Reply
Despite increasing literature on the management of symptomatic uncomplicated diverticular disease, there  is limited evidence that colonic diverticula are associated with chronic gastrointestinal symptoms or mucosal inflammation. Before recommending a therapy, we must establish the legitimacy of a condition or else we risk a delayed diagnosis and exposing our patients to unfounded risks. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: Anne F. Peery, Robert S. Sandler Tags: Letter to the Editor Source Type: research

Clarifying the Houston Consensus on Helicobacter pylori
We read with interest the recently published Houston consensus document on testing for Helicobacter pylori infection in the United States.1 We were pleased to see that the authors ’ recommendations, for the most part, aligned with those made in the recently published H pylori management guideline from the American College of Gastroenterology (ACG).2 We also applaud the authors for tackling a number of controversial topics that were not addressed in the ACG guideline. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: William D. Chey, Colin W. Howden, Grigorios I. Leontiadis Tags: Letter to the Editor Source Type: research

Screening for Celiac Disease in Canada
I read with interest the systematic review and meta-analysis by Singh et  al1 on the global prevalence of celiac disease. No data were provided from Canada, including prospective biopsy studies from Vancouver.2 In the Vancouver study, elective duodenal biopsy specimens were obtained in a tertiary care setting to determine if mucosal changes of celiac disease were presen t in 9665 adults seen between January 1982 and December 2011. Of these 9665 patients, 234 (or 2.4%) were positive, including 73 males (1.8%) and 161 females (2.8%). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: Hugh James Freeman Tags: Letter to the Editor Source Type: research

Reply
We thank Dr Freeman for his interest in our systematic review and meta-analysis.1 In his letter, he refers to the study from Vancouver in which 9665 adults underwent endoscopy over 30 years and 234 (2.4%) of them showed mucosal changes compatible with celiac disease.1,2 As the author points out, those with known positive celiac serologic testing, an established diagnosis of celiac disease, and a family history of celiac disease were excluded.1,2 However, these patients were referred for upper endoscopy for evaluation of 1 or more of the following symptoms: diarrhea, abdominal pain, weight loss, dyspepsia, and so forth. (So...
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: Prashant Singh, Govind K. Makharia Tags: Letter to the Editor Source Type: research

Reply
We thank Drs Chey, Howden, and Leontiadis for their comments. We apologize for the confusion regarding the confirmation of cure; this was only one of many stimuli for the Houston Consensus Conference, which was both planned and completed before the publication of the American College of Gastroenterology (ACG) guideline.1,2 We were pleased to see that the 2017 ACG version had corrected that error from the earlier ACG guideline. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: Hashem B. El-Serag, David Y. Graham Tags: Letter to the Editor Source Type: research

Reply
Thank you for your comments regarding the Houston consensus on testing for Helicobacter pylori infection.1 The Houston Consensus followed the lead of the Kyoto Global Consensus, which was the first to define H  pylori gastritis as an infectious disease.2 H pylori infection causes lifelong chronic gastric inflammation, alters the gut microbiome, and results in dysregulation of acid secretion and many other conditions such as iron deficiency anemia (especially in children), vitamin B12 deficiency, atrophi c gastritis, and dyspepsia. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: Hashem B. El-Serag, David Y. Graham Tags: Letter to the Editor Source Type: research

Issue Highlights
Patients with inflammatory bowel disease (IBD) are at increased risk of complications, including infections, and this risk may be further increased by the medications used to treat IBD. To determine the incidence and risk factors for herpes zoster (HZ) in IBD and the effect of immunosuppression on that risk, Khan et  al1 used the Veterans’ Affairs (VA) database, analyzing data from 2000–2016 and identifying 2 retrospective cohorts for analysis. The first cohort study compared IBD patients on 5-ASA alone (n = 13,001) with>35,500 matched non-IBD patients. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Authors: Jane Onken Tags: Issue highlights Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Source Type: research

Table of Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Source Type: research

Elsewhere in the AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Clinical Gastroenterology and Hepatology is the go-to resource on a broad spectrum of themes in clinical gastroenterology and hepatology. The official clinical practice journal of the AGA Institute brings you the best original research in the field with a unique combination of reviews, editorials, podcasts, video abstracts, and outcomes research —all supporting clinical practice. Articles on education, policy, and practice management highlight issues pertinent to clinicians. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Source Type: research

Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 27, 2018 Category: Gastroenterology Source Type: research

Effects of Alcohol Consumption and Metabolic Syndrome on Mortality in Patients With Nonalcoholic and Alcohol-Related Fatty Liver Disease
Non-alcoholic and alcohol-related fatty liver disease are overlapping diseases in which metabolic syndrome and alcohol consumption each contribute to progressive liver disease. We aimed to assess the effects of alcohol consumption and metabolic syndrome on mortality in individuals with fatty liver. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 23, 2018 Category: Gastroenterology Authors: Zobair M. Younossi, Maria Stepanova, Janus Ong, Yusuf Yilmaz, Ajay Duseja, Yuichiro Eguchi, Mohamed El Kassas, Marlen Castellanos-Fernandez, Jacob George, Ira M. Jacobson, Elisabetta Bugianesi, Vincent Wai-Sun Wong, Marco Arrese, Victor de Ledinghen, Manu Source Type: research

Association Between Intake of Red and Processed Meat  and Survival in Patients With Colorectal Cancer in a Pooled Analysis
Red and processed meat intake is associated with colorectal cancer (CRC) incidence, but it is not clear if intake is associated with patient survival after diagnosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 23, 2018 Category: Gastroenterology Authors: Prudence R. Carr, Barbara Banbury, Sonja I. Berndt, Peter T. Campbell, Jenny Chang-Claude, Richard B. Hayes, Barbara V. Howard, Lina Jansen, Eric Jacobs, Dorothy S. Lane, Reiko Nishihara, Shuji Ogino, Amanda I. Phipps, Martha L. Slattery, Marcia L. Stefan Source Type: research

Variation in Endoscopic Activity Assessment and Endoscopy Score Validation in Adults with Eosinophilic Esophagitis
We examined variations in endoscopic assessments of severity, developed and validated 3 EREFS-based scoring systems, and assessed responsiveness of these systems using data from a randomized placebo-controlled trial of patients with EoE. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 23, 2018 Category: Gastroenterology Authors: Alain M. Schoepfer, Ikuo Hirano, Michael Coslovsky, Marie C. Roumet, Marcel Zwahlen, Claudia E. Kuehni, David Hafner, Jeffrey A. Alexander, Evan S. Dellon, Nirmala Gonsalves, John Leung, Christian Bussmann, Margaret H. Collins, Robert O. Newbury, Thomas C Source Type: research

Effects of Alcohol Consumption and Metabolic Syndrome on Mortality in Patients with Non-alcoholic and Alcohol-Related Fatty Liver Disease
Non-alcoholic and alcohol-related fatty liver disease are overlapping diseases in which metabolic syndrome and alcohol consumption each contribute to progressive liver disease. We aimed to assess the effects of alcohol consumption and metabolic syndrome on mortality in individuals with fatty liver. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 23, 2018 Category: Gastroenterology Authors: Zobair M. Younossi, Maria Stepanova, Janus Ong, Yusuf Yilmaz, Ajay Duseja, Yuichiro Eguchi, Mohamed El Kassas, Marlen Castellanos-Fernandez, Jacob George, Ira M. Jacobson, Elisabetta Bugianesi, Vincent Wai-Sun Wong, Marco Arrese, Victor de Ledinghen, Manu Source Type: research

Association Between Cigarette Smoking and Alcohol Consumption and Sessile Serrated Polyps in Subjects 30 to 49 Years Old
We investigated the prevalence of sessile serrated polyps (SSPs) and the association between SSP risk and modifiable lifestyle factors in asymptomatic young adults. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 23, 2018 Category: Gastroenterology Authors: Ji Young Lee, Hye-Sook Chang, Tae Hyup Kim, Eun Ju Chung, Hye Won Park, Jong-Soo Lee, Sun Mi Lee, Dong-Hoon Yang, Jaewon Choe, Jeong-Sik Byeon Source Type: research

Safety of Tofacitinib for Treatment of Ulcerative Colitis, Based on 4.4 Years of Data From Global Clinical Trials
We report integrated safety analyses of tofacitinib-treated patients with moderate to severe UC. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 23, 2018 Category: Gastroenterology Authors: William J. Sandborn, Juli án Panés, Geert R. D’Haens, Bruce E. Sands, Chinyu Su, Michele Moscariello, Thomas Jones, Ron Pedersen, Gary S. Friedman, Nervin Lawendy, Gary Chan Source Type: research

Association Between Intake of Red and Processed Meat and Survival in Patients With Colorectal Cancer in a Pooled Analysis
Red and processed meat intake is associated with colorectal cancer (CRC) incidence, but it is not clear if intake is associated with patient survival after diagnosis (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 23, 2018 Category: Gastroenterology Authors: Prudence R. Carr, Barbara Banbury, Sonja I. Berndt, Peter T. Campbell, Jenny Chang-Claude, Richard B. Hayes, Barbara V. Howard, Lina Jansen, Eric Jacobs, Dorothy S. Lane, Reiko Nishihara, Shuji Ogino, Amanda I. Phipps, Martha L. Slattery, Marcia L. Stefan Source Type: research

Liver Fat is Associated With Markers of Inflammation and Oxidative Stress in Analysis of Data From the Framingham Heart Study
Non-alcoholic fatty liver disease is an inflammatory condition that results in progressive liver disease. It is unknown if individuals with hepatic steatosis, but not known to have liver disease, have higher serum concentrations of markers of systemic inflammation and oxidative stress (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 23, 2018 Category: Gastroenterology Authors: Zachary P. Fricker, Alison Pedley, Joseph M. Massaro, Ramachandran S. Vasan, Udo Hoffmann, Emelia J. Benjamin, Michelle T. Long Source Type: research

Association Between Black Race and Presentation and  Liver-Related Outcomes of Patients With Autoimmune Hepatitis
Small studies have found that black patient with autoimmune hepatitis (AIH) patients present with more aggressive disease. We aimed to characterize the presentation and outcome in black and white patients with AIH. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Ynto S. de Boer, Alessio Gerussi, Floris F. van den Brand, Guan-Wee Wong, Neil Halliday, Rodrigo Liberal, Joost P.H. Drenth, Douglas Thorburn, Gerd Bouma, Dutch Autoimmune Hepatitis Study Group, Michael A. Heneghan Source Type: research

Differences in Outcomes Reported by Patients With  Inflammatory Bowel Diseases vs Their Health Care Professionals
Inflammatory bowel disease (IBD) scoring systems combine patient-reported data with physicians ’ observations to determine patient outcomes, but these systems are believed to have limitations. We used real-world data from a large IBD cohort in Switzerland to compare results between patients and healthcare professionals from scoring systems for Crohn’s disease (CD) and ulcerative colitis ( UC). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Val érie Pittet, Michel H. Maillard, Thomas Simonson, Nicolas Fournier, Gerhard Rogler, Pierre Michetti Source Type: research

Accuracy of Noninvasive Scoring Systems in Assessing Risk of Death and Liver-Related Endpoints in Patients With Nonalcoholic Fatty Liver Disease
We examined the association between 4 scoring systems and incident severe liver disease and overall mortality in a large cohort of patients with biopsy-proven NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Hannes Hagstr öm, Patrik Nasr, Mattias Ekstedt, Per Stål, Rolf Hultcrantz, Stergios Kechagias Source Type: research

Predictive capacity for mortality and severe liver disease of the relative fat mass algorithm
The relative fat mass (RFM) is a new tool that estimates body fat composition better than body mass index (BMI). However, it is unknown if this new scoring system is better than currently available alternatives to BMI in predicting incident outcomes. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Anna Andreasson, Axel C. Carlsson, Kristina Önnerhag, Hannes Hagström Source Type: research

Histologic Analysis of Endoscopic Ultrasound-guided Through the Needle Microforceps Biopsies Accurately Identifies Mucinous Pancreas Cysts
It is a challenge to accurately assess pancreatic cystic lesions (PCLs) and determine their risk. We compared the yield of tissue acquired with endoscopic ultrasound (EUS)-guided microforceps (through the needle tissue biopsy, or TTNB) with that of samples collected by EUS-guided fine-needle-aspiration (EUS-FNA), and the accuracy of analyses of each sample type in the diagnosis of mucinous PCLs. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Dennis Yang, Arvind J. Trindade, Patrick Yachimski, Petros Benias, Jose Nieto, Amar Manvar, Sammy Ho, Ashwini Esnakula, Anthony Gamboa, Amrita Sethi, Anand Gupte, Harshit S. Khara, David L. Diehl, Abdul El Chafic, Janak Shah, Christopher E. Forsmark, Pete Source Type: research

Association Between Black Race and Presentation and Liver-related Outcomes of Patients With Autoimmune Hepatitis
& Aims: Small studies have found that black patient with autoimmune hepatitis (AIH) patients present with more aggressive disease. We aimed to characterize the presentation and outcome in black and white patients with AIH. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Ynto S. de Boer, Alessio Gerussi, Floris F. van den Brand, Guan-Wee Wong, Neil Halliday, Rodrigo Liberal, Joost P.H. Drenth, Douglas Thorburn, Gerd Bouma, Dutch Autoimmune Hepatitis Study Group (DAIHG), Michael A. Heneghan Source Type: research

Differences in Outcomes Reported by Patients With Inflammatory Bowel Diseases vs Their Health Care Professionals
Inflammatory bowel disease (IBD) scoring systems combine patient-reported data with physicians ’ observations to determine patient outcomes, but these systems are believed to have limitations. We used real-world data from a large IBD cohort in Switzerland to compare results between patients and healthcare professionals’ from scoring systems for Crohn’s disease (CD) and ulcerative coliti s (UC). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Val érie Pittet, Michel H. Maillard, Thomas Simonson, Nicolas Fournier, Gerhard Rogler, Pierre Michetti Source Type: research

Accuracy of Non-invasive Scoring Systems in Assessing Risk of Death and Liver-related Endpoints in Patients With Non-alcoholic Fatty Liver Disease
We examined the association between 4 scoring systems and incident severe liver disease and overall mortality in a large cohort of patients with biopsy-proven NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Hannes Hagstr öm, Patrik Nasr, Mattias Ekstedt, Per Stål, Rolf Hultcrantz, Stergios Kechagias Source Type: research

Low Frequency of Lymph Node Metastases in Patients in the United States With Early-stage Gastric Cancers That Fulfill Japanese Endoscopic Resection Criteria
In the West, early gastric cancer is increasingly managed with endoscopic resection (ER). This is, however, based on the assumption that the low prevalence and risk of lymph node metastases observed in Asian patients is applicable to patients in the United States. We sought to evaluate the frequency of and factors associated with metastasis of early gastric cancers to lymph nodes, and whether the Japanese ER criteria are applicable to patients in the US. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 21, 2018 Category: Gastroenterology Authors: Yuri Hanada, Alyssa Y. Choi, Joo Ha Hwang, Peter V. Draganov, Lauren Khanna, Amrita Sethi, Michael J. Bartel, Neha Goel, Seiichiro Abe, Rabia A. De Latour, Kenneth Park, Marcovalerio Melis, Elliot Newman, Ioannis Hatzaras, Sanjay S. Reddy, Jeffrey M. Farm Source Type: research

Exam 2: Range of Normal Liver Stiffness and Factors Associated With Increased Stiffness Measurements in Apparently Healthy Individuals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 19, 2018 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activity Source Type: research

Exam 1: Diagnostic Yield From Screening Asymptomatic Individuals at High Risk for Pancreatic Cancer: A Meta-analysis of Cohort Studies
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 19, 2018 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

Exam 2: Range of Normal Liver Stiffness and Predictors of Suspected Advanced Fibrosis in Apparently Healthy Individuals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 19, 2018 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activity Source Type: research

Population-Based Trends in Prevalence of Nonalcoholic Fatty Liver Disease in U.S. Adults With Type 2 Diabetes
Type 2 diabetes (T2D) affects more than 9% of U.S. adults.1 Nonalcoholic fatty liver disease (NAFLD) has been recognized as a common co-morbidity in T2D. However, most previous epidemiologic studies have been subject to ascertainment and selection bias or had small sample sizes. No recent studies have examined trends of the burden of NAFLD in diabetic patients. Using noninvasive scores and the National Health and Nutrition Examination Survey (NHANES), we aimed to estimate the population-based trends in prevalence of NAFLD-associated comorbidities in U.S. adults with T2D. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 17, 2018 Category: Gastroenterology Authors: Phuc Le, Alexander Chaitoff, Michael B. Rothberg, Arthur Mccullough, Niyati M. Gupta, Naim Alkhouri Tags: Research Correspondence Source Type: research

Efficacy of Induction Therapy with High-intensity Tofacitinib in 4 Patients with Acute Severe Ulcerative Colitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 17, 2018 Category: Gastroenterology Authors: Jeffrey A. Berinstein, Calen A. Steiner, Randolph E. Regal, John I. Allen, Jami A.R. Kinnucan, Ryan W. Stidham, Akbar K. Waljee, Shrinivas Bishu, Leslie B. Aldrich, Peter D.R. Higgins Source Type: research

Population-based trends in prevalence of nonalcoholic fatty liver disease in US adults with type 2 diabetes
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 17, 2018 Category: Gastroenterology Authors: Phuc Le, Alexander Chaitoff, Michael B. Rothberg, Arthur McCullough, Niyati M. Gupta, Naim Alkhouri Source Type: research

Low-Normal Thyroid Function is Associated with Advanced Fibrosis among Adults in the United States
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 17, 2018 Category: Gastroenterology Authors: Donghee Kim, Eric R. Yoo, Andrew A. Li, Christopher T. Fernandes, Sean P. Tighe, George Cholankeril, Bilal Hameed, Aijaz Ahmed Source Type: research

Rare and fatal case of upper gastrointestinal bleeding
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 16, 2018 Category: Gastroenterology Authors: Catarina Sousa F élix, Rui Mendo, Pedro Figueiredo Tags: Image of the Month Source Type: research

Incarcerated Spigelian Hernia
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 16, 2018 Category: Gastroenterology Authors: Pamela J. Leone, Mohit Girotra Tags: Image of the Month Source Type: research

Sex Difference in Celiac Disease in Undiagnosed Populations: A Systematic Review and Meta-analysis
A higher proportion of female vs male patients receive a diagnosis of celiac disease. Little is known about sex-based differences in the prevalence of celiac disease in undiagnosed populations. We aimed to address this knowledge gap with a systematic review and meta-analysis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Claire L. Jansson-Knodell, Isabel A. Hujoel, Colin P. West, Veena Taneja, Larry J. Prokop, Alberto Rubio-Tapia, Joseph A. Murray Source Type: research

Prevalence and Severity of Nonalcoholic Fatty Liver Disease Among Caregivers of Patients With Nonalcoholic Fatty Liver Disease Cirrhosis
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, affecting nearly 1 in 3 Americans.1 Nonalcoholic steatohepatitis (NASH), the clinically aggressive variant of NAFLD, has a propensity of fibrosis progression and increased risk of cirrhosis and hepatocellular carcinoma. NASH-related cirrhosis is now the most rapidly growing indication for liver transplantation (LT).2 Disease recurrence and progression to advanced fibrosis after LT are high3; however, the key contributors of these are unknown. We hypothesized that patients with NASH cirrhosis reside in a microenvironment conducive to not only...
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Mohammad Shadab Siddiqui, Salvatore Carbone, Robert Vincent, Samarth Patel, Carolyn Driscoll, Francesco S. Celi, Hayley Billingsley, Brando Rotelli, Binu John, Nicola Potere, Michele Viscusi, Veronica Adiletta, Arun J. Sanyal, Velimir A. Luketic, Trevor R Tags: Research Correspondence Source Type: research

Efficacy and Safety of Besifovir Dipivoxil Maleate Compared With Tenofovir Disoproxil Fumarate in Treatment of Chronic HBV Infection
Besifovir dipivoxil maleate (BSV) has activity against hepatitis B virus (HBV). We performed a phase 3 study to compare the antiviral efficacy and safety of BSV vs tenofovir disoproxil fumarate (TDF) in patients with chronic HBV infection in Korea. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Sang Hoon Ahn, Won Kim, Young Kul Jung, Jin Mo Yang, Jae Young Jang, Yong Oh Kweon, Yong Kyun Cho, Yoon Jun Kim, Gun Young Hong, Dong Joon Kim, Soon Ho Um, Joo Hyun Sohn, Jin Woo Lee, Sung Jae Park, Byung Seok Lee, Ju Hyun Kim, Hong Soo Kim, Seung Kew Yoo Source Type: research

Statin Use is Associated with Improved Outcomes of Patients With Primary Sclerosing Cholangitis
There is increasing evidence that statins can benefit patients with chronic liver diseases, but their effects have not been studied in patients with primary sclerosing cholangitis (PSC). We performed a nationwide study in Sweden to determine the effects of exposure to drugs, including statins, in patients with PSC. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Knut Stokkeland, Jonas H öijer, Matteo Bottai, Karin Söderberg-Löfdal, Annika Bergquist Source Type: research

Upfront Combination Therapy, Compared with Monotherapy, for Patients Not Previously Treated with a Biologic Agent Associates With Reduced Risk of Inflammatory Bowel Disease-related Complications in a Population-based Cohort Study
Although guidelines recommend inclusion of immune modulators in anti-tumor necrosis factor (TNF) initiation therapy for Crohn ’s disease (CD) or ulcerative colitis (UC), there are limited data on the incremental effectiveness of this treatment strategy from the real world. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Laura E. Targownik, Eric I. Benchimol, Charles N. Bernstein, Harminder Singh, MSc; Lisa Lix, Aruni Tennakoon, Stella Leung, Antonio Avi ña, Stephanie Coward, Jennifer Jones, Gil Kaplan, Sanjay K. Murthy, Geoffrey C. Nguyen, Juan Nicolás Peña-Sánchez Source Type: research

Validation of Serum Test for Advanced Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis
We analyzed markers of fibrosis in serum samples from patients with nonalcoholic fatty liver disease (NAFLD), assessed by liver biopsy. We used serum levels of markers to develop an algorithm to discriminate patients with advanced fibrosis from those with mild or moderate fibrosis and validated its performance in 2 independent cohorts of patients with NAFLD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Rohit Loomba, Anjali Jain, Anna Mae Diehl, Cynthia D. Guy, Dana Portenier, Ranjan Sudan, Seema Singh, Claire Faulkner, Lisa Richards, Kelly D. Hester, Lauren Okada, Xiao-jun Li, Larry Mimms, Manal F. Abdelmalek Source Type: research

An intramucosal buried clip after endoscopic submucosal dissection
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Hyun Ho Choi, Hyung-Keun Kim, Sung Soo Kim Tags: Image of the Month Source Type: research

Pathology characterization and detection of human papillomavirus type 16 in rectal squamous cell carcinomas
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Anna E. Coghill, Andrew M. Bellizzi, Charles F. Lynch, Meredith S. Shiels, Freda R. Selk, Maura Gillison, Brenda Y. Hernandez, Owen T.M. Chan, Eric A. Engels Source Type: research

Prevalence and Severity of Nonalcoholic Fatty Liver Disease (NAFLD) Among Caregivers of Patients with NAFLD Cirrhosis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Mohammad Shadab Siddiqui, Salvatore Carbone, Robert Vincent, Samarth Patel, Carolyn Driscoll, Francesco S. Celi, Hayley Billingsley, Brando Rotelli, Binu John, Nicola Potere, Michele Viscusi, Veronica Adiletta, Arun J. Sanyal, Velimir A. Luketic, Trevor R Source Type: research

Serum Concentrations of 7 α-hydroxy-4-cholesten-3-one are Associated with Bile Acid Diarrhea in Patients with Crohn’s Disease
Patients with Crohn ’s disease (CD) often have bile acid diarrhea (BAD), due to bile acid malabsorption following ileal resection (IR). Bile acid malabsorption increases production of 7α-hydroxy-4-cholesten-3-one (C4), a bile acid precursor. We investigated relationships between serum concentrations of C4 and BAD in patients with CD. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Robert Battat, Marjolijn Duijvestein, Niels Vande Casteele, Siddharth Singh, Parambir S. Dulai, Mark A. Valasek, Larry Mimms, Judson McFarland, Kelly D. Hester, Mark Renshaw, Anjali Jain, William J. Sandborn, Brigid S. Boland Source Type: research

Sex Difference in Celiac Disease in Undiagnosed Populations – a Systematic Review and Meta-Analsysis
A higher proportion of female vs male patients receive a diagnosis of celiac disease. Little is known about sex-based differences in the prevalence of celiac disease in undiagnosed populations. We aimed to address this knowledge gap with a systematic review and meta-analysis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 15, 2018 Category: Gastroenterology Authors: Claire L. Jansson-Knodell, Isabel A. Hujoel, Colin P. West, Veena Taneja, Larry J. Prokop, Alberto Rubio-Tapia, Joseph A. Murray Source Type: research

An Unusual Cause of Hematochezia
An 85-year-old man presented with scanty rectal bleeding. Physical examination was unremarkable, apart from a palpable mass on digital rectal examination. He underwent a colonoscopy that showed a 30-mm pedunculated polyp with unusual morphology in the distal rectum, near the anal margin (Figure A). After adequate lifting with a saline, indigo-carmine, and adrenaline solution, the lesion was removed en bloc using a diathermic snare and sent to pathology (Figures B and C). Histopathology described a polypoid lesion with diffuse infiltration of large, pleomorphic tumor cells (Figures B and C). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - November 4, 2018 Category: Gastroenterology Authors: Rui Mendo, Pedro C. Figueiredo, Catarina Albuquerque Tags: Electronic image of the month Source Type: research