Extensive mutational ctDNA profiles reflect High-grade serous cancer tumors and reveal emerging mutations at recurrence
CONCLUSION: Relapse ctDNA samples reflect tissue samples well and longitudinal sampling provides a timely source for mutational profiling. The emerging genetic mutations at recurrence propose that ctDNA accurately represents the widespread disease and provides possibilities for personalized therapy options.PMID:37924564 | DOI:10.1016/j.tranon.2023.101814 (Source: Translational Oncology)
Source: Translational Oncology - November 4, 2023 Category: Cancer & Oncology Authors: Giovanni Marchi Anna Rajavuori Mai T N Nguyen Kaisa Huhtinen Sinikka Oksa Sakari Hietanen Sampsa Hautaniemi Johanna Hynninen Jaana Oikkonen Source Type: research
Gene expression profiles (GEPs) of immuno-oncologic pathways as predictors of response to checkpoint inhibitors in advanced NSCLC
CONCLUSIONS: The TIS (tumor inflammation signature) and IFN-γ signatures constitute predictive biomarkers to identify patients with NSCLC patients who would possibly benefit from ICI therapies.PMID:37918166 | DOI:10.1016/j.tranon.2023.101818 (Source: Translational Oncology)
Source: Translational Oncology - November 2, 2023 Category: Cancer & Oncology Authors: Pedro De Marchi Leticia Ferro Leal Luciane Sussuchi da Silva Rodrigo de Oliveira Cavagna Flavio Augusto Ferreira da Silva Vinicius Duval da Silva Eduardo Ca da Silva Augusto O Saito Vladmir C Cordeiro de Lima Rui Manuel Reis Source Type: research
TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1 α/Twist pathway
CONCLUSION: TRPC5 induced papillary thyroid cancer metastasis and progression via up-regulated HIF-1α signaling in vivo and in vitro. High TRPC5 expression is a biomarker for lymph node metastasis at its early stages.PMID:37918167 | DOI:10.1016/j.tranon.2023.101809 (Source: Translational Oncology)
Source: Translational Oncology - November 2, 2023 Category: Cancer & Oncology Authors: Jing Yang Yue Cheng Yan Nie Bole Tian Jing Huang Rixiang Gong Zhihui Li Jingqiang Zhu Yanping Gong Source Type: research
Gene expression profiles (GEPs) of immuno-oncologic pathways as predictors of response to checkpoint inhibitors in advanced NSCLC
CONCLUSIONS: The TIS (tumor inflammation signature) and IFN-γ signatures constitute predictive biomarkers to identify patients with NSCLC patients who would possibly benefit from ICI therapies.PMID:37918166 | DOI:10.1016/j.tranon.2023.101818 (Source: Translational Oncology)
Source: Translational Oncology - November 2, 2023 Category: Cancer & Oncology Authors: Pedro De Marchi Leticia Ferro Leal Luciane Sussuchi da Silva Rodrigo de Oliveira Cavagna Flavio Augusto Ferreira da Silva Vinicius Duval da Silva Eduardo Ca da Silva Augusto O Saito Vladmir C Cordeiro de Lima Rui Manuel Reis Source Type: research
TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1 α/Twist pathway
CONCLUSION: TRPC5 induced papillary thyroid cancer metastasis and progression via up-regulated HIF-1α signaling in vivo and in vitro. High TRPC5 expression is a biomarker for lymph node metastasis at its early stages.PMID:37918167 | DOI:10.1016/j.tranon.2023.101809 (Source: Translational Oncology)
Source: Translational Oncology - November 2, 2023 Category: Cancer & Oncology Authors: Jing Yang Yue Cheng Yan Nie Bole Tian Jing Huang Rixiang Gong Zhihui Li Jingqiang Zhu Yanping Gong Source Type: research
