Differential role of glucocorticoid receptor based on its cell type specific expression on tumor cells and infiltrating lymphocytes

CONCLUSION: This study underscores the cell type-specific role of GR, where its expression on tumor cells is associated with aggressive features like EMT, while in infiltrating lymphocytes, it predicts a better prognosis, particularly within TNBC tumors. The GRsig emerges as a promising independent prognostic indicator across diverse BC subtypes.PMID:38643748 | DOI:10.1016/j.tranon.2024.101957

Source: Translational Oncology - April 21, 2024 Category: Cancer & Oncology Authors: V P Snijesh Vidya P Nimbalkar Sharada Patil Savitha Rajarajan C E Anupama S Mahalakshmi Annie Alexander Ramu Soundharya Rakesh Ramesh B S Srinath Mohit Kumar Jolly Jyothi S Prabhu Source Type: research