The Global Epidemiology of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among Patients With Type 2 Diabetes
Nonalcoholic fatty liver disease (NAFLD), now known as metabolic dysfunction associated steatotic liver disease (MASLD), is closely associated with type 2 diabetes (T2D). Our aim was to estimate the most recent global prevalence of NAFLD/MASLD, nonalcoholic steatohepatitis (NASH), now known as metabolic dysfunction associated steatohepatitis (MASH), advanced fibrosis, and mortality among patients with T2D. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 21, 2024 Category: Gastroenterology Authors: Zobair M. Younossi, Pegah Golabi, Jillian Kallman Price, Soroor Owrangi, Nagashree Gundu-Rao, Romona Satchi, James Paik Tags: Systematic Reviews and Meta-analyses Source Type: research

Ultra-Processed Food Consumption and Long-Term Risk of Irritable Bowel Syndrome: A Large-Scale Prospective Cohort Study
The considerable disease burden of irritable bowel syndrome (IBS) has coincided with the increase of ultraprocessed food (UPF) consumption over the past few decades. However, epidemiologic evidence is lacking. We aimed to examine the long-term risk of IBS associated with UPF consumption in a large-scale prospective cohort. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 21, 2024 Category: Gastroenterology Authors: Shanshan Wu, Zhirong Yang, Si Liu, Qian Zhang, Shutian Zhang, Shengtao Zhu Source Type: research

The global epidemiology of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis among patients with type 2 diabetes
Nonalcoholic fatty liver disease (NAFLD) now known as metabolic dysfunction associated steatotic liver disease (MASLD) is closely associated with type 2 diabetes (T2D). Our aim was to estimate the most recent global prevalence of NAFLD/MASLD, non-alcoholic steatohepatitis (NASH) now known as metabolic dysfunction associated steatohepatitis (MASH), advanced fibrosis, and mortality among patients with T2D. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 21, 2024 Category: Gastroenterology Authors: Zobair M. Younossi, Pegah Golabi, Jillian Kallman Price, Soroor Owrangi, Nagashree Gundu-Rao, Romona Satchi, James Paik Tags: Systematic Reviews and Meta-analyses Source Type: research

Disparities in Colorectal Cancer Screening Among Asian American Populations and Strategies to Address These Disparities
Asian Americans (AsA) are the only racial subgroup in the United States, in whom cancer remains the leading cause of death instead of heart disease.1 Per the latest cancer statistics published by the American Cancer Society, the incidence rate for colorectal cancer (CRC) in the AsA population was 24.3 per 100,000 women and 33.9 per 100,000 men (2015 –2019) and the mortality rate was 7.7 per 100,000 women and 10.9 per 100,000 men (2016–2020).2 Over the past 3 decades, even though the overall mortality of CRC in this population has steadily declined (19% in AsA vs 21% in White Americans vs 25% in Black Americans), with f...
Source: Clinical Gastroenterology and Hepatology - March 20, 2024 Category: Gastroenterology Authors: Ishani Shah, Andrew J. Gawron, Kathryn R. Byrne, John M. Inadomi Tags: Diversity, Equity, and Inclusion in GI Source Type: research

Blue Notes
This study leveraged the National Center of Health Statistics (NCHS) database to conduct a time-trend analysis evaluating CLD and cirrhosis mortality rates in the U.S. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2024 Category: Gastroenterology Authors: Charles J. Kahi Tags: Blue Notes Source Type: research

Exam 1: Global Prevalence of Fecal Incontinence in Community-Dwelling Adults: A Systematic Review and Meta-analysis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2024 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

Front Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2024 Category: Gastroenterology Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2024 Category: Gastroenterology Source Type: research

Table of Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2024 Category: Gastroenterology Source Type: research

Elsewhere in the AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 20, 2024 Category: Gastroenterology Source Type: research

Algorithm Training and Testing for a Nonendoscopic Barrett ’s Esophagus Detection Test in Prospective Multicenter Cohorts
Endoscopic Barrett ’s esophagus (BE) and esophageal adenocarcinoma (EAC) detection is invasive and expensive. Nonendoscopic BE/EAC detection tools are guideline-endorsed alternatives. We previously described a 5-methylated DNA marker (MDM) panel assayed on encapsulated sponge cell collection device (CCD) specimens. We aimed to train a new algorithm using a 3-MDM panel and test its performance in an independent cohort. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 19, 2024 Category: Gastroenterology Authors: Prasad G. Iyer, Seth W. Slettedahl, Douglas W. Mahoney, Maria Giakoumopoulos, Marilyn C. Olson, Martin Krockenberger, William R. Taylor, Patrick Foote, Calise Berger, Cadman Leggett, Tsung-Teh Wu, Eduardo Antpack, Gary W. Falk, Gregory G. Ginsberg, Julian Source Type: research

BEHAVIORAL THERAPY FOR FUNCTIONAL HEARTBURN: Recommendation Statements
Brain-gut behavior therapies (BGBT) are increasingly recognized as effective therapeutic interventions for functional heartburn. However, recommendations regarding candidacy for treatment, initial treatment selection, and navigating treatment non-response have not been established for functional heartburn specifically. The aim of this study was to establish expert-based recommendations for behavioral treatment in patients with functional heartburn. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 19, 2024 Category: Gastroenterology Authors: Livia Guadagnoli, Rena Yadlapati, John Pandolfino, Alyse Bedell, Anjali U. Pandit, Kerry B. Dunbar, Ronnie Fass, Richard Gevirtz, C Prakash Gyawali, Stephen E. Lupe, Megan Petrik, Megan E. Riehl, Jessica Salwen-Deremer, Madison Simons, Kathryn N. Tomasino Source Type: research

Algorithm Training and Testing for a Non-Endoscopic Barrett ’s Esophagus Detection Test in Prospective Multicenter Cohorts
Endoscopic Barrett ’s esophagus (BE) and esophageal adenocarcinoma (EAC) detection is invasive and expensive. Non-endoscopic BE/EAC detection tools are guideline-endorsed alternatives. We previously described a 5-methylated DNA marker (MDM) panel assayed on encapsulated sponge cell collection device (CCD) specimens. We aimed to train a new algorithm using a 3-MDM panel and test its performance in an independent cohort. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 19, 2024 Category: Gastroenterology Authors: Prasad G. Iyer, Seth W. Slettedahl, Douglas W. Mahoney, Maria Giakoumopoulos, Marilyn C. Olson, Martin Krockenberger, William R. Taylor, Patrick Foote, Calise Berger, Cadman Leggett, T.T. Wu, Eduardo Antpack, Gary W. Falk, Gregory G. Ginsberg, Julian A. A Source Type: research

Endometriosis is Associated with Higher Healthcare Utilization and Upper Gastrointestinal Symptoms
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 19, 2024 Category: Gastroenterology Authors: Madison Simons, Michael Cline, Ashley Gubbels, Cara King, Anthony Lembo, Stephen Lupe Tags: Research Letter Source Type: research

Severe Fatigue in Inflammatory Bowel Disease: Dopaminergic Therapy With Modafinil or Vitamin Therapy With Thiamine
We found Moulton et  al’s1 illustrative case series of 10 patients with inflammatory bowel disease (IBD) and chronic fatigue, all presenting with depression, particularly interesting. 1 Among the patients, 8 previously had undergone treatment with multiple psychotropic medications, and 2 had active IBD as indicated by increased fecal calprotectin levels. Remarkably, all 10 patients responded positively to open-label treatment with modafinil, a central nervous system stimulant that blocks dopamine reuptake transport, which resulted in an impressive improvement in their fatigue symptoms. At baseline, the self-re ported me...
Source: Clinical Gastroenterology and Hepatology - March 18, 2024 Category: Gastroenterology Authors: Palle Bager, Christian L. Hvas, Jens Frederik Dahlerup Tags: Letters to the Editor Source Type: research