A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma

In conclusion, this study highlights a novel co-targeting strategy using miR-105-5p mimics, MALAT-1, CCAT-1 and H19 siRNAs to efficiently hampers the immune checkpoints; PD-L1/PD-1 and CD155/TIGIT immune evasion properties in HCC.PMID:38631259 | DOI:10.1016/j.tranon.2024.101961

Source: Translational Oncology - April 17, 2024 Category: Cancer & Oncology Authors: Reem A Assal Noha M Elemam Radwa Y Mekky Abdelrahman A Attia Aya Hesham Soliman Asmaa Ibrahim Gomaa Eleni K Efthimiadou Maria Braoudaki Sherif Ashraf Fahmy Rana A Youness Source Type: research