Diagnostic and predictive significance of the ferroptosis-related gene TXNIP in lung adenocarcinoma stem cells based on multi-omics
CONCLUSION: The investigation conducted in this study systematically delved into the role of the ferroptosis-related gene TXNIP in Lung CSCs. The identification of TXNIP as a potentially valuable biomarker in this context could have significant implications for refining prognostic assessments and optimizing therapeutic strategies for advanced lung cancer.PMID:38615437 | DOI:10.1016/j.tranon.2024.101926 (Source: Translational Oncology)
Source: Translational Oncology - April 14, 2024 Category: Cancer & Oncology Authors: Yuanyuan Zheng Wei Yang Weixuan Wu Feng Jin Dehua Lu Jing Gao Shubin Wang Source Type: research
Diagnostic and predictive significance of the ferroptosis-related gene TXNIP in lung adenocarcinoma stem cells based on multi-omics
CONCLUSION: The investigation conducted in this study systematically delved into the role of the ferroptosis-related gene TXNIP in Lung CSCs. The identification of TXNIP as a potentially valuable biomarker in this context could have significant implications for refining prognostic assessments and optimizing therapeutic strategies for advanced lung cancer.PMID:38615437 | DOI:10.1016/j.tranon.2024.101926 (Source: Translational Oncology)
Source: Translational Oncology - April 14, 2024 Category: Cancer & Oncology Authors: Yuanyuan Zheng Wei Yang Weixuan Wu Feng Jin Dehua Lu Jing Gao Shubin Wang Source Type: research
Identification of clinically relevant subsets CD39 < sup > + < /sup > PD-1 < sup > + < /sup > CD8 < sup > + < /sup > T cells and CD39 < sup > + < /sup > regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF
This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze immune cell populations in fresh iCCA tumor samples and adjacent peritumor liver tissues. Notably, NK cell percentages significantly decreased in iCCA lesions compared to peritumor liver tissues. Conversely, an enrichment of immunosuppressive CD39+Foxp3+CD4+ regulatory T cells (CD39+T-regs) and exhausted-like CD8+T cells (with pronounced CD39 and PD-1 expression) within TIME was identified and confirmed by multiplex immunofluorescence staining in an independent patient cohort (n = 140). Crucially, tumor-infiltrating CD39+T-regs and CD39...
Source: Translational Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Qi-Wei Zhang Meng-Xuan Zhu Wen-Feng Liu Wei-Wei Rui Yong Chen Xiao-Yi Ding Yong-Sheng Jiang Zhi-Yuan Wu Bin-Bin Liu Source Type: research
Identification of clinically relevant subsets CD39 < sup > + < /sup > PD-1 < sup > + < /sup > CD8 < sup > + < /sup > T cells and CD39 < sup > + < /sup > regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF
This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze immune cell populations in fresh iCCA tumor samples and adjacent peritumor liver tissues. Notably, NK cell percentages significantly decreased in iCCA lesions compared to peritumor liver tissues. Conversely, an enrichment of immunosuppressive CD39+Foxp3+CD4+ regulatory T cells (CD39+T-regs) and exhausted-like CD8+T cells (with pronounced CD39 and PD-1 expression) within TIME was identified and confirmed by multiplex immunofluorescence staining in an independent patient cohort (n = 140). Crucially, tumor-infiltrating CD39+T-regs and CD39...
Source: Translational Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Qi-Wei Zhang Meng-Xuan Zhu Wen-Feng Liu Wei-Wei Rui Yong Chen Xiao-Yi Ding Yong-Sheng Jiang Zhi-Yuan Wu Bin-Bin Liu Source Type: research
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer
Transl Oncol. 2024 Apr 10;44:101960. doi: 10.1016/j.tranon.2024.101960. Online ahead of print.ABSTRACTThe interaction between tumor fatty acid metabolism and immune microenvironment is a novel topic in oncology research, and the relationship of lipid-derived factors with immune editing in tumor is unclear. The breast cancer samples from the TCGA database were used as the training set, and samples from GSE42568 were employed as the validation set for constructing a model to identify a signature associated with fatty acid metabolism through Lasso Cox regression. And the changes in immune related signatures and risk score bef...
Source: Translational Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Andi Zhao Jin Yang Ran Ran Shidi Zhao Yuxin Cui Fang Hu Yan Zhou Source Type: research
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer
Transl Oncol. 2024 Apr 10;44:101960. doi: 10.1016/j.tranon.2024.101960. Online ahead of print.ABSTRACTThe interaction between tumor fatty acid metabolism and immune microenvironment is a novel topic in oncology research, and the relationship of lipid-derived factors with immune editing in tumor is unclear. The breast cancer samples from the TCGA database were used as the training set, and samples from GSE42568 were employed as the validation set for constructing a model to identify a signature associated with fatty acid metabolism through Lasso Cox regression. And the changes in immune related signatures and risk score bef...
Source: Translational Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Andi Zhao Jin Yang Ran Ran Shidi Zhao Yuxin Cui Fang Hu Yan Zhou Source Type: research
LINC01133 regulates MARCKS expression via sponging miR-30d-5p to promote the development of lung squamous cell carcinoma
Transl Oncol. 2024 Apr 9;44:101931. doi: 10.1016/j.tranon.2024.101931. Online ahead of print.ABSTRACTLncRNAs are vital regulators for lung squamous cell carcinoma (LUSC). However, the detailed role that LINC01133 plays in LUSC is unclear. This work sought to explore the potential function of LINC01133.Levels of LINC01133, miR-30d-5p, and MARCKS were separately tested in both tissues and cells using qRT-PCR. Proliferation was assessed through MTT experiment and apoptosis was detected upon flow cytometry. Transwell experiments were implemented to evaluate migratory and invasive abilities. The interaction between two genes wa...
Source: Translational Oncology - April 10, 2024 Category: Cancer & Oncology Authors: Yajun Zhang Woda Shi Rongjin Chen Yan Gu Mengjie Zhao Jianxiang Song Zhan Shi Jixiang Wu HuiWen Chang Ming Liu Source Type: research
LINC01133 regulates MARCKS expression via sponging miR-30d-5p to promote the development of lung squamous cell carcinoma
Transl Oncol. 2024 Apr 9;44:101931. doi: 10.1016/j.tranon.2024.101931. Online ahead of print.ABSTRACTLncRNAs are vital regulators for lung squamous cell carcinoma (LUSC). However, the detailed role that LINC01133 plays in LUSC is unclear. This work sought to explore the potential function of LINC01133.Levels of LINC01133, miR-30d-5p, and MARCKS were separately tested in both tissues and cells using qRT-PCR. Proliferation was assessed through MTT experiment and apoptosis was detected upon flow cytometry. Transwell experiments were implemented to evaluate migratory and invasive abilities. The interaction between two genes wa...
Source: Translational Oncology - April 10, 2024 Category: Cancer & Oncology Authors: Yajun Zhang Woda Shi Rongjin Chen Yan Gu Mengjie Zhao Jianxiang Song Zhan Shi Jixiang Wu HuiWen Chang Ming Liu Source Type: research
Stroma AReactive Invasion Front Areas (SARIFA): a novel histopathologic biomarker in colorectal cancer patients and its association with the luminal tumour proportion
CONCLUSION: Here, we validated the relationship between SARIFA-status and prognosis in CRC patients and provided first evidence for a potential prognostic relevance in the subgroup of rectal cancer patients. Interestingly, CRCs with different SARIFA-status also showed histological differences measurable at the luminal tumour surface. Further studies to better understand the relationship between high luminal intratumoural stroma content and absence of a stroma reaction at the invasive front (SARIFA-positivity) are warranted and may inform future treatment decisions in CRC patients.PMID:38593584 | DOI:10.1016/j.tranon.2024.1...
Source: Translational Oncology - April 9, 2024 Category: Cancer & Oncology Authors: N G Reitsam B Grosser J S Enke W Mueller A Westwood N P West P Quirke B M ärkl H I Grabsch Source Type: research
Investigation of the pan-cancer property of FNDC1 and its molecular mechanism to promote lung adenocarcinoma metastasis
CONCLUSION: FNDC1 is implicated in poor prognosis of a diverse range of malignant tumors, which can promote metastasis and invasion of lung cancer through the JAK2-STAT3 signaling pathway.PMID:38593585 | DOI:10.1016/j.tranon.2024.101953 (Source: Translational Oncology)
Source: Translational Oncology - April 9, 2024 Category: Cancer & Oncology Authors: Yang Song Jun-Feng Guo Pei-Shu Lan Miao Wang Quan-Yu Du Source Type: research
Targeting sinonasal undifferentiated carcinoma with a combinatory immunotherapy approach
CONCLUSION: These data provide the pre-clinical rationale for ongoing investigation into combinatory immunotherapy approaches for SNUC.PMID:38593586 | DOI:10.1016/j.tranon.2024.101943 (Source: Translational Oncology)
Source: Translational Oncology - April 9, 2024 Category: Cancer & Oncology Authors: Austin T K Hoke Yoko Takahashi Michelle R Padget Javier Gomez Moran Amit Jared Burks Diana Bell Tongxin Xie Patrick Soon-Shiong James W Hodge Ehab Y Hanna Nyall R London Source Type: research
A retrospective cohort study of neoadjuvant chemoradiotherapy combined with immune checkpoint inhibitors in locally advanced rectal cancer
CONCLUSION: Neoadjuvant chemoradiotherapy combined with ICIs demonstrated favorable efficacy and safety in treating LARC patients.PMID:38583351 | DOI:10.1016/j.tranon.2024.101955 (Source: Translational Oncology)
Source: Translational Oncology - April 7, 2024 Category: Cancer & Oncology Authors: Zhuo Chen Zhuoling Zou Min Qian Qin Xu Guojuan Xue Juan Yang Tinglan Luo Lianjie Hu Bin Wang Source Type: research
Tertiary lymphoid structures in head and neck squamous cell carcinoma
This article will review the formation, prognosis, and predictive value of TLS as well as inducing TLS neogenesis in HNSCC.PMID:38583352 | DOI:10.1016/j.tranon.2024.101949 (Source: Translational Oncology)
Source: Translational Oncology - April 7, 2024 Category: Cancer & Oncology Authors: Jing Zhu Hui Lu Kongcheng Wang Baorui Liu Jing Yan Source Type: research
A retrospective cohort study of neoadjuvant chemoradiotherapy combined with immune checkpoint inhibitors in locally advanced rectal cancer
CONCLUSION: Neoadjuvant chemoradiotherapy combined with ICIs demonstrated favorable efficacy and safety in treating LARC patients.PMID:38583351 | DOI:10.1016/j.tranon.2024.101955 (Source: Translational Oncology)
Source: Translational Oncology - April 7, 2024 Category: Cancer & Oncology Authors: Zhuo Chen Zhuoling Zou Min Qian Qin Xu Guojuan Xue Juan Yang Tinglan Luo Lianjie Hu Bin Wang Source Type: research
Tertiary lymphoid structures in head and neck squamous cell carcinoma
This article will review the formation, prognosis, and predictive value of TLS as well as inducing TLS neogenesis in HNSCC.PMID:38583352 | DOI:10.1016/j.tranon.2024.101949 (Source: Translational Oncology)
Source: Translational Oncology - April 7, 2024 Category: Cancer & Oncology Authors: Jing Zhu Hui Lu Kongcheng Wang Baorui Liu Jing Yan Source Type: research
