Optimizing outcomes in HCC: Comment on "optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis" by Jiang et  al
Transl Oncol. 2021 Oct 14;14(12):101246. doi: 10.1016/j.tranon.2021.101246. Online ahead of print.ABSTRACTRecent years have witnessed notable advances in the management of intermediate and advanced hepatocellular carcinoma (HCC). However, several questions remain unanswered, including the timely transition from locoregional to systemic therapies and the lack of data on sequencing. In this Commentary, we critically discuss the results of the interesting meta-analysis conducted by Jiang and colleagues on the role of the combination therapy of trans-arterial chemoembolization (TACE) and sorafenib in this setting.PMID:34656968...
Source: Translational Oncology - October 17, 2021 Category: Cancer & Oncology Authors: Alessandro Rizzo Source Type: research

Optimizing outcomes in HCC: Comment on "optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis" by Jiang et  al
Transl Oncol. 2021 Oct 14;14(12):101246. doi: 10.1016/j.tranon.2021.101246. Online ahead of print.ABSTRACTRecent years have witnessed notable advances in the management of intermediate and advanced hepatocellular carcinoma (HCC). However, several questions remain unanswered, including the timely transition from locoregional to systemic therapies and the lack of data on sequencing. In this Commentary, we critically discuss the results of the interesting meta-analysis conducted by Jiang and colleagues on the role of the combination therapy of trans-arterial chemoembolization (TACE) and sorafenib in this setting.PMID:34656968...
Source: Translational Oncology - October 17, 2021 Category: Cancer & Oncology Authors: Alessandro Rizzo Source Type: research

Anti-GD2 CAR MSCs against metastatic Ewing's sarcoma
Transl Oncol. 2021 Oct 11;15(1):101240. doi: 10.1016/j.tranon.2021.101240. Online ahead of print.ABSTRACTBACKGROUND: Ewing's sarcoma (ES) is an aggressive cancer affecting children and young adults. We pre-clinically demonstrated that mesenchymal stromal/stem cells (MSCs) can deliver tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) against primary ES after local injection. However, ES is often metastatic calling for approaches able to support MSC targeting to the ES multiple remote sites. Considering that the disialoganglioside GD2 is expressed by ES and to optimise MSC tumour affinity, bi-functional (BF) M...
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Giulia Golinelli Giulia Grisendi Massimiliano Dall'Ora Giulia Casari Carlotta Spano Rebecca Talami Federico Banchelli Malvina Prapa Chiara Chiavelli Filippo Rossignoli Olivia Candini Roberto D'Amico Milena Nasi Andrea Cossarizza Livio Casarini Massimo Dom Source Type: research

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase
CONCLUSION: Overall, the present data indicate that GNMT exerts a multifaceted suppressive action by interacting with various cancer-related genes and inhibiting their expression.PMID:34649149 | DOI:10.1016/j.tranon.2021.101239 (Source: Translational Oncology)
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Maria M Simile Antonio Cigliano Panagiotis Paliogiannis Lucia Daino Roberto Manetti Claudio F Feo Diego F Calvisi Francesco Feo Rosa M Pascale Source Type: research

Mechanisms of abemaciclib, a CDK4/6 inhibitor, induced apoptotic cell death in prostate cancer cells in vitro
In this study, in vitro cytotoxic and apoptotic effects of ABE on metastatic castration-resistant prostate cancer (mCRPC) androgen receptor (AR) negative PC-3 and AR mutant LNCaP PC cells were analyzed with WST-1, Annexin V, cell cycle, reactive oxygen species (ROS), mitochondrial membrane potential, RT-PCR, western blot, and apoptosis protein array. ABE considerably inhibited the growth of PC cells in a dose-dependent manner (p
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Gamze Guney Eskiler Asuman Deveci Ozkan Ayten Haciefendi Cemil Bilir Source Type: research

68Ga-PSMA-HBED-CC PET/MRI is superior to multiparametric magnetic resonance imaging in men with biochemical recurrent prostate cancer: A prospective single-institutional study
DISCUSSION: Our findings demonstrate that PSMA PET/MRI is a better imaging modality in the detection of disease in the setting of BCR when compared to MRI alone. Combined utility with PSMA PET/MRI is a powerful tool which can aid in not only the detection of disease, but also guide in treatment planning for prostate cancer patients.PMID:34649151 | DOI:10.1016/j.tranon.2021.101242 (Source: Translational Oncology)
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Juana Martinez Kritika Subramanian Daniel Margolis Elisabeth O'Dwyer Joseph Osborne Yuliya Jhanwar Himanshu Nagar Nicholas Williams Arindam RoyChoudhury Gabriela Madera John Babich Sandra Huicochea Castellanos Source Type: research

Anti-GD2 CAR MSCs against metastatic Ewing's sarcoma
Transl Oncol. 2021 Oct 11;15(1):101240. doi: 10.1016/j.tranon.2021.101240. Online ahead of print.ABSTRACTBACKGROUND: Ewing's sarcoma (ES) is an aggressive cancer affecting children and young adults. We pre-clinically demonstrated that mesenchymal stromal/stem cells (MSCs) can deliver tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) against primary ES after local injection. However, ES is often metastatic calling for approaches able to support MSC targeting to the ES multiple remote sites. Considering that the disialoganglioside GD2 is expressed by ES and to optimise MSC tumour affinity, bi-functional (BF) M...
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Giulia Golinelli Giulia Grisendi Massimiliano Dall'Ora Giulia Casari Carlotta Spano Rebecca Talami Federico Banchelli Malvina Prapa Chiara Chiavelli Filippo Rossignoli Olivia Candini Roberto D'Amico Milena Nasi Andrea Cossarizza Livio Casarini Massimo Dom Source Type: research

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase
CONCLUSION: Overall, the present data indicate that GNMT exerts a multifaceted suppressive action by interacting with various cancer-related genes and inhibiting their expression.PMID:34649149 | DOI:10.1016/j.tranon.2021.101239 (Source: Translational Oncology)
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Maria M Simile Antonio Cigliano Panagiotis Paliogiannis Lucia Daino Roberto Manetti Claudio F Feo Diego F Calvisi Francesco Feo Rosa M Pascale Source Type: research

Mechanisms of abemaciclib, a CDK4/6 inhibitor, induced apoptotic cell death in prostate cancer cells in vitro
In this study, in vitro cytotoxic and apoptotic effects of ABE on metastatic castration-resistant prostate cancer (mCRPC) androgen receptor (AR) negative PC-3 and AR mutant LNCaP PC cells were analyzed with WST-1, Annexin V, cell cycle, reactive oxygen species (ROS), mitochondrial membrane potential, RT-PCR, western blot, and apoptosis protein array. ABE considerably inhibited the growth of PC cells in a dose-dependent manner (p
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Gamze Guney Eskiler Asuman Deveci Ozkan Ayten Haciefendi Cemil Bilir Source Type: research

68Ga-PSMA-HBED-CC PET/MRI is superior to multiparametric magnetic resonance imaging in men with biochemical recurrent prostate cancer: A prospective single-institutional study
DISCUSSION: Our findings demonstrate that PSMA PET/MRI is a better imaging modality in the detection of disease in the setting of BCR when compared to MRI alone. Combined utility with PSMA PET/MRI is a powerful tool which can aid in not only the detection of disease, but also guide in treatment planning for prostate cancer patients.PMID:34649151 | DOI:10.1016/j.tranon.2021.101242 (Source: Translational Oncology)
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Juana Martinez Kritika Subramanian Daniel Margolis Elisabeth O'Dwyer Joseph Osborne Yuliya Jhanwar Himanshu Nagar Nicholas Williams Arindam RoyChoudhury Gabriela Madera John Babich Sandra Huicochea Castellanos Source Type: research

Anti-GD2 CAR MSCs against metastatic Ewing's sarcoma
Transl Oncol. 2021 Oct 11;15(1):101240. doi: 10.1016/j.tranon.2021.101240. Online ahead of print.ABSTRACTBACKGROUND: Ewing's sarcoma (ES) is an aggressive cancer affecting children and young adults. We pre-clinically demonstrated that mesenchymal stromal/stem cells (MSCs) can deliver tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) against primary ES after local injection. However, ES is often metastatic calling for approaches able to support MSC targeting to the ES multiple remote sites. Considering that the disialoganglioside GD2 is expressed by ES and to optimise MSC tumour affinity, bi-functional (BF) M...
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Giulia Golinelli Giulia Grisendi Massimiliano Dall'Ora Giulia Casari Carlotta Spano Rebecca Talami Federico Banchelli Malvina Prapa Chiara Chiavelli Filippo Rossignoli Olivia Candini Roberto D'Amico Milena Nasi Andrea Cossarizza Livio Casarini Massimo Dom Source Type: research

Nuclear localization dictates hepatocarcinogenesis suppression by glycine N-methyltransferase
CONCLUSION: Overall, the present data indicate that GNMT exerts a multifaceted suppressive action by interacting with various cancer-related genes and inhibiting their expression.PMID:34649149 | DOI:10.1016/j.tranon.2021.101239 (Source: Translational Oncology)
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Maria M Simile Antonio Cigliano Panagiotis Paliogiannis Lucia Daino Roberto Manetti Claudio F Feo Diego F Calvisi Francesco Feo Rosa M Pascale Source Type: research

Mechanisms of abemaciclib, a CDK4/6 inhibitor, induced apoptotic cell death in prostate cancer cells in vitro
In this study, in vitro cytotoxic and apoptotic effects of ABE on metastatic castration-resistant prostate cancer (mCRPC) androgen receptor (AR) negative PC-3 and AR mutant LNCaP PC cells were analyzed with WST-1, Annexin V, cell cycle, reactive oxygen species (ROS), mitochondrial membrane potential, RT-PCR, western blot, and apoptosis protein array. ABE considerably inhibited the growth of PC cells in a dose-dependent manner (p
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Gamze Guney Eskiler Asuman Deveci Ozkan Ayten Haciefendi Cemil Bilir Source Type: research

68Ga-PSMA-HBED-CC PET/MRI is superior to multiparametric magnetic resonance imaging in men with biochemical recurrent prostate cancer: A prospective single-institutional study
DISCUSSION: Our findings demonstrate that PSMA PET/MRI is a better imaging modality in the detection of disease in the setting of BCR when compared to MRI alone. Combined utility with PSMA PET/MRI is a powerful tool which can aid in not only the detection of disease, but also guide in treatment planning for prostate cancer patients.PMID:34649151 | DOI:10.1016/j.tranon.2021.101242 (Source: Translational Oncology)
Source: Translational Oncology - October 14, 2021 Category: Cancer & Oncology Authors: Juana Martinez Kritika Subramanian Daniel Margolis Elisabeth O'Dwyer Joseph Osborne Yuliya Jhanwar Himanshu Nagar Nicholas Williams Arindam RoyChoudhury Gabriela Madera John Babich Sandra Huicochea Castellanos Source Type: research

Optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis
Transl Oncol. 2021 Oct 7;14(12):101238. doi: 10.1016/j.tranon.2021.101238. Online ahead of print.ABSTRACTBACKGROUND: The combination therapy of trans-arterial chemoembolization (TACE) and sorafenib were proved to be one of the effective methods for intermediate and advanced hepatocellular carcinoma (HCC). Although it has been confirmed that the combination therapy can prolong survival for advanced HCC effectively, the therapeutic efficacy and safety are still controversial and the clinical value has not been determined. This meta-analysis aims to evaluate the efficacy and safety of combination therapy and discuss the optim...
Source: Translational Oncology - October 10, 2021 Category: Cancer & Oncology Authors: Yanmei Dai Huijie Jiang Hao Jiang Sheng Zhao Xu Zeng Ran Sun Ruoshui Zheng Source Type: research

Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer
Transl Oncol. 2021 Oct 7;14(12):101235. doi: 10.1016/j.tranon.2021.101235. Online ahead of print.ABSTRACTAn estimated 284,000 Americans will be diagnosed with breast cancer in 2021. Of these individuals, 15-20% have basal-like triple-negative breast cancer (TNBC), which is known to be highly metastatic. Chemotherapy is standard of care for TNBC patients, but chemoresistance is a common clinical problem. There is currently a lack of alternative, targeted treatment strategies for TNBC; this study sought to identify novel therapeutic combinations to treat basal-like TNBCs. For these studies, four human basal-like TNBC cell li...
Source: Translational Oncology - October 10, 2021 Category: Cancer & Oncology Authors: Narmeen S Rashid Nicole S Hairr Graeme Murray Amy L Olex Tess J Leftwich Jacqueline M Grible Jason Reed Mikhail G Dozmorov J Chuck Harrell Source Type: research

Optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis
Transl Oncol. 2021 Oct 7;14(12):101238. doi: 10.1016/j.tranon.2021.101238. Online ahead of print.ABSTRACTBACKGROUND: The combination therapy of trans-arterial chemoembolization (TACE) and sorafenib were proved to be one of the effective methods for intermediate and advanced hepatocellular carcinoma (HCC). Although it has been confirmed that the combination therapy can prolong survival for advanced HCC effectively, the therapeutic efficacy and safety are still controversial and the clinical value has not been determined. This meta-analysis aims to evaluate the efficacy and safety of combination therapy and discuss the optim...
Source: Translational Oncology - October 10, 2021 Category: Cancer & Oncology Authors: Yanmei Dai Huijie Jiang Hao Jiang Sheng Zhao Xu Zeng Ran Sun Ruoshui Zheng Source Type: research

Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer
Transl Oncol. 2021 Oct 7;14(12):101235. doi: 10.1016/j.tranon.2021.101235. Online ahead of print.ABSTRACTAn estimated 284,000 Americans will be diagnosed with breast cancer in 2021. Of these individuals, 15-20% have basal-like triple-negative breast cancer (TNBC), which is known to be highly metastatic. Chemotherapy is standard of care for TNBC patients, but chemoresistance is a common clinical problem. There is currently a lack of alternative, targeted treatment strategies for TNBC; this study sought to identify novel therapeutic combinations to treat basal-like TNBCs. For these studies, four human basal-like TNBC cell li...
Source: Translational Oncology - October 10, 2021 Category: Cancer & Oncology Authors: Narmeen S Rashid Nicole S Hairr Graeme Murray Amy L Olex Tess J Leftwich Jacqueline M Grible Jason Reed Mikhail G Dozmorov J Chuck Harrell Source Type: research

Optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis
Transl Oncol. 2021 Oct 7;14(12):101238. doi: 10.1016/j.tranon.2021.101238. Online ahead of print.ABSTRACTBACKGROUND: The combination therapy of trans-arterial chemoembolization (TACE) and sorafenib were proved to be one of the effective methods for intermediate and advanced hepatocellular carcinoma (HCC). Although it has been confirmed that the combination therapy can prolong survival for advanced HCC effectively, the therapeutic efficacy and safety are still controversial and the clinical value has not been determined. This meta-analysis aims to evaluate the efficacy and safety of combination therapy and discuss the optim...
Source: Translational Oncology - October 10, 2021 Category: Cancer & Oncology Authors: Yanmei Dai Huijie Jiang Hao Jiang Sheng Zhao Xu Zeng Ran Sun Ruoshui Zheng Source Type: research

Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer
Transl Oncol. 2021 Oct 7;14(12):101235. doi: 10.1016/j.tranon.2021.101235. Online ahead of print.ABSTRACTAn estimated 284,000 Americans will be diagnosed with breast cancer in 2021. Of these individuals, 15-20% have basal-like triple-negative breast cancer (TNBC), which is known to be highly metastatic. Chemotherapy is standard of care for TNBC patients, but chemoresistance is a common clinical problem. There is currently a lack of alternative, targeted treatment strategies for TNBC; this study sought to identify novel therapeutic combinations to treat basal-like TNBCs. For these studies, four human basal-like TNBC cell li...
Source: Translational Oncology - October 10, 2021 Category: Cancer & Oncology Authors: Narmeen S Rashid Nicole S Hairr Graeme Murray Amy L Olex Tess J Leftwich Jacqueline M Grible Jason Reed Mikhail G Dozmorov J Chuck Harrell Source Type: research

Optimal timing of combining sorafenib with trans-arterial chemoembolization in patients with hepatocellular carcinoma: A meta-analysis
Transl Oncol. 2021 Oct 7;14(12):101238. doi: 10.1016/j.tranon.2021.101238. Online ahead of print.ABSTRACTBACKGROUND: The combination therapy of trans-arterial chemoembolization (TACE) and sorafenib were proved to be one of the effective methods for intermediate and advanced hepatocellular carcinoma (HCC). Although it has been confirmed that the combination therapy can prolong survival for advanced HCC effectively, the therapeutic efficacy and safety are still controversial and the clinical value has not been determined. This meta-analysis aims to evaluate the efficacy and safety of combination therapy and discuss the optim...
Source: Translational Oncology - October 10, 2021 Category: Cancer & Oncology Authors: Yanmei Dai Huijie Jiang Hao Jiang Sheng Zhao Xu Zeng Ran Sun Ruoshui Zheng Source Type: research

Identification of nuclear export inhibitor-based combination therapies in preclinical models of triple-negative breast cancer
Transl Oncol. 2021 Oct 7;14(12):101235. doi: 10.1016/j.tranon.2021.101235. Online ahead of print.ABSTRACTAn estimated 284,000 Americans will be diagnosed with breast cancer in 2021. Of these individuals, 15-20% have basal-like triple-negative breast cancer (TNBC), which is known to be highly metastatic. Chemotherapy is standard of care for TNBC patients, but chemoresistance is a common clinical problem. There is currently a lack of alternative, targeted treatment strategies for TNBC; this study sought to identify novel therapeutic combinations to treat basal-like TNBCs. For these studies, four human basal-like TNBC cell li...
Source: Translational Oncology - October 10, 2021 Category: Cancer & Oncology Authors: Narmeen S Rashid Nicole S Hairr Graeme Murray Amy L Olex Tess J Leftwich Jacqueline M Grible Jason Reed Mikhail G Dozmorov J Chuck Harrell Source Type: research

Comparative mRNA/micro-RNA co-expression network drives melanomagenesis by promoting epithelial-mesenchymal transition and vasculogenic mimicry signaling
This study aimed to identify a novel disease-associated differentially co-expressed mRNA-microRNA (miRNA) that is associated with vasculogenic mimicry (VM) and epithelial-to-mesenchymal transition (EMT) network at different stages of melanoma. By applying weighted gene co-expression network analysis, we constructed a VM+EMT biological network with the available microarray dataset downloaded from a public database. Quantitative real-time PCR, immunohistochemical staining, and CD31-periodic acid solution dual staining were performed to confirm the expression of genes associated with EMT and VM formation in subjects with mali...
Source: Translational Oncology - October 9, 2021 Category: Cancer & Oncology Authors: WenFeng He Gang Yang Shuya Liu Mazaher Maghsoudloo Marzieh Dehghan Shasaltaneh Parham Jabbarzadeh Kaboli Cuiwei Zhang JingHeng Zhang Maliheh Entezari Saber Imani QingLian Wen Source Type: research

Commentary: A preoperative model for predicting microvascular invasion and assisting in prognostic stratification in liver transplantation for HCC regarding empirical criteria
Transl Oncol. 2021 Oct 6;14(12):101234. doi: 10.1016/j.tranon.2021.101234. Online ahead of print.NO ABSTRACTPMID:34626954 | DOI:10.1016/j.tranon.2021.101234 (Source: Translational Oncology)
Source: Translational Oncology - October 9, 2021 Category: Cancer & Oncology Authors: Qi Ling Source Type: research

Comparative mRNA/micro-RNA co-expression network drives melanomagenesis by promoting epithelial-mesenchymal transition and vasculogenic mimicry signaling
This study aimed to identify a novel disease-associated differentially co-expressed mRNA-microRNA (miRNA) that is associated with vasculogenic mimicry (VM) and epithelial-to-mesenchymal transition (EMT) network at different stages of melanoma. By applying weighted gene co-expression network analysis, we constructed a VM+EMT biological network with the available microarray dataset downloaded from a public database. Quantitative real-time PCR, immunohistochemical staining, and CD31-periodic acid solution dual staining were performed to confirm the expression of genes associated with EMT and VM formation in subjects with mali...
Source: Translational Oncology - October 9, 2021 Category: Cancer & Oncology Authors: WenFeng He Gang Yang Shuya Liu Mazaher Maghsoudloo Marzieh Dehghan Shasaltaneh Parham Jabbarzadeh Kaboli Cuiwei Zhang JingHeng Zhang Maliheh Entezari Saber Imani QingLian Wen Source Type: research

Commentary: A preoperative model for predicting microvascular invasion and assisting in prognostic stratification in liver transplantation for HCC regarding empirical criteria
Transl Oncol. 2021 Oct 6;14(12):101234. doi: 10.1016/j.tranon.2021.101234. Online ahead of print.NO ABSTRACTPMID:34626954 | DOI:10.1016/j.tranon.2021.101234 (Source: Translational Oncology)
Source: Translational Oncology - October 9, 2021 Category: Cancer & Oncology Authors: Qi Ling Source Type: research

Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF- β/SOX9 axis in cancer progression
This study developed three-dimensional (3D) in vitro models co-cultured with OSCC cells and CAFs to examine CAF-mediated cancer migration and invasion in vitro and in vivo. Moreover, we performed an immunohistochemical analysis of alpha-smooth muscle actin and SOX9 expression in surgical specimens from 65 OSCC patients. The results indicated that CAFs promote cancer migration and invasion in migration assays and 3D in vitro models. The invading OSCC cells exhibited significant SOX9 expression and changes in the expression of epithelial-mesenchymal transition (EMT) markers, suggesting that SOX9 promotes EMT. TGF-β1 sig...
Source: Translational Oncology - October 8, 2021 Category: Cancer & Oncology Authors: Kenta Haga Manabu Yamazaki Satoshi Maruyama Masami Kawaharada Ayako Suzuki Emi Hoshikawa Nyein Nyein Chan Akinori Funayama Toshihiko Mikami Tadaharu Kobayashi Kenji Izumi Jun-Ichi Tanuma Source Type: research

Corrigendum to "Chemotherapy Modulates Endocrine Therapy-Related Resistance Mutations in Metastatic Breast Cancer" [Translational Oncology (2019) 12, 764-774]
Transl Oncol. 2021 Oct 3;14(12):101226. doi: 10.1016/j.tranon.2021.101226. Online ahead of print.NO ABSTRACTPMID:34614466 | DOI:10.1016/j.tranon.2021.101226 (Source: Translational Oncology)
Source: Translational Oncology - October 6, 2021 Category: Cancer & Oncology Authors: Dabo Zhou Liping Liu Jingyu Liu Yu Tang Mengjia Xiao Yikai Wang Qiongzhi He Zhe-Yu Hu Quchang Ouyang Source Type: research

Corrigendum to "Chemotherapy Modulates Endocrine Therapy-Related Resistance Mutations in Metastatic Breast Cancer" [Translational Oncology (2019) 12, 764-774]
Transl Oncol. 2021 Oct 3;14(12):101226. doi: 10.1016/j.tranon.2021.101226. Online ahead of print.NO ABSTRACTPMID:34614466 | DOI:10.1016/j.tranon.2021.101226 (Source: Translational Oncology)
Source: Translational Oncology - October 6, 2021 Category: Cancer & Oncology Authors: Dabo Zhou Liping Liu Jingyu Liu Yu Tang Mengjia Xiao Yikai Wang Qiongzhi He Zhe-Yu Hu Quchang Ouyang Source Type: research

Corrigendum to "Chemotherapy Modulates Endocrine Therapy-Related Resistance Mutations in Metastatic Breast Cancer" [Translational Oncology (2019) 12, 764-774]
Transl Oncol. 2021 Oct 3;14(12):101226. doi: 10.1016/j.tranon.2021.101226. Online ahead of print.NO ABSTRACTPMID:34614466 | DOI:10.1016/j.tranon.2021.101226 (Source: Translational Oncology)
Source: Translational Oncology - October 6, 2021 Category: Cancer & Oncology Authors: Dabo Zhou Liping Liu Jingyu Liu Yu Tang Mengjia Xiao Yikai Wang Qiongzhi He Zhe-Yu Hu Quchang Ouyang Source Type: research

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody
Transl Oncol. 2021 Oct 1;14(12):101232. doi: 10.1016/j.tranon.2021.101232. Online ahead of print.ABSTRACTThe pancaner molecule CD276 (B7-H3) is an attractive target for antibody based therapy. We identified from a large (1011) phage-displayed single-chain variable fragment (scFv) library, a fully human antibody, B11, which bound with high avidity (KD=0.4 nM) to CD276. B11 specifically bound to the V1/V2 domain of CD276 and competed with the antibody 8H9 (Omburtamab). It was used to design an IgG-format bispecific T cell engager B11-BiTE, which was more effective than 8H9-BiTE in 14 different cancer cell lines. B11-BiTE als...
Source: Translational Oncology - October 3, 2021 Category: Cancer & Oncology Authors: Xianglei Liu Doncho Zhelev Cynthia Adams Chuan Chen John W Mellors Dimiter S Dimitrov Source Type: research

Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors
Transl Oncol. 2021 Oct 1;14(12):101231. doi: 10.1016/j.tranon.2021.101231. Online ahead of print.ABSTRACTCommunication networks in the tumor microenvironment (TME) play a crucial role in tumor progression. Cancer-associated fibroblasts (CAFs) are among the most abundant stromal cells in the TME. Bidirectional signal transduction between cancer cells and CAFs within the TME is important for cancer development and treatment responsiveness. Extracellular vesicles (EVs) carrying proteins, miRNAs, and other biomolecules are secreted into the extracellular matrix (ECM), which has been demonstrated to be an important communicatio...
Source: Translational Oncology - October 3, 2021 Category: Cancer & Oncology Authors: Chuanshi He Linlin Wang Ling Li Guiquan Zhu Source Type: research

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody
Transl Oncol. 2021 Sep 30;14(12):101232. doi: 10.1016/j.tranon.2021.101232. Online ahead of print.ABSTRACTThe pancaner molecule CD276 (B7-H3) is an attractive target for antibody based therapy. We identified from a large (1011) phage-displayed single-chain variable fragment (scFv) library, a fully human antibody, B11, which bound with high avidity (KD=0.4 nM) to CD276. B11 specifically bound to the V1/V2 domain of CD276 and competed with the antibody 8H9 (Omburtamab). It was used to design an IgG-format bispecific T cell engager B11-BiTE, which was more effective than 8H9-BiTE in 14 different cancer cell lines. B11-BiTE al...
Source: Translational Oncology - October 3, 2021 Category: Cancer & Oncology Authors: Xianglei Liu Doncho Zhelev Cynthia Adams Chuan Chen John W Mellors Dimiter S Dimitrov Source Type: research

Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors
Transl Oncol. 2021 Sep 30;14(12):101231. doi: 10.1016/j.tranon.2021.101231. Online ahead of print.ABSTRACTCommunication networks in the tumor microenvironment (TME) play a crucial role in tumor progression. Cancer-associated fibroblasts (CAFs) are among the most abundant stromal cells in the TME. Bidirectional signal transduction between cancer cells and CAFs within the TME is important for cancer development and treatment responsiveness. Extracellular vesicles (EVs) carrying proteins, miRNAs, and other biomolecules are secreted into the extracellular matrix (ECM), which has been demonstrated to be an important communicati...
Source: Translational Oncology - October 3, 2021 Category: Cancer & Oncology Authors: Chuanshi He Linlin Wang Ling Li Guiquan Zhu Source Type: research

Effective killing of cells expressing CD276 (B7-H3) by a bispecific T cell engager based on a new fully human antibody
Transl Oncol. 2021 Sep 30;14(12):101232. doi: 10.1016/j.tranon.2021.101232. Online ahead of print.ABSTRACTThe pancaner molecule CD276 (B7-H3) is an attractive target for antibody based therapy. We identified from a large (1011) phage-displayed single-chain variable fragment (scFv) library, a fully human antibody, B11, which bound with high avidity (KD=0.4 nM) to CD276. B11 specifically bound to the V1/V2 domain of CD276 and competed with the antibody 8H9 (Omburtamab). It was used to design an IgG-format bispecific T cell engager B11-BiTE, which was more effective than 8H9-BiTE in 14 different cancer cell lines. B11-BiTE al...
Source: Translational Oncology - October 3, 2021 Category: Cancer & Oncology Authors: Xianglei Liu Doncho Zhelev Cynthia Adams Chuan Chen John W Mellors Dimiter S Dimitrov Source Type: research

Extracellular vesicle-orchestrated crosstalk between cancer-associated fibroblasts and tumors
Transl Oncol. 2021 Sep 30;14(12):101231. doi: 10.1016/j.tranon.2021.101231. Online ahead of print.ABSTRACTCommunication networks in the tumor microenvironment (TME) play a crucial role in tumor progression. Cancer-associated fibroblasts (CAFs) are among the most abundant stromal cells in the TME. Bidirectional signal transduction between cancer cells and CAFs within the TME is important for cancer development and treatment responsiveness. Extracellular vesicles (EVs) carrying proteins, miRNAs, and other biomolecules are secreted into the extracellular matrix (ECM), which has been demonstrated to be an important communicati...
Source: Translational Oncology - October 3, 2021 Category: Cancer & Oncology Authors: Chuanshi He Linlin Wang Ling Li Guiquan Zhu Source Type: research

Novel prognostic model established for patients with head and neck squamous cell carcinoma based on pyroptosis-related genes
Transl Oncol. 2021 Sep 28;14(12):101233. doi: 10.1016/j.tranon.2021.101233. Online ahead of print.ABSTRACTWe aimed at establishing a risk - score model using pyroptosis-related genes to predict the prognosis of patients with head and neck squamous cell carcinoma (HNSCC). A total of 33 pyroptosis-related genes were selected. We then evaluated the data of 502 HNSCC patients and 44 normal patients from TCGA database. Gene expression was then profiled to detect differentially expressed genes (DEGs). Using the univariate, the least absolute shrinkage and selection operator (LASSO) Cox regression analyses, we generated a risk - ...
Source: Translational Oncology - October 2, 2021 Category: Cancer & Oncology Authors: Yuchen Shen Xinyu Li Deming Wang Liming Zhang Xiao Li Tong Xia Xunjie Shang Xitao Yang Lixin Su Xindong Fan Source Type: research

Novel prognostic model established for patients with head and neck squamous cell carcinoma based on pyroptosis-related genes
Transl Oncol. 2021 Sep 28;14(12):101233. doi: 10.1016/j.tranon.2021.101233. Online ahead of print.ABSTRACTWe aimed at establishing a risk - score model using pyroptosis-related genes to predict the prognosis of patients with head and neck squamous cell carcinoma (HNSCC). A total of 33 pyroptosis-related genes were selected. We then evaluated the data of 502 HNSCC patients and 44 normal patients from TCGA database. Gene expression was then profiled to detect differentially expressed genes (DEGs). Using the univariate, the least absolute shrinkage and selection operator (LASSO) Cox regression analyses, we generated a risk - ...
Source: Translational Oncology - October 2, 2021 Category: Cancer & Oncology Authors: Yuchen Shen Xinyu Li Deming Wang Liming Zhang Xiao Li Tong Xia Xunjie Shang Xitao Yang Lixin Su Xindong Fan Source Type: research

Cytotoxicity of combinations of the pan-KRAS inhibitor BAY-293 against primary non-small lung cancer cells
In conclusion, BAY-293 exerts cytotoxicity with a wide range of drugs against Osimertinib-resistant primary NSCLC cell lines. The administration of pan-KRAS inhibitors alone may be limited in vivo by toxicity to normal tissues but made feasible by its use as part of suitable drug combinations. This study shows that BAY-293 combinations are active against NSCLC cells not further amenable to mutated EGFR-directed targeted therapy and results likewise hold relevance for pancreatic and colon cancer.PMID:34598083 | DOI:10.1016/j.tranon.2021.101230 (Source: Translational Oncology)
Source: Translational Oncology - October 1, 2021 Category: Cancer & Oncology Authors: Adelina Plangger Barbara Rath Maximilian Hochmair Martin Funovics Gerhard Hamilton Source Type: research

The induction of a mesenchymal phenotype by platelet cloaking of cancer cells is a universal phenomenon
This study aimed to understand the molecular mechanisms involved in tumour-platelet cell interactions. The interaction between cancer cells and platelets was examined in 15 epithelial cell lines, representing 7 cancer types. Gene expression analysis of EMT-associated and cancer stemness genes was performed by RT-PCR. Whole transcriptome analysis (WTA) was performed using Affymetrix 2.0ST arrays on a platelet co-cultured ovarian model. Platelet adhesion and activation occurred across all tumour types. WTA identified increases in cellular movement, migration, invasion, adhesion, development, differentiation and inflammation ...
Source: Translational Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Cathy D Spillane Niamh M Cooke Mark P Ward Dermot Kenny Gordon Blackshields Tanya Kelly Mark Bates Yanmei Huang Cara Martin Sinead Skehan Aoife Canney Michael Gallagher Paul Smyth Nathan Brady Andres Clarke Bashir Mohamed Lucy Norris Doug A Brooks Robert Source Type: research

Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
Transl Oncol. 2021 Sep 27;14(12):101224. doi: 10.1016/j.tranon.2021.101224. Online ahead of print.ABSTRACTThe genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than no...
Source: Translational Oncology - September 30, 2021 Category: Cancer & Oncology Authors: G Frega O Kepp D Turchetti A Rizzo M A Pantaleo G Brandi Source Type: research

The induction of a mesenchymal phenotype by platelet cloaking of cancer cells is a universal phenomenon
This study aimed to understand the molecular mechanisms involved in tumour-platelet cell interactions. The interaction between cancer cells and platelets was examined in 15 epithelial cell lines, representing 7 cancer types. Gene expression analysis of EMT-associated and cancer stemness genes was performed by RT-PCR. Whole transcriptome analysis (WTA) was performed using Affymetrix 2.0ST arrays on a platelet co-cultured ovarian model. Platelet adhesion and activation occurred across all tumour types. WTA identified increases in cellular movement, migration, invasion, adhesion, development, differentiation and inflammation ...
Source: Translational Oncology - September 30, 2021 Category: Cancer & Oncology Authors: Cathy D Spillane Niamh M Cooke Mark P Ward Dermot Kenny Gordon Blackshields Tanya Kelly Mark Bates Yanmei Huang Cara Martin Sinead Skehan Aoife Canney Michael Gallagher Paul Smyth Nathan Brady Andres Clarke Bashir Mohamed Lucy Norris Doug A Brooks Robert Source Type: research

Hypothesis on the possible relevance of the immunogenic cell death in the treatment of gestational trophoblastic neoplasms
Transl Oncol. 2021 Sep 27;14(12):101224. doi: 10.1016/j.tranon.2021.101224. Online ahead of print.ABSTRACTThe genetic background and the antigenic landscape of cancer cells play a critical role in the response to immunotherapies. A high tumor antigenicity, together with an increased adjuvanticity potentially induced by a peculiar type of cell death, namely immunogenic cell death (ICD), could foster the response to immunogenic therapies. The gestational trophoblastic neoplasm (GTN) is a one-of-a-kind cancer in the oncological landscape due to its exclusive genomic makeup. The prognosis of GTN is significantly better than no...
Source: Translational Oncology - September 30, 2021 Category: Cancer & Oncology Authors: G Frega O Kepp D Turchetti A Rizzo M A Pantaleo G Brandi Source Type: research

LncRNA RP1-86C11.7 exacerbates the glioma progression and oncogenicity by hsa-miR-144-3p/TFRC signaling
Transl Oncol. 2021 Sep 24;14(12):101215. doi: 10.1016/j.tranon.2021.101215. Online ahead of print.ABSTRACTGlioblastoma (GBM) remains the most common and malignant tumor of the human central nervous system. Increasing evidence has highlighted that tumor cells with high transferrin receptor (TFRC) expression show advantages in growth. Long noncoding RNAs (lncRNAs) are related to glioma progression by mediating microRNAs (miRNAs). However, the underlying mechanism among TFRC, miRNA and lncRNA in GBM is limited. In the current study, we identified a new lncRNA-induced signaling mechanism that regulates the TFRC levels in GBM. ...
Source: Translational Oncology - September 27, 2021 Category: Cancer & Oncology Authors: Qiong Ma Xiang Wang Jing Li Source Type: research

LncRNA RP1-86C11.7 exacerbates the glioma progression and oncogenicity by hsa-miR-144-3p/TFRC signaling
Transl Oncol. 2021 Sep 24;14(12):101215. doi: 10.1016/j.tranon.2021.101215. Online ahead of print.ABSTRACTGlioblastoma (GBM) remains the most common and malignant tumor of the human central nervous system. Increasing evidence has highlighted that tumor cells with high transferrin receptor (TFRC) expression show advantages in growth. Long noncoding RNAs (lncRNAs) are related to glioma progression by mediating microRNAs (miRNAs). However, the underlying mechanism among TFRC, miRNA and lncRNA in GBM is limited. In the current study, we identified a new lncRNA-induced signaling mechanism that regulates the TFRC levels in GBM. ...
Source: Translational Oncology - September 27, 2021 Category: Cancer & Oncology Authors: Qiong Ma Xiang Wang Jing Li Source Type: research

LncRNA RP1-86C11.7 exacerbates the glioma progression and oncogenicity by hsa-miR-144-3p/TFRC signaling
Transl Oncol. 2021 Sep 24;14(12):101215. doi: 10.1016/j.tranon.2021.101215. Online ahead of print.ABSTRACTGlioblastoma (GBM) remains the most common and malignant tumor of the human central nervous system. Increasing evidence has highlighted that tumor cells with high transferrin receptor (TFRC) expression show advantages in growth. Long noncoding RNAs (lncRNAs) are related to glioma progression by mediating microRNAs (miRNAs). However, the underlying mechanism among TFRC, miRNA and lncRNA in GBM is limited. In the current study, we identified a new lncRNA-induced signaling mechanism that regulates the TFRC levels in GBM. ...
Source: Translational Oncology - September 27, 2021 Category: Cancer & Oncology Authors: Qiong Ma Xiang Wang Jing Li Source Type: research

Transgenic overexpression of the miR-200b/200a/429 cluster inhibits mammary tumor initiation
This study suggests that miR-200s could be used as a preventative strategy to protect women from developing breast cancer. One concern with this approach is the potential negative impact miR-200 overexpression may have on mammary function. However, transgenic overexpression of miR-200s, on their own, did not significantly impact mammary ductal development indicating the miR-200 overexpression should not significantly impact mammary function. Thus, this study provides the initial foundation for using miR-200s for breast cancer prevention and additional studies should be performed to identify strategies for increasing mammar...
Source: Translational Oncology - September 25, 2021 Category: Cancer & Oncology Authors: Katrina L Watson Rui Yi Roger A Moorehead Source Type: research

Hsa_circ_0088212-mediated miR-520  h/APOA1 axis inhibits osteosarcoma progression
CONCLUSION: Our findings demonstrated that circ_0088212 might exert a tumor-suppressive activity in osteosarcoma by sponging and sequestering miR-520 h away from APOA1. This suggests that the circ_0088212/miR-520 h/APOA1 axis may be a promising therapeutic target for osteosarcoma intervention.PMID:34555726 | DOI:10.1016/j.tranon.2021.101219 (Source: Translational Oncology)
Source: Translational Oncology - September 23, 2021 Category: Cancer & Oncology Authors: Feng Liu Xiangyang Zhang Fei Wu Hao Peng Source Type: research

Effectiveness of 4-1BB-costimulated HER2-targeted chimeric antigen receptor T cell therapy for synovial sarcoma
CONCLUSION: To the best of our knowledge, this is the first study to indicate that HER2-targeted CAR T cells are directly effective against molecularly defined synovial sarcoma cells. Furthermore, our findings might set the basis for developing improved CAR T cell-based therapies for chemo-refractory or relapsed synovial sarcoma.PMID:34555727 | DOI:10.1016/j.tranon.2021.101227 (Source: Translational Oncology)
Source: Translational Oncology - September 23, 2021 Category: Cancer & Oncology Authors: Yudai Murayama Hiroyuki Kawashima Nobuhiro Kubo Chansu Shin Yasushi Kasahara Masaru Imamura Naoki Oike Takashi Ariizumi Akihiko Saitoh Keichiro Mihara Hajime Umezu Akira Ogose Chihaya Imai Source Type: research

Construction of a prognostic signature in Ewing's sarcoma: Based on metabolism-related genes
CONCLUSION: The experimental results suggest that the 18 metabolism-related DEGs marker may be effective in predicting the prognosis of Ewing's sarcoma to some extent, helping to individualize treatment of patients at different risks.PMID:34555728 | DOI:10.1016/j.tranon.2021.101225 (Source: Translational Oncology)
Source: Translational Oncology - September 23, 2021 Category: Cancer & Oncology Authors: Zhaoyu Fu Bo Yu Mingxi Liu Bo Wu Yuanyuan Hou Hongyu Wang Yuting Jiang Dong Zhu Source Type: research