Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2
CONCLUSION: Tetraarsenic tetrasulfide can regulate the Warburg effect by controlling HK2 expression, a finding that provides both new mechanistic insight into metabolic alterations and pharmacological evidence for the clinical treatment of B-ALL.PMID:38043497 | DOI:10.1016/j.tranon.2023.101850 (Source: Translational Oncology)
Source: Translational Oncology - December 3, 2023 Category: Cancer & Oncology Authors: Wenke Bai Diandian Liu Qianyi Cheng Xingge Yang Liwen Zhu Lijun Qin Jianpei Fang Source Type: research
Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2
CONCLUSION: Tetraarsenic tetrasulfide can regulate the Warburg effect by controlling HK2 expression, a finding that provides both new mechanistic insight into metabolic alterations and pharmacological evidence for the clinical treatment of B-ALL.PMID:38043497 | DOI:10.1016/j.tranon.2023.101850 (Source: Translational Oncology)
Source: Translational Oncology - December 3, 2023 Category: Cancer & Oncology Authors: Wenke Bai Diandian Liu Qianyi Cheng Xingge Yang Liwen Zhu Lijun Qin Jianpei Fang Source Type: research
Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2
CONCLUSION: Tetraarsenic tetrasulfide can regulate the Warburg effect by controlling HK2 expression, a finding that provides both new mechanistic insight into metabolic alterations and pharmacological evidence for the clinical treatment of B-ALL.PMID:38043497 | DOI:10.1016/j.tranon.2023.101850 (Source: Translational Oncology)
Source: Translational Oncology - December 3, 2023 Category: Cancer & Oncology Authors: Wenke Bai Diandian Liu Qianyi Cheng Xingge Yang Liwen Zhu Lijun Qin Jianpei Fang Source Type: research
Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer
Transl Oncol. 2023 Dec 1;40:101846. doi: 10.1016/j.tranon.2023.101846. Online ahead of print.ABSTRACTThe treatment of cancer patients has been mainly followed using chemotherapy and it is a gold standard in improving prognosis and survival rate of patients. Oxaliplatin (OXA) is a third-platinum anti-cancer agent that reduces DNA synthesis in cancer cells to interfere with their growth and cell cycle progression. In spite of promising results of using OXA in cancer chemotherapy, the process of drug resistance has made some challenges. OXA is commonly applied in treatment of colorectal cancer (CRC) as a malignancy of gastroi...
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Mehrdad Hashemi Nastaran Esbati Mohsen Rashidi Sadaf Gholami Rasoul Raesi Seyed Shahabadin Bidoki Mohammad Ali Sheikh Beig Goharrizi Yasamin Sadat Mousavi Motlagh Ramin Khorrami Alireza Tavakolpournegari Noushin Nabavi Rongjun Zou Leila Mohammadnahal Mali Source Type: research
Pan-cancer analysis of 60S Ribosomal Protein L7-Like 1 (RPL7L1) and validation in liver hepatocellular carcinoma
CONCLUSIONS: RPL7L1 was overexpressed in nine tumor types. Gene mutation, tumor microenvironment and methylation modification of RPL7L1 plays a key role in patient prognosis. And the high expression of RPL7L1 was associated with TMB, MSI, LOH especially LIHC and HNSC. We experimentally verified that genes can promote the proliferation and migration of tumor cells. Our study suggested that RPL7L1 biomarker can be used for treating cancer, detecting it, and predicting its prognosis.PMID:38042135 | DOI:10.1016/j.tranon.2023.101844 (Source: Translational Oncology)
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Ke-Jie He Guoyu Gong E Liang Yangbo Lv Shuiquan Lin Jianguang Xu Source Type: research
Distinctive mesenchymal-like neurofibroma stem cells shape NF1 clinical phenotypes controlled by BDNF microenvironment
CONCLUSIONS: We demonstrated that BDNF can modulate MNSCs and thereby controlling different tumor phenotypes between the head and trunk regions. Application of BDNF neutralizing antibodies may inhibit p38 MAPK pathway, therefore providing a promising strategy for managing NF1.PMID:38042136 | DOI:10.1016/j.tranon.2023.101852 (Source: Translational Oncology)
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Jingcun Shi Zihui Yang Yuhan Zhang Ahmed Abdelrehem Ziqian Wu Bingqing Zhang Meng Xiao Shijian Zhang Zhen Zhang Lei Wang Source Type: research
Anti-PD-1/PD-L1 therapy for colorectal cancer: Clinical implications and future considerations
Transl Oncol. 2023 Dec 1;40:101851. doi: 10.1016/j.tranon.2023.101851. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the third most prevalent cancer in the world. The PD-1/PD-L1 pathway plays a crucial role in modulating immune response to cancer, and PD-L1 expression has been observed in tumor and immune cells within the tumor microenvironment of CRC. Thus, immunotherapy drugs, specifically checkpoint inhibitors, have been developed to target the PD-1/PD-L1 signaling pathway, thereby inhibiting the interaction between PD-1 and PD-L1 and restoring T-cell function in cancer cells. However, the emergence of resist...
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Xiang Chen Ling-Juan Chen Xiao-Fei Peng Ling Deng Yan Wang Jiu-Jiang Li Dong-Li Guo Xiao-Hua Niu Source Type: research
Saliva as a potential non-invasive liquid biopsy for early and easy diagnosis/prognosis of head and neck cancer
Transl Oncol. 2023 Dec 1;40:101827. doi: 10.1016/j.tranon.2023.101827. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCCs) are the most devastating diseases in India and southeast Asia. It is a preventable and curable disease if detected early. Tobacco and alcohol consumption are the two major risk-factors but infection of high-risk HPVs are also associated with development of predominantly oral and oropharyngeal carcinomas. Interestingly, unlike cervical cancer, HPV-induced HNSCCs show good prognosis and better survival in contrast, majority of tobacco-associated HPV-ve HNSCCs are highly aggressi...
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Prabhat Kumar Shilpi Gupta Bhudev C Das Source Type: research
Pan-cancer analysis of 60S Ribosomal Protein L7-Like 1 (RPL7L1) and validation in liver hepatocellular carcinoma
CONCLUSIONS: RPL7L1 was overexpressed in nine tumor types. Gene mutation, tumor microenvironment and methylation modification of RPL7L1 plays a key role in patient prognosis. And the high expression of RPL7L1 was associated with TMB, MSI, LOH especially LIHC and HNSC. We experimentally verified that genes can promote the proliferation and migration of tumor cells. Our study suggested that RPL7L1 biomarker can be used for treating cancer, detecting it, and predicting its prognosis.PMID:38042135 | DOI:10.1016/j.tranon.2023.101844 (Source: Translational Oncology)
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Ke-Jie He Guoyu Gong E Liang Yangbo Lv Shuiquan Lin Jianguang Xu Source Type: research
Distinctive mesenchymal-like neurofibroma stem cells shape NF1 clinical phenotypes controlled by BDNF microenvironment
CONCLUSIONS: We demonstrated that BDNF can modulate MNSCs and thereby controlling different tumor phenotypes between the head and trunk regions. Application of BDNF neutralizing antibodies may inhibit p38 MAPK pathway, therefore providing a promising strategy for managing NF1.PMID:38042136 | DOI:10.1016/j.tranon.2023.101852 (Source: Translational Oncology)
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Jingcun Shi Zihui Yang Yuhan Zhang Ahmed Abdelrehem Ziqian Wu Bingqing Zhang Meng Xiao Shijian Zhang Zhen Zhang Lei Wang Source Type: research
Anti-PD-1/PD-L1 therapy for colorectal cancer: Clinical implications and future considerations
Transl Oncol. 2023 Dec 1;40:101851. doi: 10.1016/j.tranon.2023.101851. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the third most prevalent cancer in the world. The PD-1/PD-L1 pathway plays a crucial role in modulating immune response to cancer, and PD-L1 expression has been observed in tumor and immune cells within the tumor microenvironment of CRC. Thus, immunotherapy drugs, specifically checkpoint inhibitors, have been developed to target the PD-1/PD-L1 signaling pathway, thereby inhibiting the interaction between PD-1 and PD-L1 and restoring T-cell function in cancer cells. However, the emergence of resist...
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Xiang Chen Ling-Juan Chen Xiao-Fei Peng Ling Deng Yan Wang Jiu-Jiang Li Dong-Li Guo Xiao-Hua Niu Source Type: research
Biological landscape and nanostructural view in development and reversal of oxaliplatin resistance in colorectal cancer
Transl Oncol. 2023 Dec 1;40:101846. doi: 10.1016/j.tranon.2023.101846. Online ahead of print.ABSTRACTThe treatment of cancer patients has been mainly followed using chemotherapy and it is a gold standard in improving prognosis and survival rate of patients. Oxaliplatin (OXA) is a third-platinum anti-cancer agent that reduces DNA synthesis in cancer cells to interfere with their growth and cell cycle progression. In spite of promising results of using OXA in cancer chemotherapy, the process of drug resistance has made some challenges. OXA is commonly applied in treatment of colorectal cancer (CRC) as a malignancy of gastroi...
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Mehrdad Hashemi Nastaran Esbati Mohsen Rashidi Sadaf Gholami Rasoul Raesi Seyed Shahabadin Bidoki Mohammad Ali Sheikh Beig Goharrizi Yasamin Sadat Mousavi Motlagh Ramin Khorrami Alireza Tavakolpournegari Noushin Nabavi Rongjun Zou Leila Mohammadnahal Mali Source Type: research
Saliva as a potential non-invasive liquid biopsy for early and easy diagnosis/prognosis of head and neck cancer
Transl Oncol. 2023 Dec 1;40:101827. doi: 10.1016/j.tranon.2023.101827. Online ahead of print.ABSTRACTHead and neck squamous cell carcinomas (HNSCCs) are the most devastating diseases in India and southeast Asia. It is a preventable and curable disease if detected early. Tobacco and alcohol consumption are the two major risk-factors but infection of high-risk HPVs are also associated with development of predominantly oral and oropharyngeal carcinomas. Interestingly, unlike cervical cancer, HPV-induced HNSCCs show good prognosis and better survival in contrast, majority of tobacco-associated HPV-ve HNSCCs are highly aggressi...
Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Prabhat Kumar Shilpi Gupta Bhudev C Das Source Type: research
miR-1182-mediated ALDH3A2 inhibition affects lipid metabolism and progression in ccRCC by activating the PI3K-AKT pathway
This study delves into the unexplored landscape of Dysregulated Aldehyde Dehydrogenase 3 Family Member A2 (ALDH3A2) in ccRCC. Using a combination of "fatty acid metabolism" dataset analysis and differentially expressed genes (DEGs) derived from Gene Expression Omnibus (GEO) database, potential metabolic regulators in ccRCC were identified. Subsequent investigations utilizing public databases, clinical samples, and in vitro experiments revealed that ALDH3A2 was down-regulated in ccRCC, mediated by miR-1182, highlighting its role as an independent prognostic factor for patient survival. Functionally, ALDH3A2 exhibited tumor-...
Source: Translational Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Qingyang Lv Jian Shi Daojia Miao Diaoyi Tan Chuanyi Zhao Zhiyong Xiong Xiaoping Zhang Source Type: research
Silencing of PD-1 combined with EBV-specific killer T cells for the treatment of EBV-associated B lymphoma
In this study, immortalized B lymphoblastoid cell lines (B-LCLs) positive for EBV-specific proteins were established from human peripheral mononuclear cells (PBMCs) using EBV induction along with CpG-ODN 2006 and cyclosporin A. EBV-specific T cells (EBVST) were generated by multiple immunizations of CD3+ T lymphocytes using irradiated B-LCLs. Flow cytometry analysis confirmed the activation of EBVST through the detection of CD3+, CD4+, and CD8+ markers. Co-incubation of EBVST with EBV-positive B lymphocyte cell lines resulted in the secretion of perforin by EBVST, leading to granzyme B-mediated cell death and an increase i...
Source: Translational Oncology - December 1, 2023 Category: Cancer & Oncology Authors: Jiaping Wang Zhijuan Xu Yanli Lai Yanli Zhang Ping Zhang Qitian Mu Shujun Yang Yongcheng Sun Lixia Sheng Guifang Ouyang Source Type: research
