The Rac1-inhibitor EHop-016 attenuates AML cell migration and enhances the efficacy of daunorubicin in MOLM-13 transplanted zebrafish larvae
Transl Oncol. 2024 Feb;40:101876. doi: 10.1016/j.tranon.2024.101876. Epub 2024 Jan 6.ABSTRACTRas-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase implicated in cell migration and homing of hematopoietic cells to the hematopoietic niche, and is commonly overexpressed in acute myeloid leukemia (AML). This can lead to quiescence of leukemic blasts in the niche and reduced response to therapy. We investigated the Rac1 inhibitor EHop-016 on AML by assessing its effects on MOLM-13 cells in vitro and in zebrafish larvae, regarding cell motility and therapeutic potential in combination with daunorubicin (DNR). In vitro as...
Source: Translational Oncology - January 7, 2024 Category: Cancer & Oncology Authors: Anette Lodvir Hemsing Jan-Lukas F ørde H åkon Reikvam Lars Herfindal Source Type: research
CK1 δ/ε inhibition induces ULK1-mediated autophagy in tumorigenesis
CONCLUSION: Our results provide evidence for the role of CK1δ/ε in the regulation of tumorigenesis via the ULK1-mediated autophagy, and also suggest the impact of CK1δ/ε inhibition on tumor growth and its significance as a potential therapeutic target.PMID:38185060 | PMC:PMC10808987 | DOI:10.1016/j.tranon.2023.101863 (Source: Translational Oncology)
Source: Translational Oncology - January 7, 2024 Category: Cancer & Oncology Authors: Vivian Weiwen Xue Shanshan Liu Qi Sun Jiong Ning Huan Li Weilan Wang Sapna Sayed Xibao Zhao Li Fu Desheng Lu Source Type: research
Heterogeneity of computational pathomic signature predicts drug resistance and intra-tumor heterogeneity of ovarian cancer
CONCLUSION: Automatic image processing and feature extraction based on artificial intelligence have excellent results. Perimeter.sd can be used as a useful image feature indicator for evaluating ITH. ITH is associated with drug resistance of ovarian cancer, so ITH characteristics can be used as an effective indicator to evaluate drug resistance in patients with ovarian cancer.PMID:38185058 | DOI:10.1016/j.tranon.2023.101855 (Source: Translational Oncology)
Source: Translational Oncology - January 7, 2024 Category: Cancer & Oncology Authors: Qiuli Zhu Hua Dai Feng Qiu Weiming Lou Xin Wang Libin Deng Chao Shi Source Type: research
The Rac1-inhibitor EHop-016 attenuates AML cell migration and enhances the efficacy of daunorubicin in MOLM-13 transplanted zebrafish larvae
Transl Oncol. 2024 Jan 5;40:101876. doi: 10.1016/j.tranon.2024.101876. Online ahead of print.ABSTRACTRas-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase implicated in cell migration and homing of hematopoietic cells to the hematopoietic niche, and is commonly overexpressed in acute myeloid leukemia (AML). This can lead to quiescence of leukemic blasts in the niche and reduced response to therapy. We investigated the Rac1 inhibitor EHop-016 on AML by assessing its effects on MOLM-13 cells in vitro and in zebrafish larvae, regarding cell motility and therapeutic potential in combination with daunorubicin (DNR). In ...
Source: Translational Oncology - January 7, 2024 Category: Cancer & Oncology Authors: Anette Lodvir Hemsing Jan-Lukas F ørde H åkon Reikvam Lars Herfindal Source Type: research
CK1 δ/ε inhibition induces ULK1-mediated autophagy in tumorigenesis
CONCLUSION: Our results provide evidence for the role of CK1δ/ε in the regulation of tumorigenesis via the ULK1-mediated autophagy, and also suggest the impact of CK1δ/ε inhibition on tumor growth and its significance as a potential therapeutic target.PMID:38185060 | DOI:10.1016/j.tranon.2023.101863 (Source: Translational Oncology)
Source: Translational Oncology - January 7, 2024 Category: Cancer & Oncology Authors: Vivian Weiwen Xue Shanshan Liu Qi Sun Jiong Ning Huan Li Weilan Wang Sapna Sayed Xibao Zhao Li Fu Desheng Lu Source Type: research
Vaccine antibodies against a synthetic epidermal growth factor variant enhance the antitumor effects of inhibitors targeting the MAPK/ERK and PI3K/Akt pathways
CONCLUSIONS: Anti-EGF VacAbs enhance the antiproliferative effects of drugs targeting the ERK/MAPK and PIK3CA/Akt pathways. Our data provide a rationale for clinical trials testing anti-EGF vaccination combined with inhibitors selected according to the patient's genetic profile.PMID:38183801 | DOI:10.1016/j.tranon.2024.101878 (Source: Translational Oncology)
Source: Translational Oncology - January 6, 2024 Category: Cancer & Oncology Authors: Silvia Garc ía-Roman M ónica Garzón-Ibáñez Jordi Bertr án-Alamillo N úria Jordana-Ariza Ana Gim énez-Capitán Beatriz Garc ía-Peláez Marta Vives-Usano Jordi Codony-Servat Erik d'Hondt Rafael Rosell Miguel Ángel Molina-Vila Source Type: research
Elucidating cellular response to treatment with viral immunotherapies in pediatric high-grade glioma and medulloblastoma
Transl Oncol. 2024 Jan 4;40:101875. doi: 10.1016/j.tranon.2024.101875. Online ahead of print.ABSTRACTHSV G207, a double-stranded, DNA virus, and the polio:rhinovirus chimera, PVSRIPO, a single positive-strand RNA virus, are viral immunotherapies being used to treat pediatric malignant brain tumors in clinical trials. The purpose of this work is to elucidate general response patterns and putative biomarkers of response. Multiple pediatric high-grade glioma and medulloblastoma cell lines were treated with various multiplicities of infection of G207 or PVSRIPO. There was a significant inverse correlation between expression of...
Source: Translational Oncology - January 6, 2024 Category: Cancer & Oncology Authors: Eric M Thompson Kyung-Don Kang Kevin Stevenson Hengshan Zhang Matthias Gromeier David Ashley Michael Brown Gregory K Friedman Source Type: research
Vaccine antibodies against a synthetic epidermal growth factor variant enhance the antitumor effects of inhibitors targeting the MAPK/ERK and PI3K/Akt pathways
CONCLUSIONS: Anti-EGF VacAbs enhance the antiproliferative effects of drugs targeting the ERK/MAPK and PIK3CA/Akt pathways. Our data provide a rationale for clinical trials testing anti-EGF vaccination combined with inhibitors selected according to the patient's genetic profile.PMID:38183801 | DOI:10.1016/j.tranon.2024.101878 (Source: Translational Oncology)
Source: Translational Oncology - January 6, 2024 Category: Cancer & Oncology Authors: Silvia Garc ía-Roman M ónica Garzón-Ibáñez Jordi Bertr án-Alamillo N úria Jordana-Ariza Ana Gim énez-Capitán Beatriz Garc ía-Peláez Marta Vives-Usano Jordi Codony-Servat Erik d'Hondt Rafael Rosell Miguel Ángel Molina-Vila Source Type: research
Elucidating cellular response to treatment with viral immunotherapies in pediatric high-grade glioma and medulloblastoma
Transl Oncol. 2024 Jan 4;40:101875. doi: 10.1016/j.tranon.2024.101875. Online ahead of print.ABSTRACTHSV G207, a double-stranded, DNA virus, and the polio:rhinovirus chimera, PVSRIPO, a single positive-strand RNA virus, are viral immunotherapies being used to treat pediatric malignant brain tumors in clinical trials. The purpose of this work is to elucidate general response patterns and putative biomarkers of response. Multiple pediatric high-grade glioma and medulloblastoma cell lines were treated with various multiplicities of infection of G207 or PVSRIPO. There was a significant inverse correlation between expression of...
Source: Translational Oncology - January 6, 2024 Category: Cancer & Oncology Authors: Eric M Thompson Kyung-Don Kang Kevin Stevenson Hengshan Zhang Matthias Gromeier David Ashley Michael Brown Gregory K Friedman Source Type: research
A comprehensive radiopathological nomogram for the prediction of pathological staging in gastric cancer using CT-derived and WSI-based features
CONCLUSION: This study presents a cutting-edge radiopathomics nomogram model designed to predict pathological staging in gastric cancer, distinguishing between stages I-II and stage III. Our research leverages preoperative CT images and histopathological slides to forecast gastric cancer staging accurately, potentially facilitating the estimation of staging before radical gastric cancer surgery in the future.PMID:38141376 | DOI:10.1016/j.tranon.2023.101864 (Source: Translational Oncology)
Source: Translational Oncology - December 23, 2023 Category: Cancer & Oncology Authors: Yang Tan Li-Juan Feng Ying-He Huang Jia-Wen Xue Li-Ling Long Zhen-Bo Feng Source Type: research
Anoikis-related gene CDKN2A predicts prognosis and immune response and mediates proliferation and migration in thyroid carcinoma
This study aimed to investigate the prognosis and immune correlations of anoikis in THCA. Our study used several bioinformatics algorithms (co-expression analysis, univariate and multivariate Cox analysis) to screen anoikis-related genes (ARGs) to construct risk models. Through receiver operating characteristic (ROC) curve, nomogram, and independent prognostic analysis found that the constructed model had ideal predictive value for THCA. The consensus clustering method was used to divide ARG patterns into three subgroups, and there were significant differences in survival among the three subgroups. The CIBERSORT algorithm ...
Source: Translational Oncology - December 23, 2023 Category: Cancer & Oncology Authors: Mengjie Tang Wen Luo Yusong Zhou Zhun Zhang Zhongjun Jiang Source Type: research
Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis
CONCLUSIONS: miR-922/DEC2 axis was necessary to hypoxia-induced cell dormancy and played an important role in the lipid metabolism reprogramming of SACC.PMID:38141378 | PMC:PMC10751830 | DOI:10.1016/j.tranon.2023.101868 (Source: Translational Oncology)
Source: Translational Oncology - December 23, 2023 Category: Cancer & Oncology Authors: Li Dai Hongchun Xian Haofan Wang Mao Li Mei Zhang Xin-Hua Liang Ya-Ling Tang Source Type: research
A comprehensive radiopathological nomogram for the prediction of pathological staging in gastric cancer using CT-derived and WSI-based features
CONCLUSION: This study presents a cutting-edge radiopathomics nomogram model designed to predict pathological staging in gastric cancer, distinguishing between stages I-II and stage III. Our research leverages preoperative CT images and histopathological slides to forecast gastric cancer staging accurately, potentially facilitating the estimation of staging before radical gastric cancer surgery in the future.PMID:38141376 | DOI:10.1016/j.tranon.2023.101864 (Source: Translational Oncology)
Source: Translational Oncology - December 23, 2023 Category: Cancer & Oncology Authors: Yang Tan Li-Juan Feng Ying-He Huang Jia-Wen Xue Li-Ling Long Zhen-Bo Feng Source Type: research
Anoikis-related gene CDKN2A predicts prognosis and immune response and mediates proliferation and migration in thyroid carcinoma
This study aimed to investigate the prognosis and immune correlations of anoikis in THCA. Our study used several bioinformatics algorithms (co-expression analysis, univariate and multivariate Cox analysis) to screen anoikis-related genes (ARGs) to construct risk models. Through receiver operating characteristic (ROC) curve, nomogram, and independent prognostic analysis found that the constructed model had ideal predictive value for THCA. The consensus clustering method was used to divide ARG patterns into three subgroups, and there were significant differences in survival among the three subgroups. The CIBERSORT algorithm ...
Source: Translational Oncology - December 23, 2023 Category: Cancer & Oncology Authors: Mengjie Tang Wen Luo Yusong Zhou Zhun Zhang Zhongjun Jiang Source Type: research
Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis
CONCLUSIONS: miR-922/DEC2 axis was necessary to hypoxia-induced cell dormancy and played an important role in the lipid metabolism reprogramming of SACC.PMID:38141378 | PMC:PMC10751830 | DOI:10.1016/j.tranon.2023.101868 (Source: Translational Oncology)
Source: Translational Oncology - December 23, 2023 Category: Cancer & Oncology Authors: Li Dai Hongchun Xian Haofan Wang Mao Li Mei Zhang Xin-Hua Liang Ya-Ling Tang Source Type: research
