Upper Gastrointestinal Endoscopy off Proton Pump Inhibitor With Concurrent Telemetry Capsule pH Monitoring: Evidence Based and Cost Effective
In this current issue of Clinical Gastroenterology and Hepatology, Shah et  al1 present a carefully designed decision analytic model to assess costs and predefined health outcomes of 4 evaluation/management strategies in a patient presenting to a general gastroenterologist’s office with classic heartburn without alarm symptoms who failed a single empiric proton pump inh ibitor (PPI) trial. The authors modeled optimizing PPI without any further testing, upper gastrointestinal endoscopy (EGD) followed by continued optimized PPI if no erosions were found, EGD followed by discontinuing PPI if no erosions, and EGD plus ambul...
Source: Clinical Gastroenterology and Hepatology - January 23, 2024 Category: Gastroenterology Authors: Philip O. Katz, Gaurav Ghosh Tags: Editorial Source Type: research

Upper GI Endoscopy Off PPI with Concurrent Telemetry Capsule pH monitoring. Evidence Based and Cost Effective
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 23, 2024 Category: Gastroenterology Authors: Philip O. Katz, Gaurav Ghosh Tags: Editorial Source Type: research

Further progress to quantify histological damage in patients with celiac disease
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 23, 2024 Category: Gastroenterology Authors: Detlef Schuppan, Kamran Rostami Tags: Editorial Source Type: research

Artificial Intelligence in Medical Consultations: Optimization in Assessment and Application
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 23, 2024 Category: Gastroenterology Authors: Qingzhou Kong, Yueyue Li Tags: Letter to the Editor Source Type: research

Correction
Thiruvengadam NR, Gupta S, Buller S, et  al. The Clinical Impact and Cost-Effectiveness of Surveillance of Incidentally Detected Gastric Intestinal Metaplasia: A Microsimulation Analysis. Clin Gastroenterol Hepatol 2024;22:51-61. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 19, 2024 Category: Gastroenterology Tags: Erratum Source Type: research

The Efficacy of Tradipitant in Patients With Diabetic and Idiopathic Gastroparesis in a Phase 3 Randomized Placebo-Controlled Clinical Trial
Neurokinin receptor 1 antagonists are effective in reducing nausea and vomiting in chemotherapy-induced emesis. We investigated the safety and efficacy of tradipitant, a neurokinin receptor 1 antagonist, in patients with idiopathic and diabetic gastroparesis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 16, 2024 Category: Gastroenterology Authors: Jesse L. Carlin, Christos Polymeropoulos, Michael Camilleri, Anthony Lembo, Michaela Fisher, Caleigh Kupersmith, Darby Madonick, Paula Moszczynski, Sandra Smieszek, Changfu Xiao, Gunther Birznieks, Mihael H. Polymeropoulos Source Type: research

Misclassified Alcohol-related Liver Disease is Common in Presumed Metabolic Dysfunction-associated Steatotic Liver Disease and Highly Increases Risk for Future Cirrhosis
Alcohol overconsumption is a risk factor for disease progression in patients with presumed metabolic dysfunction-associated steatotic liver disease (MASLD). How commonly this occurs and how it affects progression to major adverse liver outcomes (MALOs) is not well known. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 16, 2024 Category: Gastroenterology Authors: Patrik Nasr, Axel Wester, Mattias Ekstedt, Rickard Strandberg, Stergios Kechagias, Ying Shang, Linnea Widman, Hannes Hagstr öm Source Type: research

The Efficacy of Tradipitant in Patients with Diabetic and Idiopathic Gastroparesis in Phase III Randomized Placebo-Controlled Clinical Trial
Neurokinin receptor 1 (NK1R) antagonists are effective in reducing nausea and vomiting in chemo-therapy induced emesis. We investigated the safety and efficacy of tradipitant, an NK1R antagonist, in patients with idiopathic and diabetic gastroparesis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 16, 2024 Category: Gastroenterology Authors: Jesse L. Carlin, Christos Polymeropoulos, Michael Camilleri, Anthony Lembo, Michaela Fisher, Caleigh Kupersmith, Darby Madonick, Paula Moszczynski, Sandra Smieszek, Changfu Xiao, Gunther Birznieks, Mihael H. Polymeropoulos Source Type: research

Misclassified ALD is common in presumed MASLD and highly increases risk for future cirrhosis
Alcohol overconsumption is a risk factor for disease progression in patients with presumed metabolic dysfunction-associated steatotic liver disease (MASLD). How commonly this occurs and how it affects progression to major adverse liver outcomes (MALO) is not well known. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 16, 2024 Category: Gastroenterology Authors: Patrik Nasr, Axel Wester, Mattias Ekstedt, Rickard Strandberg, Stergios Kechagias, Ying Shang, Linnea Widman, Hannes Hagstr öm Source Type: research

Features of Gastrointestinal Malignant Melanoma on Endoscopic Ultrasonography
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 10, 2024 Category: Gastroenterology Authors: Jian Qin, Ka Shing Cheung, Yue Guo Tags: Images and Videos Source Type: research

Prevalence and determinants of liver disease in relatives of Italian patients with advanced MASLD
Metabolic dysfunction associated steatotic liver disease (MASLD) has strong genetic components. The aim of this study was to examine non-invasively the prevalence of MASLD and of advanced fibrosis in relatives of patients with advanced MASLD and the risk factors for liver involvement, with a focus on the contribution of common genetic risk variants. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 10, 2024 Category: Gastroenterology Authors: S. Pelusi, L. Ronzoni, J. Rondena, C. Rosso, Pennisi G, P. Dongiovanni, S. Margarita, R. Carpani, G. Soardo, D. Prati, A. Cespiati, S. Petta, E. Bugianesi, L. Valenti Source Type: research

Impact of Treatment Response on Risk of Serious Infections in Patients with Crohn ’s Disease: Secondary Analysis of the PYRAMID Registry
Traditional risk factors for serious infections with advanced therapies in patients with Crohn ’s disease (CD) have been assessed at baseline prior to starting therapy. We evaluated the impact of treatment response on the risk of serious infections in adalimumab-treated patients with CD through secondary analysis of the PYRAMID registry (NCT00524537). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 10, 2024 Category: Gastroenterology Authors: Dhruv Ahuja, Jiyu Luo, Yuchen Qi, Gaurav Syal, Brigid S. Boland, John Chang, Christopher Ma, Vipul Jairath, Ronghui Xu, Siddharth Singh Source Type: research

High comorbidity of gastrointestinal disorders among those seeking care for dyspareunia
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 9, 2024 Category: Gastroenterology Authors: Casey Silvernale, Grace Harris, Kyle Staller Tags: Research Letter Source Type: research

Metastatic Renal Cell Carcinoma Mimicking a Colonic Pseudopolyp
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 9, 2024 Category: Gastroenterology Authors: Jessica C. Petrov, Johanna Chan, Jana G. Hashash Tags: Images and Videos Source Type: research

Reply
We thank Dr Bassotti for his in-depth assessment of our article “Perceptions, definitions, and therapeutic interventions for occasional constipation: a Rome Working Group consensus document”,1 and we agree with his assessment of some of its limitations. Although occasional constipation is not a new concept, it cannot be ignored that until recently,1,2 consen sus definitions for occasional constipation (OC) did not exist. Consequently, as he states and we clearly define in the article, most of the therapeutic evidence has been extrapolated from early results of chronic constipation trials. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - January 8, 2024 Category: Gastroenterology Authors: Darren M. Brenner, Maura Corsetti, Douglas Drossman, Jan Tack, Arnold Wald Tags: Letters to the Editor Source Type: research