Esophageal Cancer -- Two Separate Diseases Esophageal Cancer -- Two Separate Diseases
Genomic study suggests esophageal squamous cell carcinoma and adenocarcinoma are separate diseases, which could lead to the development of new targeted therapies.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 23, 2017 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Researchers identify mechanism of oncogene action in lung cancer
Researchers have identified a genetic promoter of cancer that drives a major form of lung cancer. In a new paper, researchers provide genetic evidence that Ect2 drives lung adenocarcinoma tumor formation. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 19, 2017 Category: Science Source Type: news

Mayo researchers identify mechanism of oncogene action in lung cancer
(Mayo Clinic) Researchers at Mayo Clinic have identified a genetic promoter of cancer that drives a major form of lung cancer. In a new paper published this week in Cancer Cell, Mayo Clinic researchers provide genetic evidence that Ect2 drives lung adenocarcinoma tumor formation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 19, 2017 Category: Cancer & Oncology Source Type: news

Mayo researchers identify mechanism of oncogene action in lung cancer
JACKSONVILLE, Fla. ? Researchers at Mayo Clinic have identified a genetic promoter of cancer that drives a major form of lung cancer. In a new paper published this week in Cancer Cell, Mayo Clinic researchers provide genetic evidence that Ect2 drives?lung adenocarcinoma tumor formation. ?This paper demonstrates, for the first time, that Ect2 is required [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - January 18, 2017 Category: Databases & Libraries Source Type: news

[Report] Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance
Prostate cancer relapsing from antiandrogen therapies can exhibit variant histology with altered lineage marker expression, suggesting that lineage plasticity facilitates therapeutic resistance. The mechanisms underlying prostate cancer lineage plasticity are incompletely understood. Studying mouse models, we demonstrate that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation. Additional loss of Trp53 causes resistance to antiandrogen therapy. Gene expression profiling indicates that mouse tumors resemble human prostate cancer neuroendocrine variants; both mouse and...
Source: ScienceNOW - January 5, 2017 Category: Science Authors: Sheng Yu Ku Source Type: news

Low Progression Risk With Barrett's Esophagus Less Than 1 Cm Low Progression Risk With Barrett's Esophagus Less Than 1 Cm
The risk of progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) is very low among patients with Barrett ' s esophagus less than 1 cm, according to a new study.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - December 30, 2016 Category: Pathology Tags: Gastroenterology News Source Type: news

PD-L1 Testing, and Pembrolizumab,'Changes Approach to Every Patient'PD-L1 Testing, and Pembrolizumab,'Changes Approach to Every Patient '
Pembrolizumab ' s remarkable impact means ' we now have to change our approach to every single patient with adenocarcinoma and squamous cell carcinoma, ' argues Mark Kris.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 23, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology Commentary Source Type: news

Remarkable Developments in Lung Cancer Treatment Call for New Game Plans Remarkable Developments in Lung Cancer Treatment Call for New Game Plans
Pembrolizumab ' s remarkable impact means ' we now have to change our approach to every single patient with adenocarcinoma and squamous cell carcinoma, ' argues Mark Kris.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 23, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology Commentary Source Type: news

Remarkable Developments in Lung Cancer Treatment Calls for New Game Plans Remarkable Developments in Lung Cancer Treatment Calls for New Game Plans
Pembrolizumab ' s remarkable impact means ' we now have to change our approach to every single patient with adenocarcinoma and squamous cell carcinoma, ' argues Mark Kris.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - December 23, 2016 Category: Cancer & Oncology Tags: Hematology-Oncology Commentary Source Type: news

Tumor DNA in blood may serve as prognostic marker of pancreatic cancer
The presence of circulating tumor DNA (ctDNA) isolated from blood samples of patients with pancreatic adenocarcinoma was associated with poor outcomes, report investigators. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 19, 2016 Category: Science Source Type: news

Tumor DNA in blood may serve as prognostic marker of pancreatic cancer
(American Association for Cancer Research) The presence of circulating tumor DNA (ctDNA) isolated from blood samples of patients with pancreatic adenocarcinoma was associated with poor outcomes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 19, 2016 Category: Cancer & Oncology Source Type: news

Metastatic Papillary Adenocarcinoma in a 22-Year-Old: Is Her History of Mayer-Rokitansky-K ├╝ster-Hauser Syndrome Causative or Incidental?
A 22-year-old college student with primary amenorrhea due to M ├╝llerian agenesis presented with a headache, dysarthria, nausea, vomiting, and left upper extremity weakness. MRI of the brain showed numerous intracranial lesions. (Source: CancerNetwork)
Source: CancerNetwork - December 15, 2016 Category: Cancer & Oncology Authors: Colin Weekes, MD, PhD Joshua H. Petit, MD Lars Widdel, MD Patricia S. Huguelet, MD Regina J. Brown, MD Tags: Brain Tumors Case Studies Oncology Journal Source Type: news

Lindsay Norris from Kansas apologises to her patients after being diagnosed with cancer
Lindsay Norris, 33, from Kansas, was diagnosed with stage three Rectal Adenocarcinoma in September after the birth of her second child. She is currently in the first stage of treatment. (Source: the Mail online | Health)
Source: the Mail online | Health - November 29, 2016 Category: Consumer Health News Source Type: news

HC-based NGS impacts treatment decisions in lung cancer patients with adenocarcinoma
(International Association for the Study of Lung Cancer) The use of hybrid capture-based next-generation sequencing to identify targetable oncogenic drivers in patients with lung adenocarcinoma results in the detection of genomic alterations not identified in routine screening, and impacts treatment decisions and clinical outcomes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 16, 2016 Category: Cancer & Oncology Source Type: news

Monitoring the Premalignant Potential of Barrett's Esophagus Monitoring the Premalignant Potential of Barrett's Esophagus
How can we better identify those patients with Barrett ' s esophagus who are at high risk of developing esophageal adenocarcinoma?Frontline Gastroenterology (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - November 11, 2016 Category: Radiology Tags: Gastroenterology Journal Article Source Type: news