A Braf kinase-inactive mutant induces lung adenocarcinoma
(Centro Nacional de Investigaciones Oncol รณ gicas (CNIO)) The initiating oncogenic event in half of human lung adenocarcinomas is still unknown, a fact that complicates the development of selective targeted therapies. Researchers at the CNIO have demonstrated that the expression of an endogenous Braf kinase-inactive isoform in mice triggers lung adenocarcinoma in vivo, indicating that BRAF-inactivating mutations are initiating events in lung oncogenesis. The paper indicates that the signal intensity of the MAPK pathway is a critical determinant in tumor development. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 2, 2017 Category: Cancer & Oncology Source Type: news
Halozyme initiates Phase Ib/II oncology combination trial
US-based biotechnology firm Halozyme Therapeutics has initiated a Phase Ib/II clinical trial of PEGPH20 and atezolizumab (Tecentriq) combination to treat metastatic pancreatic ductal adenocarcinoma. (Source: Drug Development Technology)
Source: Drug Development Technology - July 16, 2017 Category: Pharmaceuticals Source Type: news
As One Type of Esophageal Cancer Declines, Another Rises Sharply As One Type of Esophageal Cancer Declines, Another Rises Sharply
Even as the incidence of esophageal squamous cell carcinoma (ESCC) continues to decline in most countries, the incidence of esophageal adenocarcinoma (EAC) is rising to at least a comparable extent, according to a new study of 12 nations.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 28, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Small-Bowel Adenocarcinoma Shows Unique Genomic Profile Small-Bowel Adenocarcinoma Shows Unique Genomic Profile
Genomic profiling demonstrates that small-bowel adenocarcinoma (SBA) is significantly different from colorectal cancer and gastric carcinoma, according to a large study.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 22, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news
Docetaxel-Based Triplet New Standard in Gastric Cancer
Perioperative chemotherapy with a docetaxel-based triplet should be considered the new standard of care for resectable gastric or GEJ adenocarcinoma. (Source: CancerNetwork)
Source: CancerNetwork - June 21, 2017 Category: Cancer & Oncology Authors: Mark L. Fuerst Tags: Gastrointestinal Cancer News Source Type: news
