Survival Trends for Resectable Pancreatic Cancer Using a Multidisciplinary Conference: the Impact of Post-operative Chemotherapy
AbstractPurposeDespite advances in various treatment modalities, surgical resection for pancreatic ductal adenocarcinoma (PDA) remains the only curative treatment. Data remains limited regarding survival rates for resectable PDA when managed by a multidisciplinary pancreas conference (MDPC). The aim of this study is to assess survival rates, identify significant predictors of mortality, and assess the benefits of adjuvant chemotherapy for resectable PDA following presentation at a MDPC.MethodsAll patients presented from April 2013 to August 2016 with resectable PDA were discussed at a MDPC at a tertiary care center and wer...
Source: Journal of Gastrointestinal Cancer - October 12, 2019 Category: Cancer & Oncology Source Type: research

Microbiome Dysbiosis and Predominant Bacterial Species as Human Cancer Biomarkers
ConclusionAlteration in the cell cycle by means of different mechanisms such as inflammation, alteration in cell signaling, invasion and immune evasion, specific niche colonization, induction of DNA damage and mutation, expression of some microRNAs, and enhancing epigenetic effects are the most common mechanisms employed by bacterial species. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 12, 2019 Category: Cancer & Oncology Source Type: research

Tumor Lysis Syndrome After Laparoscopic Microwave Ablation of Colorectal Liver Metastases
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 21, 2019 Category: Cancer & Oncology Source Type: research

The Improvement in 1-Year Survival Rate of Patients with Hepatocellular Carcinoma BCLC Stage A and B after the Implementation of Comprehensive Management
ConclusionsThe 1-year survival rate of BCLC A and BCLC B HCC patients in Cipto Mangunkusumo National Hospital improved significantly after the implementation of comprehensive management of HCC in 2015. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 10, 2019 Category: Cancer & Oncology Source Type: research

Oxaliplatin-Induced Multiple Focal Nodular Hyperplasia Masquerading as Colorectal Liver Metastasis —Case Report and Review of Literature
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 7, 2019 Category: Cancer & Oncology Source Type: research

Effects of Curcumin and Silymarin on the Shigella dysenteriae and Campylobacter jejuni In vitro
AbstractObjectiveAntimicrobial properties of silymarin and curcumin have been assessed against several infectious agents. The aim of this study was to investigate the anti-apoptotic and antibacterial effects of both compounds on the expression of genes amongShigella dysenteriae ATCC 12022 andCampylobacter jejuni subsp.jejuni strain ATCC 33560 standard strains.MethodsS. dysenteriae andC. jejuni standard strains were prepared from reference laboratory. Additionally, two clinical multidrug-resistant (MDR) isolates were adopted. Silymarin and curcumin stocks were purchased from Sigma Corporation (USA), and after preparation of...
Source: Journal of Gastrointestinal Cancer - September 4, 2019 Category: Cancer & Oncology Source Type: research

Assessment of Serum MicroRNA-21 Gene Expression for Diagnosis and Prognosis of Colorectal Cancer
AbstractBackgroundMicroRNAs (miRNAs) are small, non-coding RNAs that are involved in carcinogenesis through posttranscriptional gene regulatory activity. The current study aimed to evaluate serum miR-21 expression levels as potential biomarkers for diagnosis and prognosis of colorectal cancer (CRC) patients.MethodsQuantitative real-time RT-PCR was applied to determine the relative expression level of miR-21 in serum. At the same time, the sensitivity and specificity of this marker were evaluated by receiver operating characteristic (ROC) curve analysis.ResultsmiR-21 expression levels of serum were 3.4 and 1.25 in patient a...
Source: Journal of Gastrointestinal Cancer - September 3, 2019 Category: Cancer & Oncology Source Type: research

A Complete Response Achieved in a Patient with Hepatic Metastasis from Sigmoid Colon Cancer by a Regimen Containing Ramucirumab: a Case Report
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 3, 2019 Category: Cancer & Oncology Source Type: research

Synchronous Inflammatory Myofibroblastic Tumour of Liver and Carcinoma Head of Pancreas in a Young Male: a Diagnostic Dilemma
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 2, 2019 Category: Cancer & Oncology Source Type: research

Author Correction: The Expression Analysis of Intestinal Cancer Stem Cell Marker Lgr5 in Colorectal Cancer Patients and the Correlation with Histopathological Markers
The original version of this article unfortunately contained a mistake. In the author group section, the correct name of the first author is “Shirin Salehzadeh.” The authors apologize for this oversight and for any confusion it may have caused. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 2, 2019 Category: Cancer & Oncology Source Type: research

Multi-Targeted Tyrosine Kinase Inhibitor-Induced Hyperammonemic Encephalopathy: a Report of Two Cases Using Pazopanib, Sunitinib, and Regorafenib
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 30, 2019 Category: Cancer & Oncology Source Type: research

Superficially Spreading Signet-Ring Cell Carcinoma Perpendicularly Colliding with Gastric Adenoma: a Rare Case Report
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 1, 2019 Category: Cancer & Oncology Source Type: research

Cutaneous Large B Cell Lymphoma Involving the Duodenum and the Bile Duct: a Case Report
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 1, 2019 Category: Cancer & Oncology Source Type: research

Giant Duodenal Lipoma: a Rare Cause of Vomiting, Anorexia, Unintentional Weight Loss, and Duodenal Intussusception
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 1, 2019 Category: Cancer & Oncology Source Type: research

Pancreaticoduodenectomy with Replaced Common Hepatic Artery and Portal Vein Reconstruction in Primary Carcinoma Duodenum: a Case Report and Literature Review
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 1, 2019 Category: Cancer & Oncology Source Type: research

A Case of Alpha-Fetoprotein-Producing Adenocarcinoma of the Esophagogastric Junction in which Long-Term Survival Was Achieved by Means of Individualized Multidisciplinary Therapy
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 1, 2019 Category: Cancer & Oncology Source Type: research

Hanging Undifferentiated Embryonal Sarcoma of the Liver in Adult: an Unusual Presentation of an Aggressive Tumor
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - August 1, 2019 Category: Cancer & Oncology Source Type: research

Comparison Between Multidetector CT and High –Field 3T MR Imaging in Diagnostic and Tumour Extension Evaluation of Patients with Cholangiocarcinoma
ConclusionsThe comparative concordant results of our study suggest that MRI with MRCP represents a valid alternative to MDCT for the diagnostic evaluation of patients with CCA to establish tumour resectability providing multiplanar scanning of high-contrast imaging quality; MDCT should be preferred in uncooperative patients, in the presence of biliary stents or when MRI is absolutely contraindicated for incompatible medical devices. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 29, 2019 Category: Cancer & Oncology Source Type: research

Associated Factors of Survival Rate and Screening for Colorectal Cancer in Iran: a Systematic Review
ConclusionRemarkably, knowledge, attitude, and behaviors about CRC screening in Iran are very moderate to poor. According to diversity of survival rates and low tendency to screening, we need to further and deepen studies of barrier and facilitators of screening. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 24, 2019 Category: Cancer & Oncology Source Type: research

Anticancer Activity of Earthworm Powder ( Lumbricus terrestris ) Against MCF-7 and PC-3 Cancer Cell Lines
ConclusionThe results of the present study contribute additional evidence for the antitumor activity of earthworm extracts. Therefore, further research should concentrate on isolating and identifying the earthworm ’s active biomolecules that have antitumor activity by investigating the molecular mechanism, genetics, and pathways responsible for the antitumor activity of these biomolecules. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 19, 2019 Category: Cancer & Oncology Source Type: research

Gastrointestinal Mantle Cell Lymphoma with Varied Findings
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 16, 2019 Category: Cancer & Oncology Source Type: research

Inhibitory Traits of Dendrosome Curcumin (DNC) on Breast Cancer Compared to Curcumin Single Compound
ConclusionsThe rate of apoptosis (programmed cell death) was enhanced, but necrosis was decreased in treated cancer cells compared to those treated with single curcumin. Accordingly, the DNC can be applied to hinder the growth and dissemination of cancer cells as a preferred approach to reduce the complications of other strategies such as chemotherapy and radiation therapy. Indeed, we concluded that DNC enhanced the expression of MEG3, a tumor suppressor, at 25  μm dose, but reduced the expression of the FOXCUT gene, possibly via the methylation of the gene. Thereby, DNC exerted a promising tumor inhibitory growth ...
Source: Journal of Gastrointestinal Cancer - July 9, 2019 Category: Cancer & Oncology Source Type: research

Altered Expression of CD44, SIRT1, CXCR4, miR-21, miR-34a, and miR-451 Genes in MKN-45 Cell Line After Docetaxel Treatment
AbstractPurposeToday it is known that the gene expression profile of cancer stem cells differs from other cancer cells, which may lead to the resistance to routine treatments. The aim of this study was to investigate the effect of docetaxel (DOC) treatment on CD44+ cell frequency in human gastric cancer (GC) MKN-45 cell line and its effect on expression levels of SIRT1, CXCR4, microRNA (miR)-21, miR-451, and miR-34a that are closely correlated with the chemoresistance or self-renewal of cancer stem cells (CSCs).MethodsThe cytotoxic effect of DOC on MKN-45 cell line was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl...
Source: Journal of Gastrointestinal Cancer - July 5, 2019 Category: Cancer & Oncology Source Type: research

Molecular Genetics and the Role of Molecularly Targeted Agents in Metastatic Colorectal Carcinoma
ConclusionsAlterations in several oncogenes are associated with CRC, among those RAS, BRAF, and HER2 are of current clinical importance. Chemotherapy drugs, along with vascular endothelial growth factor or epidermal growth factor receptor monoclonal antibodies, are proven to be efficient with manageable toxicity profiles in metastatic CRC. Additional researches on Her-2-directed therapy, BRAF-targeted agents, immunotherapeutic, and newer molecularly targeted agents are needed for further improvement in outcome. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 5, 2019 Category: Cancer & Oncology Source Type: research

Utility of Prognostic Prediction Models in the Terminal Stage of Gastrointestinal Cancer
ConclusionsPPI and BPS were found to be accurate prediction models for short-term survival of terminal gastrointestinal cancer patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 29, 2019 Category: Cancer & Oncology Source Type: research

High-Grade Large Cell Neuroendocrine Carcinoma: Case Report and Literature Review
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 28, 2019 Category: Cancer & Oncology Source Type: research

Hepatitis B Virus Infection and Susceptibility to Esophageal Cancer in China: Implications of Ethnicity-Related Interleukin-17 Gene Polymorphism?
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 28, 2019 Category: Cancer & Oncology Source Type: research

Induction Chemotherapy for Locally Advanced Esophageal Cancer
ConclusionsOur data suggest that the addition of IC to standard CRT  + S does not increase the pCR rate in locally advanced EC. No difference in OS was observed between pts. that received or not IC. Regardless of the treatment received, pts. achieving a pCR presented improved TTF. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 25, 2019 Category: Cancer & Oncology Source Type: research

Patterns of Care and Outcomes of Adjuvant Chemoradiation for Node-Positive Pancreatic Adenocarcinoma
AbstractPurposeThe literature has been conflicting on the superiority of adjuvant chemoradiation over chemotherapy for node-positive adenocarcinoma of the pancreas following definitive surgery. We aimed to evaluate the patterns of care and outcomes of these two treatment options using the National Cancer Database (NCDB).MethodsPatients diagnosed with non-metastatic, node-positive adenocarcinoma of the pancreas from 2006 to 2014 who received oncologic resection with negative margins were identified in the NCDB. Patient- and clinical-related factors were compared between those who received adjuvant chemotherapy alone (aC) ve...
Source: Journal of Gastrointestinal Cancer - June 25, 2019 Category: Cancer & Oncology Source Type: research

Primary Gastric Leiomyosarcoma: a Case Report and Review of the Literature
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 22, 2019 Category: Cancer & Oncology Source Type: research

The Prognostic Value of Serum Semaphorin3A and VEGF Levels in Patients with Metastatic Colorectal Cancer
ConclusionPre-treatment semaphorin 3A level can be a prognostic marker for the mCRC patients who were treated with bevacizumab in patients with metastatic colorectal cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 20, 2019 Category: Cancer & Oncology Source Type: research

Primary Tumor Location Is a Predictor of Poor Prognosis in Patients with Locally Advanced Esophagogastric Cancer Treated with Perioperative Chemotherapy
ConclusionIn our analysis, pathological staging and primary site were main prognostic factors. Moreover, a small group of EGJ/HER2+ had very poor survival. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 10, 2019 Category: Cancer & Oncology Source Type: research

Robotic Surgery as an Alternative Approach for Reoperation of Incidental Gallbladder Cancer
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 8, 2019 Category: Cancer & Oncology Source Type: research

Insulin Resistance and Colorectal Cancer Risk: the Role of Elevated Plasma Resistin Levels
This study was conducted as a case-control study and 170 subjects, including 88 controls and 82 cases with CRC, were enrolled and their plasma levels of glucoe, insulin, and resistin were measured using glucose oxidase or ELISA methods. Moreover, IR was calculated according to HOMA-IR index.ResultsThe cases with CRC had a higher HOMA-IR than the controls (1.8  ± 0.4 versus 1.4 ± 0.3,P 
Source: Journal of Gastrointestinal Cancer - June 6, 2019 Category: Cancer & Oncology Source Type: research

Colonoscopy Surveillance After Colorectal Cancer: the Optimal Interval for Follow-Up
ConclusionsPatients with a history of colorectal cancer have an increased risk for a second colorectal tumour. Therefore, we recommend a colonoscopic surveillance programme with the first colonoscopy performed 1  year after curative surgery, which is in accordance with national guidelines. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 3, 2019 Category: Cancer & Oncology Source Type: research

Extremely Aggressive Behavior of a Completely Resected Case of Gallbladder Undifferentiated Carcinoma, Giant Cell Type: a Rare Case with Breast, Neck Nodes, and Subcutaneous Scalp Nodules Metastasis
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 3, 2019 Category: Cancer & Oncology Source Type: research

A Path Less Traveled: Metastatic Esophageal Carcinoma from a Primary Ovarian Malignancy
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 3, 2019 Category: Cancer & Oncology Source Type: research

Expression Level of miR-34a in Tumor Tissue from Patients with Esophageal Squamous Cell Carcinoma
ConclusionsmiR-34a may be involved in the pathogenesis and development of esophageal cancer and have the potential to be used as a diagnostic and therapeutic marker in esophageal cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: research

Sentinel Node Navigation in Gastric Cancer: Where Do We Stand?
ConclusionThe real clinical application of SN biopsy in gastric cancer treatment has been more than challenging due to the “complicated” nature of gastric lymphatic drainage and the high possibility of “skip” metastasis phenomenon. Notably, sophisticated technical aspects, such as the preferred tracer used and the potential “ideal” method to verify the presence of metastases in the resected SLNs, made SN bio psy application in gastric cancer field extremely demanding. Assessing the potential role of SN navigation for gastric cancer treatment in the era of advanced technology, where the m...
Source: Journal of Gastrointestinal Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: research

Retrospective Assessment of the Diagnostic Accuracy of the Depth of Invasion by Narrow Band Imaging Magnifying Endoscopy in Patients with Superficial Esophageal Squamous Cell Carcinoma
ConclusionsThe additional use of NBI magnifying endoscopy can enhance the diagnostic accuracy of the depth of invasion in patients with S-ESCC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: research

Colonic Adenocarcinoma with Florid Vascular Proliferation Related to Intussusception
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: research

Neuroendocrine Carcinoma of Gallbladder: A Step Beyond Palliative Therapy, Experience of 25 Cases
ConclusionsIn carefully selected patients of GB NECs, downsizing with NACT facilitates radical resection with negative margins. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 3, 2019 Category: Cancer & Oncology Source Type: research

Qualitative and Quantitative Analysis of Posttreatment Strategy After Endoscopic Resection for Patients with T1 Colorectal Cancer at High Risk of Lymph Node Metastasis
ConclusionsAge, comorbidities, and lower-rectal cancer location were considered in deciding posttreatment strategy among high-risk T1CRC patients, alongside with positive vertical margin, depth, lymphovascular invasion, poor histologic grade, and budding. During the research period, there was no prognostic difference between the FU and AS groups. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 2, 2019 Category: Cancer & Oncology Source Type: research

Unusual and Aggressive Cause of Gall Bladder Mass —Neuroendocrine Tumor
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 30, 2019 Category: Cancer & Oncology Source Type: research

Clinical Impact of Circulated miR-1291 in Plasma of Patients with Liver Cirrhosis (LC) and Hepatocellular Carcinoma (HCC): Implication on Glypican-3 Expression
ConclusionsOur findings might indicate that miR-1291 exert oncogenic effects in hepatic carcinogenesis through positive regulation of GPC3 expression. We propose that GPC3 overexpression and its associated oncogenic effects are linked to the upregulation of miR-1291 in HCV patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

Immune Checkpoint Inhibitors in Locally Advanced, Unresectable, and Metastatic Upper Gastrointestinal Malignancies
ConclusionsBased on recent and ongoing studies, eligible patients who have progressed beyond the first-line cytotoxic chemotherapy may benefit from immunotherapy. This review outlines the checkpoint inhibitors that are currently or previously being investigated for patients with metastatic UGI cancers. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

Liver Transplantation for High-Grade Primary Hepatic Neuroendocrine Tumor with Diffuse Liver Metastasis
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 27, 2019 Category: Cancer & Oncology Source Type: research

Gut Microbiota as a Positive Potential Therapeutic Factor in Carcinogenesis: an Overview of Microbiota-Targeted Therapy
AbstractCancer therapeutic methods comprising chemotherapy, radiotherapy, and surgery are so routine in cancer treatment. Remarkably, there are several personal features which affect the effectiveness of such treatments including nutrition, microbiome diversity, and physical activity which has distinct significant roles during and after therapies along with their bilateral connections. In this way, the ability of gut microbiota36 in modulating the efficacy of chemotherapeutic medications in cancer and other types of disorders is of great importance. In addition, the role of dietary, probiotic, and synthetically engineered ...
Source: Journal of Gastrointestinal Cancer - April 26, 2019 Category: Cancer & Oncology Source Type: research

Increased Expression of MiR-27a and MiR-24-2 in Esophageal Squamous Cell Carcinoma
AbstractPurposeEsophageal squamous cell carcinoma (ESCC) is one of the predominant types of esophageal cancer with poor prognosis which shows high prevalence in eastern countries. Studying microRNAs that were considered for their capabilities such as tissue-specific expression and involvement in different cell features may be informative in the field of diagnostic and prognostic tumor markers. The expression levels of miR-27a and miR-24-2 have been reported to be dysregulated in various cancers and contribute in tumorigenesis and progression; thus, evaluating their expressional behavior and its association with tumor state...
Source: Journal of Gastrointestinal Cancer - April 25, 2019 Category: Cancer & Oncology Source Type: research

Treatment Patterns and Economic Burden by Lines of Therapy Among Patients with Advanced Hepatocellular Carcinoma Treated with Systemic Cancer Therapy
ConclusionsFindings confirm high 1-year mortality for advanced HCC, suggesting a high cost burden. While no 2L therapy was available during this analysis, recently approved 2L agents have the potential to improve survival after sorafenib failure or intolerance. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 23, 2019 Category: Cancer & Oncology Source Type: research