The Potential Association of TFR1/SLC11A2/GPX4 with Ferroptosis in Mediating Lipid Metabolism Disorders in Atherosclerosis

CONCLUSION: Ferroptosis exacerbated the lipid metabolism disorder in atherosclerotic mice. The core mechanism of its effect is that ferroptosis activates the TFR1/SLC11A2/GPX4 signaling pathway, which leads to the up-regulation of oxidative stress in ApoE-/- mice, and ultimately aggravates the abnormal lipid metabolism in ApoE-/- mice.PMID:38213145 | DOI:10.2174/0113862073271348231213071225

Source: Combinatorial Chemistry and High Throughput Screening - January 12, 2024 Category: Chemistry Authors: Yuan Cao Nan Song Ying Wang Xue Leng Qun Wang Yixin Ma Si Chen Xing Ju Lianqun Jia Source Type: research