Comprehensive genomic and clinical analyses identify APOBEC mutational signatures as a brain metastasis risk factor in lung adenocarcinoma patients
CONCLUSION: APOBEC mutational signatures related to upregulated TGFβ and EMT, could serve as an independent risk factor for BM and BM-free survival in metastatic lung adenocarcinoma patients. Further investigations are warranted to tailor personalized treatments to improve the susceptible patient's outcomes.PMID:38402722 | DOI:10.1016/j.tranon.2024.101921
Source: Translational Oncology - Category: Cancer & Oncology Authors: Qiang Li Meng Jiang Shiqiang Hong Jing Yang Xiaoying Wu Jiaohui Pang Yedan Chen Xiaotian Zhao Xiao Ding Source Type: research
More News: Adenocarcinoma | Brain | Brain Cancers | Cancer & Oncology | Genetics | Men | MRI Scan | Neurology