A literature-based approach for curating gene signatures in multifaceted diseases
The task of identifying a representative and yet manageable target gene list for assessing the pathogenesis of complicated and multifaceted diseases is challenging. Using Inflammatory Bowel Disease (IBD) as an... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 10, 2020 Category: Research Authors: Mathieu Garand, Manoj Kumar, Susie Shih Yin Huang and Souhaila Al Khodor Tags: Methodology Source Type: research

Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma
Oropharyngeal squamous cell carcinoma (OPSCC) is often diagnosed at an advanced stage because the disease often causes minimal symptoms other than metastasis to neck lymph nodes. Better tools are required to a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 10, 2020 Category: Research Authors: G. C. Mayne, C. M. Woods, N. Dharmawardana, T. Wang, S. Krishnan, J. C. Hodge, A. Foreman, S. Boase, A. S. Carney, E. A. W. Sigston, D. I. Watson, E. H. Ooi and D. J. Hussey Tags: Research Source Type: research

Evolving geographic diversity in SARS-CoV2 and in silico analysis of replicating enzyme 3CLpro targeting repurposed drug candidates
Severe acute respiratory syndrome (SARS) has been initiating pandemics since the beginning of the century. In December 2019, the world was hit again by a devastating SARS episode that has so far infected almos... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 9, 2020 Category: Research Authors: Nitin Chitranshi, Vivek K. Gupta, Rashi Rajput, Angela Godinez, Kanishka Pushpitha, Ting Shen, Mehdi Mirzaei, Yuyi You, Devaraj Basavarajappa, Veer Gupta and Stuart L. Graham Tags: Research Source Type: research

Proceedings of the 7th Annual United States Army Institute of Surgical Research Summer Internship Program 2019
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 8, 2020 Category: Research Tags: Meeting abstracts Source Type: research

Correction to: l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 8, 2020 Category: Research Authors: Guangyan Wu, Mengwei Niu, Wenli Tang, Jingjuan Hu, Guoquan Wei, Zhanke He, Yangping Chen, Yong Jiang and Peng Chen Tags: Correction Source Type: research

The brains of aged mice are characterized by altered tissue diffusion properties and cerebral microbleeds
Brain aging is a major risk factor in the progression of cognitive diseases including Alzheimer ’s disease (AD) and vascular dementia. We investigated a mouse model of brain aging up to 24 months old (mo). (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 8, 2020 Category: Research Authors: Erik N. Taylor, Nasi Huang, Jonathan Wisco, Yandan Wang, Kathleen G. Morgan and James A. Hamilton Tags: Research Source Type: research

Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach
The Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) outbreak originating in Wuhan, China, has raised global health concerns and the pandemic has now been reported on all inhabited continen... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 7, 2020 Category: Research Authors: Syed Ovais Aftab, Muhammad Zubair Ghouri, Muhammad Umer Masood, Zeshan Haider, Zulqurnain Khan, Aftab Ahmad and Nayla Munawar Tags: Research Source Type: research

A novel signature based on microvascular invasion predicts the recurrence of HCC
In hepatocellular carcinoma (HCC) patients, microvascular invasion (MVI) is associated with worse outcomes regardless of treatment. No single reliable preoperative factor exists to predict MVI. The aim of the ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 6, 2020 Category: Research Authors: Binbin Du, Fang Wang, Beers Jarad, Zhihui Wang and Yanzhou Zhang Tags: Research Source Type: research

Comprehensive molecular profiling of intrahepatic cholangiocarcinoma in the Chinese population and therapeutic experience
The genomic alterations of intrahepatic cholangiocarcinoma (ICC) in the Chinese population have not been fully revealed. Molecular profiling may provide a reference for clinical management, especially targeted... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 6, 2020 Category: Research Authors: Longrong Wang, Hongxu Zhu, Yiming Zhao, Qi Pan, Anrong Mao, Weiping Zhu, Ning Zhang, Zhenhai Lin, Jiamin Zhou, Yilin Wang, Yongfa Zhang, Miao Wang, Yun Feng, Xigan He, Weiqi Xu and Lu Wang Tags: Research Source Type: research

Systematic review of the registered clinical trials for coronavirus disease 2019 (COVID-19)
Since the outbreak of coronavirus disease 2019 (COVID-19), many researchers in China have performed related clinical research. However, systematic reviews of the registered clinical trials are still lacking. T... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 6, 2020 Category: Research Authors: Rui-fang Zhu, Yu-lu Gao, Sue-Ho Robert, Jin-ping Gao, Shi-gui Yang and Chang-tai Zhu Tags: Review Source Type: research

ICON: a randomized phase IIb study evaluating immunogenic chemotherapy combined with ipilimumab and nivolumab in patients with metastatic hormone receptor positive breast cancer
Immunotherapy with checkpoint inhibitors (CPI) targeting PD-1 or CTLA-4 has emerged as an important treatment modality for several cancer forms. In hormone receptor positive breast cancer (HR  + BC), this thera... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 3, 2020 Category: Research Authors: J. A. Kyte, N. K. Andresen, H. G. Russnes, S. Ø. Fretland, R. S. Falk, O. C. Lingjærde and B. Naume Tags: Protocol Source Type: research

The timeline and risk factors of clinical progression of COVID-19 in Shenzhen, China
The novel coronavirus disease 2019 (COVID-19) broke out globally. Early prediction of the clinical progression was essential but still unclear. We aimed to evaluate the timeline of COVID-19 development and ana... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 3, 2020 Category: Research Authors: Fang Wang, Mengyuan Qu, Xuan Zhou, Kai Zhao, Changxiang Lai, Qiyuan Tang, Wenjie Xian, Ruikun Chen, Xuan Li, Zhiyu Li, Qing He and Lei Liu Tags: Research Source Type: research

Presence of a 34-gene signature is a favorable prognostic marker in squamous non-small cell lung carcinoma
The tumor immune microenvironment is a heterogeneous entity. Gene expression analysis allows us to perform comprehensive immunoprofiling and may assist in dissecting the different components of the immune infi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 3, 2020 Category: Research Authors: W. S. M. E. Theelen, O. Krijgsman, K. Monkhorst, T. Kuilman, D. D. G. C. Peters, S. Cornelissen, M. A. Ligtenberg, S. M. Willems, J. L. G. Blaauwgeers, C. J. M. van Noesel, D. S. Peeper, M. M. van den Heuvel and K. Schulze Tags: Research Source Type: research

External validation of the European risk assessment tool for chronic cardio-metabolic disorders in a Middle Eastern population
High burden of chronic cardio-metabolic disorders including type 2 diabetes mellitus (T2DM), chronic kidney disease (CKD), and cardiovascular disease (CVD) have been reported in the Middle East and North Afric... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 2, 2020 Category: Research Authors: Samaneh Asgari, Fatemeh Moosaie, Davood Khalili, Fereidoun Azizi and Farzad Hadaegh Tags: Research Source Type: research

Intensive care unit-acquired hyponatremia in critically ill medical patients
Previous research has focused on intensive care unit (ICU)-acquired hypernatremia; however, ICU-acquired hyponatremia has frequently been overlooked and has rarely been studied in surgical or mixed ICUs. The a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 2, 2020 Category: Research Authors: Jae Kyeom Sim, Ryoung-Eun Ko, Soo Jin Na, Gee Young Suh and Kyeongman Jeon Tags: Research Source Type: research

Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT
NUDT15 and TPMT variants are strong genetic determinants of thiopurine-induced hematological toxicity that results in therapeutic failure in pediatric acute lymphoblastic leukemia (ALL). However, many patients wi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 1, 2020 Category: Research Authors: Yoomi Park, Hyery Kim, Heewon Seo, Jung Yoon Choi, Youngeun Ma, Sunmin Yun, Byung-Joo Min, Myung-Eui Seo, Keon Hee Yoo, Hyoung Jin Kang, Ho Joon Im and Ju Han Kim Tags: Research Source Type: research

Comparable prevalence of distant metastasis and survival of different primary site for LN  + pancreatic tumor
Few studies have delved into the prevalence of distant metastasis (DM  +) and survival for patients with lymph node metastases (LN +) by primary site. We aimed to detect differences in distant metastasis and pr... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 1, 2020 Category: Research Authors: Xin Lou, Jun Li, Ya-Qing Wei, Zhi-Jia Jiang, Ming Chen and Jin-Jin Sun Tags: Research Source Type: research

The establishment of a rheumatoid arthritis primate model in Macaca fascicularis
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that mostly affects the joints and leads to the destruction of cartilage. An RA model in non-human primates is especially useful because of their cl... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 30, 2020 Category: Research Authors: Hyun Sik Na, Seon-yeong Lee, Hong Ki Min, Wan-je Park, Jung-hwan Lee, Ka-hee Cho, Shin-hee Hong, Dae-hoon Kim, Jooyeon Jhun, Jeong-Won Choi, Sung-Min Kim, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park Tags: Research Source Type: research

Changes in heart morphometric parameters over the course of a monocrotaline-induced pulmonary arterial hypertension rat model
Aim of this study was to assess changes in cardiac morphometric parameters at different stages of pulmonary arterial hypertension (PAH) using a monocrotaline-induced rat model. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 30, 2020 Category: Research Authors: Mateusz K. Ho łda, Elżbieta Szczepanek, Joanna Bielawska, Natalia Palka, Dorota Wojtysiak, Paulina Frączek, Michał Nowakowski, Natalia Sowińska, Zbigniew Arent, Piotr Podolec and Grzegorz Kopeć Tags: Research Source Type: research

Boning up: amino-bisphophonates as immunostimulants and endosomal disruptors of dendritic cell in SARS-CoV-2 infection
Amino-bisphosphonates such as zoledronic acid (ZA) can possibly ameliorate or prevent severe COVID-19 disease by at least three distinct mechanisms: (1) as immunostimulants which could boost γδ T cell expansio... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 29, 2020 Category: Research Authors: Adam Brufsky, Juan Luis Gomez Marti, Azadeh Nasrazadani and Michael T. Lotze Tags: Review Source Type: research

Nutritional management of lactose intolerance: the importance of diet and food labelling
Worldwide, 70% of the adult population has limited expression of lactase enzyme with a wide variation among different regions and countries. Lactase deficiency may lead to lactose intolerance (LI). Depending b... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 26, 2020 Category: Research Authors: Maria Sole Facioni, Benedetta Raspini, Francesca Pivari, Elena Dogliotti and Hellas Cena Tags: Review Source Type: research

Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)
The recent global pandemic has placed a high priority on identifying drugs to prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), caused by Coronavirus disease... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 25, 2020 Category: Research Authors: Jason Kim, Jenny Zhang, Yoonjeong Cha, Sarah Kolitz, Jason Funt, Renan Escalante Chong, Scott Barrett, Rebecca Kusko, Ben Zeskind and Howard Kaufman Tags: Research Source Type: research

Correction to: Accumulation of blood-circulating PD-L1-expressing M-MDSCs and monocytes/macrophages in pretreatment ovarian cancer patients is associated with soluble PD-L1
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 25, 2020 Category: Research Authors: Karolina Ok ła, Alicja Rajtak, Arkadiusz Czerwonka, Marcin Bobiński, Anna Wawruszak, Rafał Tarkowski, Wiesława Bednarek, Justyna Szumiło and Jan Kotarski Tags: Correction Source Type: research

Comments on: Huang et al. (2019) Emerging trends and research foci in gastrointestinal microbiome ’, J. Transl. Med., 17: 67
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 25, 2020 Category: Research Authors: Yuh-Shan Ho Tags: Letter to the Editor Source Type: research

WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target
Overexpression of Wilms ’ tumor-1 (WT1) transcription factor facilitates proliferation in acute myeloid leukemia (AML). However, whether WT1 is enriched in the leukemia-initiating cells (LICs) and leukemia stem ce... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 24, 2020 Category: Research Authors: Bin Zhou, Xianghong Jin, Weiwei Jin, Xingzhou Huang, Yanfei Wu, Haiying Li, Weijian Zhu, Xiaoyi Qin, Haige Ye and Shenmeng Gao Tags: Research Source Type: research

A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma
Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineag... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 24, 2020 Category: Research Authors: Zhenyang Liu, Michael Ho-Young Ahn, Tomohiro Kurokawa, Amy Ly, Gong Zhang, Fuyou Wang, Teppei Yamada, Ananthan Sadagopan, Jane Cheng, Cristina R. Ferrone, Andrew S. Liss, Kim C. Honselmann, Gregory R. Wojtkiewicz, Soldano Ferrone and Xinhui Wang Tags: Research Source Type: research

Evaluating blood –brain barrier permeability in a rat model of type 2 diabetes
This is an exploratory study using a novel imaging modality, quantitative ultrashort time-to-echo, contrast enhanced (QUTE-CE) magnetic resonance imaging to evaluate the permeability of the blood –brain barrier... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 24, 2020 Category: Research Authors: Ju Qiao, Christopher M. Lawson, Kilian F. G. Rentrup, Praveen Kulkarni and Craig F. Ferris Tags: Methodology Source Type: research

Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas
With the aim of providing a dynamic evaluation of the effects of basic environmental parameters on COVID-19-related death rate, we assessed the correlation between average monthly high temperatures and populat... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 23, 2020 Category: Research Authors: Francesca Benedetti, Maria Pachetti, Bruna Marini, Rudy Ippodrino, Robert C. Gallo, Massimo Ciccozzi and Davide Zella Tags: Research Source Type: research

ALICE: a randomized placebo-controlled phase II study evaluating atezolizumab combined with immunogenic chemotherapy in patients with metastatic triple-negative breast cancer
Immunotherapy with checkpoint inhibitors (CI) represents an important novel development in cancer treatment. Metastatic triple-negative breast cancer (mTNBC) is incurable, with a median survival of only  ~ 13 m... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 23, 2020 Category: Research Authors: J. A. Kyte, A. R øssevold, R. S. Falk and B. Naume Tags: Protocol Source Type: research

“Right-to-Try” experimental drugs: an overview
The “Right-to-Try” experimental drugs act passed by Donald Trump in 2018 provides an opportunity of early access to experimental drugs for the treatment of life-threatening diseases and a potential boon to man... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 23, 2020 Category: Research Authors: Vijay Mahant Tags: Review Source Type: research

Epidemiological and clinical factors associated with post-exertional malaise severity in patients with myalgic encephalomyelitis/chronic fatigue syndrome
Post-exertional malaise (PEM), the cardinal feature of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), occurs generally after exposure to a stressor. It is characterized by the worsening of ME/CFS... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 22, 2020 Category: Research Authors: Alaa Ghali, Paul Richa, Carole Lacout, Aline Gury, Anne-Berengere Beucher, Chadi Homedan, Christian Lavigne and Geoffrey Urbanski Tags: Research Source Type: research

Involvement of glutathione peroxidases in the occurrence and development of breast cancers
Glutathione peroxidases (GPxs) belong to a family of enzymes that is important in organisms; these enzymes promote hydrogen peroxide metabolism and protect cell membrane structure and function from oxidative d... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 22, 2020 Category: Research Authors: Man-Li Zhang, Hua-Tao Wu, Wen-Jia Chen, Ya Xu, Qian-Qian Ye, Jia-Xin Shen and Jing Liu Tags: Review Source Type: research

The unique association between the level of peripheral blood monocytes and the prevalence of diabetic retinopathy: a cross-sectional study
The attraction and influx of monocytes into the retina has been considered a critical step in the development of diabetic retinopathy (DR). However, large population studies about the association between perip... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 22, 2020 Category: Research Authors: Heng Wan, Yan Cai, Yuying Wang, Sijie Fang, Chi Chen, Yi Chen, Fangzhen Xia, Ningjian Wang, Minghao Guo and Yingli Lu Tags: Research Source Type: research

Tumor cells derived-exosomes as angiogenenic agents: possible therapeutic implications
Angiogenesis is a multistep process and various molecules are involved in regulating it. Extracellular vesicles are cell-derived particles, secreted from several types of cells and are known to mediate cell-to... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 22, 2020 Category: Research Authors: Mahdi Ahmadi and Jafar Rezaie Tags: Review Source Type: research

MicroRNA-181a as novel liquid biopsy marker of central nervous system involvement in pediatric acute lymphoblastic leukemia
Refractory central nervous system (CNS) involvement is among the major causes of therapy failure in childhood acute leukemia. Applying contemporary diagnostic methods, CNS disease is often underdiagnosed. To e... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 22, 2020 Category: Research Authors: B álint Egyed, Nóra Kutszegi, Judit C. Sági, András Gézsi, Andrea Rzepiel, Tamás Visnovitz, Péter Lőrincz, Judit Müller, Marianna Zombori, Csaba Szalai, Dániel J. Erdélyi, Gábor T. Kovács and Ágnes F. Semsei Tags: Research Source Type: research

Evaluation of T-activated proteins as recall antigens to monitor Epstein –Barr virus and human cytomegalovirus-specific T cells in a clinical trial setting
Pools of overlapping synthetic peptides are routinely used for ex vivo monitoring of antigen-specific T-cell responses. However, it is rather unlikely that these peptides match those resulting from naturally p... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 17, 2020 Category: Research Authors: Nina K örber, Uta Behrends, Ulrike Protzer and Tanja Bauer Tags: Methodology Source Type: research

Clinical significance of circulating tumor cells and metabolic signatures in lung cancer after surgical removal
Lung cancer (LC) remains the deadliest form of cancer globally. While surgery remains the optimal treatment strategy for individuals with early-stage LC, what the metabolic consequences are of such surgical in... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 17, 2020 Category: Research Authors: Dawei Yang, Xiaofang Yang, Yang Li, Peige Zhao, Rao Fu, Tianying Ren, Ping Hu, Yaping Wu, Hongjun Yang and Na Guo Tags: Research Source Type: research

Duplications involving the long range HMX1 enhancer are associated with human isolated bilateral concha-type microtia
Microtia is a congenital anomaly of ear that ranges in severity from mild structural abnormalities to complete absence of the outer ears. Concha-type microtia is considered to be a mild form. The H6 family hom... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 17, 2020 Category: Research Authors: Nuo Si, Xiaolu Meng, Xiaosheng Lu, Zhe Liu, Zhan Qi, Lianqing Wang, Chuan Li, Meirong Yang, Ye Zhang, Changchen Wang, Peipei Guo, Lingdong Zhu, Lei Liu, Zhengyong Li, Zhenyu Zhang, Zhen Cai & hellip; Tags: Research Source Type: research

Estrogen receptor α as a predictive biomarker for survival in human papillomavirus-positive oropharyngeal squamous cell carcinoma
Although oropharyngeal squamous cell carcinoma (OPSCC) with human papillomavirus (HPV) infection has a good prognosis, the accurate prediction of survival and risk of treatment failure is essential to design d... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 16, 2020 Category: Research Authors: Soohyeon Kwon, Soon-Hyun Ahn, Woo-Jin Jeong, Young Ho Jung, Yun Jung Bae, Jin Ho Paik, Jin-Haeng Chung and Hyojin Kim Tags: Research Source Type: research

Mesenchymal stem cells activate Notch signaling to induce regulatory dendritic cells in LPS-induced acute lung injury
Mesenchymal stem cells (MSCs) have been shown to alleviate acute lung injury (ALI) and induce the production of regulatory dendritic cells (DCregs), but the potential link between these two cell types remains ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 16, 2020 Category: Research Authors: Zhonghua Lu, Shanshan Meng, Wei Chang, Shanwen Fan, Jianfeng Xie, Fengmei Guo, Yi Yang, Haibo Qiu and Ling Liu Tags: Research Source Type: research

Development and validation of a prognostic model of resectable small-cell lung cancer: a large population-based cohort study and external validation
Survival outcomes of patients with resected SCLC differ widely. The aim of our study was to build a model for individualized risk assessment and accurate prediction of overall survival (OS) in resectable SCLC ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 15, 2020 Category: Research Authors: Yu Wang, Zhaofei Pang, Xiaowei Chen, Tao Yan, Jichang Liu and Jiajun Du Tags: Research Source Type: research

White-coat hypertension and incident end-stage renal disease in patients with non-dialysis chronic kidney disease: results from the C-STRIDE Study
Controversy remains whether white coat hypertension (WCH) is associated with renal prognosis in patients with chronic kidney disease (CKD). (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 15, 2020 Category: Research Authors: Qin Wang, Yu Wang, Jinwei Wang, Luxia Zhang and Ming-hui Zhao Tags: Research Source Type: research

Comparable endocrine and neuromuscular adaptations to variable vs. constant gravity-dependent resistance training among young women
Variable resistance has been shown to induce greater total work and muscle activation when compared to constant resistance. However, little is known regarding the effects of chronic exposure to variable resist... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 15, 2020 Category: Research Authors: Hamid Arazi, Lida Salek, Elham Nikfal, Mani Izadi, James J. Tufano, Bradley T. Elliott and Matt Brughelli Tags: Research Source Type: research

A novel patient-derived organoids-based xenografts model for preclinical drug response testing in patients with colorectal liver metastases
Cancer-related mortality in patients with colorectal cancer (CRC) is predominantly caused by development of colorectal liver metastases (CLMs). How to screen the sensitive chemotherapy and targeted therapy is ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 12, 2020 Category: Research Authors: Mi Jian, Li Ren, Guodong He, Qi Lin, Wentao Tang, Yijiao Chen, Jingwen Chen, Tianyu Liu, Meiling Ji, Ye Wei, Wenju Chang and Jianmin Xu Tags: Research Source Type: research

Association between body mass index and survival outcomes for cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis
Immune checkpoint inhibitors (ICIs) have been increasingly applied in the treatment of several kinds of malignancies. Some clinical demographic characteristics were reported to be associated with the ICIs effi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 12, 2020 Category: Research Authors: Yue An, Zhonghua Wu, Ningning Wang, Zhidong Yang, Yue Li, Boyang Xu and Mingjun Sun Tags: Research Source Type: research

Human induced pluripotent stem cell line banking for the production of rare blood type erythrocytes
The in vitro production of mature human red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) has been the focus of research to meet the high demand for blood transfusions. However, limitations li... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 12, 2020 Category: Research Authors: Yu Jin Park, Su-Hee Jeon, Hyun-Kyung Kim, Eun Jung Suh, Seung Jun Choi, Sinyoung Kim and Hyun Ok Kim Tags: Research Source Type: research

A comprehensive custom panel evaluation for routine hereditary cancer testing: improving the yield of germline mutation detection
In the context of our Regional Program of Hereditary Cancer, individuals fulfilling the criteria are tested for germline mutations to subsequently establish the clinical management. Our standard diagnostic app... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 10, 2020 Category: Research Authors: Carolina Vel ázquez, Enrique Lastra, Francisco Avila Cobos, Luis Abella, Virginia de la Cruz, Blanca Ascensión Hernando, Lara Hernández, Noemí Martínez, Mar Infante and Mercedes Durán Tags: Research Source Type: research

COVID-19: viral –host interactome analyzed by network based-approach model to study pathogenesis of SARS-CoV-2 infection
Epidemiological, virological and pathogenetic characteristics of SARS-CoV-2 infection are under evaluation. A better understanding of the pathophysiology associated with COVID-19 is crucial to improve treatmen... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 10, 2020 Category: Research Authors: Francesco Messina, Emanuela Giombini, Chiara Agrati, Francesco Vairo, Tommaso Ascoli Bartoli, Samir Al Moghazi, Mauro Piacentini, Franco Locatelli, Gary Kobinger, Markus Maeurer, Alimuddin Zumla, Maria R. Capobianchi, Francesco Nicola Lauria and Giuseppe Tags: Research Source Type: research

Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration
Inflammation-related atherosclerotic peripheral vascular disease is a major end organ complication of diabetes mellitus that results in devastating morbidity and mortality. Extracellular vesicles (EVs) are nan... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 9, 2020 Category: Research Authors: Sharon F. Wu, Nicole Noren Hooten, David W. Freeman, Nicolle A. Mode, Alan B. Zonderman and Michele K. Evans Tags: Research Source Type: research

Collapsing the list of myocardial infarction-related differentially expressed genes into a diagnostic signature
Myocardial infarction (MI) is one of the most severe manifestations of coronary artery disease (CAD) and the leading cause of death from non-infectious diseases worldwide. It is known that the central componen... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - June 9, 2020 Category: Research Authors: German Osmak, Natalia Baulina, Philipp Koshkin and Olga Favorova Tags: Research Source Type: research