Development and validation of a deep learning signature for predicting lymphovascular invasion and survival outcomes in clinical stage IA lung adenocarcinoma: A multicenter retrospective cohort study
CONCLUSION: The effectiveness of the DL signature in the diagnosis of LVI and prognosis prediction in patients with clinical stage IA lung adenocarcinoma was demonstrated. These findings suggest the potential of the model in clinical decision-making.PMID:38324961 | PMC:PMC10851213 | DOI:10.1016/j.tranon.2024.101894 (Source: Translational Oncology)
Source: Translational Oncology - February 7, 2024 Category: Cancer & Oncology Authors: Kunfeng Liu Xiaofeng Lin Xiaojuan Chen Biyun Chen Sheng Li Kunwei Li Huai Chen Li Li Source Type: research
Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture
CONCLUSIONS: These studies show that cancer-specific T cells exist across HNSCC patients with rescuable immunogenicity and can be identified on a single-cell level. These data lay the foundation for development of patient-specific T cell immunotherapies in HNSCC.PMID:38320395 | PMC:PMC10851216 | DOI:10.1016/j.tranon.2024.101899 (Source: Translational Oncology)
Source: Translational Oncology - February 6, 2024 Category: Cancer & Oncology Authors: Joseph Zenga Musaddiq Awan Anne Frei Jamie Foeckler Rachel Kuehn Oscar Villareal Espinosa Jennifer Bruening Becky Massey Stuart Wong Aditya Shreenivas Monica Shukla Julia Kasprzak Yunguang Sun Md Shaheduzzaman Fanghong Chen Tyce Kearl Heather A Himburg Source Type: research
ARID5A stabilizes Indoleamine 2,3-dioxygenase expression and enhances CAR T cell exhaustion in colorectal cancer
In this study, we investigated the role of ARID5A (AT-rich interactive domain 5A) in resistance to CAR-T cell therapy. Our findings revealed that ARID5A upregulation in tumor cells induces T cell exhaustion and immune evasion. Mechanistically, ARID5A plays a crucial role in resistance to CAR-T cell therapy by stabilizing IDO1 mRNA, leading to upregulation of IDO1 expression. Elevated IDO1 expression facilitates the conversion of tryptophan to kynurenine, which contributes to CAR-T cell exhaustion. Moreover, kynurenine accumulation within CAR-T cells activates the aryl hydrocarbon receptor (AhR), further exacerbating the ex...
Source: Translational Oncology - February 5, 2024 Category: Cancer & Oncology Authors: Dandan Wu Guijun Wang Shuang Wen Xian Liu Qiang He Source Type: research
Distinct leukocyte populations and cytokine secretion profiles define tumoral and peritumoral areas in renal cell carcinoma
Transl Oncol. 2024 Feb 3;42:101891. doi: 10.1016/j.tranon.2024.101891. Online ahead of print.ABSTRACTRenal cell carcinoma (RCC) is a common malignancy frequently diagnosed at the metastatic stage. We performed a comprehensive analysis of the tumor immune microenvironment (TIME) in RCC patients, including the peritumoral tissue microenvironment, to characterize the phenotypic patterns and functional characteristics of infiltrating immune cells. T cells from various compartments (peripheral blood, tumor, peritumoral area, and adjacent healthy renal tissue) were assessed using flow cytometry and Luminex analyses, both before ...
Source: Translational Oncology - February 4, 2024 Category: Cancer & Oncology Authors: Martina Borcinova Robin Bartolini Lily Koumbas Foley Vojtech Novak Pavla Taborska Dmitry Stakheev Michal Rataj Daniel Smrz Martina Fialova Jaromir Hacek Martin Komarc Stepan Vesely Marek Babjuk Ilja Striz Jirina Bartunkova Tomas Buchler Zuzana Ozaniak Str Source Type: research
Transforming growth factor- β1 and soluble co-inhibitory immune checkpoints as putative drivers of immune suppression in patients with basal cell carcinoma
Transl Oncol. 2024 Feb 2;42:101867. doi: 10.1016/j.tranon.2023.101867. Online ahead of print.ABSTRACTThe current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, n = 17) and a group of humoral modulators of immune suppressor cells (n = 7) in a cohort of patients with basal cell carcinoma (BCC, n = 40) and a group of healthy control subjects (n = 20). The seven humoral modulators of immunosuppressor cells were represented by the enzymes, arginase 1 and fibroblast activation protein (FAP), the chemokine, RANTES (CCL5) and the cytokines, interleukin-10 and transforming gr...
Source: Translational Oncology - February 3, 2024 Category: Cancer & Oncology Authors: Mahlatse C M Kgokolo Nonkululeko Z Malinga Helen C Steel Pieter W A Meyer Teresa Smit Ronald Anderson Bernardo L Rapoport Source Type: research
A novel clinical nomogram for predicting cancer-specific survival in patients with non-serous epithelial ovarian cancer: A real-world analysis based on the Surveillance, Epidemiology, and End Results database and external validation in a tertiary center
CONCLUSION: We developed a nomogram with high predictive accuracy to predict survival in patients with non-serous EOC.PMID:38308920 | PMC:PMC10847761 | DOI:10.1016/j.tranon.2024.101898 (Source: Translational Oncology)
Source: Translational Oncology - February 3, 2024 Category: Cancer & Oncology Authors: Hui Zheng Jingjing Chen Jimiao Huang Huan Yi Shaoyu Zhang Xiangqin Zheng Source Type: research
Corresponding ctDNA and tumor burden dynamics in metastatic melanoma patients on systemic treatment
Transl Oncol. 2024 Feb 1;42:101883. doi: 10.1016/j.tranon.2024.101883. Online ahead of print.ABSTRACTRadiographic imaging is the current standard for monitoring progression of tumor-burden and therapeutic resistance in patients with metastatic melanoma. Plasma circulating tumor DNA (ctDNA) has shown promise as a survelience tool, but longitudinal data on the dynamics between plasma ctDNA concentrations and radiographic imaging is lacking. We evaluated the relationship between longitudinal radiographic measures of tumor burden and ctDNA concentrations in plasma on 30 patients with metastatic melanoma on systemic treatment. ...
Source: Translational Oncology - February 2, 2024 Category: Cancer & Oncology Authors: Michael E Egger Evan Alexander Tracy Van Meter Maiying Kong Aye Aye Maung Roland Valdes Melissa Barousse Hall Mark W Linder Source Type: research
PARVB promotes malignant melanoma progression and is enhanced by hypoxic conditions
Transl Oncol. 2024 Jan 31;42:101861. doi: 10.1016/j.tranon.2023.101861. Online ahead of print.ABSTRACTBeta-Parvin (PARVB) is an actin-binding protein with functionality in extracellular matrix binding. Recent studies suggest its potential as a biomarker for various cancers, given its role in governing several malignancies. Yet, its involvement and modulatory mechanisms in malignant melanoma remain under-explored. In this research, we undertook a comprehensive pan-cancer analysis centered on PARVB. We probed its aberrant expression and prognostic implications, and assessed correlations between PARVB expression and immunocyt...
Source: Translational Oncology - February 1, 2024 Category: Cancer & Oncology Authors: Ting Wang Zhiqiang Wu Yifeng Bi Yao Wang Chenglong Zhao Haitao Sun Zhipeng Wu Zhen Tan Hao Zhang Haifeng Wei Wangjun Yan Source Type: research
The role of tertiary lymphoid structure and B cells in nasopharyngeal carcinoma: Based on bioinformatics and experimental verification
CONCLUSION: Our findings demonstrate the functional importance of distinct B cell subsets in the prognosis of NPC. Additionally, we confirmed that B cells and TLS may serve as prognostic biomarkers of survival for NPC patients.PMID:38295746 | PMC:PMC10846412 | DOI:10.1016/j.tranon.2024.101885 (Source: Translational Oncology)
Source: Translational Oncology - January 31, 2024 Category: Cancer & Oncology Authors: Chujun Chen Yan Zhang Xiaoting Wu Juan Shen Source Type: research
Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker
Transl Oncol. 2024 Mar;41:101882. doi: 10.1016/j.tranon.2024.101882. Epub 2024 Jan 29.ABSTRACTABCC1 belongs to the ATP-binding cassette (ABC) superfamily, which encompasses a total of 48 constituent members. ABCC1 has been shown to be associated with the growth, progression, and drug resistance of various types of cancer. However, the impact of ABCC1 on cancer immune infiltration and pan-cancer prognosis has been rarely studied. Our comprehensive pan-cancer analysis unveiled elevated ABCC1 expression across various cancers. ABCC1 overexpression consistently predicted unfavorable outcomes based on TCGA data. Moreover, ABCC1...
Source: Translational Oncology - January 30, 2024 Category: Cancer & Oncology Authors: Tiantian Wang Dean Rao Chenan Fu Yiming Luo Junli Lu Huifang Liang Limin Xia Wenjie Huang Source Type: research
Identification of HSPD1 as a novel invasive biomarker associated with mitophagy in pituitary adenomas
CONCLUSION: The downregulation of HSPD1 may serve as a predictive indicator for identifying invasive pituitary adenomas.PMID:38290248 | PMC:PMC10840335 | DOI:10.1016/j.tranon.2024.101886 (Source: Translational Oncology)
Source: Translational Oncology - January 30, 2024 Category: Cancer & Oncology Authors: Yu Zhang Xin Ma Congyu Liu Zhixu Bie Gemingtian Liu Pinan Liu Zhijun Yang Source Type: research
Clinical utility of Next Generation Sequencing of plasma cell-free DNA for the molecular profiling of patients with NSCLC at diagnosis and disease progression
CONCLUSIONS: The present study confirms the potential of liquid biopsy to detect tumour molecular heterogeneity in NSCLC patients at the diagnosis and at PD, demonstrating that a significant number of druggable mutations and mechanisms of resistance can be detected by NGS analysis on ctDNA.PMID:38290249 | PMC:PMC10859238 | DOI:10.1016/j.tranon.2023.101869 (Source: Translational Oncology)
Source: Translational Oncology - January 30, 2024 Category: Cancer & Oncology Authors: Marzia Del Re Giovanna Irene Luculli Iacopo Petrini Andrea Sbrana Vieri Scotti Diego de Miguel Perez Lorenzo Livi Stefania Crucitta Mauro Iannopollo Francesca Mazzoni Martina Ruglioni Carmelo Tibaldi Emanuela Olmetto Irene Stasi Editta Baldini Giacomo All Source Type: research
Small molecule agents for triple negative breast cancer: Current status and future prospects
Transl Oncol. 2024 Mar;41:101893. doi: 10.1016/j.tranon.2024.101893. Epub 2024 Jan 29.ABSTRACTTriple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis. The number of cases increased by 2.26 million in 2020, making it the most commonly diagnosed cancer type in the world. TNBCs lack hormone receptor (HR) and human epidermal growth factor 2 (HER2), which limits treatment options. Currently, paclitaxel-based drugs combined with other chemotherapeutics remain the main treatment for TNBC. There is currently no consensus on the best therapeutic regimen for TNBC. However, there have been successful cl...
Source: Translational Oncology - January 30, 2024 Category: Cancer & Oncology Authors: Yan Ou Mengchao Wang Qian Xu Binxu Sun Yingjie Jia Source Type: research
Identification and validation of stemness-based and ferroptosis-related molecular clusters in pancreatic ductal adenocarcinoma
In conclusion, we developed a stemness-based and ferroptosis-related prognostic model, which could help predict overall survival for PDAC patients. Targeting ferroptosis may be a promising therapeutic strategy to inhibit PDAC progression by suppressing CSCs.PMID:38262107 | PMC:PMC10832490 | DOI:10.1016/j.tranon.2024.101877 (Source: Translational Oncology)
Source: Translational Oncology - January 23, 2024 Category: Cancer & Oncology Authors: Shiye Ruan Hailiang Wang Zhongyan Zhang Qian Yan Yubin Chen Jinwei Cui Shanzhou Huang Qi Zhou Chuanzhao Zhang Baohua Hou Source Type: research
BRMS1L confers anticancer activity in non-small cell lung cancer by transcriptionally inducing a redox imbalance in the GPX2-ROS pathway
Transl Oncol. 2024 Mar;41:101870. doi: 10.1016/j.tranon.2023.101870. Epub 2024 Jan 22.ABSTRACTLow expression levels of breast cancer metastasis suppressor 1 like (BRMS1L) have been associated with the growth of cancer cells. However, the mechanisms underlying the role of BRMS1L as an antitumour transcription factor in the progression of NSCLC have not been explored. Herein, we reveal that BRMS1L plays a key role as a tumour suppressor in inhibiting NSCLC proliferation and metastasis. Mechanistically, BRMS1L overexpression results in the downregulation of glutathione peroxidase 2 (GPX2) expression and consequently causes ab...
Source: Translational Oncology - January 23, 2024 Category: Cancer & Oncology Authors: Penglong Cao Juebin Gu Mulin Liu Yingxin Wang Mingying Chen Yizhu Jiang Xiaoyan Wang Siqi Zhu Xue Gao Shijun Li Source Type: research
