Comprehensive genomic and clinical analyses identify APOBEC mutational signatures as a brain metastasis risk factor in lung adenocarcinoma patients

CONCLUSION: APOBEC mutational signatures related to upregulated TGFβ and EMT, could serve as an independent risk factor for BM and BM-free survival in metastatic lung adenocarcinoma patients. Further investigations are warranted to tailor personalized treatments to improve the susceptible patient's outcomes.PMID:38402722 | DOI:10.1016/j.tranon.2024.101921

Source: Translational Oncology - February 25, 2024 Category: Cancer & Oncology Authors: Qiang Li Meng Jiang Shiqiang Hong Jing Yang Xiaoying Wu Jiaohui Pang Yedan Chen Xiaotian Zhao Xiao Ding Source Type: research