HCC and Tumor Biomarkers: Does One Size Fits All?
AbstractHepatocellular carcinoma (HCC) is a highly malignant disease and early diagnosis rates remain to be unsatisfactory. Owing to this limitation, advances in treatment options including liver transplantation (LT) are limited to improve survival. Recent HCC guidelines no longer recommend alpha-fetoprotein (AFP) as a surveillance and diagnostic tool for HCC. Hence, utilization of novel biomarkers has become imperative to improve disease management strategies. Noninvasive, serum-based biomarkers are potential options to aid early diagnosis as well as prompting treatment. However, further studies are required to find out t...
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint
AbstractHepatocellular carcinoma is one of the most common cancers and an important health problem all over the world. Its prognosis is poor. For better patient care, early diagnosis is essential. Although new imaging techniques have a big impact on hepatocellular carcinoma diagnosis, histopathological examination is still the gold standard for precise diagnosis. Histopathological evaluation gives exact diagnosis in the meaning of tumor size, histological subtypes, grading, and differential diagnosis from metastasis and other tumors. Immunohistochemistry as a part of diagnostic histopathological technique plays an importan...
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Pediatric Hepatocellular Carcinoma
ConclusionTreatment of pediatric HCC is challenging. Complete surgical resection is essential for the cure. To this end, different neoadjuvant chemotherapy protocols have been designed to convert non-resectable tumors into resectable tumors. For tumors that cannot be resected, liver transplantation for each patient with childhood HCC should be decided individually. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Psychosocial Outcomes of Donors Whose Recipients Died After Living Donor Liver Transplantation
ConclusionRegular follow-up of the donors should be done psychosocially in the postoperative period, especially the donors whose recipients have died should be followed up more frequently, and their support and treatment should be provided when needed. The donors should also be informed about the psychosocial implications of operative management and postoperative period. More studies are needed regarding the psychosocial problems of the donors. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Do We Need to Be Limited by Matching Milan Criteria for Survival in Living Donor Liver Transplantation?
ConclusionThere is no ideal marker or an extended criterion for selecting patients with HCC beyond the Milan criteria and it needs further research to find an effective biomarker that has prognostic significance to select patients with advanced tumors. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

The Timing of Liver Transplantation Following Downstaging: Wait of Not to Wait?
ConclusionCurrently, there are no surrogate markers for surveillance of response to locoregional therapies as well as the antitumor immune response that develops as a result of down-staging. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Portal Vein Thrombosis and Markers of Inflammation in Hepatocellular Carcinoma
ConclusionsIndices of inflammation, especially serum GGTP levels, related significantly to the presence of PVT and to survival in HCC patients with PVT. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Malatya and Other Criteria for Liver Transplantation in Hepatocellular Carcinoma
ConclusionIt is clear that morphological criteria consisting only of tumor size and number are insufficient in patient selection for liver transplantation and should thus be combined with biological, inflammatory, radiological, pathological and genetic markers that predict the biological behavior of the tumor. Efforts to find the best criteria are still ongoing and 5-year overall survival should be greater than 60%. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Clinicopathological Features of Two Extremely Rare Hepatocellular Carcinoma Variants: a Brief Review of Fibrolamellar and Scirrhous Hepatocellular Carcinoma
ConclusionThe clinical, radiological, gross, histopathological, immunohistochemical, and molecular features of these two tumors, which are defined by the World Health Organization (WHO), are mentioned. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Radiomics in Hepatocellular Carcinoma
AbstractBackgroundRadiomics is an emerging field that extracts high-throughput imaging data from different types of images to build models and predict clinical outcomes ina non-invasive manner. This field currently is in the initial growth phase and lacks standardized evaluation criteria but remains a very promising tool for the future todevelop suitable biomarkers for diagnosis, prognosis, and treatment response assessments. The analysis of hepatocellular carcinoma by radiomics will contribute toearly diagnosis and treatment of tumors and improve survival and cure rates.AimHerein, we aimed to provide an up-to-date overvie...
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

The Importance of AFP in Liver Transplantation for HCC
ConclusionAFP ’s performance as a screening, diagnostic, and prognostic marker for HCC is not ideal, but it is the most frequently used biomarker in the management of HCC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

What Are the Immune Obstacles to Liver Xenotransplantation Which Is Promising for Patients with Hepatocellular Carcinoma?
ConclusionThe future is yet to come, there are developments made in the field of genetic editing, immunosuppressive medication, and pretransplant desensitization techniques. Therefore, we believe that xenotransplantation will be in clinical practice, at least for treatment of critically ill patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Is Macroscopic Portal Vein Tumor Thrombosis of HCC Really an Exclusion for Liver Transplantation?
ConclusionsTherefore, these patients should be subject of multimodality treatment, and liver transplantation should be offered whenever objective and significant response is obtained by locoregional therapies. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Microvascular Venous Invasion in Hepatocellular Carcinoma: Why Do Recurrences Occur?
ConclusionTherefore, further research is needed to define ideal marker associated with microscopic vascular invasion. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Management of Recurrent HCC After Liver Transplantation
AbstractBackgroundLiver transplantation is the best treatment option for hepatocellular carcinoma (HCC). Although centers use strict selection criteria, there is a risk of recurrence, reaching up to 20% which are mostly observed within two years following the procedure. The survival after the recurrence is poor and it has been reported to be between 7-16 months. This poor prognosis is due to the systemic course of the recurrence even its presentation is local initially.ResultsThe clinical management and treatment algorithm of recurrence is challenging and there is no guideline regarding the situation. Staging of the diseas...
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Living Donor Versus Deceased Donor Liver Transplantation for HCC
ConclusionReports of different clinics about the postoperative course and tumor recurrence rates comparing living donor versus deceased donor liver transplantations, besides patient selection criteria, are reviewed along with our clinic ’s experiences. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Tumor Diameter for Hepatocellular Carcinoma: Why Should Size Matter?
ConclusionsCombined with biological, inflammatory, radiological, pathological and genetic markers that predict the biological behavior of the tumor, today, tumor size is one of the best aggressiveness markers until new markers are found. So, tumor size is matter. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

What Should Be the Rules for Downstaging for Hepatocellular Carcinoma?
ConclusionAlthough candidates for downstaging is still controversial, with the absence of main contraindications, LRT can be applied to selected HCCs, which have a certain degree of tumor burden. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Introduction to Special Issue on Liver Transplant and HCC at Inonu University, Turkey
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Author Correction: Epidemiological and Clinical Patterns of Newly Diagnosed Hepatocellular Carcinoma in Brazil: the Need for Liver Disease Screening Programs Based on Real-World Data
The original version of this article unfortunately contained a mistake in the author group section. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 26, 2020 Category: Cancer & Oncology Source Type: research

The Effects of Supplement Therapy on HCV-Related HCC: a Case Report of a Patient Who Had Undergone TACE for Six Times
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 23, 2020 Category: Cancer & Oncology Source Type: research

Current Opinion on Peritoneal Carcinomatosis Treatment: a Survey of the Indian Society of Peritoneal Surface Malignancies (ISPSM)
ConclusionsCurrent treatment modalities fall short to satisfy the needs (cure, symptom relief) of patients with PC. Alternative systemic and intraperitoneal treatment modalities should be assessed. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 19, 2020 Category: Cancer & Oncology Source Type: research

Prognostic and Predictive Value of NAR Score in Gastric Cancer
AbstractIntroductionNeoadjuvant treatment is a widely accepted approach for locally advanced rectum cancer. Efforts to explore a surrogate endpoint for clinical trials revealed a new prognostic scoring system which is named as neoadjuvant rectal score (NAR) in patients who received neoadjuvant treatment for rectal cancer.Material and Methods88 patients who met inclusion criteria were included in the study. The optimal cutoff value of the NAR score was 17.6 with 71% sensitivity and 63% specificity. Patients with NAR score>  17.6 (n: 48, 54%) were defined as the high-risk group and those with NAR score  ≤...
Source: Journal of Gastrointestinal Cancer - October 16, 2020 Category: Cancer & Oncology Source Type: research

147 Pancreatoduodenectomies: a Single Center ’s Perspective into the Epidemiology and Surgical Outcomes of Periampullary and Pancreatic Cancers in South India
ConclusionOver the last decade, there has been a significant improvement in the mortality rate, but morbidity remains high and must be looked into as the department enters the new decade as a young high-volume center. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 14, 2020 Category: Cancer & Oncology Source Type: research

Enhancer of Zeste Homolog 2 (EZH2) in Malignant Progression of Gallbladder Carcinoma
ConclusionThis study highlights the crucial role of the key epigenetic regulators EZH2 in the pathobiology and evolution of gallbladder carcinogenesis. Given the reversibility of epigenetic alterations, EZH2 may be a novel therapeutic target for gallbladder carcinogenesis. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 14, 2020 Category: Cancer & Oncology Source Type: research

Epidemiology of Gastric Cancer in North Africa and the Middle East from 1990 to 2017
ConclusionDespite a decrease in the incidence of gastric cancer and, possibly, due to late diagnosis and poor health services, the attenuation of gastric cancer is high in MENA countries. Therefore, it is recommended to reduce the attenuation of screening programs before 50  years old for early detection in addition to prevention programs and to reduce smoking, especially in men. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 14, 2020 Category: Cancer & Oncology Source Type: research

Extricating the Association Between the Prognostic Factors of Colorectal Cancer
AbstractPurposeColorectal cancer (CRC) is one of the recurring and lethal gastrointestinal tract disease rankings as the primary cause of worldwide morbidity and mortality. In general, the tumour node metastasis (TNM) and Dukes classification assist in diagnosis, prognosis and treatments of CRC along with haematological examinations and tumour demographic characterisations in patients.MethodsThe present investigation is carried out on clinically acknowledged sixty-five CRC patients based on haematological findings and are sorted into stages using TNM and Dukes. The present study is to find the association between haematolo...
Source: Journal of Gastrointestinal Cancer - October 13, 2020 Category: Cancer & Oncology Source Type: research

Association Between the hOGG1 1245C & gt;G (rs1052133) Polymorphism and Susceptibility to Colorectal Cancer: a Meta-analysis Based on 7010 Cases and 10,674 Controls
ConclusionsInconsistent with the previous meta-analysis, these meta-analysis results revealed that the hOGG1 1245C>G polymorphism might be associated with an increased risk of CRC, especially in Caucasians. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 5, 2020 Category: Cancer & Oncology Source Type: research

Assessment of oncogenic role of intestinal microbiota in colorectal cancer patients
AbstractIntroductionThe direct association between some microbial species and cancers, such as in colorectal cancer (CRC), has been disclosed.ObjectiveThe aim of this study was to evaluate the changes in intestinal microbiota in subjects with CRC compared with healthy group.MethodsThree-hundred fecal specimens were gathered from patients with CRC and 300 from healthy individuals during March 2014 to October 2019 from two hospitals in Tehran. The informed consent form and the questionnaire were completed by the patients. Following the identification ofLactobaccilus acidophilus (L. acidophilus),Lactobacillus palntarom (L. pa...
Source: Journal of Gastrointestinal Cancer - October 2, 2020 Category: Cancer & Oncology Source Type: research

Trends in Tumor Indices in Relation to Increased Hepatocellular Carcinoma Size: Evidence for Tumor Evolution as a Function of Growth
AbstractBackgroundThe prognosis of HCC depends in large measure on maximum tumor diameter (MTD).AimsTo examine characteristics of tumor aggressiveness over an MTD range of
Source: Journal of Gastrointestinal Cancer - October 1, 2020 Category: Cancer & Oncology Source Type: research

Cancer and Coronavirus Disease (COVID-19): Comorbidity, Mechanical Ventilation, and Death Risk
ConclusionsAccording to the findings of this study, cancer was not among the most prevalent underlying diseases in patients with confirmed COVID-19. Moreover, cancer patients infected with COVID-19 had the lowest risk of mechanical ventilation or death than the non-cancer infected patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 30, 2020 Category: Cancer & Oncology Source Type: research

Chemo-Resistant Locally Advanced Left-Sided Pancreatic Cancer Encasing Portal Venous Confluence, Celiac and Superior Mesenteric Arteries: Management Strategy
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 30, 2020 Category: Cancer & Oncology Source Type: research

The Risk and Prevalence of COVID-19 Infection in Colorectal Cancer Patients: a Systematic Review and Meta-analysis
ConclusionsThis study results revealed that Chinese CRC patients harbored a higher risk of COVID-19 infection. However, more multicenter, larger sample sizes and high-quality studies are required to verify this meta-analysis result. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 29, 2020 Category: Cancer & Oncology Source Type: research

The Prognostic Significance of Lymph Node Status and Lymph Node Ratio (LNR) on Survival of Right Colon Cancer Patients: a Tertiary Center Experience
ConclusionOur study confirms the validity of LNR as a prognostic tool that correlates with the survival of patients. Moreover, LNR cutoff values may help predict those of high chance of tumor recurrence.Trial RegistrationMS/20.03.1087 (Institutional IRB), date of registration: March 10, 2020, “retrospectively registered”. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 28, 2020 Category: Cancer & Oncology Source Type: research

Incidence and Prognosis of Biliary Tract and Gallbladder Cancers in a Belgian Academic Hospital
AbstractBackgroundBiliary tract and gallbladder cancers are rare tumors with a poor prognosis (except the ampulla type). The evolution of hepatobiliary cancer incidence varies widely around the world. According to the Belgian Cancer Registry, the number of hepatobiliary cancers has increased every year since 2004.Materials and MethodsThis retrospective study included patients diagnosed with cholangiocarcinoma, ampulla cancer, or gallbladder cancer at the university hospital, CHU UCL, Godinne site, in Namur, Belgium, between 1997 and 2017. The evolution of cancer incidence was evaluated with the Mann-Kendall method, by anal...
Source: Journal of Gastrointestinal Cancer - September 27, 2020 Category: Cancer & Oncology Source Type: research

DNA Mismatch Repair –Deficient Colorectal Carcinoma: Referral Rate for Genetic Cancer Risk Assessment in a Brazilian Cancer Center
ConclusionOverall, genetic referral was less than expected in our population. Most of dMMR CRC patients did not receive GC, even in a cancer center, either due to the absence of referral or personal decision and few patients who pursued genetic counseling performed genetic testing. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: research

Mesenteric Cyst in 22 Cases
ConclusionAlthough mesenteric cysts are rarely seen, although most of them are not histopathologically malignant, they can reach large sizes and require extensive surgical operation, and related morbidities can be seen. Therefore, mesenteric cysts should be followed carefully in the postoperative period as well as during the diagnosis and surgical treatment process. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 23, 2020 Category: Cancer & Oncology Source Type: research

Incidence and Preoperative Predictor Factors of Gallbladder Cancer Before Laparoscopic Cholecystectomy: a Systematic Review
ConclusionIncidence of iGBC was 0.365% varying between 0.19 and 1.6% of laparoscopic cholecystectomy and about 50% of GBC cases. This highlights the deficiency of preoperative diagnostic features. Despite the efforts made, the rate of this condition is still high, underlining the need of new radiological technologies. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 22, 2020 Category: Cancer & Oncology Source Type: research

What About Gastric Schwannoma? A Review Article
ConclusionsLocal or more extended surgery involved a larger cohort of patients and reported satisfactory long-term results compared with endoscopy group. Surgery in absence of a definite preoperative diagnosis is considered the gold standard treatment for resectable Gs. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 22, 2020 Category: Cancer & Oncology Source Type: research

Peri-operative Outcomes and Survival Following Palliative Gastrectomy for Gastric Cancer: a Systematic Review and Meta-analysis
This study was registered with the PROSPERO database (CRD42019159136).ResultsOne hundred and twenty-eight papers which included 58,675 patients contributed data. At 1 year, there was a significantly improved survival in patients who underwent palliative gastrectomy when compared to non-resectional surgery and no treatment. At 2 years following treatment, palliative gastrectomy was associated with significantly improved survival compared to chemotherapy only; however, there was no significant improvement in survival compared to patients who underwent non-resectional surgery after 1 year. Palliative resections were associate...
Source: Journal of Gastrointestinal Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: research

Thyroid Follicle –Like Cholangiocarcinoma in Liver: a Novel Variant and What We Know So Far?
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: research

Lymph Node Ratio Is an Independent Prognostic Factor for Patients with Siewert Type II Adenocarcinoma of Esophagogastric Junction: Results from a 10-Year Follow-up Study
AbstractPurposeEmerging evidences suggest that lymph node ratio (LNR), the number of metastatic lymph node (LN) to the total number of dissected lymph nodes (NDLN), may predict survival in multiple types of solid tumor. However, the prognostic role of LNR in adenocarcinoma of the esophagogastric junction (AEG) remains uninvestigated. The present study is intended to determine the prognostic value of LNR in the patients with Siewert type II AEG.MethodsA total of 342 patients with Siewert type II AEG who underwent R0 resection were enrolled in this study. The optimal cutoff of LNR was stratified into tertiles using X-tile so...
Source: Journal of Gastrointestinal Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Locally Advanced Gastric Adenocarcinoma with Impressive Response to Hemostatic Radiation: the Possible Role of p53 Status and Eosinophilic Infiltrate
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: research

Cumulative Evidence for Association Between IL-8 -251T & gt;A and IL-18 -607C & gt;A Polymorphisms and Colorectal Cancer Susceptibility: a Systematic Review and Meta-analysis
ConclusionsOur results revealed that the IL-8 -251T>A and IL-18 -607C>A polymorphisms were not associated with an increased susceptibility to CRC. We strongly call for further studies with larger sample sizes and different ethnicities to confirm our findings. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: research

Durable Disease Control with Regorafenib in a Patient with Metastatic KIT-Mutated Colorectal Cancer
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: research

Post-Operative Morbidity and Mortality Following Total Neoadjuvant Therapy Versus Conventional Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer
AbstractBackgroundStandard of care for locally advanced rectal cancer (LARC) (stage II/III) includes preoperative chemoradiation (CRT) followed by resection and adjuvant chemotherapy. Total neoadjuvant therapy (TNT) is a new treatment paradigm that delivers systemic therapy prior to CRT aimed at improving outcomes for high-risk patients. Here we analyzed the national cancer database (NCDB) comparing short-term post-operative outcomes between patients receiving TNT and CRT.MethodsThe NCDB was queried to identify patients with LARC between the 2004 and 2014 treated with TNT or CRT. Primary outcomes included post-operative 30...
Source: Journal of Gastrointestinal Cancer - September 15, 2020 Category: Cancer & Oncology Source Type: research

The Diagnostic Value of Cadherin 17 and CDX2 Expression as Immunohistochemical Markers in Colorectal Adenocarcinoma
ConclusionCadherin 17 is a more sensitive marker than CDX2 in diagnosis of carcinoma of unknown primary site especially when colorectal carcinoma is suspected. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 14, 2020 Category: Cancer & Oncology Source Type: research

Imaging Accuracy in Diagnosis of Different Focal Liver Lesions: A Retrospective Study in North of Iran
ConclusionIt seems that CT scan is more appropriate and useful in the diagnosis of hepatic masses due to its higher diagnostic accuracy than the ultrasound. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 14, 2020 Category: Cancer & Oncology Source Type: research

Molecular Mechanism of Helicobacter pylori -Induced Gastric Cancer
ConclusionThe bacterium has various virulence factors, including cytotoxin- associated gene A, vacuolating cytotoxin A, and the different outer membrane proteins that cause cancer by different mechanisms. These virulence factors activate cell signaling pathways such as PI3-kinase/Akt, JAK/STAT and Ras, Raf, and ERK signaling that control cell proliferation. Uncontrolled proliferation can lead to cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 13, 2020 Category: Cancer & Oncology Source Type: research

Atypical Expression of CK7 and CK20 in Adenosquamous Carcinoma, Colon —a Rare Case
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 13, 2020 Category: Cancer & Oncology Source Type: research