Combinatorial Chemistry and High Throughput Screening This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Proteomic Analysis Based on TMT Regarding the Therapeutic Action of Rhizoma Drynariae on Rats in an Osteoporosis Model
CONCLUSIONS: We used TMT-based proteomics to analyze the positive effects of TCM Drynaria rhizome, which can regulate related proteins through the unique roles of multiple mechanisms, targets, and pathways. This treatment approach can regulate oxidative stress, improve lipid metabolism, reduce the inflammatory response mechanism, and improve bone density. These benefits highlight the unique advantages of TCM in the treatment of primary osteoporosis.PMID:38099525 | DOI:10.2174/0113862073261905231110061401 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - December 15, 2023 Category: Chemistry Authors: Hui Su Binghan Yan Ruochong Wang Zhichao Li Zhanwang Xu Haipeng Xue Guoqing Tan Source Type: research

Chemical Probes Review: Choosing the Right Path Towards Pharmacological Targets in Drug Discovery, Challenges and Future Perspectives
Comb Chem High Throughput Screen. 2023 Dec 11. doi: 10.2174/0113862073283304231118155730. Online ahead of print.ABSTRACTChemical probes are essential for academic research and target validation for disease identification. They facilitate drug discovery, target function investigation, and translation studies. A chemical probe provides starting material that can accelerate therapeutic values and safety measures for identifying any biological target in drug discovery. Essential read outs depend on their versatility in biochemical testing, proving the hypothesis, selectivity, specificity, affinity towards the target site, and ...
Source: Combinatorial Chemistry and High Throughput Screening - December 12, 2023 Category: Chemistry Authors: Ashima Ahuja Sonia Singh Yogesh Murti Source Type: research

FTIR, 1H, and 13C NMR Characterization and Antibacterial Activity of the Combination of Euphorbia Honey and Potato Starch
CONCLUSION: These results suggest that EH-PS has potential as an alternative candidate to conventional antibiotics.PMID:38031781 | DOI:10.2174/0113862073243939231031064916 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Moussa Ahmed Mokhtar Amirat Source Type: research

Computational Approaches: A New Frontier in Cancer Research
Comb Chem High Throughput Screen. 2023 Nov 28. doi: 10.2174/0113862073265604231106112203. Online ahead of print.ABSTRACTCancer is a broad category of disease that can start in virtually any organ or tissue of the body when aberrant cells assault surrounding organs and proliferate uncontrollably. According to the most recent statistics, cancer will be the cause of 10 million deaths worldwide in 2020, accounting for one death out of every six worldwide. The typical approach used in anti-cancer research is highly time-consuming and expensive, and the outcomes are not particularly encouraging. Computational techniques have bee...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Shubham Srivastava Pushpendra Jain Source Type: research

Effectiveness of Chinese Herbal Medicine in Postoperative Fatigue Syndrome Following Total Joint Arthroplasty or Hip Fracture Surgery: Evidence from Randomized Controlled Trials
CONCLUSION: The application of CHM improved the fatigue status of POFS patients after TJA or HFS and increased the levels of transferrin and IgG in serum, which is conducive to promoting the postoperative rehabilitation process of patients. The subgroup analysis results showed that the application of CHM to intervene in POFS in HFS patients had obvious benefits.PMID:38031783 | DOI:10.2174/0113862073258802231107060433 (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Jinlong Zhao Guanghui Zhou Zhongsheng Wang Guihong Liang Xingde Wei Bangxin Sha Weiyi Yang Jun Liu Hongyun Chen Source Type: research

Current Perspectives of Immunotherapy for Hepatocellular Carcinoma
Comb Chem High Throughput Screen. 2023 Nov 29. doi: 10.2174/0113862073255266231025111125. Online ahead of print.ABSTRACTHepatocellular carcinoma is the sixth most common tumor and the third leading cause of cancer death worldwide. It ranks fourth in the spectrum of malignant tumor incidence and second in the order of death from major malignant tumors in China. Hepatocellular carcinoma is a complex ecosystem containing non-tumor cells (mainly immune-related cells), and its immunotherapy can stimulate the recognition of specific tumor antigens, inhibit the proliferation of cancer cells, and produce over-memory lymphocytes, w...
Source: Combinatorial Chemistry and High Throughput Screening - November 30, 2023 Category: Chemistry Authors: Xiaoyi Liu Xiaoyong Lei Sheng Huang Xiaoyan Yang Source Type: research