In vivo Study of a Newly Synthesized Chromen-4-one Derivative as an Antitumor Agent against HCC
ConclusionThe ability of the new Ch derivative to control the primary initiators of HCC such as TNF- α offers this derivative an anti-tumor activity and encourages further researches to follow and monitor its effect on the molecular level.Graphical Abstract (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 26, 2021 Category: Cancer & Oncology Source Type: research

Cost-Effectiveness of Screening Helicobacter pylori for Gastric Cancer Prevention: a Systematic Review
In this study, when screening techniques were compared to no-screening, serology screening techniques showed to be cost-effective. The lowest ICER calculated was US$$1230 cost per life-year gained (LYG) and US$1500 cost per quality-adjusted life-year (QALY). However, determining the optimal strategy compared to other strategies was depended on parameters such as context-specific, type of cost, threshold, and perspective, and also, it influenced by the framework of the cost-effectiveness analysis. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 25, 2021 Category: Cancer & Oncology Source Type: research

Association of Interleukin-10 Polymorphisms with Susceptibility to Colorectal Cancer and Gastric Cancer: an Updated Meta-analysis Based on 106 Studies
ConclusionsOur pooled data show a significant association of IL-10-819  T/C and IL-10-1082A/G polymorphisms with CRC and GC in overall population, respectively. However, other factors may influence these associations, and large-scale studies with adequate methodological quality are necessary to confirm the impact on CRC and GC risk. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 25, 2021 Category: Cancer & Oncology Source Type: research

Squamous Cell Carcinoma Arising from Perianal Buschke-Lowenstein Tumor (Giant Condyloma Acuminatum): Comprehensive Literature Review
ConclusionGiant condyloma acuminatum is a rare variant of anogenital warts. It is known that this tumor, which is mostly thought to be benign, has a high potential for local recurrence and transformation into invasive cancer. Therefore, it is vital that the tumor is resected with clean surgical margins, even if it looks benign, and that aggressive treatment options are not avoided when necessary. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 25, 2021 Category: Cancer & Oncology Source Type: research

Effect of Pressurized Intraperitoneal Aerosol Chemotherapy on the Survival Rate of Patients with Peritoneal Carcinomatosis of Gastric Origin
AbstractIntroductionPressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new surgical technique for the treatment of initially unresectable peritoneal carcinomatosis (PC). Our objective was to compare the results of PIPAC associated with systemic chemotherapy (PIPAC_CHEM) with those of systemic chemotherapy alone (ONLY_CHEM) in patients with gastric PC without metastasis other than peritoneal, and the WHO performance status  
Source: Journal of Gastrointestinal Cancer - October 22, 2021 Category: Cancer & Oncology Source Type: research

Significance of microRNA-330-5p/TYMS Expression Axis in the Pathogenesis of Colorectal Tumorigenesis
ConclusionThe microRNA-330 inhibited cell proliferation by suppressing thymidylate synthase (TYMS) in colorectal cancer. Therefore, suggesting that they are valuable factors for further studies of alternative treatment and diagnostic methods. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 14, 2021 Category: Cancer & Oncology Source Type: research

Pancreaticobiliary Malignancies in the Emergency Room: Management of Acute Complications and Oncological Emergencies
ConclusionPatients with PB malignancies are at increased risk of a wide variation of medical emergencies. Clinical knowledge, early recognition and collaboration with the relevant specialties are critical to manage these complications effectively, tailoring overall management around the actual prognosis and individuals ’ expectations. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 14, 2021 Category: Cancer & Oncology Source Type: research

A Resected Primary Angiosarcoma of the Pancreas Presenting Aggressive Metastatic Liver Recurrence with Uncontrollable Intra-abdominal Bleeding: a Case Report
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 14, 2021 Category: Cancer & Oncology Source Type: research

Hepatocellular Carcinoma Tumor Microenvironment and Its Implications in Terms of Anti-tumor Immunity: Future Perspectives for New Therapeutics
ConclusionThere are intricate mechanisms that drive hepatocarcinogenesis. The tumor microenvironment is at the center of all the complex and diverse mechanisms. Effective and multistep immunotherapies should be developed to target different components of the tumor microenvironment. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 8, 2021 Category: Cancer & Oncology Source Type: research

Systematic Review and Meta-analysis of the Most Common Genetic Mutations in Esophageal Squamous Cell Carcinoma
ConclusionThis systematic review and meta-analysis revealed that more than 10% of ESCC patients had changes in TP53, CCND1, MDM2, NOTCH1/2/3, KMT2D, CDKN2A, PIK3CA, and FAT1 genes, which can highlight their role in developing ESCC. TP53, CCND1, and MDM2 are the most prevalent, demonstrating 68.6%, 39.3%, and 24.9% of the mutations in ESCC patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 6, 2021 Category: Cancer & Oncology Source Type: research

Hepatitis B/D-Related Hepatocellular Carcinoma. A Clinical Literature Review
ConclusionOwing to the dependence of HDV on HBV, it is not clear whether HCC is a consequence of the cumulative effect of both HBV and HDV, an effect of the underlying cirrhosis, or a direct oncogenic effect of HDV. Many questions concerning the oncogenic role of HDV remain unanswered. To better understand the role of HDV in carcinogenesis, studies at the molecular level that consider genotype differences should be increased. Multicenter, high-volume, and prospective studies that compare HBV/HDV co-infected and HBV-infected individuals will be pivotal in determining the oncogenic role of HDV. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 6, 2021 Category: Cancer & Oncology Source Type: research

The Importance of the Immunosuppressive Regime on Hepatocellular Carcinoma Recurrence After Liver Transplantation
ConclusionThere is a need for well-designed, randomized, controlled clinical studies with larger numbers of patients on this subject. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 6, 2021 Category: Cancer & Oncology Source Type: research

Relationships Between Indices of Tumor Aggressiveness in Hepatocellular Carcinoma
ConclusionsMultifocality and PVT appear to be separate processes, each increasing with increase in MTD and AFP levels. The data support the hypothesis that in hepatocarcinogenesis, various factors cause increase in MTD, that in turn causes increased multifocality and PVT, which are non-co-dependent. However, both multifocality and PVT mechanisms involve both HCC cell growth and invasiveness, multifocality in liver parenchyma, and PVT in the portal vein. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 6, 2021 Category: Cancer & Oncology Source Type: research

Concomittant Liver Transplantation and Low Anterior Resection in Patient with Neuroendocrine Tumor and Chronic Hepatitis B Infection
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 6, 2021 Category: Cancer & Oncology Source Type: research

Survival Outcomes Among Pancreatic Cancer Patients at Kenyatta National Hospital
ConclusionThe mortality rate of pancreatic cancer in the present study was 20%. The overall mean survival estimate for pancreatic cancer was 48.7  ± 9.7 months, and the majority had disease progression in the last follow-up period. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 3, 2021 Category: Cancer & Oncology Source Type: research

Cupping Therapy as an Anti-inflammation Therapy and Immunomodulator in Cancer Patients
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 1, 2021 Category: Cancer & Oncology Source Type: research

Role of Sarcopenia in Predicting the Postoperative Morbidity and Perioperative Mortality in Patients Undergoing Elective Surgery for Gastric Cancer
This study was done to assess the effect of sarcopenia and other risk factors on the postoperative morbidity and perioperative mortality of patients undergoing elective surgery for gastric cancer.MethodsThis was a prospective cohort study comprising a single group of patients undergoing elective surgery for gastric cancer carried out in a tertiary care center in India. Patients diagnosed with gastric cancer underwent contrast-enhanced computed tomography preoperatively. Patients were considered sarcopenic when their skeletal muscle index (SMI) was  
Source: Journal of Gastrointestinal Cancer - September 24, 2021 Category: Cancer & Oncology Source Type: research

Virtual Biopsy by Electrical Impedance Spectroscopy in Barrett ’s Carcinoma
ConclusionIn summary, EIS was able to distinguish different tissue characteristics in the different esophageal tissues. EIS thus holds potential for further development of targeted biopsies during surveillance endoscopy.Trial RegistrationNCT04046601 (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 24, 2021 Category: Cancer & Oncology Source Type: research

Phase II Prospective Study of Trastuzumab in Combination with S-1 and Oxaliplatin (SOX100) Therapy for HER2-Positive Advanced Gastric Cancer
ConclusionSOX100 combined with trastuzumab was effective with a favorable safety profile in patients with HER2-positive AGC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 22, 2021 Category: Cancer & Oncology Source Type: research

Hepatocellular Carcinoma (HCC) in North-Western India: A Retrospective Study Focusing on Epidemiology, Risk Factors, and Survival
ConclusionMultifocality was independent predicator for poor survival in HCC. Further clinical studies are necessary to improve the outcomes of patients with high risk features. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 22, 2021 Category: Cancer & Oncology Source Type: research

Author Correction: A Case Study on Modeling the Time to Recurrence of Gastric Cancer Patients
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 21, 2021 Category: Cancer & Oncology Source Type: research

Management and Survival Analysis of Gastrointestinal Neuroendocrine Tumors by Different Tumor Characteristics: Tertiary Center Experience
ConclusionsThe tumor grade and the presence of metastasis in gastrointestinal neuroendocrine tumors were found to be the most important prognostic factors affecting overall survival. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 15, 2021 Category: Cancer & Oncology Source Type: research

The Impact of the COVID-19 Epidemic on Diagnosis, Treatment, Concerns, Problems, and Mental Health in Patients with Gastric Cancer
ConclusionConsidering the effects of COVID-19 epidemic on gastric cancer and on the other hand, the continuation of the epidemic in the society, it is necessary for the officials and experts of the health system to design and implement necessary interventions to minimize the negative effects of epidemic on patients with gastric cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 14, 2021 Category: Cancer & Oncology Source Type: research

The Glasgow Prognostic Score Before Curative Resection May Predict Postoperative Complications in Patients with Gastric Cancer
ConclusionThe preoperative GPS may be a useful predictive factor for postoperative complications in patients with stage II/III GC. Being aware of the risk of complications after surgery as indicated by the GPS before surgery may promote safe and minimally invasive surgery that we expect will improve outcomes in patients with a GPS of 1 or 2. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 14, 2021 Category: Cancer & Oncology Source Type: research

Epidemiologic and Pathologic Study of Pancreatic Cancer in Hamadan, Iran (2008 to 2018)
ConclusionPancreatic cancer has been increasing trend in terms of time. Pancreatic cancer was most common age in the sixth decade of life and is more common in men than women. The most common type of pancreatic cancer was adenocarcinoma. Diagnosis usually occurs at higher stages. More preventive considerations were found to be beneficial among this population. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 12, 2021 Category: Cancer & Oncology Source Type: research

Barriers and Facilitators Associated with Delays in the Diagnosis and Treatment of Gastric Cancer: a Systematic Review
ConclusionsIt seems that to reduce delay in the diagnosis and treatment of gastric cancer, factors such as implementing screening programs using acceptable methods with high sensitivity and accuracy with a high level of participation, increasing insurance coverage and reducing the share of people in payments, increasing people ’s access to diagnostic services, educating people about the symptoms and risks of gastric cancer, undertaking proper follow-up in patients and suspects cases identified in screening, as well as increasing patients’ access to medical services through financial and insurance support are si...
Source: Journal of Gastrointestinal Cancer - September 9, 2021 Category: Cancer & Oncology Source Type: research

Hypermethylation of MIR129-2 Regulates SOX4 Transcription and Associates with Metastasis in Patients with Colorectal Cancer
ConclusionsIt seems thatMIR192-2 promoter hypermethylation might regulate the expression of SOX4 and therefore modulate metastasis in CRC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 9, 2021 Category: Cancer & Oncology Source Type: research

Mitochondrial DNA Copy Number Variations in Gastrointestinal Tract Cancers: Potential Players
AbstractAlterations of mitochondria have been linked to several cancers. Also, the mitochondrial DNA copy number (mtDNA-CN) is altered in various cancers, including gastrointestinal tract (GIT) cancers, and several research groups have investigated its potential as a cancer biomarker. However, the exact causes of mtDNA-CN variations are not yet revealed. This review discussed the conceivable players in this scheme, including reactive oxygen species (ROS), mtDNA genetic variations, DNA methylation, telomere length, autophagy, immune system activation, aging, and infections, and discussed their possible impact in the initiat...
Source: Journal of Gastrointestinal Cancer - September 6, 2021 Category: Cancer & Oncology Source Type: research

Utilization of Mutational Analysis (MA) in Gastrointestinal Stromal Tumor (GIST) Management in British Columbia (BC) Between January 2008 to December 2017: a Retrospective Population-Based Study
ConclusionMA use has remained stable for localized disease but has increased after 2015 in the metastatic setting which may be due to evolving sequencing technology, expansion of metastatic treatment options, and enhanced awareness of MA. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 6, 2021 Category: Cancer & Oncology Source Type: research

Analysis of Post-operative Adjuvant Chemotherapy Versus Adjuvant Chemoradiation Therapy Outcomes in Non-metastatic Cholangiocarcinoma: an NCDB Review
AbstractBackgroundEach year, approximately 8000 cases of cholangiocarcinoma are recorded in the USA. Surgical resection is considered to be the only curative option. Despite surgery as a curative approach, many patients will require adjuvant therapies in the form of chemotherapy (ChT) or chemoradiotherapy (CRT). As such, we sought to analyze outcomes in patients with non-metastatic cholangiocarcinoma receiving adjuvant ChT or CRT following surgical resection.MethodsWe queried the National Cancer Database (NCDB) for patients with a diagnosis of non-metastatic cholangiocarcinoma between the years 2010 and 2015 who underwent ...
Source: Journal of Gastrointestinal Cancer - September 6, 2021 Category: Cancer & Oncology Source Type: research

Pancreaticoduodenectomy: Impact of Volume on Outcomes at a Tertiary Care Center —Our Experience in Single Institute of Nepal
ConclusionThere has been a decrease in rate of all these postoperative adverse events and improvement in the intraoperative blood loss and surgical duration with advancing years and increasing number of cases. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 4, 2021 Category: Cancer & Oncology Source Type: research

Moderate Prognostic Value of lncRNA FOXD2-AS1 in Gastric Cancer with Helicobacter pylori Infection
AbstractPurposeGastric cancer (GC) is one of the most frequent tumors worldwide and identification of a sensitive and specific prognostic biomarker is of great importance. Long non-coding RNAs (lncRNAs) play crucial roles in tumorigenesis of various malignancies. In the present study, we investigated lncRNA FOXD2-AS1 expression in gastric tumors and assessed its potential as a prognostic biomarker.MethodsA total of 95 tumor and corresponding adjacent non-tumor tissue specimens were collected from patients with GC from Imam Reza hospital, Tabriz, Iran. Total RNA was isolated and FOXD2-AS1 expression was measured using quant...
Source: Journal of Gastrointestinal Cancer - September 3, 2021 Category: Cancer & Oncology Source Type: research

The Role of Tumor Necrosis Factor- α (TNF-α) Polymorphisms in Gastric Cancer: a Meta-Analysis
ConclusionsThis study suggested thatTNF- α-857 andTNF- α-1031 polymorphisms may be associated with the increased gastric cancer risk. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 3, 2021 Category: Cancer & Oncology Source Type: research

Anticancer Activity of Aqueous Fenugreek Seed Extract Against Pancreatic Cancer, Histological Evidence
ConclusionGerminated fenugreek seed extract can be used to fight pancreatic cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 1, 2021 Category: Cancer & Oncology Source Type: research

A Rare Case Report of Skin Metastasis in Gastric Cancer
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 19, 2021 Category: Cancer & Oncology Source Type: research

Primary Splenic Angiosarcoma with Liver Metastasis Caused by Malign Transformation of Hemangioma: A Case Report and Literature Review
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 19, 2021 Category: Cancer & Oncology Source Type: research

Bleeding Beyond the Line: Anorectal Melanoma as a Cause of Lower Gastrointestinal Bleeding
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 19, 2021 Category: Cancer & Oncology Source Type: research

Overall Survival of Hepatocellular Carcinoma Patients Underwent Radiofrequency Ablation (RFA) Treatment: a Retrospective Cohort Study from Two Referral Hospitals in Indonesia
ConclusionRFA still can be used as initial modality therapy nor combination with another therapy for the early and intermediate stage of HCC. BCLC staging and response after RFA had shown to be the independent factors related to survival. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 11, 2021 Category: Cancer & Oncology Source Type: research

A Case Study on Modeling the Time to Recurrence of Gastric Cancer Patients
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 11, 2021 Category: Cancer & Oncology Source Type: research

Primary ALK-Positive Large B Cell Lymphoma of Pancreas
ConclusionPresent case is the first case of ALK positive LBCL reported in pancreas. Expression of mature B-cell markers such as CD20, CD79a and light chain restriction may be seen unlike previous claims. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 10, 2021 Category: Cancer & Oncology Source Type: research

Evaluation of CRISPR/Cas9 System Effects on Knocking Out NEAT1 Gene in AGS Gastric Cancer Cell Line with Therapeutic Perspective
AbstractAimGastric cancer (GC) is one of the most common malignant tumors globally, with an increasing incidence rate. Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNAs) responsible for regulating cell cycle progression, apoptosis, cell growth, proliferation, and migration in various cells. The present survey was performed to assess the effects of NEAT1 gene knocking out by CRISPR/Cas9 system in human gastric cancer cells.MethodsThe CRISPR/Cas9 genome editing technique was used to knockout NEAT1 in AGS cells as a gastric cancer model. After the design and construction of the vector, transf...
Source: Journal of Gastrointestinal Cancer - August 6, 2021 Category: Cancer & Oncology Source Type: research

State-of-the-art Hepatocellular Carcinoma Biomarker Detection by Biosensor Technology —a Review
AbstractBiosensors have become a very interesting field in recent years, thanks to their potential to be converted into self-diagnostic technologies. Being able to analyze a biomarker with different biosensor systems has great potential. This potential is important in terms of time, cost, and practicality with its use in the analysis of difficult-to-diagnose diseases in clinical studies. In this review, the biosensors used in the determination of hepatocellular carcinoma (HCC) biomarkers were compiled. Electrochemical, optical, and piezoelectric biosensors used in the analysis of proteins, DNA, RNA, and cells with varying ...
Source: Journal of Gastrointestinal Cancer - August 4, 2021 Category: Cancer & Oncology Source Type: research

Identifying the Risk Factors for Mortality in Patients with Cancer and COVID-19 in Hamadan, the West of Iran
AbstractPurposeSince cancer patients are at higher risk of COVID-19, the present study was conducted to investigate the epidemiology of these patients and identify the affecting risk factors on their mortality.MethodsThe present retrospective cohort study was conducted on 66 hospitalized patients with cancer and COVID-19 in Hamadan in 2020. In the present study, demographic, clinical, and laboratory information and patients ’ outcome were collected through a checklist and its impact on death was assessed. Data were analyzed in SPSS-24 software and the significance level of the tests was considered at 5%.ResultsThe me...
Source: Journal of Gastrointestinal Cancer - August 4, 2021 Category: Cancer & Oncology Source Type: research

Anorectal Melanoma —Brownish Black Mass Not Always a Hemorrhoid
We report 2 cases of this rare tumor. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 4, 2021 Category: Cancer & Oncology Source Type: research

Procalcitonin and C-Reactive Protein as an Early Predictor of Infection in Elective Gastrointestinal Cancer Surgery —a Prospective Observational Study
ConclusionRaised serum PCT values on postoperative day 3 indicate the presence of infections and should prompt the surgeon to consider other investigations to confirm the presence of IAI and other postoperative infections and plan early intervention thus expediting the postoperative recovery.Clinical Trial Registration NumberCTRI/2018/12/016695 (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 30, 2021 Category: Cancer & Oncology Source Type: research

Significant Response to Camrelizumab Plus Targeted Drugs in Recurrent Intrahepatic Cholangiocarcinoma: a Case Report and Literature Review
ConclusionCombined immunotherapy and targeted therapy regimens are a promising approach for refractory intrahepatic cholangiocarcinoma. Further well-designed prospective clinical trials are needed to confirm the efficacy and safety. Since intrahepatic cholangiocarcinoma is characterized by high heterogeneity and with complex crosstalk among oncogenic pathways, further exploration is required to more deeply understand the mechanism of action of this treatment approach and guide individualized treatment selection. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 26, 2021 Category: Cancer & Oncology Source Type: research

A Case of Colonic Micropapillary Carcinoma with a High Frequency of Apoptosis
We examined the case using immunohistochemistry. In many of the tumor glands (TGs) of the MPC, empty spaces and tumor cell detachment toward the gland interior were observed. Moreover, TG ruptures were scattered, with PDCs adjacent to them. Apoptosis occurred mainly at the TG and PDC p eripheries in the middle and deep tumor layers, and transforming growth factor beta 1 (TGF-β1) positivity was evident in those tumor cells. Cells positive for apoptosis-related M30 were distributed mainly in the deep layer with a significant PDC and TB presence. However, apoptosis and M30 positivit y were low in the TBs. Non-tumorous bu...
Source: Journal of Gastrointestinal Cancer - July 24, 2021 Category: Cancer & Oncology Source Type: research

Prognostic Factors for Survival in Transverse Colon Cancers
ConclusionTCC has molecular features and prognostic factors more likely RCC and no differences between proximal and distal sub-parts. BRAF V600E mutation status is an independent predictor of survival even in the early stages of TCC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 24, 2021 Category: Cancer & Oncology Source Type: research

Combination Therapy with KRAS and P38 α siRNA Suppresses Colorectal Cancer Growth and Development in SW480 Cell Line
ConclusionThe current study showed that combination therapy with p38 α and KRAS siRNA may be considered a novel therapy for colorectal tumor in future.Graphical abstract (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 22, 2021 Category: Cancer & Oncology Source Type: research

Computed Tomographic Sarcopenia in Pancreatic Cancer: Further Utilization to Plan Patient Management
ConclusionOur study has shown that computed tomographic skeletal muscle analysis at the time of a diagnostic CT for patients with pancreatic cancer is feasible and can detect sarcopenia and malnourished patients who are much less likely to take up chemotherapy. These patients could be triaged to oncology assessment prior to EUS-B to avoid unnecessary investigations. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 22, 2021 Category: Cancer & Oncology Source Type: research