Combinatorial Chemistry and High Throughput Screening This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Exploring the Potential Mechanisms of Action of Gentiana Veitchiorum Hemsl. Extract in the Treatment of Cholestasis using UPLC-MS/MS, Systematic Network Pharmacology, and Molecular Docking
CONCLUSIONS: In this study, UPLC-MS/MS analysis, network pharmacology, and experiment validation were used to explore potential mechanisms of action of GV in the treatment of cholestasis.PMID:38357941 | DOI:10.2174/0113862073275657231210055250 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 15, 2024 Category: Chemistry Authors: Yue Wang Nixia Tan Rong Su Zhenhua Liu Qi Dong Na Hu Source Type: research

Observation of the Short-term Efficacy of Technetium-99 Conjugated with Methylene Diphosphonate Combined Therapy in the Treatment of Postmenopausal Osteoporosis
CONCLUSION: Yunke combined therapy can effectively relieve the pain symptoms, increase BMD, and reduce the risk of fracture in patients with PMOP in a short period, which is an effective method for the treatment of PMOP.PMID:38357942 | DOI:10.2174/0113862073266467231228124942 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 15, 2024 Category: Chemistry Authors: Wen Sun Quan Xie Juan-Juan Yan Ying Huang Ying Zhou Chao-Qun Wang Huan Xiao Source Type: research

A Six-gene Prognostic Model Based on Neutrophil Extracellular Traps (NETs)-related Gene Signature for Lung Adenocarcinoma
CONCLUSION: Altogether, this study has identified a novel NET-score signature based on six novel NET-related genes to predict the prognosis of LUAD and ABCC2 and has also explored a new method for personalized chemo-/immuno-therapy of LUAD.PMID:38357943 | DOI:10.2174/0113862073282003240119064337 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 15, 2024 Category: Chemistry Authors: Guiyan Mo Xuan Long Limin Cao Yuling Tang Yusheng Yan Ting Guo Source Type: research

Phage Therapy in Bacterial Pneumonia Models: A Systematic Review and Meta-Analysis
CONCLUSION: There was a significant role of phage therapy in the reduction of deaths in the bacterial pneumonia models.PMID:38357944 | DOI:10.2174/0113862073267755240126111628 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 15, 2024 Category: Chemistry Authors: Mohammad Akhlaquer Rahman Kapil Kumar Verma Mahesh Kumar Posa Source Type: research

A Novel KIF4A-Related Model for Predicting Immunotherapy Response and Prognosis in Kidney Renal Clear Cell Carcinoma
CONCLUSION: We identified four KIF4A-related biomarkers that hold potential for prognostic assessment in KIRC. Specifically, early implementation of immunotherapy targeting these biomarkers may yield improved outcomes for patients with KIRC.PMID:38357945 | DOI:10.2174/0113862073296897240212114403 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 15, 2024 Category: Chemistry Authors: Guang Hua Yang Xu Dong Ma Xi Feng Wei Ran Lu Liu Chao Wang Source Type: research

Construction and Application of a Traditional Chinese Medicine Syndrome Differentiation Model for Dysmenorrhea Based on Machine Learning
CONCLUSION: The study paves the way for a synergistic approach in TCM diagnostics, merging ancient wisdom with computational acuity, potentially innovating the diagnosis and treatment mode of TCM. Despite the promising outcomes, further research is needed to validate these models in real-world settings and extend this approach to other diseases addressed by TCM.PMID:38351686 | DOI:10.2174/0113862073293191240212091028 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 14, 2024 Category: Chemistry Authors: Limin Zhang Jianing You Yiqing Huang Ruiqi Jing Yifei He Yujie Wen Lulu Zheng Yong Zhao Source Type: research

Prognosis and clinical significance of Piezo2 in tumor: a meta-analysis and database validation
CONCLUSION: Piezo2 may be associated with poor prognosis and clinicopathological parameters in tumor patients.PMID:38347800 | DOI:10.2174/0113862073251440231025111358 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 13, 2024 Category: Chemistry Authors: Tong Liang Junhong Wang Chenglou Zhu Yongli Hu Zhenhua Gao Mingxu Da Source Type: research

Matrine: A Promising Treatment for Ulcerative Colitis by Targeting the HMGB1/NLRP3/Caspase-1 Pathway
CONCLUSION: MAT could significantly alleviate DSS-induced UC symptoms by reducing the expressions of pro-inflammatory cytokines, such as IL-1β, TNF-α, and IL-6, the mechanism of which is related to the inhibition of HMGB1/NLRP3/Caspase-1 signaling pathway.PMID:38347801 | DOI:10.2174/0113862073292384240209095838 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 13, 2024 Category: Chemistry Authors: Kexin Sun Weiye Lin Qianran Hong Shuangyu Chen Jiayang Li Shengliang Qiu Source Type: research

Research Progress of TCM Therapy for Rotator Cuff Injury
Comb Chem High Throughput Screen. 2024 Feb 2. doi: 10.2174/0113862073264977240103070432. Online ahead of print.ABSTRACTRotator cuff injury is a common orthopedic disease with high morbidity, which is one of the most important reasons for shoulder pain and limited movement. With the development of more research, the Traditional Chinese Medicine (TCM) therapy for rotator cuff injury is increasingly rich and has achieved a good curative effect. TCM has certain characteristics and advantages, which may become the main development trend of the treatment. By consulting the relevant literature on TCM therapy for rotator cuff inju...
Source: Combinatorial Chemistry and High Throughput Screening - February 6, 2024 Category: Chemistry Authors: Xianquan Zhang Guanghui Zhou Zhuoxu Gu Minghui Luo Guihong Liang Source Type: research

Potential Antidiabetic Activity of β-sitosterol from Zingiber roseum Rosc. via Modulation of Peroxisome Proliferator-activated Receptor Gamma (PPARγ)
CONCLUSION: It can be concluded that β-sitosterol from Z. roseum attenuates Type-II diabetes by modulating PPARγ activity.PMID:38305397 | DOI:10.2174/0113862073260323231120134826 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - February 2, 2024 Category: Chemistry Authors: Muhammed Amanat A F M Shahid Ud Daula Randhir Singh Source Type: research