LGR5, a prognostic stem cell target, promotes endometrial cancer proliferation through autophagy activation
Transl Oncol. 2023 Dec 21;40:101853. doi: 10.1016/j.tranon.2023.101853. Online ahead of print.ABSTRACTEndometrial cancer (EC) is a common malignant tumor in women worldwide. Although early EC has a good prognosis, advanced endometrial cancer is still associated with the risk of drug resistance and recurrence. Cancer stem cells (CSCs), a category closely related to drug resistance and recurrence, are rarely studied at present. Here, we constructed a risk model containing ten stemness-related prognostic genes. Compared with patients in the low-risk group, patients in the high-risk group had a shorter overall survival time. T...
Source: Translational Oncology - December 22, 2023 Category: Cancer & Oncology Authors: Chengcheng Li Xiao Yang Yuan Cheng Jianliu Wang Source Type: research
Tumor associated neutrophils governs tumor progression through an IL-10/STAT3/PD-L1 feedback signaling loop in lung cancer
Transl Oncol. 2023 Dec 20;40:101866. doi: 10.1016/j.tranon.2023.101866. Online ahead of print.ABSTRACTTumor-associated neutrophils (TANs) can exist in either a pro-inflammatory or an anti-inflammatory state, known as N1 and N2, respectively. Anti-inflammatory TANs have been shown to correlate with poor prognosis and tumor progression in patients. To explore the role and mechanisms of TANs in lung cancer development, we isolated neutrophils from both peripheral blood and tumor tissues of patients/mice, and assessed their functional interaction with lung cancer cells both in vitro and in vivo. Our results revealed that tumor...
Source: Translational Oncology - December 21, 2023 Category: Cancer & Oncology Authors: Shuai Zhang Lei Sun Jingfang Zuo Dongjie Feng Source Type: research
Applying deep learning to segmentation of murine lung tumors in pre-clinical micro-computed tomography
In conclusion, we have developed a deep learning model which can perform fast, accurate, and fully automated segmentation of µCT scans of murine lung tumors.PMID:38128467 | DOI:10.1016/j.tranon.2023.101833 (Source: Translational Oncology)
Source: Translational Oncology - December 21, 2023 Category: Cancer & Oncology Authors: Mary Katherine Montgomery Chong Duan Lisa Manzuk Stephanie Chang Aiyana Cubias Sonja Brun Anand Giddabasappa Ziyue Karen Jiang Source Type: research
Tumor associated neutrophils governs tumor progression through an IL-10/STAT3/PD-L1 feedback signaling loop in lung cancer
Transl Oncol. 2023 Dec 20;40:101866. doi: 10.1016/j.tranon.2023.101866. Online ahead of print.ABSTRACTTumor-associated neutrophils (TANs) can exist in either a pro-inflammatory or an anti-inflammatory state, known as N1 and N2, respectively. Anti-inflammatory TANs have been shown to correlate with poor prognosis and tumor progression in patients. To explore the role and mechanisms of TANs in lung cancer development, we isolated neutrophils from both peripheral blood and tumor tissues of patients/mice, and assessed their functional interaction with lung cancer cells both in vitro and in vivo. Our results revealed that tumor...
Source: Translational Oncology - December 21, 2023 Category: Cancer & Oncology Authors: Shuai Zhang Lei Sun Jingfang Zuo Dongjie Feng Source Type: research
Applying deep learning to segmentation of murine lung tumors in pre-clinical micro-computed tomography
In conclusion, we have developed a deep learning model which can perform fast, accurate, and fully automated segmentation of µCT scans of murine lung tumors.PMID:38128467 | DOI:10.1016/j.tranon.2023.101833 (Source: Translational Oncology)
Source: Translational Oncology - December 21, 2023 Category: Cancer & Oncology Authors: Mary Katherine Montgomery Chong Duan Lisa Manzuk Stephanie Chang Aiyana Cubias Sonja Brun Anand Giddabasappa Ziyue Karen Jiang Source Type: research
Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma
CONCLUSION: High SII is correlated with worse outcome and can be a novel prognostic biomarker for IMA patients accepted radical surgery.PMID:38101174 | PMC:PMC10727949 | DOI:10.1016/j.tranon.2023.101865 (Source: Translational Oncology)
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Wei Sun Pengpeng Zhang Bicheng Ye Min-Yi Situ Wei Wang Yue Yu Source Type: research
A comprehensive analysis of the expression, immune infiltration, prognosis and partial experimental validation of CHST family genes in gastric cancer
Transl Oncol. 2023 Dec 14;40:101843. doi: 10.1016/j.tranon.2023.101843. Online ahead of print.ABSTRACTPrevious studies have demonstrated that carbohydrate sulfotransferase family proteins (CHSTs) play a crucial role in the extracellular matrix structural constituent and cancer progression, however, the effect of CHSTs on gastric cancer is still superficial. To investigate these, our study seeks to provide a comprehensive understanding of CHSTs' expression, immune infiltration, and prognostic implications in gastric cancer, utilizing data from the TCGA, GEO and GTEx databases. Furthermore, we conducted experimental validati...
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Jinbo Zhan Ling Zhou Hongjiao Zhang Juanjuan Zhou Yan He Tingting Hu Yi Le Yun Lin Jingru Wang Haiming Yu Yawen Liu Xiaojun Xiang Source Type: research
Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma
CONCLUSION: High SII is correlated with worse outcome and can be a novel prognostic biomarker for IMA patients accepted radical surgery.PMID:38101174 | PMC:PMC10727949 | DOI:10.1016/j.tranon.2023.101865 (Source: Translational Oncology)
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Wei Sun Pengpeng Zhang Bicheng Ye Min-Yi Situ Wei Wang Yue Yu Source Type: research
A comprehensive analysis of the expression, immune infiltration, prognosis and partial experimental validation of CHST family genes in gastric cancer
Transl Oncol. 2023 Dec 14;40:101843. doi: 10.1016/j.tranon.2023.101843. Online ahead of print.ABSTRACTPrevious studies have demonstrated that carbohydrate sulfotransferase family proteins (CHSTs) play a crucial role in the extracellular matrix structural constituent and cancer progression, however, the effect of CHSTs on gastric cancer is still superficial. To investigate these, our study seeks to provide a comprehensive understanding of CHSTs' expression, immune infiltration, and prognostic implications in gastric cancer, utilizing data from the TCGA, GEO and GTEx databases. Furthermore, we conducted experimental validati...
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Jinbo Zhan Ling Zhou Hongjiao Zhang Juanjuan Zhou Yan He Tingting Hu Yi Le Yun Lin Jingru Wang Haiming Yu Yawen Liu Xiaojun Xiang Source Type: research
Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma
CONCLUSION: High SII is correlated with worse outcome and can be a novel prognostic biomarker for IMA patients accepted radical surgery.PMID:38101174 | DOI:10.1016/j.tranon.2023.101865 (Source: Translational Oncology)
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Wei Sun Pengpeng Zhang Bicheng Ye Min-Yi Situ Wei Wang Yue Yu Source Type: research
A comprehensive analysis of the expression, immune infiltration, prognosis and partial experimental validation of CHST family genes in gastric cancer
Transl Oncol. 2023 Dec 14;40:101843. doi: 10.1016/j.tranon.2023.101843. Online ahead of print.ABSTRACTPrevious studies have demonstrated that carbohydrate sulfotransferase family proteins (CHSTs) play a crucial role in the extracellular matrix structural constituent and cancer progression, however, the effect of CHSTs on gastric cancer is still superficial. To investigate these, our study seeks to provide a comprehensive understanding of CHSTs' expression, immune infiltration, and prognostic implications in gastric cancer, utilizing data from the TCGA, GEO and GTEx databases. Furthermore, we conducted experimental validati...
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Jinbo Zhan Ling Zhou Hongjiao Zhang Juanjuan Zhou Yan He Tingting Hu Yi Le Yun Lin Jingru Wang Haiming Yu Yawen Liu Xiaojun Xiang Source Type: research
Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma
CONCLUSION: High SII is correlated with worse outcome and can be a novel prognostic biomarker for IMA patients accepted radical surgery.PMID:38101174 | DOI:10.1016/j.tranon.2023.101865 (Source: Translational Oncology)
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Wei Sun Pengpeng Zhang Bicheng Ye Min-Yi Situ Wei Wang Yue Yu Source Type: research
A comprehensive analysis of the expression, immune infiltration, prognosis and partial experimental validation of CHST family genes in gastric cancer
Transl Oncol. 2023 Dec 14;40:101843. doi: 10.1016/j.tranon.2023.101843. Online ahead of print.ABSTRACTPrevious studies have demonstrated that carbohydrate sulfotransferase family proteins (CHSTs) play a crucial role in the extracellular matrix structural constituent and cancer progression, however, the effect of CHSTs on gastric cancer is still superficial. To investigate these, our study seeks to provide a comprehensive understanding of CHSTs' expression, immune infiltration, and prognostic implications in gastric cancer, utilizing data from the TCGA, GEO and GTEx databases. Furthermore, we conducted experimental validati...
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Jinbo Zhan Ling Zhou Hongjiao Zhang Juanjuan Zhou Yan He Tingting Hu Yi Le Yun Lin Jingru Wang Haiming Yu Yawen Liu Xiaojun Xiang Source Type: research
Systemic immune-inflammation index predicts survival in patients with resected lung invasive mucinous adenocarcinoma
CONCLUSION: High SII is correlated with worse outcome and can be a novel prognostic biomarker for IMA patients accepted radical surgery.PMID:38101174 | DOI:10.1016/j.tranon.2023.101865 (Source: Translational Oncology)
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Wei Sun Pengpeng Zhang Bicheng Ye Min-Yi Situ Wei Wang Yue Yu Source Type: research
A comprehensive analysis of the expression, immune infiltration, prognosis and partial experimental validation of CHST family genes in gastric cancer
Transl Oncol. 2023 Dec 14;40:101843. doi: 10.1016/j.tranon.2023.101843. Online ahead of print.ABSTRACTPrevious studies have demonstrated that carbohydrate sulfotransferase family proteins (CHSTs) play a crucial role in the extracellular matrix structural constituent and cancer progression, however, the effect of CHSTs on gastric cancer is still superficial. To investigate these, our study seeks to provide a comprehensive understanding of CHSTs' expression, immune infiltration, and prognostic implications in gastric cancer, utilizing data from the TCGA, GEO and GTEx databases. Furthermore, we conducted experimental validati...
Source: Translational Oncology - December 15, 2023 Category: Cancer & Oncology Authors: Jinbo Zhan Ling Zhou Hongjiao Zhang Juanjuan Zhou Yan He Tingting Hu Yi Le Yun Lin Jingru Wang Haiming Yu Yawen Liu Xiaojun Xiang Source Type: research
