Pancreatobiliary reflux increases macrophage-secreted IL-8 and activates the PI3K/NF κB pathway to promote cholangiocarcinoma progression

CONCLUSIONS: PBR is one of the primary causes of biliary disease. IL-8 secreted by macrophages or bile duct epithelial cells stimulated by high-amylase bile promotes cholangiocarcinoma progression.PMID:38653100 | DOI:10.1016/j.tranon.2024.101967

Source: Translational Oncology - April 23, 2024 Category: Cancer & Oncology Authors: Tingting Wu Ruiqian Gao Xiaowei Wang Dong Guo Yuwei Xie Bingzi Dong Xiwei Hao Chengzhan Zhu Source Type: research