Stroma AReactive Invasion Front Areas (SARIFA): a novel histopathologic biomarker in colorectal cancer patients and its association with the luminal tumour proportion

CONCLUSION: Here, we validated the relationship between SARIFA-status and prognosis in CRC patients and provided first evidence for a potential prognostic relevance in the subgroup of rectal cancer patients. Interestingly, CRCs with different SARIFA-status also showed histological differences measurable at the luminal tumour surface. Further studies to better understand the relationship between high luminal intratumoural stroma content and absence of a stroma reaction at the invasive front (SARIFA-positivity) are warranted and may inform future treatment decisions in CRC patients.PMID:38593584 | DOI:10.1016/j.tranon.2024.101913

Source: Translational Oncology - April 9, 2024 Category: Cancer & Oncology Authors: N G Reitsam B Grosser J S Enke W Mueller A Westwood N P West P Quirke B M ärkl H I Grabsch Source Type: research