VARGADO data
Vargatef ® plus docetaxel could be an option after failure of immunotherapy in lung cancerResults from a real-world study1  support a recent update to the ESMO guidelines2 recommending nintedanib (Vargatef®) plus docetaxel following first-line chemotherapy (+/- immunotherapy) in advanced NSCLC of adenocarcinoma histology (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - December 13, 2018 Category: Research Source Type: news

Intraoperative Consultation on Surgical Margins 98% Accurate in Gastric Cancer Intraoperative Consultation on Surgical Margins 98% Accurate in Gastric Cancer
The false-negative rate of intraoperative consultation (IOC) on surgical margins during resection of gastric and gastroesophageal adenocarcinoma is less than 2% overall, according to a retrospective study at a specialty center.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - November 6, 2018 Category: Surgery Tags: Hematology-Oncology News Source Type: news

Short-term ADT with RT improves survival over RT alone up to 10 years
(NRG Oncology) The long-term follow up of the NRG Oncology trial RTOG 9408, studying the addition of short-term androgen-deprivation therapy (ADT) to radiotherapy (RT) for men with early, localized prostate adenocarcinoma, indicated that RT combined with ADT is superior to RT alone for overall survival (OS) up to 10.4 years following treatment. However, when researchers assessed these results up to 18 years, the benefits of adding ADT to RT dissipated. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 22, 2018 Category: International Medicine & Public Health Source Type: news

Pancreatic cancer genetic marker may predict outcomes with radiation therapy
(Thomas Jefferson University) scientists find that a gene involved in the immune system called IDO2 plays a significant role in pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer. The discovery may help physicians provide better treatment options for patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 22, 2018 Category: Cancer & Oncology Source Type: news

Increased survival in patients with metastatic NSCLC receiving treatment in academic centers
(International Association for the Study of Lung Cancer) Patients with metastatic NSCLC receiving treatment at academic centers (ACs) have an increased 2-year survival compared to patients treated at community-based centers (CCs). An overall histology-dependent survival was also noted in patients with adenocarcinoma verses squamous cell carcinoma and varied by treatment facility. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 10, 2018 Category: Cancer & Oncology Source Type: news

UCLA researchers discover aggressive prostate and lung cancers are driven by common mechanisms
UCLA researchers have discovered a common process in the development of late-stage, small cell cancers of the prostate and lung. These shared molecular mechanisms could lead to the development of drugs to treat not just prostate and lung cancers, but small cell cancers of almost any organ.The key finding: Prostate and lung cells have very different patterns of gene expression when they ’re healthy, but almost identical patterns when they transform into small cell cancers. The research suggests that different types of small cell tumors evolve similarly, even when they come from different organs.The study, led by Dr. O...
Source: UCLA Newsroom: Health Sciences - October 4, 2018 Category: Universities & Medical Training Source Type: news

Nano-Optic Endoscope Offers Anatomic Pathologists, Medical Laboratories Higher Resolution and Precision Optical Imaging
New metalens technology from MGH and SEAS researchers gives greater endoscopic optical imaging resolution and sample detail for anatomic pathologists performing diagnostics Anatomic pathologists and clinical laboratories know that biopsy samples are necessary to diagnose many diseases. But, current endoscopic imaging techniques used by physicians sometimes fail to clearly visualize disease sites. Consequently, biopsies collected […] (Source: Dark Daily)
Source: Dark Daily - September 26, 2018 Category: Laboratory Medicine Authors: Jude Tags: Instruments & Equipment Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Laboratory Testing Management & Operations adenocarcinoma anatomic path Source Type: news

Is AI the Key to Diving Deeper into Images and Pathology?
In a tale of two studies, it appears artificial intelligence is helping researchers analyze cells in ways that weren't possible before. In one study, published this week in Nature Methods, scientists at the Allen Institute in Seattle, WA used machine learning to train computers to see parts of the cell that the human eye cannot easily distinguish. Using 3D images of fluorescently labeled cells, the team taught computers to find structures inside living cells without fluorescent labels, using only black and white images generated by an inexpensive technique known as brightfield microscopy. Fluorescence microscop...
Source: MDDI - September 19, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Imaging Source Type: news

Reducing Risk of Esophageal Cancer in Barrett's Esophagus Reducing Risk of Esophageal Cancer in Barrett's Esophagus
Patients with Barrett's esophagus have a high risk of developing esophageal adenocarcinoma. Can PPIs and H2 receptor antagonists mitigate the risk?Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 18, 2018 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Circulating Tumor Cell Dynamics in Pancreatic Adenocarcinoma Circulating Tumor Cell Dynamics in Pancreatic Adenocarcinoma
What is the clinical significance of circulating tumor cells in pancreatic ductal adenocarcinoma?Annals of Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 10, 2018 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

Barrett's Tied to Better Survival in Esophageal Ca
(MedPage Today) -- Data suggests existence of two distinct types of esophageal adenocarcinoma (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - September 6, 2018 Category: Gastroenterology Source Type: news

Endocervical Cells With Gastric-Type Mucin on Pap Smears Endocervical Cells With Gastric-Type Mucin on Pap Smears
Does gastric-type mucin observed on Pap smears provide diagnostic value for endocervical adenocarcinoma and its precursors?American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 4, 2018 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Could HPV Be Prognostic in Esophageal Cancer Too? Could HPV Be Prognostic in Esophageal Cancer Too?
HPV positivity is associated with significantly better outcomes in patients with Barrett's high-grade dysplasia or esophageal adenocarcinoma, suggesting less intensive therapy might be considered.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 3, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Post-Prostatectomy Radiation Therapy: Patient Selection, Timing, Imaging, and Therapy Intensification
A 62-year-old man with prostate adenocarcinoma elected to proceed with radical prostatectomy as definitive management. After his pathology report showed stage IIIB disease, he elected for observation. What happened next? (Source: CancerNetwork)
Source: CancerNetwork - July 18, 2018 Category: Cancer & Oncology Authors: Tyler P. Robin, MD, PhD, Paul D. Maroni, MD, Bennett B. Chin, MD, Francisco G. La Rosa, MD, Brandon Bernard, MD, MPH, Thomas J. Pugh, MD Source Type: news

Complex Glandular Patterns in Lung Adenocarcinoma Complex Glandular Patterns in Lung Adenocarcinoma
This study provides new insight into the potential role of complex glandular patterns in clinical management of lung adenocarcinoma.American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 10, 2018 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Survival in Pancreatic Cancer With Germline Mutations Survival in Pancreatic Cancer With Germline Mutations
Platinum-based therapy may improve survival in pancreatic ductal adenocarcinoma carrying deleterious germline mutations.JCO Precision Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 6, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Five-year survival rate for most common pancreatic cancer just 3%
The “outrageous” five‐year survival rate in England for patients with the most common type of pancreatic cancer ‐ pancreatic ductal adenocarcinoma (PDAC) ‐ has been revealed for the first time in a study, commissioned by the charity Pancreatic Cancer UK (Source: Nursing Times)
Source: Nursing Times - June 20, 2018 Category: Nursing Source Type: news

Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases
The majority of patients with pancreatic ductal adenocarcinoma (PDA) develop metastatic disease after resection of their primary tumor. We found that livers from patients and mice with PDA harbor single disseminated cancer cells (DCCs) lacking expression of cytokeratin 19 (CK19) and major histocompatibility complex class I (MHCI). We created a mouse model to determine how these DCCs develop. Intraportal injection of immunogenic PDA cells into preimmunized mice seeded livers only with single, nonreplicating DCCs that were CK19– and MHCI–. The DCCs exhibited an endoplasmic reticulum (ER) stress response but parad...
Source: ScienceNOW - June 14, 2018 Category: Science Authors: Pommier, A., Anaparthy, N., Memos, N., Kelley, Z. L., Gouronnec, A., Yan, R., Auffray, C., Albrengues, J., Egeblad, M., Iacobuzio-Donahue, C. A., Lyons, S. K., Fearon, D. T. Tags: Medicine, Diseases, Online Only r-articles Source Type: news

ASCO: mFOLFIRINOX Improves Survival in Pancreatic Cancer
MONDAY, June 4, 2018 -- The oxaliplatin, leucovorin, irinotecan, and 5-fluorouracil (mFOLFIRINOX) regimen is associated with longer median disease-free and overall survival in pancreatic ductal adenocarcinoma; and, receiving chemotherapy before... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 4, 2018 Category: Pharmaceuticals Source Type: news

Worse Survival for BRCA Germline Mutation Carriers in Pancreatic CA
WEDNESDAY, May 30, 2018 -- BRCA1/BRCA2 germline mutation carriers with pancreatic ductal adenocarcinoma (PDAC) have worse survival after resection, according to a study published in the April issue of the Journal of the American College of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 30, 2018 Category: Pharmaceuticals Source Type: news

Mortality Risk Persists for Cancer Tied to Prenatal DES Exposure
Women with DES - related clear - cell adenocarcinoma had 27 - fold higher mortality at 10 to 34 years (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 3, 2018 Category: Cancer & Oncology Tags: Gynecology, Oncology, Journal, Source Type: news

Mortality Risk Persists for Cancer Tied to Prenatal DES Exposure
THURSDAY, May 3, 2018 -- Diethylstilbestrol (DES)-related clear-cell adenocarcinoma of the vagina and cervix is associated with increased risk of death, even in older women, according to a letter to the editor published in the May 3 issue of the New... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 3, 2018 Category: Pharmaceuticals Source Type: news

The DES saga: Death risk high for young women exposed in utero
(University of Chicago Medical Center) A letter in the May 3, 2018, NEJM updates reports on the risks of exposure during pregnancy to a supplement, diethylstilbestrol (DES), that is linked to a rare cancer. The study found that DES-exposed patients with clear-cell adenocarcinoma had 'increased mortality across their life span.' For women aged 10 to 34 with DES-related clear-cell adenocarcinoma, the risk of death was 27 times higher than for other US women in that age group. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 2, 2018 Category: Cancer & Oncology Source Type: news

Novel theranostic approach for treating pancreatic cancer patients shows promise
(Society of Nuclear Medicine and Molecular Imaging) German researchers have developed a novel diagnostic and therapeutic (theranostic) procedure for patients with ductal pancreatic adenocarcinoma, a deadly cancer with an extremely poor prognosis (five-year survival rate of less than 5 percent) and limited treatment options. The study is featured in the May issue of The Journal of Nuclear Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 1, 2018 Category: Cancer & Oncology Source Type: news

Metastatic Adenocarcinoma Involving Atypical Meningioma Metastatic Adenocarcinoma Involving Atypical Meningioma
A patient with a history of stage IV lung adenocarcinoma presented to the emergency department with aphasia. What was the cause?Applied Radiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 30, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Presence and amount of gut bacteria can predict how fast pancreatic cancer cells grow
(Natural News) Pancreatic ductal adenocarcinoma, or PDA, is the most common and by far the most lethal form of pancreatic cancer. Pancreapedia reports that it is extremely aggressive, and for most patients their only hope of survival hinges on the total surgical removal of the tumor. Unfortunately, such tumors cannot be removed in upwards of... (Source: NaturalNews.com)
Source: NaturalNews.com - April 25, 2018 Category: Consumer Health News Source Type: news

CDx & #039;s WATS3D Highly Effective in Real World Setting
CDx Diagnostics said results from a recent multicenter prospective trial show the use of its WATS3D test increases the detection of both Barrett’s esophagus and esophageal dysplasia by more than 80%. The results were published in the latest issue of United European Gastroenterology Journal and featured in the American Society for Gastrointestinal Endoscopy (ASGE’s) Scope Tech Talk Video Series. The trial was conducted at 25 community-based gastrointestinal (GI) centers across the U.S. In the study, 4,203 patients were tested for esophageal disease. The findings show that with the inclusion of WATS3D overal...
Source: MDDI - March 26, 2018 Category: Medical Devices Authors: Omar Ford Tags: Business Design News Source Type: news

Bacteria may promote pancreatic cancer by suppressing the immune system
(American Association for Cancer Research) Bacterial load was significantly higher in pancreatic tumor samples from patients with pancreatic ductal adenocarcinoma compared with pancreatic tissue from normal individuals, and in studies using mice, eliminating certain 'bad' bacteria slowed the growth of pancreatic cancer, reversed immune suppression, and upregulated the immune checkpoint protein PD1. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 22, 2018 Category: Cancer & Oncology Source Type: news

Can Microbubbles Deliver Gene Therapy?
An Italian diagnostic imaging company is teaming with a Chicago startup to study whether microbubbles can deliver personalized gene therapy to treat high LDL cholesterol. Microbubble technology, combined with contrast-enhanced ultrasound, has been used diagnostically for years and more recently has inspired research for treatment of disease. Milan-based Bracco Imaging, S.p.A. is working with Steven Feinstein, a professor of medicine at Rush University Medical Center and president of SonoGene, LLC to pursue the treatment possibilities further. A CEUS researcher, Feinstein is also co-president of the  International Cont...
Source: MDDI - February 9, 2018 Category: Medical Devices Authors: Nancy Crotti Tags: R & D Source Type: news

Incidence of Lung Adenocarcinoma in Never Smokers Incidence of Lung Adenocarcinoma in Never Smokers
Despite a decrease in exposure to secondhand smoke, never smokers continue to be at risk for lung cancer.Journal of the National Cancer Institute (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 23, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Researchers develop swallowable test to detect pre-cancerous Barrett's esophagus
(Case Western Reserve University) Investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center have developed a simple, swallowable test for early detection of Barrett's esophagus that offers promise for preventing deaths from esophageal adenocarcinoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 17, 2018 Category: Cancer & Oncology Source Type: news

Keratin 17: A Biomarker in Endocervical Glandular Neoplasia Keratin 17: A Biomarker in Endocervical Glandular Neoplasia
This study ascertained that expression of keratin 17 is associated with decreased survival of patients with endocervical adenocarcinoma.American Journal of Clinical Pathology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 15, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic les...
Source: ScienceNOW - December 14, 2017 Category: Science Authors: Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., Chipashvili, O., Hagan, T., Walker, M., Ramachandran, A., Diosdado, B., Serna, G., Mulet, N., Landolfi, S., Ramon y Cajal, S., Tags: Medicine, Diseases reports Source Type: news

FDA approves first biosimilar for the treatment of certain breast and stomach cancers
The U.S. Food and Drug Administration today approved Ogivri (trastuzumab-dkst) as a biosimilar to Herceptin (trastuzumab) for the treatment of patients with breast or metastatic stomach cancer (gastric or gastroesophageal junction adenocarcinoma) whose tumors overexpress the HER2 gene (HER2+). Ogivri is the first biosimilar approved in the U.S. for the treatment of breast cancer or stomach cancer and the second biosimilar approved in the U.S. for the treatment of cancer. (Source: World Pharma News)
Source: World Pharma News - December 1, 2017 Category: Pharmaceuticals Tags: Featured FDA Regulatory Affairs Source Type: news

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils
Bone marrow–derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to tumor growth remains poorly understood. Here, we show in mice and cancer patients (n = 70) that lung adenocarcinomas increase bone stromal activity in the absence of bone metastasis. Animal studies reveal that the cancer-induced bone phenotype involves bone-resident osteocalcin-expressing (Ocn+) osteoblastic cells. These cells promote cancer by remotely supplying a distinct subset of tumor-infiltrat...
Source: ScienceNOW - November 30, 2017 Category: Science Authors: Engblom, C., Pfirschke, C., Zilionis, R., Da Silva Martins, J., Bos, S. A., Courties, G., Rickelt, S., Severe, N., Baryawno, N., Faget, J., Savova, V., Zemmour, D., Kline, J., Siwicki, M., Garris, C., Pucci, F., Liao, H.-W., Lin, Y.-J., Newton, A., Yaghi, Tags: Medicine, Diseases r-articles Source Type: news

Vargatef ® (nintedanib*) approved in the EU for lung cancer patients with advanced adenocarcinoma after first-line chemotherapy
Vargatef ® (nintedanib*) approved in the EU for lung cancer patients with advanced adenocarcinoma after first-line chemotherapy (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 27, 2017 Category: Research Source Type: news

NICE recommends VARGATEF ® (nintedanib*) in combination with docetaxel as an option for patients with non-small cell lung cancer of adenocarcinoma histology within its licensed indication
NICE recommends VARGATEF ® (nintedanib*) in combination with docetaxel as an option for patients with non-small cell lung cancer of adenocarcinoma histology within its licensed indication (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 27, 2017 Category: Research Source Type: news

VARGATEF ® plus docetaxel significantly reduced tumour burden in lung cancer patients with advanced adenocarcinoma compared to docetaxel alone
VARGATEF ® plus docetaxel significantly reduced tumour burden in lung cancer patients with advanced adenocarcinoma compared to docetaxel alone (Source: Boehringer Ingelheim Corporate News)
Source: Boehringer Ingelheim Corporate News - November 27, 2017 Category: Research Source Type: news

Biomarker Panel to Identify Early-Stage Pancreatic Cancer Biomarker Panel to Identify Early-Stage Pancreatic Cancer
A biomarker panel may add significantly to the predictive power of CA 19-9 to detect early-stage pancreatic ductal adenocarcinoma.Journal of the National Cancer Institute (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 27, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Wider sampling of tumor tissues may guide drug choice, improve outcomes
This study challenges current guidelines and supports evaluation of metastatic lesions and circulating tumor DNA. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 15, 2017 Category: Cancer & Oncology Source Type: news

Gastroesophageal Junction Adenocarcinoma
Title: Gastroesophageal Junction AdenocarcinomaCategory: Diseases and ConditionsCreated: 11/7/2017 12:00:00 AMLast Editorial Review: 11/7/2017 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - November 7, 2017 Category: Cancer & Oncology Source Type: news

Many EEs on pancreatic ductal adenocarcinoma not high quality
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - November 1, 2017 Category: Drugs & Pharmacology Source Type: news

Biomarkers for Selecting Lung Adenocarcinoma Therapy Biomarkers for Selecting Lung Adenocarcinoma Therapy
Review recent advances in diagnosis and treatment of advanced nonsquamous NSCLC.Journal of Oncology Practice (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 23, 2017 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Electronic Nose Promising for Barrett's Esophagus Detection
(MedPage Today) -- Test may facilitate surveillance for esophageal adenocarcinoma (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - October 17, 2017 Category: Gastroenterology Source Type: news

Does Adjuvant Chemo Improve Survival in Gastroesophageal Cancer? Does Adjuvant Chemo Improve Survival in Gastroesophageal Cancer?
n patients with locally advanced gastroesophageal adenocarcinoma treated with preoperative chemoradiation and resection, adjuvant chemotherapy is associated with improved overall survival.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - October 2, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Adjuvant Chemo Beneficial in Advanced Gastroesophageal CA
Improved overall survival for patients with locally - advanced gastroesophageal adenocarcinoma (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 26, 2017 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pharmacy, Radiology, Surgery, Journal, Source Type: news

Merck ’s Keytruda receives accelerated FDA approval for GEJ adenocarcinoma
Merck ’s Keytruda (pembrolizumab) has received approval from the US Food and Drug Administration (FDA) to treat patients with recurrent locally advanced or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma. (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - September 24, 2017 Category: Pharmaceuticals Source Type: news

The RNA-editing enzyme ADAR promotes lung adenocarcinoma migration and invasion by stabilizing FAK
Large-scale, genome-wide studies report that RNA binding proteins are altered in cancers, but it is unclear how these proteins control tumor progression. We found that the RNA-editing protein ADAR (adenosine deaminase acting on double-stranded RNA) acted as a facilitator of lung adenocarcinoma (LUAD) progression through its ability to stabilize transcripts encoding focal adhesion kinase (FAK). In samples from 802 stage I LUAD patients, increased abundance of ADAR at both the mRNA and protein level correlated with tumor recurrence. Knocking down ADAR in LUAD cells suppressed their mesenchymal properties, migration, and inva...
Source: Signal Transduction Knowledge Environment - September 19, 2017 Category: Science Authors: Amin, E. M., Liu, Y., Deng, S., Tan, K. S., Chudgar, N., Mayo, M. W., Sanchez-Vega, F., Adusumilli, P. S., Schultz, N., Jones, D. R. Tags: STKE Research Articles Source Type: news

Highlight: RNA-binding proteins in cancer
ADAR promotes lung adenocarcinoma migration and invasion through stabilization of FAK. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 19, 2017 Category: Science Authors: Yaffe, M. B. Tags: STKE Editors ' Choice Source Type: news

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2',2'-difluorodeoxycytidine) into its inactive form, 2',2'-difluorodeoxyuridine. Metabolism was dependent on the expression of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteobacteria. In a colon cancer mouse model, gemcitabine resistance was induced by intratumor Gammaproteobacteria, dependent on bacterial CDDL expression, and abrogated by cotreatment with the antibiotic ciprofloxa...
Source: ScienceNOW - September 14, 2017 Category: Science Authors: Geller, L. T., Barzily-Rokni, M., Danino, T., Jonas, O. H., Shental, N., Nejman, D., Gavert, N., Zwang, Y., Cooper, Z. A., Shee, K., Thaiss, C. A., Reuben, A., Livny, J., Avraham, R., Frederick, D. T., Ligorio, M., Chatman, K., Johnston, S. E., Mosher, C. Tags: Medicine, Diseases reports Source Type: news