandeep Gujral, Dylan Sperling, Jason Glass, Manasi Agrawal, Simon Hong, Garrett Lawlor, David Hudesman, Shannon Chang, Shailja Shah, Vijay Yajnik, Ashwin Ananthakrishnan, Hamed Khalili Source Type: research

Relative Efficacy of Tegaserod in a Systematic Review and Network Meta-analysis of Licensed Therapies for Irritable Bowel Syndrome with Constipation
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 11, 2019 Category: Gastroenterology Authors: Christopher J. Black, Nicholas E. Burr, Alexander C. Ford Source Type: research

A Uncommon Cause of Gastric Varix and Ascites
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 11, 2019 Category: Gastroenterology Authors: Shu-Wei Liang, Ming-Wun Wong, Chien-Lin Chen Tags: Image of the Month Source Type: research

Are We Moving in the Right Direction by Altering Gastric Motility for Weight Loss?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 11, 2019 Category: Gastroenterology Authors: Reem Z. Sharaiha, Vivek Kumbhari Source Type: research

Reply
We want to thank Jacques et  al1 for their comments on our recent review on the role of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) for colorectal neoplasia. Currently in the West, piecemeal EMR remains the first-line treatment for most large benign colorectal polyps, whereas ESD has been tra ditionally reserved for those lesions suspected of harboring superficial submucosal invasion. The main drawback of this approach, as alluded to in their commentary, is our inability to accurately predict submucosal invasion based on our current classification systems, and that the prevalence of o...
Source: Clinical Gastroenterology and Hepatology - July 10, 2019 Category: Gastroenterology Authors: Dennis Yang, Peter V. Draganov Tags: Letter to the Editor Source Type: research

Response
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 10, 2019 Category: Gastroenterology Authors: Dennis Yang, Peter V. Draganov Source Type: research

Ulcerative Colitis and Crohn ’s Disease Have the Same Burden and Goals for Treatment
It is unclear whether ulcerative colitis (UC) is a progressive disease like Crohn ’s disease (CD). Patients with UC are often undertreated, because of the possibility of curative colectomy and the perception that the disease burden is lower than that of CD. We discuss findings from studies that aimed to determine whether UC and CD have the same disease burden and should be trea ted in the same intensive way. We discuss the similarities between CD and UC, including effects on quality of life, long-term complications, strictures, increased risk of cancer, pseudopolyps, functional abnormalities, and anorectal dysfunctio...
Source: Clinical Gastroenterology and Hepatology - July 10, 2019 Category: Gastroenterology Authors: Catherine Le Berre, Ashwin N. Ananthakrishnan, Silvio Danese, Siddharth Singh, Laurent Peyrin-Biroulet Source Type: research

Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients
Studies in mice have shown that the intestinal microbiota can contribute to obesity via the anorexigenic gut hormone glucagon-like peptide 1 (GLP1) and bile acids, which affect lipid metabolism. We performed a randomized, placebo-controlled pilot study of the effects of fecal microbiota transplantation (FMT) in obese, metabolically uncompromised patients. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 10, 2019 Category: Gastroenterology Authors: Jessica R. Allegretti, Zain Kassam, Benjamin H. Mullish, Austin Chiang, Madeline Carrellas, Jonathan Hurtado, Julian R. Marchesi, Julie A.K. McDonald, Alexandros Pechlivanis, Grace F. Barker, Jesus Miguens Blanco, Isabel Garcia-Perez, Wing Fei Wong, Ylain Source Type: research

Reply
Patients with inflammatory bowel disease (IBD) have heightened risk of colorectal cancer (CRC) and poor compliance with surveillance colonoscopy. DNA methylation is broadly informative for CRC in the general population1 and Lynch syndrome.2 We recently reported that stool assay of methylated BMP3 and VAV3, both normalized by methylated ZDHHC1, were highly discriminate for the combined endpoint of high-grade dysplasia and CRC in patients with IBD. In their recent letter, Peppelenbosch et  al highlight that a target of the VAV3 protein, p21RAC, can be inactivated by thiopurine therapy. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 4, 2019 Category: Gastroenterology Authors: John B. Kisiel, Douglas W. Mahoney, William R. Taylor, Paquale Klepp Tags: Letter to the Editor Source Type: research

Response to: Value of VAV3 methylation in stool DNA might be restricted to non-thiopurine treated inflammatory bowel disease patients (CGH-D-19-01071)
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 4, 2019 Category: Gastroenterology Authors: John B. Kisiel, Douglas W. Mahoney, William R. Taylor, Paquale Klepp Source Type: research

An Unexpected Case of Right Iliac Fossa Pain: Amyand Hernia
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 4, 2019 Category: Gastroenterology Authors: Teo Qi Tian, Kam Juinn Huar, Tousif Kabir Source Type: research

Additional Intestinal Mucosal Biopsy Sampling for Research is Safe During Pediatric Endoscopic Procedures
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 4, 2019 Category: Gastroenterology Authors: Christopher J. Moran, Julia Noreck, Harland S. Winter, Emma X. Li, Jeffrey A. Biller, Esther J. Israel, Jess L. Kaplan Source Type: research

Do Alterations in Bone Mineral Density Go Beyond Borders In Adults With Celiac Disease?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 4, 2019 Category: Gastroenterology Authors: Gloria Galli, Edith Lahner, Bruno Annibale Source Type: research

Respectful Payer Provider Collaboration Can Achieve the Best in Value-Based Care
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 4, 2019 Category: Gastroenterology Authors: Lili Brillstein, Joel V. Brill, Brian Currie Source Type: research

Medical Professional Liability in Gastroenterology: Understanding the Claims Landscape and Proposed Mechanisms for Reform
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 4, 2019 Category: Gastroenterology Authors: Megan A. Adams, John I. Allen Source Type: research

Hepatocellular Carcinoma Among Hispanics: An Understudied Public Health  Priority
We read the article by Kim et  al,1 “Disparate Trends in Mortality of Etiology-Specific Chronic Liver Disease Among Hispanic Sub-populations”, with great interest. Liver cancer, and hepatocellular carcinoma (HCC) in particular, has historically disproportionately impacted Hispanics in the United States. Although considerabl e and important differences have been documented by disaggregated Hispanic subgroups,2–4 this variation has largely been overlooked in liver cancer prevention and control efforts. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - June 28, 2019 Category: Gastroenterology Authors: Karen E. Callahan, Paulo S. Pinheiro Tags: Letter to the Editor Source Type: research