Tofacitinib and Peficitinib inhibitors of Janus kinase for autoimmune diseases treatments: A Quantum Biochemistry Description
Phys. Chem. Chem. Phys., 2024, Accepted Manuscript DOI: 10.1039/D3CP06332A, PaperJackson Lima Amaral, Naiara Lucredi, Victor L. B. Fran ça, Samuel J. M. Santos, Francisco F. Maia, Pablo A. Morais, Pedro F. N. Souza, Jurandir F. Comar, Valder N. Freire Autoimmune inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis are associated with uncontrolled production of cytokines leading to the pronounced inflammatory response of these disorders. The therapy is... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - April 12, 2024 Category: Chemistry Authors: Jackson Lima Amaral Source Type: research
Satellite Glial Cells in Human Disease
Cells. 2024 Mar 23;13(7):566. doi: 10.3390/cells13070566.ABSTRACTSatellite glial cells (SGCs) are the main type of glial cells in sensory ganglia. Animal studies have shown that these cells play essential roles in both normal and disease states. In a large number of pain models, SGCs were activated and contributed to the pain behavior. Much less is known about SGCs in humans, but there is emerging recognition that SGCs in humans are altered in a variety of clinical states. The available data show that human SGCs share some essential features with SGCs in rodents, but many differences do exist. SGCs in DRG from patients suf...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Menachem Hanani Source Type: research
Association between Life's Essential 8 and all-cause or cardiovascular-specific mortality in patients with rheumatoid arthritis
CONCLUSIONS: CVH measured by the LE8 score is a robust and independent predictor of all-cause mortality among U.S. RA patients.PMID:38607691 | DOI:10.55563/clinexprheumatol/ppsp71 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Xiufang Kong Wei Wang Source Type: research
Satellite Glial Cells in Human Disease
Cells. 2024 Mar 23;13(7):566. doi: 10.3390/cells13070566.ABSTRACTSatellite glial cells (SGCs) are the main type of glial cells in sensory ganglia. Animal studies have shown that these cells play essential roles in both normal and disease states. In a large number of pain models, SGCs were activated and contributed to the pain behavior. Much less is known about SGCs in humans, but there is emerging recognition that SGCs in humans are altered in a variety of clinical states. The available data show that human SGCs share some essential features with SGCs in rodents, but many differences do exist. SGCs in DRG from patients suf...
Source: Herpes - April 12, 2024 Category: Infectious Diseases Authors: Menachem Hanani Source Type: research
Association between Life's Essential 8 and all-cause or cardiovascular-specific mortality in patients with rheumatoid arthritis
CONCLUSIONS: CVH measured by the LE8 score is a robust and independent predictor of all-cause mortality among U.S. RA patients.PMID:38607691 | DOI:10.55563/clinexprheumatol/ppsp71 (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - April 12, 2024 Category: Rheumatology Authors: Xiufang Kong Wei Wang Source Type: research
New | phs003417.v2.p1 | The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis
The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis (study page |release notes) (Source: dbGaP, the database of Genotypes and Phenotypes)
Source: dbGaP, the database of Genotypes and Phenotypes - April 11, 2024 Category: Genetics & Stem Cells Tags: StudyRelease Source Type: research
Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecuar mechanisms
Crit Rev Microbiol. 2024 Apr 11:1-31. doi: 10.1080/1040841X.2024.2339260. Online ahead of print.ABSTRACTPeriodontitis is an immuno-inflammatory disease of the soft tissues surrounding the teeth. Periodontitis is linked to many communicable and non-communicable diseases such as diabetes, cardiovascular disease, rheumatoid arthritis, and cancers. The oral-systemic link between periodontal disease and systemic diseases is attributed to the spread of inflammation, microbial products and microbes to distant organ systems. Oral bacteria reach the gut via swallowed saliva, whereby they induce gut dysbiosis and gastrointestinal dy...
Source: Critical Reviews in Microbiology - April 11, 2024 Category: Microbiology Authors: Sayantan Mukherjee Aditi Chopra Shaswata Karmakar Subraya Giliyar Bhat Source Type: research
The effect of Schizophyllan on the differentiation of osteoclasts and osteoblasts
In this study, its effects on bone cells, particularly osteoclasts and osteoblasts, were examined. We demonstrated that SPG dose-dependently inhibited osteoclastogenesis and reduced gene expression associated with osteoclast differentiation. SPG also decreased bone resorption and F-actin ring formation. This inhibition could have been due to the downregulation of transcription factors c-Fos and nuclear factor of activated T cells 1 (NFATc1) via the MAPKs (JNK and p38), IκBα, and PGC1β/PPARγ pathways. In coculture, SPG lowered osteoclastogenic activity in calvaria-derived osteoblasts by reducing macrophage colony-stimul...
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Soo-Ho Kim Keun Ha Park Jun Lee Seoung Hoon Lee Jeong-Hwa Baek Source Type: research
Glycolysis, a driving force of rheumatoid arthritis
Int Immunopharmacol. 2024 Apr 9;132:111913. doi: 10.1016/j.intimp.2024.111913. Online ahead of print.ABSTRACTResident synoviocytes and synovial microvasculature, together with immune cells from circulation, contribute to pannus formation, the main pathological feature of rheumatoid arthritis (RA), leading to destruction of adjacent cartilage and bone. Seeds, fibroblast-like synoviocytes (FLSs), macrophages, dendritic cells (DCs), B cells, T cells and endothelial cells (ECs) seeds with high metabolic demands undergo metabolic reprogramming from oxidative phosphorylation to glycolysis in response to poor soil of RA synovium ...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Pei-Rong Gan Hong Wu Yu-Long Zhu Yin Shu Yi Wei Source Type: research
The effect of Schizophyllan on the differentiation of osteoclasts and osteoblasts
In this study, its effects on bone cells, particularly osteoclasts and osteoblasts, were examined. We demonstrated that SPG dose-dependently inhibited osteoclastogenesis and reduced gene expression associated with osteoclast differentiation. SPG also decreased bone resorption and F-actin ring formation. This inhibition could have been due to the downregulation of transcription factors c-Fos and nuclear factor of activated T cells 1 (NFATc1) via the MAPKs (JNK and p38), IκBα, and PGC1β/PPARγ pathways. In coculture, SPG lowered osteoclastogenic activity in calvaria-derived osteoblasts by reducing macrophage colony-stimul...
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Soo-Ho Kim Keun Ha Park Jun Lee Seoung Hoon Lee Jeong-Hwa Baek Source Type: research
Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecuar mechanisms
Crit Rev Microbiol. 2024 Apr 11:1-31. doi: 10.1080/1040841X.2024.2339260. Online ahead of print.ABSTRACTPeriodontitis is an immuno-inflammatory disease of the soft tissues surrounding the teeth. Periodontitis is linked to many communicable and non-communicable diseases such as diabetes, cardiovascular disease, rheumatoid arthritis, and cancers. The oral-systemic link between periodontal disease and systemic diseases is attributed to the spread of inflammation, microbial products and microbes to distant organ systems. Oral bacteria reach the gut via swallowed saliva, whereby they induce gut dysbiosis and gastrointestinal dy...
Source: Critical Reviews in Microbiology - April 11, 2024 Category: Microbiology Authors: Sayantan Mukherjee Aditi Chopra Shaswata Karmakar Subraya Giliyar Bhat Source Type: research
Glycolysis, a driving force of rheumatoid arthritis
Int Immunopharmacol. 2024 Apr 9;132:111913. doi: 10.1016/j.intimp.2024.111913. Online ahead of print.ABSTRACTResident synoviocytes and synovial microvasculature, together with immune cells from circulation, contribute to pannus formation, the main pathological feature of rheumatoid arthritis (RA), leading to destruction of adjacent cartilage and bone. Seeds, fibroblast-like synoviocytes (FLSs), macrophages, dendritic cells (DCs), B cells, T cells and endothelial cells (ECs) seeds with high metabolic demands undergo metabolic reprogramming from oxidative phosphorylation to glycolysis in response to poor soil of RA synovium ...
Source: International Immunopharmacology - April 11, 2024 Category: Allergy & Immunology Authors: Pei-Rong Gan Hong Wu Yu-Long Zhu Yin Shu Yi Wei Source Type: research
The effect of Schizophyllan on the differentiation of osteoclasts and osteoblasts
In this study, its effects on bone cells, particularly osteoclasts and osteoblasts, were examined. We demonstrated that SPG dose-dependently inhibited osteoclastogenesis and reduced gene expression associated with osteoclast differentiation. SPG also decreased bone resorption and F-actin ring formation. This inhibition could have been due to the downregulation of transcription factors c-Fos and nuclear factor of activated T cells 1 (NFATc1) via the MAPKs (JNK and p38), IκBα, and PGC1β/PPARγ pathways. In coculture, SPG lowered osteoclastogenic activity in calvaria-derived osteoblasts by reducing macrophage colony-stimul...
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Soo-Ho Kim Keun Ha Park Jun Lee Seoung Hoon Lee Jeong-Hwa Baek Source Type: research
