Inhibition of Taurine-upregulated Gene 1 Upregulates MiR-34a-5p to Protect against Myocardial Ischemia/Reperfusion via Autophagy Regulation
CONCLUSION: These findings indicated that inhibiting TUG1 may reduce the extent of myocardial I/R injury by regulating miR-34a-5p. Taken together, these results suggest that LncRNA TUG1 may represent a novel therapeutic target for myocardial I/R injury.PMID:38299288 | DOI:10.2174/0113862073267559231106074309 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Qunjun Duan Aiqiang Dong Haifeng Cheng Shufen Zhang Wei Chen Weijun Yang Source Type: research

Network Pharmacology and Experimental Validation to Elucidate the Pharmacological Mechanisms of Luteolin Against Chondrocyte Senescence
CONCLUSION: In summary, luteolin demonstrated beneficial properties against aging and degeneration in EPCs, offering novel insights to mitigate the progression of intervertebral disc degeneration (IVDD).PMID:38299289 | DOI:10.2174/0113862073273675231114112804 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Ling Long Xiaokai Tang Yi Wang Jiaxiang Gu Jiachao Xiong Hao Luo Hao Lv Faxin Zhou Kai Cao Sijian Lin Source Type: research

Identification of Novel Hub Genes Associated with Inflammation and Autophagy in Astragaloside Membranaceus ameliorates Lupus Nephritis by Bioinformatics Analysis and Molecular Dynamics Simulation
CONCLUSION: IL-1β, CASP3, STAT1, and PPARγ could be potential biomarkers and therapeutic targets in AM ameliorates LN.PMID:38299290 | DOI:10.2174/0113862073255980231113071412 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Kaili Kong Xiaomei Qiao Ting Liu Xiaoxia Wang Rui Li Jingai Fang Xiaodong Zhang Source Type: research

GATA6 Suppresses Lung Adenocarcinoma Progression by Activating CFTR to Modulate Arachidonic Acid Metabolism
CONCLUSION: The activation of CFTR by GATA6 hampered LUAD progression by modulating the AA metabolism pathway, suggesting that GATA6/CFTR axis might be a therapeutic target for LUAD patients.PMID:38299406 | DOI:10.2174/0113862073269158240122072743 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Yong Lin Yushan Chen Yi Zhang Jianming Weng Rongqiang Shen Wenshan Zhang Yulin Lin Source Type: research

Investigating the Effect of Vitamin a on Orthodontic Tooth Movement: An Experimental Study
CONCLUSION: Despite the known effects of vitamin A on bone metabolism, the results of this study suggest that vitamin A did not increase alveolar bone remodeling and orthodontic tooth movement in male rats.PMID:38299407 | DOI:10.2174/0113862073273572240115105350 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Pengxiang Shi Jing Zhao Feng Wang Source Type: research

Prediction of Anti-rheumatoid Arthritis Natural Products of Xanthocerais Lignum Based on LC-MS and Artificial Intelligence
CONCLUSION: In this study, we utilized AI technology to learn from a large number of compounds and predict the activity of natural products from Xanthocerais lignum on specific targets. By combining AI technology and the LC-MS approach, rapid screening and prediction of the activity of natural products based on specific targets can be achieved, significantly enhancing the efficiency of discovering new bioactive molecules from medicinal plants.PMID:38299408 | DOI:10.2174/0113862073282138240116112348 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 1, 2024 Category: Chemistry Authors: Hao Qian Zhibing Xiao Lei Su Yaqiong Yang XiangYang Tian Xiaoqin Wang Source Type: research

Clinical and Animal Studies of Waist and Knee Scraping Therapy for Knee Osteoarthritis
CONCLUSION: Scraping therapy can significantly alleviate knee joint pain and stiffness, improve joint function, and improve clinical efficacy, and the short-term and long-term effects of waist and knee scraping therapy are more significant. The scraping therapy has a definite therapeutic effect on KOA rats, which can improve the threshold of cold hyperalgesia and mechanical hyperalgesia, and the waist and knee scraping therapy is more obvious. This may be related to reducing inflammatory reactions in synovial and ganglion tissues.CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR230070623.PMID:38284729 | DOI:10.2174/01138620732643...
Source: Combinatorial Chemistry and High Throughput Screening - January 29, 2024 Category: Chemistry Authors: Qianhong Jin Mingrui Chen Jing Kong Dandan Chen Xuan Wu Xiaoqing Shi Lishi Jie Likai Yu Sha Li Zhengxiang Dai Source Type: research

The Role of Zuo Jin Wan in Modulating the Tumor Microenvironment of Colorectal Cancer
CONCLUSIONS: ZJW regulates a range of cells in the CRC microenvironment, including malignant CRC, immune cells, and stromal cells. In CRC cell lines, downregulation of TIMP1 and MTDH by ZJW may play an important role in the immunomodulation in CRC.PMID:38284730 | DOI:10.2174/0113862073281374231228041841 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 29, 2024 Category: Chemistry Authors: Jiajia Wang Dongming Hua Mengyao Li Ningning Liu Yingru Zhang Yiyang Zhao Shasha Jiang Xueqing Hu Yan Wang Huirong Zhu Source Type: research

Application of Carbon-based Nano Adsorbents in the Extraction of Amphetamines from Urine Samples
Comb Chem High Throughput Screen. 2024 Jan 25. doi: 10.2174/0113862073279265231222060539. Online ahead of print.ABSTRACTAmphetamines, as psychoactive drugs, are extensively abused in society and cause serious mental and physical disorders among young people. Furthermore, the extremely euphoric and excited sense of stimulant consumption leads to dramatic social problems. Determination of various analytes and related metabolites in the complex biological matrices at trace levels has made sample preparation an indispensable part of forensic sciences. According to the problems above, providing high sensitivity, solving some an...
Source: Combinatorial Chemistry and High Throughput Screening - January 27, 2024 Category: Chemistry Authors: Arezou Taghvimi Siavoush Dastmalchi Samin Hamidi Sevinc Kurbanoglu Anis Khoshkbar Sadigh Yousef Javadzadeh Source Type: research

Magnetic Nanomaterials for Sample Preparation of Disease-related Biomarkers
Comb Chem High Throughput Screen. 2024 Jan 25. doi: 10.2174/0113862073278749231220074740. Online ahead of print.ABSTRACTMeasuring clinically relevant biomarkers is critical for disease screening, diagnosis, and therapeutic monitoring. However, analyzing trace biomarkers in complex biological fluids remains challenging. Magnetic solid phase extraction (MSPE) has recently emerged as a promising sample preparation approach due to its simplicity, efficiency, and ability to selectively isolate biomarkers. Databases, including PubMed, Web of Science, and Scopus, were systematically searched for studies on MSPE for clinical bioma...
Source: Combinatorial Chemistry and High Throughput Screening - January 27, 2024 Category: Chemistry Authors: Samin Hamidi Mohammadreza Siahi-Shadbad Arezou Taghvimi Sevinc Kurbanoglu Source Type: research

Guidelines for the Diagnosis and Treatment of Rotator Cuff Tear with Integrated Traditional Chinese and Western Medicine
Comb Chem High Throughput Screen. 2024 Jan 25. doi: 10.2174/0113862073276030231219115111. Online ahead of print.ABSTRACTRotator cuff tear is one of the common diseases among middle-aged and elderly people, which has a great impact on patients' physical and mental health and quality of life. The integrative medicine based on traditional Chinese medicine has certain characteristics and advantages in the diagnosis and treatment of Rotator cuff tear. Chinese medicine, which mainly focus on plant-based natural products, has a relatively stable and reliable curative effect. It is of great significance to formulate the combined d...
Source: Combinatorial Chemistry and High Throughput Screening - January 27, 2024 Category: Chemistry Authors: Ling-Feng Zeng Xian-Quan Zhang Wei-Yi Yang Jun Liu Source Type: research

Electrochemical Sensors for Detection of Phytomolecules: A Mechanistic Approach
This article reviews the electrochemical basis of plants, contrasting it with more conventional techniques and offering both positive and negative perspectives on the topic. Because few studies have been devoted to the concept of merging the domains, we've expanded the scope of this work by including pertinent non-phytochemical reports for better report comparison.PMID:38279749 | DOI:10.2174/0113862073282883231218145941 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 27, 2024 Category: Chemistry Authors: Deepti Katiyar None Manish Rashmi Saxena Pal Priya Bansal Abhishek Kumar Surya Prakash Source Type: research

Fructus mori: An Updated Review on Botany, Phytonutrient, Detection, Bioactivity, Quality Marker, and Application
CONCLUSIONS: This review made a comprehensive description of F. mori, including botany, phytonutrient, detection, bioactivity, quality marker, and application. It will not only provide some important clues for further studying F. mori, but also provide some valuable suggestions for indepth research and development of F. mori.PMID:38279750 | DOI:10.2174/0113862073270666231206093528 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 27, 2024 Category: Chemistry Authors: Ling-Na Li Source Type: research

Recent Advances in Electrochemical Biosensors Targeting Stress Markers
CONCLUSION: This biomarker sensor strategy can analyze various biofluids (sweat, plasma, urine, and saliva).PMID:38279751 | DOI:10.2174/0113862073278547231210170007 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 27, 2024 Category: Chemistry Authors: Deepti Katiyar None Manish Source Type: research

Association between Postmenopausal Osteoporosis and IL-6 、TNF-α: A Systematic Review and A Meta-analysis
CONCLUSIONS: The levels of inflammatory cytokines IL-6 and TNF-α were significantly increased in PMOP patients compared with controls, suggesting that persistent chronic inflammatory reaction exists in PMOP patients, which may be an important cause of aggravated osteoporosis in postmenopausal women. Therefore, the level of IL-6 and TNF-α indexes may be of great significance for the early prevention, diagnosis, treatment and prognosis assessment of PMOP.PMID:38275059 | DOI:10.2174/0113862073262645231121025911 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - January 26, 2024 Category: Chemistry Authors: Xudong Huang Baihe Ni Qi Li Meichen Liu Minghua Zhao Yanqi Zhang Xiaolin Shi Weiguo Wang Source Type: research