Pathological Predictors of Response to Neoadjuvant Treatment in Rectal Carcinoma
ConclusionIn this study, it was determined that the investigated factors have a significant relationship with response to treatment and could be used to predict the response to treatment, and if a low possibility of positive response exists, prevention of the complications of neoadjuvant chemoradiotherapy for the patients could occur. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 9, 2020 Category: Cancer & Oncology Source Type: research

Author Correction: Liver Transplantation for Hepatocellular Carcinoma: Malatya Experience and Proposals for Expanded Criteria
The original version of this article unfortunately contained a mistake in the author group section. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 8, 2020 Category: Cancer & Oncology Source Type: research

Family History of Cancer as Potential Prognostic Factor in Stage III Colorectal Cancer: a Retrospective Monoinstitutional Study
ConclusionIn this retrospective analysis, FHC-positive stage III CRC patients had a significantly longer OS compared to FHC-negative. Moreover, this survival benefit seems to increase according to the FHC burden. Further prospective studies, with longer follow-up and larger sample size, are necessary to confirm FHC as prognostic factor in this setting. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 6, 2020 Category: Cancer & Oncology Source Type: research

Value of Adding Dexmedetomidine in Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis for Treatment of Pancreatic Cancer-Associated Pain
ConclusionThe addition of dexmedetomidine to bupivacaine 0.5% in EUS-CPN demonstrated beneficial effects as regards the degree and duration of pain relieve with negligible effect on the patient survival. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 4, 2020 Category: Cancer & Oncology Source Type: research

Evaluation of the Effects of Valproic Acid Treatment on Cell Survival and Epithelial-Mesenchymal Transition-Related Features of Human Gastric Cancer Cells
ConclusionsOur results showed that VPA induces apoptosis and inhibits the cell proliferation and the migratory ability of AGS gastric cancer cells and may prove useful in the development of therapeutic agents for human gastric cancer. However, these preliminary findings call for further investigations to clarify the precise molecular mechanisms by which VPA modulates the EMT process in a cell type –specific manner. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 3, 2020 Category: Cancer & Oncology Source Type: research

DNA Methylation Profiling of hTERT Gene Alongside with the Telomere Performance in Gastric Adenocarcinoma
ConclusionEpigenetic alteration and regulation of hTERT gene expression are critical in controlling telomerase activity and its expression.Graphical Abstract (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 2, 2020 Category: Cancer & Oncology Source Type: research

Can Hematological Inflammatory Parameters Predict Mortality in Hepatocellular Carcinoma?
ConclusionThere was a strong correlation between NLR-PLR levels and mortality. PLR and NLR levels can be used in conjunction with other staging systems to regulate, monitor, and predict the survival of HCC patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 2, 2020 Category: Cancer & Oncology Source Type: research

Is it Possible to Increase Survival of Patients with Intrahepatic Cholangiocarcinoma? A Case Report
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 2, 2020 Category: Cancer & Oncology Source Type: research

Does Neutrophil-to-Lymphocyte Ratio (NLR) Predict Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma?
ConclusionIn patients with locally advanced esophageal SCC, NLR is not a useful marker to predict pathologic response to nCRT. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 1, 2020 Category: Cancer & Oncology Source Type: research

Gastric Remnant Carcinosarcoma: Case Report and Review of the Literature
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - July 1, 2020 Category: Cancer & Oncology Source Type: research

Towards Standardization of Liver Resections in India: Five Hundred Consecutive Oncological Liver Resections- Trends, Techniques and Outcomes
ConclusionA dedicated multidisciplinary treatment approach along with standardization of liver resections culminates into optimal treatment outcomes. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 29, 2020 Category: Cancer & Oncology Source Type: research

Gastrointestinal Stromal Tumor (GIST) in Long-Standing Crohn ’s Disease on Anti-TNF Therapy
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 26, 2020 Category: Cancer & Oncology Source Type: research

Dysregulated Expression of Apoptosis-Associated Genes and MicroRNAs and Their Involvement in Gastric Carcinogenesis
ConclusionOur study provided some evidence of low activity of the intrinsic apoptosis pathway, as well as the influence ofH. pylori on let-7a and let-7b expression. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 24, 2020 Category: Cancer & Oncology Source Type: research

Prediction of Peritoneal Recurrence in Patients with Gastric Cancer: a Multicenter Study
ConclusionFemale gender, T4 tumor stage, undifferentiated histopathology, and signet cell type had a tendency to peritoneal recurrence after adjusted for treatment modalities. Patients with 3 or 4 risk factors had an 8.8-fold increased risk for the development of peritoneal recurrence. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 24, 2020 Category: Cancer & Oncology Source Type: research

Perceived Threats toward Esophageal Cancer among Immediate Relatives of Sufferers: a Qualitative Study
ConclusionsImmediate relatives of patients with esophagus cancer perceived high severity and susceptibility toward this disease and considered themselves vulnerable to this disease. Hence, they suffered from a lot of psychological stress. Development of appropriate interventions regarding the effects of disease-related individual and environmental factors and empowerment of individuals with regard to preventive disease behaviors can be an important step for improving the health of this group.Registration NumberIRCT20180725040588N1, date registered: 2 October 2018. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 24, 2020 Category: Cancer & Oncology Source Type: research

Ectopic Thyroid in the Common Bile Duct: First Case Report
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 16, 2020 Category: Cancer & Oncology Source Type: research

Hemobilia in the Setting of Billroth II Anatomy and Recurrent Gastric Adenocarcinoma
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 15, 2020 Category: Cancer & Oncology Source Type: research

Clinical Outcomes and Prognostic Factors in Gastric Carcinoma Patients with Curative Surgery Followed by Adjuvant Treatment: Real-World Scenario
AbstractBackgroundA wide range of adjuvant treatment regimens exist in gastric carcinoma patients which include chemotherapy, radiotherapy, and/or both either sequential or concurrent. The study aimed to assess the benefit of adjuvant sequential chemotherapy followed by radiotherapy for operable gastric cancers and evaluate  the prognostic factors associated with clinical outcomes.MethodsPatients of stage IB-III gastric carcinoma who underwent radical surgery followed by adjuvant treatment from January 2013 to December 2016 were analyzed retrospectively. Survival was computed using Kaplan-Meier method and prognos...
Source: Journal of Gastrointestinal Cancer - June 13, 2020 Category: Cancer & Oncology Source Type: research

Preoperative Staging of Gastric Cancer Using Computed Tomography and Its Correlation with Histopathology with Emphasis on Multi-planar Reformations and Virtual Gastroscopy
ConclusionMDCT using gaseous and hydro-distension of stomach is an excellent modality for near accurate preoperative T staging of gastric cancer. However, CT has a limited role in the N staging of gastric cancer. This study also suggested that the combined use of virtual gastroscopy and MPR images helps in better detection of early gastric cancers. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 13, 2020 Category: Cancer & Oncology Source Type: research

The Correlation Between Helicobacter pylori Infection and Lnc-OC1 Expression in Gastric Cancer Tissues in an Iranian Population
ConclusionThe findings of the present study revealed that deregulation of Lnc_OC1 may have a role in theH. pylori-associated pathogenesis of GC. Moreover, a direct association can be speculated between GC formation and Lnc_OC1 expression. The mentioned findings highlight the potential role of Lnc_OC1 as a prognostic biomarker of GC. Hence, further evaluations are required in this respect. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 11, 2020 Category: Cancer & Oncology Source Type: research

Incidental Finding of Primary Mucinous Adenocarcinoma of Gall Bladder: a Histopathological Diagnosis
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 11, 2020 Category: Cancer & Oncology Source Type: research

Physical Inactivity and Pancreatic Cancer Mortality
ConclusionThese results suggest that RPI prior to PC diagnosis is associated with a higher risk of death. Future studies with larger sample sizes are needed to explore whether this association varies across tumor histology. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Downstaging and Histological Effects Might Be Reliable Predictors of the Efficacy of DOC+CDDP+5-FU (DCF) as Neoadjuvant Therapy for Stage III or Borderline Resectable Esophageal Cancer: a Single Institute Experience
AbstractPurposeIn Japan, two courses of CDDP+5-FU (CF) therapy followed by surgery are accepted as a standard treatment for stage II/III esophageal cancer (EC) based on the results of the JCOG9907 trial. To gain a better survival, benefit especially for stage III patients in comparison with CF therapy, a three-arm phase III trial (neoadjuvant setting: CF vs. CF + radiation vs. DOC+CF [DCF]) is ongoing. We have aggressively performed DCF therapy for stage III or IV patients since October 2014. We herein review the outcomes of DCF therapy.MethodsWe retrospectively reviewed the cases of 27 patients with stage III or IV EC (ma...
Source: Journal of Gastrointestinal Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

To Study the  Anti-cancer Effects of Shigella Flexneri in AspC-1 Pancreatic Cancer Cell Line in Approach to Bax and bcl-2 Genes
ConclusionIn general, due to defects in the apoptotic pathway in cancer cells and the existence of drug-resistant cells, the detection of new apoptotic inducers such asShigella flexneri cell extract can be used for further studies on cancer therapy. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 10, 2020 Category: Cancer & Oncology Source Type: research

Evaluation of the  Anti-cancer Effect of Syzygium cumini Ethanolic Extract on HT-29 Colorectal Cell Line
ConclusionThe outcome of this study suggests thatSyzygium cumini might be contemplating as a future chemotherapeutic agent and suitable candidate for in vivo trial. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 6, 2020 Category: Cancer & Oncology Source Type: research

Resected High-Risk Rectal GIST Harboring NTRK1 Fusion: a Case Report and Review of the Literature
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 6, 2020 Category: Cancer & Oncology Source Type: research

Decrease of miR-125a-5p in Gastritis and Gastric Cancer and Its Possible Association with H. pylori
ConclusionWe suggest that decreased expression of the miRNA-125a-5p associated with the presence of theH. pylori is an important mechanism in gastric diseases and could be a possible marker for early diagnosis of gastric cancer. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 6, 2020 Category: Cancer & Oncology Source Type: research

Liver Transplantation for Hepatocellular Carcinoma: Malatya Experience and Proposals for Expanded Criteria
AbstractSurvival was examined from a Turkish liver transplant center of patients with HCC, to identify prognostic factors. Data from 215 patients who underwent predominantly live donor liver transplant for HCC at our institute over 12  years were included in the study and prospectively recorded. They were 152 patients within and 63 patients beyond Milan criteria. Patients beyond Milan criteria were divided into two groups according to presence or absence of tumor recurrence. Recurrence-associated factors were analyzed. These fac tors were then applied to the total cohort for survival analysis. We identified four facto...
Source: Journal of Gastrointestinal Cancer - June 5, 2020 Category: Cancer & Oncology Source Type: research

Mutation Status and Prognostic Value of KRAS and BRAF in Southeast Iranian Colorectal Cancer Patients: First Report from Southeast of Iran
ConclusionMutations were found in bothKRAS andBRAF genes in Iranian colorectal cancers patients and were associated with clinical/clinicopathologic features. Our data emphasizes the importance of these molecular features in Iranian CRC patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 3, 2020 Category: Cancer & Oncology Source Type: research

Advanced Biliary Tract Cancer Treated with Gemcitabine plus Cisplatin (GEMCIS) and Novel Inflammatory Markers
In this study, we wanted to examine the effect of neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), and prognostic nutritional index (PNI) on survival in advanced BTC treated with gemcitabine plus cisplatin (GEMCIS) regimen.MethodsForty-two patients with advanced BTC treated with GEMCIS regimen were included in the study. Measurements for NLR, dNLR and PNI were calculated with available formulas. NLR, dNLR, and PNI values were dichotomized based on receiver operating characteristic curve analysis (cut-off values 3.94, 2.66, and 46, respectively). Univariate and multivariate analyses were ...
Source: Journal of Gastrointestinal Cancer - June 3, 2020 Category: Cancer & Oncology Source Type: research

An Uncommon Polyp of the Right Colon: an Unusual Presentation of Melanoma
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 3, 2020 Category: Cancer & Oncology Source Type: research

Very Rare Recurrence Site of Hepatocellular Carcinoma After Living Donor Liver Transplantation: Subcutaneous Abdominal Drain Tract
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - June 3, 2020 Category: Cancer & Oncology Source Type: research

Assessment of MMP29 Gene Expression and Silver Nanoparticles Effects on Colon Cancer Cell Line (HT29)
In this study, the toxicity of silver nanoparticle on the colon cancer cell line (HT29) and expression of matrix metalloproteinase (MMP29) gene was investigated.Materials and MethodsThe silver nanoparticle (AgNPs) was synthesized and assessed by transmission electron microscopy (TEM). The cytotoxicity of synthesized AgNP on the HT29 cell line was evaluated using the MTT assay. Furthermore, the expression of MMP29 gene was investigated by the quantitative real-time PCR (RT-qPCR).ResultsThe TEM results revealed that the fabricated AgNPs were mostly spherical in shape and had an average diameter of 22  nm. The results ou...
Source: Journal of Gastrointestinal Cancer - May 7, 2020 Category: Cancer & Oncology Source Type: research

DCLK1 as a Promising Marker for Radioresistance in Colorectal Cancer
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 7, 2020 Category: Cancer & Oncology Source Type: research

Targeting the SPHK1/HIF1 Pathway to Inhibit Colorectal Cancer Stem Cells Niche
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 7, 2020 Category: Cancer & Oncology Source Type: research

A Rare Case of Paraneoplastic Hypoglycemia Induced by Abdominopelvic Gastrointestinal Stromal Tumor
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - May 4, 2020 Category: Cancer & Oncology Source Type: research

Primary Hepatic Gastrointestinal Stromal Tumour (GIST): Unusual Presentation and Diagnosis
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 25, 2020 Category: Cancer & Oncology Source Type: research

Primary Lymphoma of Liver —a Rare Space-Occupying Lesion
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 24, 2020 Category: Cancer & Oncology Source Type: research

The Youngest Patient with Metastatic Leiomyosarcoma of the Pancreas
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 24, 2020 Category: Cancer & Oncology Source Type: research

Factors to Improve Endoscopic Screening for Colorectal Cancer
ConclusionsThe experience for more than 5  years (p = 0.017) and at least 200 colonoscopies per year (p = 0.004) are the main factors that allow to perform complete colonoscopy in 90% or more of cases. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 17, 2020 Category: Cancer & Oncology Source Type: research

Cystic Ileal Gastrointestinal Stromal Tumor Masquerading as Metastatic Adnexal Carcinoma
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 17, 2020 Category: Cancer & Oncology Source Type: research

Age-Related and Gender-Related Increases in Colorectal Cancer Mortality Rates in Brazil Between 1979 and 2015: Projections for Continuing Rises in Disease
ConclusionOur dataset suggests that both CC and RC events may lead to a significantly increasing number of deaths in the Brazilian male population in coming years. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - April 4, 2020 Category: Cancer & Oncology Source Type: research

Prognostic Significance of VEGF and HIF-1 α in Hepatocellular Carcinoma Patients Receiving Sorafenib Versus Metformin Sorafenib Combination
AbstractBackgroundHepatocellular carcinoma (HCC) is a major health problem. HCC burden has been increasing in Egypt in the past 10  years. Most HCC cases are diagnosed at an advanced stage with limited treatment options. Sorafenib is the standard therapy for advanced HCC, but the effectiveness is not satisfied. Metformin may decrease the risk of HCC development in diabetic patients, reduces tumor invasion, and augments sensiti vity to sorafenib; however, safety and efficacy of combined treatment are still unclear. As HCC is characterized by high vascularity, and vascular endothelial growth factor (VEGF) plays an impor...
Source: Journal of Gastrointestinal Cancer - March 24, 2020 Category: Cancer & Oncology Source Type: research

Correction: Identification of Novel Pathogenic Sequence Variants of the Mismatch Repair Genes During Screening for Lynch Syndrome in a Single Centre of Eastern Hungary
The original version of this article unfortunately contained a mistake. The variants listed in Table 3 of the original version of this article are not in line with the latest HGVS (Human Genome Variation Society) nomenclature (version 19.01). (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - March 24, 2020 Category: Cancer & Oncology Source Type: research

Prevalence of Mismatch Repair-Deficient Colorectal Adenoma/Polyp in Early-Onset, Advanced Cases: a Cross-Sectional Study Based on Iranian Hereditary Colorectal Cancer Registry
ConclusionNo individual with MMR genetic disorder was identified by IHC screening of early-onset advanced colorectal adenomas. This strategy is therefore not an effective strategy for detecting MMR mutation carriers. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - March 19, 2020 Category: Cancer & Oncology Source Type: research

Treatment Modality and Trends in Survival for Gallbladder Cancer: a Population-Based Study
ConclusionsMost cases of GBC continue to be diagnosed in the late stage. Five-year survival for the surgical resection group has markedly improved over time, specifically for patients with stage I –II disease which increased from 30% in 2007 to 70% in 2015. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - March 18, 2020 Category: Cancer & Oncology Source Type: research

The Effect of Inflammatory Markers on Survival in Advanced Biliary Tract Carcinoma Treated with Gemcitabine/Oxaliplatin Regimen
This study aimed to determine the effect of neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), C-reactive protein (CRP)/albumin ratio (CAR), and prognostic nutritional index (PNI) on the survival of BTC patients treated with gemcitabine/oxaliplatin (GEMOX) r egimen.MethodsData of 53 patients with advanced BTC were evaluated retrospectively. Association between inflammatory markers and 6-month PFS and 12-month OS were compared by the log-rank test. The optimal cutoff values were determined by a receiver operating characteristic (ROC) curve analysis. NLR, dNLR, CAR, and PNI were grouped base...
Source: Journal of Gastrointestinal Cancer - March 18, 2020 Category: Cancer & Oncology Source Type: research

Benefits of the 8th American Joint Committee on Cancer System for Hepatocellular Carcinoma Staging
ConclusionThe staging criteria, in the most recent edition of AJCC, are simplified and allowed tumor understaging. These changes do not have independent prognostic value. The prognostic impact of pT understaging should be evaluated in larger cohorts. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - March 16, 2020 Category: Cancer & Oncology Source Type: research

Hepatocellular Carcinoma in Paediatric Patients with Alagille Syndrome: Case Series and Review of Literature
(Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - March 16, 2020 Category: Cancer & Oncology Source Type: research

Angiopoietin-2 as a Prognostic Factor in Patients with Incurable Stage IV Colorectal Cancer
ConclusionsOur findings suggest that the serum Ang-2 level is associated with disease progression and is an important predictor of mortality in incurable stage IV CRC patients. Thus, it may be a useful prognostic biomarker in these patients. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - March 13, 2020 Category: Cancer & Oncology Source Type: research