Hepatic Adenomatosis in Aicardi Syndrome: a Clinical Report and Review of the Literature
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 18, 2021 Category: Cancer & Oncology Source Type: research

A Recipient and Donor Both Have COVID-19 Disease. Should We Perform a Liver Transplant?
We present a case of donor and recipient who initially both tested positive for COVID-19. This liver transplantation scenario has not previously been reported in the literature. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 18, 2021 Category: Cancer & Oncology Source Type: research

Post-surgery Survival in Patients with Adenocarcinoma of Stomach Using Multistate Model
This study aimed to identify the related factors on recurrent and deaths following stomach neoplasms.MethodsIn this cohort study, information on 672 patients with adenocarcinoma who were hospitalized during 1995 –2012 was used. Multistate models were applied to determine the effective factors on recurrent and death events.ResultsMedian of survival time (months) and 5-year survival was estimated as 24.5 and 25%, respectively. The probability of death was 57% for non-recurrent patients, which increased to 88% among recurrent patients. Hazard of death was 49% lower for females (Hazard Ratio (HR):0.51,P = 0.009...
Source: Journal of Gastrointestinal Cancer - February 16, 2021 Category: Cancer & Oncology Source Type: research

Bilateral Vision Loss as the First Presentation of Colon Adenocarcinoma: Report of a Rare Case
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 15, 2021 Category: Cancer & Oncology Source Type: research

Impact of PIN1 Inhibition on Tumor Progression and Chemotherapy Sensitivity in Colorectal Cancer
ConclusionOur results indicated that targeting of PIN1 serves as a promising therapeutic solution for the suppression of tumor progression processes in CRC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 13, 2021 Category: Cancer & Oncology Source Type: research

Low-grade Mucinous Appendiceal Neoplasm: a Tumor in Disguise of Appendicitis
We report a case of low-grade appendiceal mucinous neoplasm in a 65-year-old female with past history of surgery for benign bilateral adnexal lesions. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 11, 2021 Category: Cancer & Oncology Source Type: research

Plasmacytic Differentiation in MALT Lymphoma: a Clue to Paraproteinemia —an Unusual Case of MALT Lymphoma of Small Intestine with IgA Heavy Chain Production and Kappa Light Chain Restriction
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 10, 2021 Category: Cancer & Oncology Source Type: research

Prognostic Role of a New Index Tested in European and Korean Advanced Biliary Tract Cancer Patients: the PECS Index
AbstractBackground and AimThe aim of the present study is to evaluate a new index (PECS (PsECogSii)index) influenced by PS ECOG and systemic immune-inflammation index (SII) in unresectable locally advanced or metastatic BTC patients treated with first-line chemotherapy.MethodsThis multicenter, international, study was conducted on a training cohort of 130 patients and in three European and Korean validation cohorts The PECS index was calculated as ECOG × SII index (neutrophil count × platelet count/lymphocyte count). Event-time distributions were estimated using the Kaplan–Meier method and survival curves...
Source: Journal of Gastrointestinal Cancer - February 5, 2021 Category: Cancer & Oncology Source Type: research

Trastuzumab  ± Capecitabine Maintenance After the First-Line Treatment of HER2-Positive Advanced Gastric Cancer: Retrospective Observational Real-Life Data of Turkish Oncology Group
ConclusionTrastuzumab maintenance  ± capecitabine after 6 cycles of trastuzumab plus combined chemotherapy treatment revealed efficacy and safety in non-progressive HER2-positive advanced gastric cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 4, 2021 Category: Cancer & Oncology Source Type: research

Malignant Gastrointestinal Neuroectodermal Tumour —Case Report with Review of Literature
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - February 1, 2021 Category: Cancer & Oncology Source Type: research

Cancer Beliefs Associated with Posttraumatic Stress Disorder in Neuroendocrine Tumor Survivors
ConclusionNET patients with probable PTSD were more likely to be women with greater physical and emotional burden due to their cancer. Our findings suggest that specific threatening cancer-related beliefs, not disease characteristics, predict a higher risk of PTSD among NET survivors. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 28, 2021 Category: Cancer & Oncology Source Type: research

An Evaluation of the Fecal Microbiome in Lynch Syndrome
ConclusionsThe fecal microbiome of LS patients with extraintestinal cancer differs that of LS patients without cancer. Further studies are needed to explore microbiome changes in these high risk patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 25, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Onion Extract Encapsulated on Nano Chitosan: A Promising Anticancer Agent
The original version of this article unfortunately contained a mistake in the author group section. The correct name of the first author is “Abdulrahman Ali Alzandi.” The original article has been corrected. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 25, 2021 Category: Cancer & Oncology Source Type: research

Importance of Heme Oxygenase-1 in Gastrointestinal Cancers: Functions, Inductions, Regulations, and Signaling
ConclusionThe precise mechanism accountable for the anti-inflammatory features of HO-1 is not completely understood; nevertheless, the CO signaling function associated with the antioxidant property shown by bilirubin possibly will play an act in the improvement of inflammation. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 23, 2021 Category: Cancer & Oncology Source Type: research

Management of Solid and Pseudopapillary Tumors of the Pancreas: About 3 Case Reports
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 23, 2021 Category: Cancer & Oncology Source Type: research

Metastasis to Appendix Presenting as Acute Appendicitis —A Rare Case Report and Review of Literature
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 23, 2021 Category: Cancer & Oncology Source Type: research

Endoscopic Management of Diminutive Duodenal Neuroendocrine Tumors
AbstractIntroductionAlthough duodenal neuroendocrine tumors (dNETs) are rare, the incidence, particularly for lesions ≤ 10 mm, continues to rise with the advent of widely available, high-quality endoscopy. Given their rarity and controversy regarding prognostication factors, limited guidelines exist for resection of well-differentiated, ≤ 20-mm dNETs. Importantly, lesions ≤ 10 mm in a duodenal locatio n are ideal for consideration of endoscopic management given both morbidity and technical challenges associated with surgery and their accessibility to a wide range of endoscopic techni...
Source: Journal of Gastrointestinal Cancer - January 20, 2021 Category: Cancer & Oncology Source Type: research

The Management of Recurrence of Hepatocellular Carcinoma Occurring Within 6  Months After Hepatic Resection: A Comparative Study Using a Propensity Score Matching Analysis
AbstractBackgroundHepatectomy is currently recommended as the most reliable treatment for hepatocellular carcinoma. However, the association between the choice of treatment for recurrence and the timing of recurrence remains controversial.MethodsThree-hundred thirty-nine patients who underwent hepatectomy were retrospectively analyzed using a propensity score matching analysis for the risk factors and outcomes for early recurrences within 6  months. The remnant liver volumes and laboratory data were measured postoperatively using multidetector computed tomography on days 7 and months 1, 2, and 5 after surgery. The Stu...
Source: Journal of Gastrointestinal Cancer - January 20, 2021 Category: Cancer & Oncology Source Type: research

Preoperative Utility of the Glasgow Prognostic Score on Outcomes of Patients with Locally Advanced Gastric Cancer
ConclusionGPS before curative resection might be a useful predictive factor for perioperative complications and survival in locally advanced GC. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 18, 2021 Category: Cancer & Oncology Source Type: research

Undifferentiated Pancreatic Carcinoma with Osteoclast-like Giant Cells: a Review and Case Report Analysis
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 14, 2021 Category: Cancer & Oncology Source Type: research

Red Blood Cell Distribution Width (RDW) Correlates to the Anatomical Location of Colorectal Cancer. Implications for Clinical Use
AbstractPurposeThe pathological, clinical, and therapeutic features of colorectal cancer (CRC) depend on its anatomical localization. We investigated possible associations between the red blood cell distribution width (RDW) and CRC localization.MethodsTwo-hundred eighty-eight consecutive patients with CRC were retrospectively studied. Demographic, clinical, pathological and laboratory data were retrieved from clinical records and reports.ResultsMedian RDW values were significantly higher in patients with right-sided CRC when compared to those with CRC in other localizations (16.2, IQR: 14.5 –20.0 vs 13.8, IQR: 13.0–16.1,p 
Source: Journal of Gastrointestinal Cancer - January 12, 2021 Category: Cancer & Oncology Source Type: research

Frequent Downregulation and Promoter Hypermethylation of DLC1: Relationship with Clinical Outcome in Gallbladder Cancer
ConclusionOur findings suggested that dysregulated expression of DLC1 and its hypermethylation may be one of the events playing roles in tumorigenesis of GBC and may serve as a potential target for development of future GBC gene therapy. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 8, 2021 Category: Cancer & Oncology Source Type: research

Gender Differences in Psychological Distress in Patients with Colorectal Cancer and Its Correlates in the Northeast of Iran
ConclusionsThe frequency of anxiety and depression is high among colorectal cancer survivors, especially in women. Therefore, screening for psychological distress is recommended in clinical settings and there is a need to pay attention to women. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 8, 2021 Category: Cancer & Oncology Source Type: research

Extended Total Mesorectal Excision (e-TME) for Locally Advanced Rectal Cancer
Conclusione-TME with curative intent, though a complex procedure, is associated with high wound-related morbidity, R1 resection, but improved median survival benefit. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 8, 2021 Category: Cancer & Oncology Source Type: research

Onion Extract Encapsulated on Nano Chitosan: a Promising Anticancer Agent
ConclusionOnion extract encapsulated on nano chitosan can be used as protective agents from cancer, antitumor, or act synergistically with the cancer chemotherapy. This greatly participates in improving the use of natural products in cancer therapy instead of chemotherapy. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 8, 2021 Category: Cancer & Oncology Source Type: research

Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer
ConclusionsThis study demonstrates that decreased level of TRIM3 mRNA expression is associated with poor prognosis in patients with gastric cancer. TRIM3 may play a protective role in gastric cancer by relieving the effects of cancer progressive genes and could be considered for further investigations as a prognostic biomarker. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: research

Gastric Cancer Incidence and Mortality in French Guiana: South American or French?
ConclusionsGastric cancer affected more males and the median age was younger than in France. Standardized incidence and mortality rates for gastric cancer in French Guiana were between those of France and those of Latin America, and they were comparable to those of the French West Indies. The downward trend in a context of rapid economic growth suggests further gains that could be achieved by improving electricity, water, and sanitation coverage throughout the territory despite challenging geography, and better access to care andHelicobacter pylori eradication. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: research

TERRA Gene Expression in Gastric Cancer: Role of hTERT
ConclusionTelomere and telomerase are useful therapeutic goal. According to the main roles of hTERT in tumorigenesis, growth, migration, and cancer invasion,  hTERT and regulatory mechanisms that control the expression of hTERT are attractive therapeutic targets for cancer treatment.Graphical abstract (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: research

Endoscopic Ultrasonography is a Promising Tool for Preoperative Prediction of the Operability of Pancreatic Carcinoma
This study also shows significant elevation in serum CA19-9 in the presenting cases to confirm a close relation between cancer pancreas and CA19-9 as a good biochemical marker for PC. EUS was found to be able to detect masses less than 20 mm in diameter. Moreover, EUS can accurately detect the mass nature. EUS showed correct information as regards lymph node involvement and vascular invasion which affected the results of respectability of pancreatic masses. Finally, this study clearly showed that EUS is an accurate pre-operative tool in the assessment of nodal staging, vascular invasion, and respectability in patients with...
Source: Journal of Gastrointestinal Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: research

Immunohistochemical Expression Pattern of MLH1, MSH2, MSH6, and PMS2 in Tumor Specimen of Iranian Gastric Carcinoma Patients
ConclusionAccording to the obtained results, the expression of MLH1, MSH2, MSH6, and PMS2 in tumor specimens is positive in 8.6% of the total Iranian gastric cancer sample size, which is mainly positive in female subjects. However, it is not related to the location and stage of the tumor. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: research

Endoscopic Ultrasound-Guided Ethanol Injection Associated with Trans-arterial Embolization of a Giant Intra-abdominal Cavernous Hemangioma: Case Report and New Therapeutic Option
ConclusionTransgastric EUS-guided ethanol injection in the treatment of giant intra-abdominal cavernous hemangioma can provide good outcomes without major complications and can be repeated if necessary. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: research

Safety and tolerability of regorafenib: a real-life experience
ConclusionIn our cohort, the best-tolerated dose of regorafenib was 80 mg. Toxicity and intolerability of regorafenib lead to treatment discontinuation in nearly a quarter of patients. Patient age may influence tolerance and adherence to regorafenib. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 7, 2021 Category: Cancer & Oncology Source Type: research

Socioeconomic Disparities in Gastric Cancer and Identification of a Single SES Variable for Predicting Risk
ConclusionEducation level was the single most reliable measure of GC risk among 3 SES variables and can be employed as an ideal single indicator of SES-related GC risk when multiple SES factors cannot be obtained. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 6, 2021 Category: Cancer & Oncology Source Type: research

PAX8-Positive Intrahepatic Cholangiocarcinoma —a Rare and Hardly Recognized Entity
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 6, 2021 Category: Cancer & Oncology Source Type: research

Outcomes of Squamous Cell Carcinoma Anal Canal treated with IMRT-VMAT –based Concurrent Chemoradiation: a Single Institutional Experience
ConclusionIMRT-based chemoradiation should be the standard of care in locally advanced carcinoma of the anal canal. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 5, 2021 Category: Cancer & Oncology Source Type: research

Gastric Collision Tumor of MALT Lymphoma and Signet Ring Cell Adenocarcinoma: a Rare Preoperative Diagnosis
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 5, 2021 Category: Cancer & Oncology Source Type: research

Metastatic Pancreatic Cancer Second-Line Treatment Options: Is the Difference Only in Cost?
ConclusionAs a result, second-line treatments were compared, and no statistically significant difference was found between them. For this reason, the side effects of previously used drugs and the side effects of new drugs to be used, as well as their costs, should be evaluated when choosing a treatment. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 5, 2021 Category: Cancer & Oncology Source Type: research

Disaggregating Data on Pacific Islander Gastric Cancer Patients Reveals Survival Disparity
ConclusionsWe present an analysis of the largest cohort of Pacific Islander gastric cancer patients. Pacific Islanders have different sociodemographic characteristics and inferior survival compared to Asian patients and should be independently studied. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 4, 2021 Category: Cancer & Oncology Source Type: research

Incidence and Risk Factors of Colorectal Cancer in the Iranian Population: a Systematic Review
ConclusionThe incidence of CRC has a marked variation in different parts of Iran, and various risk factors are associated with colorectal cancer. According to incidence rate and various risk factors, precise planning is needed to control colorectal cancer in the future. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 4, 2021 Category: Cancer & Oncology Source Type: research

Apoptosis Detection Methods in Diagnosis of Cancer and Their Potential Role in Treatment: Advantages and Disadvantages: a Review
ConclusionAccurate diagnosis of cell apoptotic biopathways at different stages assists in evaluating near to exact apoptotic index, which is the perfect sign andindicator for metastasis and also prognosis, thus foreseeing treatment outcome. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 4, 2021 Category: Cancer & Oncology Source Type: research

Prognostic Role of Peripheral Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy
ConclusionPretreatment high PLR is associated with worse OS and DFS in patients with rectal cancer. To use in daily practice, further studies are needed on its validation. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 4, 2021 Category: Cancer & Oncology Source Type: research

Incidence, Survival and Prognostic Factors of Oesophagogastric Cancer
AbstractIntroductionOesophagogastric cancer is one of the leading causes of cancer death worldwide due to its aggressive nature. Despite the high mortality rate, there is limited information regarding this cancer in Brunei.AimTo estimate the incidence and survival duration of oesophagogastric cancer patients, to identify prognostic factors of oesophagogastric cancer and associated factors for late-stage oesophagogastric cancer detection.MethodsA retrospective study on all oesophagogastric cancer patients registered in the population-based national cancer registry in Brunei from January 2010 to December 2018. Kaplan-Meier a...
Source: Journal of Gastrointestinal Cancer - January 4, 2021 Category: Cancer & Oncology Source Type: research

Mixed Neuroendocrine Non-neuroendocrine Neoplasm of Anorectum with Goblet Cell Morphology
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - January 4, 2021 Category: Cancer & Oncology Source Type: research

HCC and Tumor Biomarkers: Does One Size Fits All?
AbstractHepatocellular carcinoma (HCC) is a highly malignant disease and early diagnosis rates remain to be unsatisfactory. Owing to this limitation, advances in treatment options including liver transplantation (LT) are limited to improve survival. Recent HCC guidelines no longer recommend alpha-fetoprotein (AFP) as a surveillance and diagnostic tool for HCC. Hence, utilization of novel biomarkers has become imperative to improve disease management strategies. Noninvasive, serum-based biomarkers are potential options to aid early diagnosis as well as prompting treatment. However, further studies are required to find out t...
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint
AbstractHepatocellular carcinoma is one of the most common cancers and an important health problem all over the world. Its prognosis is poor. For better patient care, early diagnosis is essential. Although new imaging techniques have a big impact on hepatocellular carcinoma diagnosis, histopathological examination is still the gold standard for precise diagnosis. Histopathological evaluation gives exact diagnosis in the meaning of tumor size, histological subtypes, grading, and differential diagnosis from metastasis and other tumors. Immunohistochemistry as a part of diagnostic histopathological technique plays an importan...
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Pediatric Hepatocellular Carcinoma
ConclusionTreatment of pediatric HCC is challenging. Complete surgical resection is essential for the cure. To this end, different neoadjuvant chemotherapy protocols have been designed to convert non-resectable tumors into resectable tumors. For tumors that cannot be resected, liver transplantation for each patient with childhood HCC should be decided individually. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Psychosocial Outcomes of Donors Whose Recipients Died After Living Donor Liver Transplantation
ConclusionRegular follow-up of the donors should be done psychosocially in the postoperative period, especially the donors whose recipients have died should be followed up more frequently, and their support and treatment should be provided when needed. The donors should also be informed about the psychosocial implications of operative management and postoperative period. More studies are needed regarding the psychosocial problems of the donors. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Do We Need to Be Limited by Matching Milan Criteria for Survival in Living Donor Liver Transplantation?
ConclusionThere is no ideal marker or an extended criterion for selecting patients with HCC beyond the Milan criteria and it needs further research to find an effective biomarker that has prognostic significance to select patients with advanced tumors. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

The Timing of Liver Transplantation Following Downstaging: Wait of Not to Wait?
ConclusionCurrently, there are no surrogate markers for surveillance of response to locoregional therapies as well as the antitumor immune response that develops as a result of down-staging. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research

Portal Vein Thrombosis and Markers of Inflammation in Hepatocellular Carcinoma
ConclusionsIndices of inflammation, especially serum GGTP levels, related significantly to the presence of PVT and to survival in HCC patients with PVT. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - October 30, 2020 Category: Cancer & Oncology Source Type: research