LOX rises as a potential survival biomarker: A commentary on "Identification of LOX as a candidate prognostic biomarker in Glioblastoma multiforme" by Liu et al
Transl Oncol. 2024 Jun;44:101777. doi: 10.1016/j.tranon.2023.101777. Epub 2023 Sep 2.NO ABSTRACTPMID:38641375 | DOI:10.1016/j.tranon.2023.101777 (Source: Translational Oncology)
Source: Translational Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Eduardo Silva-Pavez Hery Urra Source Type: research
Synergistic anticancer effects of doxorubicin and metformin combination therapy: A systematic review
CONCLUSION: The findings of this study show that the combined treatment regimen including doxorubicin and metformin has significant promise in fighting cancer. The observed synergistic effects suggest that this combination therapy could be valuable, in a setting. This study highlights the need for clinical research to validate and enhance the application of the doxorubicin metformin regimen.PMID:38636389 | DOI:10.1016/j.tranon.2024.101946 (Source: Translational Oncology)
Source: Translational Oncology - April 18, 2024 Category: Cancer & Oncology Authors: Fereshtehsadat Jalali Fatemeh Fakhari Afrah Sepehr Jaber Zafari Behnam Omidi Sarajar Pouria Sarihi Emad Jafarzadeh Source Type: research
A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma
In conclusion, this study highlights a novel co-targeting strategy using miR-105-5p mimics, MALAT-1, CCAT-1 and H19 siRNAs to efficiently hampers the immune checkpoints; PD-L1/PD-1 and CD155/TIGIT immune evasion properties in HCC.PMID:38631259 | DOI:10.1016/j.tranon.2024.101961 (Source: Translational Oncology)
Source: Translational Oncology - April 17, 2024 Category: Cancer & Oncology Authors: Reem A Assal Noha M Elemam Radwa Y Mekky Abdelrahman A Attia Aya Hesham Soliman Asmaa Ibrahim Gomaa Eleni K Efthimiadou Maria Braoudaki Sherif Ashraf Fahmy Rana A Youness Source Type: research
A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma
In conclusion, this study highlights a novel co-targeting strategy using miR-105-5p mimics, MALAT-1, CCAT-1 and H19 siRNAs to efficiently hampers the immune checkpoints; PD-L1/PD-1 and CD155/TIGIT immune evasion properties in HCC.PMID:38631259 | DOI:10.1016/j.tranon.2024.101961 (Source: Translational Oncology)
Source: Translational Oncology - April 17, 2024 Category: Cancer & Oncology Authors: Reem A Assal Noha M Elemam Radwa Y Mekky Abdelrahman A Attia Aya Hesham Soliman Asmaa Ibrahim Gomaa Eleni K Efthimiadou Maria Braoudaki Sherif Ashraf Fahmy Rana A Youness Source Type: research
Neoadjuvant followed by adjuvant pembrolizumab in melanoma: time biases in the data analysis of the SWOG S1801 trial
Transl Oncol. 2024 Apr 14;45:101959. doi: 10.1016/j.tranon.2024.101959. Online ahead of print.ABSTRACTThe SWOG S1801 trial investigated the role of pembrolizumab, an anti-PD1 immune checkpoint inhibitor, in the perioperative setting of stage III or IV melanoma. This phase 2 trial compared two groups: one receiving pembrolizumab both before and after surgery (neoadjuvant-adjuvant), and another receiving it only post-surgery (adjuvant-only), with event-free survival (EFS) as the primary endpoint. Neoadjuvant strategies, involving pre-surgical drug administration, potentially offer rapid tumor control and a unique opportunity...
Source: Translational Oncology - April 15, 2024 Category: Cancer & Oncology Authors: Timoth ée Olivier Vinay Prasad Source Type: research
Neoadjuvant followed by adjuvant pembrolizumab in melanoma: time biases in the data analysis of the SWOG S1801 trial
Transl Oncol. 2024 Apr 14;45:101959. doi: 10.1016/j.tranon.2024.101959. Online ahead of print.ABSTRACTThe SWOG S1801 trial investigated the role of pembrolizumab, an anti-PD1 immune checkpoint inhibitor, in the perioperative setting of stage III or IV melanoma. This phase 2 trial compared two groups: one receiving pembrolizumab both before and after surgery (neoadjuvant-adjuvant), and another receiving it only post-surgery (adjuvant-only), with event-free survival (EFS) as the primary endpoint. Neoadjuvant strategies, involving pre-surgical drug administration, potentially offer rapid tumor control and a unique opportunity...
Source: Translational Oncology - April 15, 2024 Category: Cancer & Oncology Authors: Timoth ée Olivier Vinay Prasad Source Type: research
Diagnostic and predictive significance of the ferroptosis-related gene TXNIP in lung adenocarcinoma stem cells based on multi-omics
CONCLUSION: The investigation conducted in this study systematically delved into the role of the ferroptosis-related gene TXNIP in Lung CSCs. The identification of TXNIP as a potentially valuable biomarker in this context could have significant implications for refining prognostic assessments and optimizing therapeutic strategies for advanced lung cancer.PMID:38615437 | DOI:10.1016/j.tranon.2024.101926 (Source: Translational Oncology)
Source: Translational Oncology - April 14, 2024 Category: Cancer & Oncology Authors: Yuanyuan Zheng Wei Yang Weixuan Wu Feng Jin Dehua Lu Jing Gao Shubin Wang Source Type: research
Diagnostic and predictive significance of the ferroptosis-related gene TXNIP in lung adenocarcinoma stem cells based on multi-omics
CONCLUSION: The investigation conducted in this study systematically delved into the role of the ferroptosis-related gene TXNIP in Lung CSCs. The identification of TXNIP as a potentially valuable biomarker in this context could have significant implications for refining prognostic assessments and optimizing therapeutic strategies for advanced lung cancer.PMID:38615437 | DOI:10.1016/j.tranon.2024.101926 (Source: Translational Oncology)
Source: Translational Oncology - April 14, 2024 Category: Cancer & Oncology Authors: Yuanyuan Zheng Wei Yang Weixuan Wu Feng Jin Dehua Lu Jing Gao Shubin Wang Source Type: research
Identification of clinically relevant subsets CD39 < sup > + < /sup > PD-1 < sup > + < /sup > CD8 < sup > + < /sup > T cells and CD39 < sup > + < /sup > regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF
This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze immune cell populations in fresh iCCA tumor samples and adjacent peritumor liver tissues. Notably, NK cell percentages significantly decreased in iCCA lesions compared to peritumor liver tissues. Conversely, an enrichment of immunosuppressive CD39+Foxp3+CD4+ regulatory T cells (CD39+T-regs) and exhausted-like CD8+T cells (with pronounced CD39 and PD-1 expression) within TIME was identified and confirmed by multiplex immunofluorescence staining in an independent patient cohort (n = 140). Crucially, tumor-infiltrating CD39+T-regs and CD39...
Source: Translational Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Qi-Wei Zhang Meng-Xuan Zhu Wen-Feng Liu Wei-Wei Rui Yong Chen Xiao-Yi Ding Yong-Sheng Jiang Zhi-Yuan Wu Bin-Bin Liu Source Type: research
Identification of clinically relevant subsets CD39 < sup > + < /sup > PD-1 < sup > + < /sup > CD8 < sup > + < /sup > T cells and CD39 < sup > + < /sup > regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF
This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze immune cell populations in fresh iCCA tumor samples and adjacent peritumor liver tissues. Notably, NK cell percentages significantly decreased in iCCA lesions compared to peritumor liver tissues. Conversely, an enrichment of immunosuppressive CD39+Foxp3+CD4+ regulatory T cells (CD39+T-regs) and exhausted-like CD8+T cells (with pronounced CD39 and PD-1 expression) within TIME was identified and confirmed by multiplex immunofluorescence staining in an independent patient cohort (n = 140). Crucially, tumor-infiltrating CD39+T-regs and CD39...
Source: Translational Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Qi-Wei Zhang Meng-Xuan Zhu Wen-Feng Liu Wei-Wei Rui Yong Chen Xiao-Yi Ding Yong-Sheng Jiang Zhi-Yuan Wu Bin-Bin Liu Source Type: research
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer
Transl Oncol. 2024 Apr 10;44:101960. doi: 10.1016/j.tranon.2024.101960. Online ahead of print.ABSTRACTThe interaction between tumor fatty acid metabolism and immune microenvironment is a novel topic in oncology research, and the relationship of lipid-derived factors with immune editing in tumor is unclear. The breast cancer samples from the TCGA database were used as the training set, and samples from GSE42568 were employed as the validation set for constructing a model to identify a signature associated with fatty acid metabolism through Lasso Cox regression. And the changes in immune related signatures and risk score bef...
Source: Translational Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Andi Zhao Jin Yang Ran Ran Shidi Zhao Yuxin Cui Fang Hu Yan Zhou Source Type: research
Resonance of fatty acid metabolism and immune infiltration in anti-PD-1 monotherapy for breast cancer
Transl Oncol. 2024 Apr 10;44:101960. doi: 10.1016/j.tranon.2024.101960. Online ahead of print.ABSTRACTThe interaction between tumor fatty acid metabolism and immune microenvironment is a novel topic in oncology research, and the relationship of lipid-derived factors with immune editing in tumor is unclear. The breast cancer samples from the TCGA database were used as the training set, and samples from GSE42568 were employed as the validation set for constructing a model to identify a signature associated with fatty acid metabolism through Lasso Cox regression. And the changes in immune related signatures and risk score bef...
Source: Translational Oncology - April 11, 2024 Category: Cancer & Oncology Authors: Andi Zhao Jin Yang Ran Ran Shidi Zhao Yuxin Cui Fang Hu Yan Zhou Source Type: research
LINC01133 regulates MARCKS expression via sponging miR-30d-5p to promote the development of lung squamous cell carcinoma
Transl Oncol. 2024 Apr 9;44:101931. doi: 10.1016/j.tranon.2024.101931. Online ahead of print.ABSTRACTLncRNAs are vital regulators for lung squamous cell carcinoma (LUSC). However, the detailed role that LINC01133 plays in LUSC is unclear. This work sought to explore the potential function of LINC01133.Levels of LINC01133, miR-30d-5p, and MARCKS were separately tested in both tissues and cells using qRT-PCR. Proliferation was assessed through MTT experiment and apoptosis was detected upon flow cytometry. Transwell experiments were implemented to evaluate migratory and invasive abilities. The interaction between two genes wa...
Source: Translational Oncology - April 10, 2024 Category: Cancer & Oncology Authors: Yajun Zhang Woda Shi Rongjin Chen Yan Gu Mengjie Zhao Jianxiang Song Zhan Shi Jixiang Wu HuiWen Chang Ming Liu Source Type: research
LINC01133 regulates MARCKS expression via sponging miR-30d-5p to promote the development of lung squamous cell carcinoma
Transl Oncol. 2024 Apr 9;44:101931. doi: 10.1016/j.tranon.2024.101931. Online ahead of print.ABSTRACTLncRNAs are vital regulators for lung squamous cell carcinoma (LUSC). However, the detailed role that LINC01133 plays in LUSC is unclear. This work sought to explore the potential function of LINC01133.Levels of LINC01133, miR-30d-5p, and MARCKS were separately tested in both tissues and cells using qRT-PCR. Proliferation was assessed through MTT experiment and apoptosis was detected upon flow cytometry. Transwell experiments were implemented to evaluate migratory and invasive abilities. The interaction between two genes wa...
Source: Translational Oncology - April 10, 2024 Category: Cancer & Oncology Authors: Yajun Zhang Woda Shi Rongjin Chen Yan Gu Mengjie Zhao Jianxiang Song Zhan Shi Jixiang Wu HuiWen Chang Ming Liu Source Type: research
Stroma AReactive Invasion Front Areas (SARIFA): a novel histopathologic biomarker in colorectal cancer patients and its association with the luminal tumour proportion
CONCLUSION: Here, we validated the relationship between SARIFA-status and prognosis in CRC patients and provided first evidence for a potential prognostic relevance in the subgroup of rectal cancer patients. Interestingly, CRCs with different SARIFA-status also showed histological differences measurable at the luminal tumour surface. Further studies to better understand the relationship between high luminal intratumoural stroma content and absence of a stroma reaction at the invasive front (SARIFA-positivity) are warranted and may inform future treatment decisions in CRC patients.PMID:38593584 | DOI:10.1016/j.tranon.2024.1...
Source: Translational Oncology - April 9, 2024 Category: Cancer & Oncology Authors: N G Reitsam B Grosser J S Enke W Mueller A Westwood N P West P Quirke B M ärkl H I Grabsch Source Type: research
