Distinctive mesenchymal-like neurofibroma stem cells shape NF1 clinical phenotypes controlled by BDNF microenvironment

CONCLUSIONS: We demonstrated that BDNF can modulate MNSCs and thereby controlling different tumor phenotypes between the head and trunk regions. Application of BDNF neutralizing antibodies may inhibit p38 MAPK pathway, therefore providing a promising strategy for managing NF1.PMID:38042136 | DOI:10.1016/j.tranon.2023.101852

Source: Translational Oncology - December 2, 2023 Category: Cancer & Oncology Authors: Jingcun Shi Zihui Yang Yuhan Zhang Ahmed Abdelrehem Ziqian Wu Bingqing Zhang Meng Xiao Shijian Zhang Zhen Zhang Lei Wang Source Type: research