Identifying Outcomes in Clinical Trials of Pouchitis for the Development of a Core Outcome Set
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 27, 2018 Category: Gastroenterology Authors: Christopher Ma, Jonathan Athayde, Sarah C. Davies, Claire E. Parker, Tran M. Nguyen, Reena Khanna, Brian G. Feagan, Vipul Jairath Source Type: research

Increasing Trends in Transplantation of HCV –Positive Livers Into Uninfected Recipients
The introduction of direct-acting antiviral (DAA) agents and the opioid epidemic have resulted in an increased interest in liver transplantation (LT) of organs from donors with hepatitis C virus (HCV)-related viremia.1 In March of 2015, the Organ Procurement and Transplantation Network/United Network for Organ Sharing (OPTN/UNOS) implemented a policy to perform HCV nucleic acid testing (NAT) in all HCV-seropositive donors. An open-label, single-center experience with 10 patients using a multistep informed consent reported successful transplantation of HCV-seropositive viremic (HCV-V) kidneys into HCV-seronegative recipient...
Source: Clinical Gastroenterology and Hepatology - September 27, 2018 Category: Gastroenterology Authors: George Cholankeril, Andrew A. Li, Brittany B. Dennis, Alice E. Toll, Donghee Kim, C. Andrew Bonham, Satheesh Nair, Aijaz Ahmed Tags: Original article Source Type: research

Is Mass Screening for Barrett ’s Esophagus a Myth or Reality?
Esophageal adenocarcinoma (EAC) is the main histologic type of esophageal cancer in the West with an estimated incidence of 52,000 cases worldwide in 2012.1 Mathematical models predict a continued increase in EAC incidence with a near doubling of mortality in the United States between 2011 and 2030 compared with the previous 20 years.2 More than 40 % of patients with EAC are diagnosed after the disease has metastasized, which translates to dismal survival.3 Hope lies in the fact that the cancer can be reliably cured when detected early and if detected at a mucosal stage, it can even be treated endoscopically. (Source: Clin...
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Prashanthi N. Thota, Amitabh Chak Tags: Editorial Source Type: research

Endoscopic Mucosal Resection vs Endoscopic Submucosal Dissection For Barrett ’s Esophagus and Colorectal Neoplasia
Endoscopic resection has become the first-line therapy for the management of superficial neoplasia throughout the gastrointestinal tract. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are established yet distinct techniques for the treatment of superficial gastrointestinal neoplasia. EMR is simpler and faster but is limited by its ability to resect large lesions en bloc. Limitations of piecemeal EMR of large lesions include a high rate of recurrence and a less-than-ideal tissue specimen for accurate histologic evaluation. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Dennis Yang, Mohamed Othman, Peter V. Draganov Tags: Review Source Type: research

Young Adults With Esophageal Adenocarcinoma Present With More Advanced Stage Tumors and Have Shorter Survival Times
Obesity is increasing in younger populations. Barrett ’s esophagus is associated with central obesity, so we investigated the occurrence of esophageal adenocarcinoma (EAC) in younger patients and compared them with older patients to determine differences in features at presentation and survival times. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Tarek Sawas, Gerardo Calderon Manrique, Prasad G. Iyer, Kenneth K. Wang, David A. Katzka Source Type: research

Time to Tailor Surveillance Intervals of Nondysplastic Barrett ’s Esophagus According to Segment Length and Persistence Over Multiple Endoscopies
During the past 4 decades, there has been a rapid increase in the incidence of esophageal adenocarcinoma (EA), such that EA is one of the fastest increasing cancers in incidence among Western populations.1 Among white males in the United States, EA incidence has increased almost 10-fold and rates continue to increase.2 Strikingly, 40% of EA patients in the United States still are diagnosed with distant stage disease, and less than 20% of all EA patients survive for 5 years after EA diagnosis.2 (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Aaron P. Thrift, Andrew T. Kunzmann Tags: Editorial Source Type: research

Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Antigen in Individuals With Chronic Hepatitis B Virus Infection
For chronic hepatitis B patients, hepatitis B e antigen (HBeAg) seroclearance signals a transition from an immunologically active phase to an inactive carrier state with a reduction in hepatitis B virus (HBV) DNA levels and a reduced risk of hepatocellular carcinoma (HCC).1 Predictors of HBeAg seroclearance include lower HBV DNA levels, viral genotype, the precore mutation, and higher serum alanine aminotransferase (ALT) levels.2 (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Jessica Liu, Hui-Han Hu, Chia-Ling Chang, Chin-Lan Jen, Mei-Hsuan Lee, Sheng-Nan Lu, Li-Yu Wang, Quan Yuan, Ning-Shao Xia, Masaya Sugiyama, Nao Nishida, Masashi Mizokami, Chien-Jen Chen, Pei-Jer Chen, Hwai-I. Yang Tags: Research Correspondence Source Type: research

Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases
Individuals with inflammatory bowel diseases (IBDs) have an increased risk of developing colorectal cancer (CRC). Although family history of CRC is a well-established risk factor in healthy individuals, its role in patients with IBD is less clear. We aimed to estimate the risk of CRC in a cohort of patients with IBD from Utah and the significance of family history of CRC in a first-degree relative (FDR). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: N. Jewel Samadder, John F. Valentine, Stephen Guthery, Harminder Singh, Charles N. Bernstein, Jonathan A. Leighton, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Randall W. Burt, Karen Curtin, Ken R. Smith Source Type: research

EDITORIAL: Time to tailor surveillance intervals of non-dysplastic Barrett ’s esophagus according to segment length and persistence over multiple endoscopies
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Aaron P. Thrift, Andrew T. Kunzmann Source Type: research

Mass Screening for Barrett ’s esophagus: Myth or Reality?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Prashanthi N. Thota, Amitabh Chak Source Type: research

Prebiotics and Probiotics in Digestive Health
As the importance of the gut microbiota in health and disease is increasingly recognized interest in interventions that can modulate the microbiota and its interactions with its host has soared. Apart from diet, prebiotics and probiotics represent the most commonly used substances taken in an effort to sustain a healthy microbiome or restore balance when it is believed bacterial homeostasis has been disturbed in disease. While a considerable volume of basic science attests to the ability of various prebiotic molecules and probiotic strains to beneficially influence host immune responses, metabolic processes and neuro-endoc...
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Eamonn M.M. Quigley Source Type: research

Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for Barrett ’s Esophagus and Colorectal Neoplasia
Endoscopic resection has become the first-line therapy for the management of superficial neoplasia throughout the gastrointestinal tract. Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are established yet distinct techniques for the treatment of superficial gastrointestinal neoplasia. EMR is simpler and faster but is limited by its ability to resect large lesions en-bloc. Limitations of piecemeal EMR of large lesions include a high rate of recurrence and a less than ideal tissue specimen for accurate histologic evaluation. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Dennis Yang, Mohamed Othman, Peter V. Draganov Source Type: research

Young Adults with Esophageal Adenocarcinoma Present With More-advanced Stage Tumors and Have Shorter Survival Times
Obesity is increasing in younger populations. Barrett ’s esophagus is associated with central obesity, so we investigated the occurrence of esophageal adenocarcinoma (EAC) in younger patients and compared them with older patients to determine differences in features at presentation and survival times. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Tarek Sawas, Gerardo Calderon Manrique, Prasad G. Iyer, Kenneth K. Wang, David A. Katzka Source Type: research

Low Sensitivity of Simtomax Point of Care Test in Detection of Celiac Disease in a Prospective Multicenter Study
Point of care tests (POCTs) might be used to identify patients with undiagnosed celiac disease who require further evaluation. We performed a large multicenter study to determine the performance of a POCT for celiac disease and assessed celiac disease prevalence in endoscopy centers. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Paul Tangermann, Federica Branchi, Alice Itzlinger, Jens Aschenbeck, Stefan Schubert, Jochen Maul, Thomas Liceni, Andreas Schr öder, Frank Heller, Wolfgang Spitz, Ulrich Möhler, Ulrich Graefe, Michael Radke, Stefan Trenkel, Markus Schmitt, Christoph Lod Source Type: research

Combination Therapy with Infliximab and Azathioprine Improves Infliximab Pharmacokinetic Features and Efficacy —a Post-hoc analysis
Among immunosuppressive- and biologic-na ïve patients with moderate to severely active Crohn’s disease (CD), a higher proportion of those treated with the combination of infliximab and azathioprine achieved corticosteroid-free remission at week 26 (CSFR26) than those given infliximab monotherapy; patients given the combination therapy a lso had higher serum concentrations of infliximab. Enhanced benefit of combination therapy may occur through synergistic modes of action or the influence of azathioprine on infliximab pharmacokinetics. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Jean Frederic Colombel, Omoniyi J. Adedokun, Christopher Gasink, Long-Long Gao, Freddy J. Cornillie, Geert R. D'Haens, Paul J. Rutgeerts, Walter Reinisch, William J. Sandborn, Stephen B. Hanauer Source Type: research

Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of HBeAg in Individuals With Chronic HBV Infection
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: Jessica Liu, Hui-Han Hu, Chia-Ling Chang, Chin-Lan Jen, Mei-Hsuan Lee, Sheng-Nan Lu, Li-Yu Wang, Quan Yuan, Ning-Shao Xia, Masaya Sugiyama, Nao Nishida, Masashi Mizokami, Chien-Jen Chen, Pei-Jer Chen, Hwai-I. Yang Source Type: research

Family History is Associated With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases
Individuals with inflammatory bowel diseases (IBD) carry an increased risk of developing colorectal cancer (CRC). Though family history of CRC is a well-established risk factor in healthy individuals, its role in IBD patients is less clear. The aim of this study was to estimate the risk of CRC in a cohort of IBD patients from Utah and the significance of family history of CRC in a first-degree relative (FDR). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 26, 2018 Category: Gastroenterology Authors: N. Jewel Samadder, John F. Valentine, Stephen Guthery, Harminder Singh, Charles N. Bernstein, Jonathan A. Leighton, Yuan Wan, Jathine Wong, Kenneth Boucher, Lisa Pappas, Kerry Rowe, Randall W. Burt, Karen Curtin, Ken R. Smith Source Type: research

Outcomes of Endoscopic Balloon Dilation vs Surgical Resection for Primary Ileocolic Strictures in Patients With Crohn ’s Disease
We read with great interest the article by Lan et  al.1 This retrospective study identified that there is a high frequency of salvage surgery although endoscopic balloon dilation is successful initially with minimal adverse events, and initial ileocolic resection is associated with a higher morbidity but a longer surgery-free interval. Herein, we would like to raise the following comments. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Authors: Ju-Dong Li, Xin-Fei Xu, Hao Xing Tags: Letter to the Editor Source Type: research

That Cursed Dyspepsia
Koduru et  al1 are to be congratulated for their article regarding dyspepsia. The authors take a gargantuan beast and describe its shape, characteristics, habits, how it has grown and changed over many years, along with the best ways to understand it and deal with it. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Authors: W. Michael Mcdonnell Tags: Letter to the Editor Source Type: research

Opioid Toxicity in Inflammatory Bowel Disease Patients Likely Includes Direct Enterocyte Effects That Exacerbate Disease
We read the article by Burr et  al1 with great interest. Opioid use in patients with inflammatory bowel disease is unfortunately all too common, and it is important that the risks of opioid therapy in this population be well understood. The authors mention several possible mechanisms by which opioids may be increasing mortality, including canonical opioid toxicities (such as respiratory depression), and that opioid use may be associated with more severe disease and thus worse outcomes. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Authors: Jason R. Goldsmith, R. Balfour Sartor Tags: Letter to the Editor Source Type: research

The Association Between Consumption of Sweetened Beverages and the Risk of Inflammatory Bowel Disease
We read with interest the article by Khalili et  al1 investigating the association between consumption of sweetened beverages and later risk of Crohn’s disease or ulcerative colitis. The author observed no evidence for associations between consumption of sweetened beverages and later risk of Crohn’s disease or ulcerative colitis from 2 large prospective cohort studies from Sweden. Because their findings are different from previous studies, this issue deserves further discussion. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Authors: Cong Dai, Min Jiang, Ming-Jun Sun Tags: Letter to the Editor Source Type: research

Barrett ’s Esophagus
Barrett ’s esophagus occurs when the cells lining the esophagus (the tube that links your mouth and stomach) change into abnormal cells, increasing the risk of long-term problems. It does not cause any symptoms that you can feel, but it puts you at greater risk for a type of cancer that forms in the esoph agus. The true cause is unknown, but there are a few things that could increase your chances of getting it, such as: (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Tags: AGA Patient Education Section Source Type: research

Reply
We thank Dr McDonnell for his comments on our review1 and for raising the thorny topic of pyloric dysfunction. Pylorospasm, or pyloric dysmotility, has enjoyed a long and checkered career in the annals of dyspepsia. Pyloric dysfunction has been touted as one of the manifestations of diabetic gastroenteropathy,2 although the contribution of spasm, per se, has been disputed. Much of the debate has centered around technical issues and, in particular, the challenges presented by the accurate recording of tonic and phasic pressure patterns from such a small area over prolonged periods, especially after meal ingestion. (Source: ...
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Authors: Eamonn M.M. Quigley, Pramoda Koduru, Malcolm Irani Tags: Letter to the Editor Source Type: research

Reply
We appreciate the interest of Li et  al in our work and are grateful for the opportunity to address the points they raised. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Authors: Nan Lan, Luca Stocchi, Bo Shen Tags: Letter to the Editor Source Type: research

Issue Highlights
Studies have shown a positive association between systemic markers of inflammation and the risk of future cardiovascular disease. It is believed that this risk is mediated by prothrombotic changes in the vasculature as a response to inflammation. Systemic inflammatory diseases such as inflammatory bowel disease (IBD) may increase the risk for coronary artery disease by this mechanism, although prior epidemiologic studies show mixed results. In this issue of Clinical Gastroenterology and Hepatology, Aniwan and colleagues1 evaluated the risk of acute myocardial infarction and heart failure in patients with ulcerative colitis...
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Authors: Ziad Gellad Tags: Issue highlights Source Type: research

Editorial Board
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Source Type: research

Contents
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Source Type: research

Elsewhere in The AGA Journals
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Source Type: research

Information for Authors and Readers
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Source Type: research

Cover
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 21, 2018 Category: Gastroenterology Source Type: research

How Quickly Do Inflammatory Bowel Disease Medications Really Work?
Rapid symptom improvement is important for patients with inflammatory bowel disease (IBD). For a lifelong relapsing and remitting condition, in which unpredictability is the hallmark of disease, rapid resolution of symptoms, particularly abdominal pain, diarrhea, and rectal bleeding, is rated by patients as one of the most important attributes of therapy. In this issue of Clinical Gastroenterology and Hepatology, Feagan et  al1 and Hanauer et al2 performed post hoc analyses of patient-reported symptoms from phase 3 randomized controlled trials (RCTs) to describe when patients can expect symptom improvement after ...
Source: Clinical Gastroenterology and Hepatology - September 19, 2018 Category: Gastroenterology Authors: Ailsa L. Hart, Sonia Bouri Tags: Editorial Source Type: research

Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 19, 2018 Category: Gastroenterology Authors: Wai-Kay Seto, Thomas Sau-Yan Chan, Yu-Yan Hwang, Lung-Yi Mak, Danny Ka-Ho Wong, James Fung, Kevin Sze-Hang Liu, Ka-Shing Cheung, Ching-Lung Lai, Yok-Lam Kwong, Man-Fung Yuen Source Type: research

Onset of action of Inflammatory Bowel Disease medications: how quickly do they really work?
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 19, 2018 Category: Gastroenterology Authors: Ailsa L. Hart, Sonia Bouri Source Type: research

Colonic Schistosoma Granulomas: An Unusual Cause of Colonic Subepithelial Lesions
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 19, 2018 Category: Gastroenterology Authors: Minah Jon, Chang Kyun Lee, Hyo Jong Kim Tags: Image of the Month Source Type: research

Primary localized gastric amyloidosis mimicking a submucosal tumor-like gastrointestinal tumor
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 19, 2018 Category: Gastroenterology Authors: Hideaki Kinugasa, Takehiro Tanaka, Hiroyuki Okada Tags: Image of the Month Source Type: research

Analysis of Midesophageal Biopsies Increases Sensitivity of Detection of Eosinophilic Esophagitis
Eosinophilic esophagitis (EoE) is defined by the presence of abundant eosinophils in the squamous epithelium of the esophagus. There has been remarkable progress recently in the understanding of the pathogenesis, diagnosis, and treatment of EoE.1 Because undiagnosed EoE leads to an increase in fibrostenotic complications including strictures, timely diagnosis is critical.2 (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 18, 2018 Category: Gastroenterology Authors: Kasey Radicic, R. Fraser Stokes Tags: Research Correspondence Source Type: research

Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians
Advances in technical capabilities for reading out complex human microbiomes are leading to an explosion of microbiome research, leading in turn to intense interest among clinicians in applying these techniques to their patients. In this review, we discuss the content of the human microbiome, including inter- and intra-subject variability, considerations of study design including important confounding factors, and different methods in the laboratory and on the computer to read out the microbiome and its resulting gene products and metabolites. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 18, 2018 Category: Gastroenterology Authors: Celeste Allaband, Daniel McDonald, Yoshiki V ázquez-Baeza, Jeremiah J. Minich, Anupriya Tripathi, David A. Brenner, Rohit Loomba, Larry Smarr, William J. Sandborn, Bernd Schnabl, Pieter Dorrestein, Amir Zarrinpar, Rob Knight Source Type: research

Small Bowel Ulcers from Cryocrystalglobulinemia
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 18, 2018 Category: Gastroenterology Authors: Patrick McCabe, Nikhil Agarwal, Ryan Johnson Tags: Image of the Month Source Type: research

Analysis of Mid-esophageal Biopsies Increases Sensitivity of Detection of Eosinophilic Esophagitis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 18, 2018 Category: Gastroenterology Authors: Kasey Radicic, R. Fraser Stokes Source Type: research

Colonic MicroRNA Profiles, Identified by a Deep Learning Algorithm, That Predict Responses to Therapy of Patients With Acute Severe Ulcerative Colitis
Acute severe ulcerative colitis (ASUC) is a life-threatening condition managed with intravenous steroids followed by infliximab, cyclosporine, or colectomy (for patients with steroid resistance). There are no biomarkers to identify patients most likely to respond to therapy; ineffective medical treatment can delay colectomy and increase morbidity and mortality. We aimed to identify biomarkers of response to medical therapy for patients with ASUC. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 14, 2018 Category: Gastroenterology Authors: Ian Morilla, Mathieu Uzzan, David Laharie, Dominique Cazals-Hatem, Quentin Denost, Fanny Daniel, Genevieve Belleannee, Yoram Bouhnik, Gilles Wainrib, Yves Panis, Eric Ogier-Denis, Xavier Treton Source Type: research

Colonic microRNA Profiles, Identified by a Deep-learning Algorithm, That Predict Responses of Patients With Acute Severe Ulcerative Colitis to Therapy
Acute severe ulcerative colitis (ASUC) is a life-threatening condition managed with intravenous steroids followed by infliximab, cyclosporine, or colectomy (for patients with steroid resistance). There are no biomarkers to identify patients most likely to respond to therapy; ineffective medical treatment can delay colectomy and increase morbidity and mortality. We aimed to identify biomarkers of response to medical therapy for patients with ASUC. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 14, 2018 Category: Gastroenterology Authors: Ian Morilla, Mathieu Uzzan, David Laharie, Dominique Cazals-Hatem, Quentin Denost, Fanny Daniel, Genevieve Belleannee, Yoram Bouhnik, Gilles Wainrib, Yves Panis, Eric Ogier-Denis, Xavier Treton Source Type: research

Reply
We thank Mazzarelli and colleagues for their comments on our study and their proposal of transjugular intrahepatic portosystemic shunt (TIPS) as an alternative to anticoagulation for the management of portal vein thrombosis (PVT) in patients with cirrhosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 12, 2018 Category: Gastroenterology Authors: Vincenzo La Mura, Massimo Primignani Tags: Letter to the Editor Source Type: research

Growing and Retaining an Endoscopy Nurse
Today ’s endoscopy units perform increasingly complex procedures on older patients with many comorbidities. As the procedures have become more advanced and patients more complex, so too has the sedation and nursing practices. Whereas in the past many endoscopy nurses were part of an outpatient surgical unit, today endoscopy nursing has become a specialty that requires knowledge of endoscopy practice, experience with preprocedure and post-procedure processes, and acute assessment specific for endoscopy units. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 12, 2018 Category: Gastroenterology Authors: Catherine Bauer, Bryan G. Sauer Tags: Practice Management: The Road Ahead Source Type: research

Author reply
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 12, 2018 Category: Gastroenterology Authors: Vincenzo La Mura, Massimo Primignani Source Type: research

Primary follicular lymphoma of gallbladder presenting as multiple polyps
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 12, 2018 Category: Gastroenterology Authors: Hyo Jung An, Woohyung Lee, Chi-Young Jeong Tags: Image of the Month Source Type: research

Growing & Retaining an Endoscopy Nurse
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 12, 2018 Category: Gastroenterology Authors: Catherine Bauer, Bryan G. Sauer Source Type: research

Incorporating Advanced Practice Providers into Gastroenterology Practice
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 12, 2018 Category: Gastroenterology Authors: Monica Christine R. Nandwani, John O. Clarke Source Type: research

Innovating in Your Practice: Overcoming Barriers to Create New Opportunities
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 12, 2018 Category: Gastroenterology Authors: V. Raman Muthusamy, Srinadh Komanduri Source Type: research

Combined Celiac Ganglia and Plexus Neurolysis Shortens Survival, Without Benefit, vs Plexus Neurolysis Alone
Pancreatic cancer produces debilitating pain that opioids often ineffectively manage. The suboptimal efficacy of celiac plexus neurolysis (CPN) might result from brief contact of the injectate with celiac ganglia. We compared the effects of endoscopic ultrasound-guided celiac ganglia neurolysis (CGN) vs the effects of CPN on pain, quality of life (QOL), and survival. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 11, 2018 Category: Gastroenterology Authors: Michael J. Levy, Ferga C. Gleeson, Mark D. Topazian, Larissa L. Fujii-Lau, Felicity T. Enders, Joseph J. Larson, Kristin Mara, Barham K. Abu Dayyeh, Steven R. Alberts, Christopher L. Hallemeier, Prasad G. Iyer, Michael L. Kendrick, William D. Mauck, Randa Source Type: research

Incidence of Progression of Persistent Nondysplastic Barrett ’s Esophagus to Malignancy
The risk of esophageal adenocarcinoma (EAC) in patients with non-dysplastic Barrett ’s esophagus (NDBE) is low, so there is debate over the role of ongoing surveillance for patients with NDBE. It is important to identify patients at low risk for progression. We assessed cancer risk based on the subsequent number of endoscopies showing persistence of NDBE in a nationwide study in the Netherlands. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 10, 2018 Category: Gastroenterology Authors: Yonne Peters, Judith Honing, Wietske Kievit, Christine Kestens, Wiebe Pestman, Iris D. Nagtegaal, Rachel S. van der Post, Peter D. Siersema Source Type: research