Preclinical evaluation of engineered L-asparaginase variants to improve the treatment of Acute Lymphoblastic Leukemia
CONCLUSION: EcA variants demonstrated better pharmacological properties compared to WT that makes them good candidates for further development.PMID:38412663 | DOI:10.1016/j.tranon.2024.101909 (Source: Translational Oncology)
Source: Translational Oncology - February 27, 2024 Category: Cancer & Oncology Authors: Soumika Sengupta Mainak Biswas Khushboo A Gandhi Saurabh Kumar Gupta Poonam B Gera Vikram Gota Avinash Sonawane Source Type: research
XIAP overexpressing inflammatory breast cancer patients have high infiltration of immunosuppressive subsets and increased TNFR1 signaling targetable with Birinapant
CONCLUSION: Using immunophenotyping and gene expression analysis in patient biospecimens along with in silico modeling and a preclinical model with a pan-IAP antagonist, this study revealed an interplay between increased TAMs, TNF-α signaling, and XIAP activation during (immune) stress in IBC. These data demonstrate the potential of IAP antagonists as immunomodulators for improving IBC therapeutic regimens.PMID:38412664 | DOI:10.1016/j.tranon.2024.101907 (Source: Translational Oncology)
Source: Translational Oncology - February 27, 2024 Category: Cancer & Oncology Authors: Christophe Van Berckelaer Steven Van Laere Seayoung Lee Michael A Morse Joseph Geradts Luc Dirix Mark Kockx Fran çois Bertucci Peter Van Dam Gayathri R Devi Source Type: research
Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancer
Transl Oncol. 2024 Feb 26;43:101848. doi: 10.1016/j.tranon.2023.101848. Online ahead of print.ABSTRACTEpithelial to Mesenchymal transition (EMT) drives cancer metastasis and is governed by genetic and epigenetic alterations at multiple levels of regulation. It is well established that loss/mutation of p53 confers oncogenic function to cancer cells and promotes metastasis. Though transcription factors like ZEB1, SLUG, SNAIL and TWIST have been implied in EMT signalling, p53 mediated alterations in the epigenetic machinery accompanying EMT are not clearly understood. This work attempts to explore epigenetic signalling during...
Source: Translational Oncology - February 27, 2024 Category: Cancer & Oncology Authors: Shreya Sharma Harsha Rani Yeshwanth Mahesh Mohit Kumar Jolly Jagannath Dixit Vijayalakshmi Mahadevan Source Type: research
The highly selective and oral phosphoinositide 3-kinase delta (PI3K- δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition
Transl Oncol. 2024 Feb 26;43:101857. doi: 10.1016/j.tranon.2023.101857. Online ahead of print.ABSTRACTTargeting aberrantly expressed kinases in malignant pleural mesothelioma (MPM) is a promising therapeutic strategy. We here investigated the effect of the novel and highly selective Phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib (IOA-244) on MPM cells and on the immune cells in MPM microenvironment. To this aim, we analyzed the expression of PI3K-δ by immunohistochemistry in specimens from primary MPM, cell viability and death in three different MPM cell lines treated with roginolisib alone and in combina...
Source: Translational Oncology - February 27, 2024 Category: Cancer & Oncology Authors: Claudia Kalla German Ott Francesca Finotello Karolina Niewola-Staszkowska Giusy Di Conza Michael Lahn Lars van der Veen Julia Sch üler Roger Falkenstern-Ge Joanna Kopecka Chiara Riganti Source Type: research
Comprehensive analysis and experimental verification of the mechanism of action of T cell-mediated tumor-killing related genes in Colon adenocarcinoma
CONCLUSION: Our research findings established a new gene signature for COAD. This gene signature helps to accurately stratify the risk of COAD patients and improve the current status of individualized care.PMID:38412662 | DOI:10.1016/j.tranon.2024.101918 (Source: Translational Oncology)
Source: Translational Oncology - February 27, 2024 Category: Cancer & Oncology Authors: Jing Chen Zhengfang Wang Qin Zhu Shiqi Ren Yanhua Xu Guangzhou Wang Lin Zhou Source Type: research
Preclinical evaluation of engineered L-asparaginase variants to improve the treatment of Acute Lymphoblastic Leukemia
CONCLUSION: EcA variants demonstrated better pharmacological properties compared to WT that makes them good candidates for further development.PMID:38412663 | DOI:10.1016/j.tranon.2024.101909 (Source: Translational Oncology)
Source: Translational Oncology - February 27, 2024 Category: Cancer & Oncology Authors: Soumika Sengupta Mainak Biswas Khushboo A Gandhi Saurabh Kumar Gupta Poonam B Gera Vikram Gota Avinash Sonawane Source Type: research
XIAP overexpressing inflammatory breast cancer patients have high infiltration of immunosuppressive subsets and increased TNFR1 signaling targetable with Birinapant
CONCLUSION: Using immunophenotyping and gene expression analysis in patient biospecimens along with in silico modeling and a preclinical model with a pan-IAP antagonist, this study revealed an interplay between increased TAMs, TNF-α signaling, and XIAP activation during (immune) stress in IBC. These data demonstrate the potential of IAP antagonists as immunomodulators for improving IBC therapeutic regimens.PMID:38412664 | DOI:10.1016/j.tranon.2024.101907 (Source: Translational Oncology)
Source: Translational Oncology - February 27, 2024 Category: Cancer & Oncology Authors: Christophe Van Berckelaer Steven Van Laere Seayoung Lee Michael A Morse Joseph Geradts Luc Dirix Mark Kockx Fran çois Bertucci Peter Van Dam Gayathri R Devi Source Type: research
Comprehensive genomic and clinical analyses identify APOBEC mutational signatures as a brain metastasis risk factor in lung adenocarcinoma patients
CONCLUSION: APOBEC mutational signatures related to upregulated TGFβ and EMT, could serve as an independent risk factor for BM and BM-free survival in metastatic lung adenocarcinoma patients. Further investigations are warranted to tailor personalized treatments to improve the susceptible patient's outcomes.PMID:38402722 | DOI:10.1016/j.tranon.2024.101921 (Source: Translational Oncology)
Source: Translational Oncology - February 25, 2024 Category: Cancer & Oncology Authors: Qiang Li Meng Jiang Shiqiang Hong Jing Yang Xiaoying Wu Jiaohui Pang Yedan Chen Xiaotian Zhao Xiao Ding Source Type: research
Comprehensive genomic and clinical analyses identify APOBEC mutational signatures as a brain metastasis risk factor in lung adenocarcinoma patients
CONCLUSION: APOBEC mutational signatures related to upregulated TGFβ and EMT, could serve as an independent risk factor for BM and BM-free survival in metastatic lung adenocarcinoma patients. Further investigations are warranted to tailor personalized treatments to improve the susceptible patient's outcomes.PMID:38402722 | DOI:10.1016/j.tranon.2024.101921 (Source: Translational Oncology)
Source: Translational Oncology - February 25, 2024 Category: Cancer & Oncology Authors: Qiang Li Meng Jiang Shiqiang Hong Jing Yang Xiaoying Wu Jiaohui Pang Yedan Chen Xiaotian Zhao Xiao Ding Source Type: research
CT-guided high dose rate brachytherapy can induce multiple systemic proteins of proliferation and angiogenesis predicting outcome in HCC
CONCLUSION: Increased plasma levels of EGF and Angiopoietin-1 after HDR-BT for HCC are associated with poor response and may therefore function as predictive biomarkers of outcome.PMID:38401507 | DOI:10.1016/j.tranon.2024.101919 (Source: Translational Oncology)
Source: Translational Oncology - February 24, 2024 Category: Cancer & Oncology Authors: Lukas Salvermoser Shraga Nahum Goldberg Marianna Alunni-Fabbroni Philipp Maximilian Kazmierczak Moritz Nikolaus Gr öper Jan Niklas Sch äfer Elif Öcal Tanja Burkard Stefanie Corradini Najib Ben Khaled Agnese Petrera Moritz Wildgruber Jens Ricke Matthias Source Type: research
CT-guided high dose rate brachytherapy can induce multiple systemic proteins of proliferation and angiogenesis predicting outcome in HCC
CONCLUSION: Increased plasma levels of EGF and Angiopoietin-1 after HDR-BT for HCC are associated with poor response and may therefore function as predictive biomarkers of outcome.PMID:38401507 | DOI:10.1016/j.tranon.2024.101919 (Source: Translational Oncology)
Source: Translational Oncology - February 24, 2024 Category: Cancer & Oncology Authors: Lukas Salvermoser Shraga Nahum Goldberg Marianna Alunni-Fabbroni Philipp Maximilian Kazmierczak Moritz Nikolaus Gr öper Jan Niklas Sch äfer Elif Öcal Tanja Burkard Stefanie Corradini Najib Ben Khaled Agnese Petrera Moritz Wildgruber Jens Ricke Matthias Source Type: research
Apigenin enhances sorafenib anti-tumour efficacy in hepatocellular carcinoma
CONCLUSIONS: In conclusion, Apigenin could enhance the therapeutic efficacy of Sorafenib against liver cancer and may be a promising therapeutic approach for treating HCC. However, further research is imperative to gain more in-depth mechanistic insights.PMID:38394865 | DOI:10.1016/j.tranon.2024.101920 (Source: Translational Oncology)
Source: Translational Oncology - February 23, 2024 Category: Cancer & Oncology Authors: Deepti Singh Mohammad Afsar Khan Dhruv Mishra Aditya Goel Mairaj Ahmed Ansari Kafil Akhtar Hifzur R Siddique Source Type: research
Genetic testing for hereditary cancer syndromes in Tunisian patients: Impact on health system
CONCLUSION: Our study calls for comprehensive genetic education and the implementation of genetic screening in Tunisia and other African countries health systems, to reduce the burden of hereditary diseases and improve cancer outcomes in resource-stratified settings.PMID:38387387 | DOI:10.1016/j.tranon.2024.101912 (Source: Translational Oncology)
Source: Translational Oncology - February 22, 2024 Category: Cancer & Oncology Authors: Nouha Jandoubi Maroua Boujemaa Najah Mighri Nesrine Mejri Sonia Ben Nasr Hanen Bouaziz Yosra Berrazega Haifa Rachdi Nouha Daoud Aref Zribi Jihene Ayari Houda El Benna Soumaya Labidi Abderazzek Haddaoui Ridha Mrad Slim Ben Ahmed Hamouda Boussen Sonia Abdel Source Type: research
Machine learning developed an intratumor heterogeneity signature for predicting prognosis and immunotherapy benefits in cholangiocarcinoma
CONCLUSION: Integrative machine learning analysis was performed to construct a novel IRS in cholangiocarcinoma. This IRS acted as an indicator for predicting the prognosis and immunotherapy benefits of cholangiocarcinoma patients.PMID:38387388 | DOI:10.1016/j.tranon.2024.101905 (Source: Translational Oncology)
Source: Translational Oncology - February 22, 2024 Category: Cancer & Oncology Authors: Xu Chen Bo Sun Yu Chen Yili Xiao Yinghui Song Sulai Liu Chuang Peng Source Type: research
Genetic testing for hereditary cancer syndromes in Tunisian patients: Impact on health system
CONCLUSION: Our study calls for comprehensive genetic education and the implementation of genetic screening in Tunisia and other African countries health systems, to reduce the burden of hereditary diseases and improve cancer outcomes in resource-stratified settings.PMID:38387387 | DOI:10.1016/j.tranon.2024.101912 (Source: Translational Oncology)
Source: Translational Oncology - February 22, 2024 Category: Cancer & Oncology Authors: Nouha Jandoubi Maroua Boujemaa Najah Mighri Nesrine Mejri Sonia Ben Nasr Hanen Bouaziz Yosra Berrazega Haifa Rachdi Nouha Daoud Aref Zribi Jihene Ayari Houda El Benna Soumaya Labidi Abderazzek Haddaoui Ridha Mrad Slim Ben Ahmed Hamouda Boussen Sonia Abdel Source Type: research
