Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma
Hepatocellular carcinoma is the second most deadly cancer with late presentation and limited treatment options, highlighting an urgent need to better understand HCC to facilitate the identification of early-st... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 20, 2019 Category: Research Authors: Yu Jin, Wai Yeow Lee, Soo Ting Toh, Chandana Tennakoon, Han Chong Toh, Pierce Kah-Hoe Chow, Alexander Y.-F. Chung, Samuel S. Chong, London L.-P.-J. Ooi, Wing-Kin Sung and Caroline G.-L. Lee Tags: Research Source Type: research

A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation
Neointimal hyperplasia and its related arterial stiffness are the crucial pathophysiological features in atherosclerosis and in-stent restenosis. Cluster of differentiation 147 (CD147), a member of the immunog... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 20, 2019 Category: Research Authors: Kisoo Pahk, Hyojin Noh, Chanmin Joung, Mi Jang, Hwa Young Song, Kyung Won Kim, Kihoon Han, Jong-Ik Hwang, Sungeun Kim and Won-Ki Kim Tags: Research Source Type: research

First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells
ACAM2000, a thymidine kinase (TK)-positive strain of vaccinia virus, is the current smallpox vaccine in the US. Preclinical testing demonstrated potent oncolytic activity of ACAM2000 against several tumor type... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 19, 2019 Category: Research Authors: Boris R. Minev, Elliot Lander, John F. Feller, Mark Berman, Bernadette M. Greenwood, Ivelina Minev, Antonio F. Santidrian, Duong Nguyen, Dobrin Draganov, Mehmet O. Killinc, Anna Vyalkova, Santosh Kesari, Edward McClay, Gabriel Carabulea, Francesco M. Mari Tags: Research Source Type: research

Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men
The effects of fasting on health in non-human models have been widely publicised for a long time and emerging evidence support the idea that these effects can be applicable to human practice. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 19, 2019 Category: Research Authors: Iftikhar Alam, Rahmat Gul, Joni Chong, Crystal Tze Ying Tan, Hui Xian Chin, Glenn Wong, Radhouene Doggui and Anis Larbi Tags: Research Source Type: research

Meeting abstracts from the 9th International Conference on cGMP: Generators, Effectors and Therapeutic Implications
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 15, 2019 Category: Research Tags: Meeting abstracts Source Type: research

miR-21 induces endothelial progenitor cells proliferation and angiogenesis via targeting FASLG and is a potential prognostic marker in deep venous thrombosis
Deep venous thrombosis (DVT) of lower extremities is a common thrombotic disease, occurring either in isolation or as a complication of other diseases or procedures. MiR-21 is one of important microRNAs which ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 15, 2019 Category: Research Authors: Xiaolong Du, Lei Hong, Lili Sun, Hongfei Sang, Aiming Qian, Wendong Li, Hao Zhuang, Huoqi Liang, Dandan Song, Chenglong Li, Wenbin Wang and Xiaoqiang Li Tags: Research Source Type: research

New paradigm for stage III melanoma: from surgery to adjuvant treatment
Recently the 8th version of the American Joint Committee on Cancer (AJCC) classification has been introduced, and has attempted to define a more accurate and precise definition of prognosis in line with the ma... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 14, 2019 Category: Research Authors: Paolo Antonio Ascierto, Lorenzo Borgognoni, Gerardo Botti, Michele Guida, Paolo Marchetti, Simone Mocellin, Paolo Muto, Giuseppe Palmieri, Roberto Patuzzo, Pietro Quaglino and Ignazio Stanganelli Tags: Review Source Type: research

B7-H3 participates in human salivary gland epithelial cells apoptosis through NF- κB pathway in primary Sjögren’s syndrome
Primary Sj ögren’s syndrome (pSS) is an autoimmune disorder mainly characterized by exocrine gland injury. Costimulatory molecules play an important role in immune-regulatory networks. Although B7 family costim... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 14, 2019 Category: Research Authors: Ping Li, Ying Yang, Yi Jin, Rui Zhao, Chen Dong, Wenjie Zheng, Tianyi Zhang, Jing Li and Zhifeng Gu Tags: Research Source Type: research

Overinterpretation of high throughput sequencing data in medical genetics: first evidence against TMPRSS3/GJB2 digenic inheritance of hearing loss
Hearing loss (HL) is the most common disability of human senses characterized by a great allelic heterogeneity. GJB2 and TMPRSS3 are two well-known HL genes typically underlying its monogenic form. Recently, TMPR... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 14, 2019 Category: Research Authors: Monika O łdak, Urszula Lechowicz, Agnieszka Pollak, Dominika Oziębło and Henryk Skarżyński Tags: Research Source Type: research

Kinetics of MSC-based enzyme therapy for immunoregulation
Mesenchymal stromal cells (MSC) demonstrate innate and regulatory immunologic functions and have been widely explored for cell therapy applications. Mechanisms by which MSCs achieve therapeutic effects are the... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 13, 2019 Category: Research Authors: Alexandra Burr and Biju Parekkadan Tags: Research Source Type: research

The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases
Diabetic nephropathy (DN) affects about 40% of diabetes mellitus (DM) patients and is the leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) all over the world, especially in high... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 13, 2019 Category: Research Authors: Gang Wang, Jian Ouyang, Shen Li, Hui Wang, Baofeng Lian, Zhihong Liu and Lu Xie Tags: Research Source Type: research

Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation
Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function rem... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 13, 2019 Category: Research Authors: Koen D. W. Hendriks, Isabel M. A. Br üggenwirth, Hanno Maassen, Albert Gerding, Barbara Bakker, Robert J. Porte, Robert H. Henning and Henri G. D. Leuvenink Tags: Research Source Type: research

In vivo efficacy of endothelial growth medium stimulated mesenchymal stem cells derived from patients with critical limb ischemia
Cell therapy has been proposed for patients with critical limb ischemia (CLI). Autologous bone marrow derived cells (BMCs) have been mostly used, mesenchymal stem cells (MSCs) being an alternative. The aim of ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 9, 2019 Category: Research Authors: Rida Al-Rifai, Philippe Nguyen, Nicole Bouland, Christine Terryn, Lukshe Kanagaratnam, Ga ël Poitevin, Caroline François, Catherine Boisson-Vidal, Marie-Antoinette Sevestre and Claire Tournois Tags: Research Source Type: research

Eosinophilic esophagitis in children: doubts and future perspectives
Eosinophilic esophagitis (EoE) is a chronic immune-mediated inflammatory disorder and represents the leading cause of food impaction. The pathogenesis of EoE is the result of an interplay between genetic, envi... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 9, 2019 Category: Research Authors: Elena Cavalli, Andrea Brusaferro, Elena Sofia Pieri, Rita Cozzali, Edoardo Farinelli, Gian Luigi de ’ Angelis and Susanna Esposito Tags: Review Source Type: research

SNORD89 promotes stemness phenotype of ovarian cancer cells by regulating Notch1-c-Myc pathway
Ovarian cancer is the leading cause of death in gynecological cancer. Cancer stem cells (CSCs) contribute to the occurrence, progression and resistance. Small nucleolar RNAs (SnoRNAs), a class of small molecul... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 8, 2019 Category: Research Authors: Wenjing Zhu, Jumin Niu, Miao He, Liwen Zhang, Xuemei Lv, Fangxiao Liu, Longyang Jiang, Jing Zhang, Zhaojin Yu, Lin Zhao, Jia Bi, Yuanyuan Yan, Qian Wei, Hong Huo, Yue Fan, Yuzong Chen & hellip; Tags: Research Source Type: research

MLMDA: a machine learning approach to predict and validate MicroRNA –disease associations by integrating of heterogenous information sources
Emerging evidences show that microRNA (miRNA) plays an important role in many human complex diseases. However, considering the inherent time-consuming and expensive of traditional in vitro experiments, more an... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 8, 2019 Category: Research Authors: Kai Zheng, Zhu-Hong You, Lei Wang, Yong Zhou, Li-Ping Li and Zheng-Wei Li Tags: Research Source Type: research

Adipose afferent reflex is enhanced by TNF α in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats
The adipose afferent reflex (AAR), a sympatho-excitatory reflex, can promote the elevation of sympathetic nerve activity (SNA) and blood pressure (BP). Inflammation in the paraventricular nucleus (PVN) involve... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 7, 2019 Category: Research Authors: Lei Ding, Ying Kang, Hang-Bing Dai, Fang-Zheng Wang, Hong Zhou, Qing Gao, Xiao-Qing Xiong, Feng Zhang, Tian-Run Song, Yan Yuan, Ming Liu, Guo-Qing Zhu and Ye-Bo Zhou Tags: Research Source Type: research

Genome-wide profiling reveals alternative polyadenylation of mRNA in human non-small cell lung cancer
Lung cancer is the second most common cancer with an extremely poor overall survival rate. Post-transcriptional regulation of gene expression play many important roles in human cancer, and one of the potential... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 7, 2019 Category: Research Authors: Shirong Zhang, Xiaochen Zhang, Wei Lei, Jiafeng Liang, Yasi Xu, Hailiang Liu and Shenglin Ma Tags: Research Source Type: research

Large-scale expansion and characterization of CD3+ T-cells in the Quantum ® Cell Expansion System
The rapid evolution of cell-based immunotherapies such as chimeric antigen receptor T-cells for treatment of hematological cancers has precipitated the need for a platform to expand these cells ex vivo in a sa... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 7, 2019 Category: Research Authors: Claire Coeshott, Boah Vang, Mark Jones and Brian Nankervis Tags: Research Source Type: research

A methodology for deriving the sensitivity of pooled testing, based on viral load progression and pooling dilution
Pooled testing, in which biological specimens from multiple subjects are combined into a testing pool and tested via a single test, is a common testing method for both surveillance and screening activities. Th... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 6, 2019 Category: Research Authors: Ngoc T. Nguyen, Hrayer Aprahamian, Ebru K. Bish and Douglas R. Bish Tags: Research Source Type: research

Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer
Noninvasive and effective methods of early diagnosis of colorectal cancer (CRC) are underexplored. Inflammation is known to play an important role in the tumor microenvironment of CRC. Therefore, the aim of th... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 6, 2019 Category: Research Authors: Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu and Yi Zhang Tags: Research Source Type: research

Identifying subpathway signatures for individualized anticancer drug response by integrating multi-omics data
Individualized drug response prediction is vital for achieving personalized treatment of cancer and moving precision medicine forward. Large-scale multi-omics profiles provide unprecedented opportunities for p... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 6, 2019 Category: Research Authors: Yanjun Xu, Qun Dong, Feng Li, Yingqi Xu, Congxue Hu, Jingwen Wang, Desi Shang, Xuan Zheng, Haixiu Yang, Chunlong Zhang, Mengting Shao, Mohan Meng, Zhiying Xiong, Xia Li and Yunpeng Zhang Tags: Research Source Type: research

Novel method for simultaneously detecting HPA and HLA antibodies using Luminex microbeads
Alloantibodies against human platelet antigens (HPAs) and human leukocyte antigen (HLA) are implicated in several immune-mediated platelet disorders. Detection of these antibodies is crucial in the diagnosis a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 5, 2019 Category: Research Authors: Sudan Tao, Shu Chen, Xiaozhen Hong, Ji He and Faming Zhu Tags: Research Source Type: research

Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function
Here, we isolated, expanded and functionally characterized regulatory T cells (Tregs) from patients with end stage kidney and liver disease, waiting for kidney/liver transplantation (KT/LT), with the aim to es... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 5, 2019 Category: Research Authors: Francesca Ulbar, Tiziana Montemurro, Tatiana Jofra, Miriam Capri, Giorgia Comai, Valentina Bertuzzo, Cristiana Lavazza, Alessandra Mandelli, Mariele Vigan ò, Silvia Budelli, Maria Giulia Bacalini, Chiara Pirazzini, Paolo Garagnani, Valeria Giudice, Daria Tags: Research Source Type: research

Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a common complication of diabetes and is characterized by chronic myocardial inflammation. Mesenchymal stem cell (MSC) infusions have recently been suggested to alleviate myoca... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 5, 2019 Category: Research Authors: Liyuan Jin, Zihui Deng, Jinying Zhang, Chen Yang, Jiejie Liu, Weidong Han, Ping Ye, Yiling Si and Guanghui Chen Tags: Research Source Type: research

In vivo model of human post-traumatic heterotopic ossification demonstrates early fibroproliferative signature
The relationship between the tissue injury healing response and development of heterotopic ossification (HO) is poorly understood. Here we compare a rat blast model and human traumatized muscle from a blast in... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 2, 2019 Category: Research Authors: Jaira F. de Vasconcellos, Sonia Zicari, Stephen D. Fernicola, Daniel W. Griffin, Youngmi Ji, Emily H. Shin, Patrick Jones, Gregory T. Christopherson, Husain Bharmal, Carl Cirino, Thao Nguyen, Astor Robertson, Vincent D. Pellegrini Jr. and Leon J. Nesti Tags: Research Source Type: research

The epigenome as a putative target for skin repair: the HDAC inhibitor Trichostatin A modulates myeloid progenitor plasticity and behavior and improves wound healing
The molecular pathways that drive bone marrow myeloid progenitors (BMMP) development are very well understood and include a tight controlled multi-stage gene hierarch. Monocytes are versatile cells that displa... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 31, 2019 Category: Research Authors: Mariana Cabanel, Thayse Pinheiro da Costa, Marcia Cury EL-Cheikh and Katia Carneiro Tags: Research Source Type: research

Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma
Plexiform fibromyxoma (PF) is a rare gastric tumor often confused with gastrointestinal stromal tumor. These so-called “benign” tumors often present with upper GI bleeding and gastric outlet obstruction. It wa... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 30, 2019 Category: Research Authors: Sudeep Banerjee, Christopher L. Corless, Markku M. Miettinen, Sangkyu Noh, Rowan Ustoy, Jessica L. Davis, Chih-Min Tang, Mayra Yebra, Adam M. Burgoyne and Jason K. Sicklick Tags: Research Source Type: research

Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy
Melanoma is one of the most aggressive cancers with extremely poor prognosis, and the median survival time for stage IV patients is approximately 6 to 8 months. Unlike cutaneous melanoma, mucosal melanoma is a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 29, 2019 Category: Research Authors: Longwen Xu, Zhiyuan Cheng, Chuanliang Cui, Xiaowen Wu, Huan Yu, Jun Guo and Yan Kong Tags: Research Source Type: research

European mitochondrial haplogroups predict liver-related outcomes in patients coinfected with HIV and HCV: a retrospective study
Mitochondrial DNA (mtDNA) haplogroups have been associated with advanced liver fibrosis and cirrhosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Our aim was to ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 26, 2019 Category: Research Authors: Teresa Ald ámiz-Echevarría, Salvador Resino, José M. Bellón, María A. Jiménez-Sousa, Pilar Miralles, Luz M. Medrano, Ana Carrero, Cristina Díez, Leire Pérez-Latorre, Chiara Fanciulli, Pilar Garcia-Broncano and Juan Berenguer Tags: Research Source Type: research

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice
Current human influenza vaccines lack the adaptability to match the mutational rate of the virus and therefore require annual revisions. Because of extensive manufacturing times and the possibility that antige... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 25, 2019 Category: Research Authors: Patrick Tjok Joe, Ioanna Christopoulou, Lien van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens and Joeri L. Aerts Tags: Research Source Type: research

Impact of probiotics on pathogen survival in an innovative human plasma biofilm model (hpBIOM)
Despite of medical advances, the number of patients suffering on non-healing chronic wounds is still increasing. This fact is attended by physical and emotional distress and an economic load. The majority of c... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 25, 2019 Category: Research Authors: M. Besser, J. Terberger, L. Weber, B. Ghebremedhin, E. A. Naumova, W. H. Arnold and E. K. Stuermer Tags: Research Source Type: research

A strategy to protect off-the-shelf cell therapy products using virus-specific T-cells engineered to eliminate alloreactive T-cells
The use of “off-the-shelf” cellular therapy products derived from healthy donors addresses many of the challenges associated with customized cell products. However, the potential of allogeneic cell products to... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 24, 2019 Category: Research Authors: David H. Quach, Luis Becerra-Dominguez, Rayne H. Rouce and Cliona M. Rooney Tags: Research Source Type: research

Preparing for cell culture scale-out: establishing parity of bioreactor- and flask-expanded mesenchymal stromal cell cultures
Cell-based therapies have the potential to become treatment options for many diseases, but efficient scale-out of these therapies has proven to be a major hurdle. Bioreactors can be used to overcome this hurdl... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 24, 2019 Category: Research Authors: Ruud Das, Rens Roosloot, Melissa van Pel, Koen Schepers, Marijn Driessen, Willem E. Fibbe, Joost Dick de Bruijn and Helene Roelofs Tags: Research Source Type: research

Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice
Obesity is a chronic and systemic inflammatory disorder and an important risk factor for the onset of several chronic syndromes. Adipose tissue (AT) plays a crucial role in the development of obesity, promotin... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 23, 2019 Category: Research Authors: Federica Tomay, Alessandra Marinelli, Valerio Leoni, Claudio Caccia, Andrea Matros, Hans-Peter Mock, Chiara Tonelli and Katia Petroni Tags: Research Source Type: research

Wolfram syndrome, a rare neurodegenerative disease: from pathogenesis to future treatment perspectives
Wolfram syndrome (WS), a rare genetic disorder, is considered the best prototype of endoplasmic reticulum (ER) diseases. Classical WS features are childhood-onset diabetes mellitus, optic atrophy, deafness, di... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 23, 2019 Category: Research Authors: Maria Teresa Pallotta, Giorgia Tascini, Roberta Crispoldi, Ciriana Orabona, Giada Mondanelli, Ursula Grohmann and Susanna Esposito Tags: Review Source Type: research

Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy
Indoleamine 2,3-dioxygenase catalyzes the conversion of tryptophan to kynurenine, an immunosuppressive metabolite involved in T regulatory cell differentiation. Indoleamine 2,3-dioxygenase is expressed in many... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 23, 2019 Category: Research Authors: Concetta Elisa Onesti, Fran çois Boemer, Claire Josse, Stephane Leduc, Vincent Bours and Guy Jerusalem Tags: Research Source Type: research

Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Macrophage cholesterol efflux capacity has been identified as a predictor for cardiovascular disease. We assessed the relationship between adipocyte-derived extracellular vesicle microRNAs and macrophage chole... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 22, 2019 Category: Research Authors: Matthew D. Barberio, Lora J. Kasselman, Martin P. Playford, Samuel B. Epstein, Heather A. Renna, Madeleine Goldberg, Joshua DeLeon, Iryna Voloshyna, Ashley Barlev, Michael Salama, Sarah C. Ferrante, Evan P. Nadler, Nehal Mehta, Allison B. Reiss and Robert Tags: Research Source Type: research

Detection of lymph node metastasis in lung cancer patients using a one-step nucleic acid amplification assay: a single-centre prospective study
The use of one-step nucleic acid amplification (OSNA) allows for lymph node (LN) metastasis to be detected rapidly and accurately. We conducted a prospective single-centre clinical trial to evaluate OSNA assay... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 22, 2019 Category: Research Authors: Mar ía Escalante Pérez, María Teresa Hermida Romero, Begoña Otero Alén, Mónica Álvarez Martínez, Ricardo Fernández Prado, Mercedes de la Torre Bravos and Ángel Concha López Tags: Research Source Type: research

Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th –1 December 1st, 2018, Naples, Italy)
Diagnosis of melanocytic lesions, correct prognostication of patients, selection of appropriate adjuvant and systemic therapies, and prediction of response to a given therapy remain very real challenges in mel... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 22, 2019 Category: Research Authors: Paolo A. Ascierto, Sanjiv S. Agarwala, Gerardo Botti, Alfredo Budillon, Michael A. Davies, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Silvia Formenti, Thomas F. Gajewski, Claus Garbe, Omid Hamid, Roger S. Lo, Jason J. Luke, Oliver Michielin, Giusepp Tags: Meeting report Source Type: research

PCR-based zebrafish model for personalised medicine in head and neck cancer
Currently, in vivo model for personalised cancer drug testing is challenging. A zebrafish larvae xenograft model has been applied in recent years to cancer research, particularly for drug testing purposes, sho... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 22, 2019 Category: Research Authors: Ahmed Al-Samadi, Katja Tuomainen, Anne Kivim äki, Abdelhakim Salem, Sakhr Al-Kubati, Aini Hyytiäinen, Mataleena Parikka, Karri Mesimäki, Tommy Wilkman, Antti Mäkitie, Reidar Grenman and Tuula Salo Tags: Research Source Type: research

The circulating exosomal microRNAs related to albuminuria in patients with diabetic nephropathy
Diabetic nephropathy (DN) is associated with high risk of cardiovascular disease and mortality. Exosomal microRNAs (miRNAs) regulate gene expression in a variety of tissues and play important roles in the path... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 22, 2019 Category: Research Authors: Hyoungnae Kim, Yun-Ui Bae, Jin Seok Jeon, Hyunjin Noh, Hyeong Kyu Park, Dong Won Byun, Dong Cheol Han, Seongho Ryu and Soon Hyo Kwon Tags: Research Source Type: research

Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy
Chemotherapy-induced left ventricular dysfunction represents a major clinical problem, which is often only recognised at an advanced stage, when supportive therapy is ineffective. Although an early heart failu... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 19, 2019 Category: Research Authors: M ária Lódi, Dániel Priksz, Gábor Áron Fülöp, Beáta Bódi, Alexandra Gyöngyösi, Lilla Nagy, Árpád Kovács, Attila Béla Kertész, Judit Kocsis, István Édes, Zoltán Csanádi, István Czuriga, Zoltán Kisvárday, Béla Juhász, István Lekli, Tags: Research Source Type: research

Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis
Bone metastases occur rarely in patients suffering from malignant melanoma, although their onset severely worsens both prognosis and quality of life. Extracellular vesicles (EVs) including exosomes (Exos) are ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 19, 2019 Category: Research Authors: Francesco Mannavola, Marco Tucci, Claudia Felici, Anna Passarelli, Stella D ’Oronzo and Francesco Silvestris Tags: Research Source Type: research

Dysbiosis of the gut microbiome is associated with CKD5 and correlated with clinical indices of the disease: a case –controlled study
Chronic kidney disease (CKD) is a universal chronic disease in China. The balance of the gut microbiome is highly crucial for a healthy human body, especially for the immune system. However, the relationship b... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 17, 2019 Category: Research Authors: Yang Li, Xinhuan Su, Lei Zhang, Yanwei Liu, Min Shi, Chenxiao Lv, Ying Gao, Dongmei Xu and Zunsong Wang Tags: Research Source Type: research

Clinicohistopathological implications of MMP/VEGF expression in retinoblastoma: a combined meta-analysis and bioinformatics analysis
No in-depth systematic evidence is available for assessing retinoblastoma malignancy and eligibility for subsequent treatment. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 16, 2019 Category: Research Authors: Jingyi Zhu, Xi Zhang, Liqianyu Ai, Rongdi Yuan and Jian Ye Tags: Research Source Type: research

Personalizing the safe, appropriate and effective concentration(s) of ozone for a non-diabetic individual and four type II diabetic patients in autohemotherapy through blood hemoglobin analysis
Diabetes is a chronic disease associated with many problems and high costs. In recent decades, a lot of research has been carried out in order to improve methods of treatment of diabetic patients. One of the c... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 16, 2019 Category: Research Authors: Fouad Mehraban, Arefeh Seyedarabi, Shahin Ahmadian, Vahid Mirzaaghaei and Ali Akbar Moosavi-Movahedi Tags: Research Source Type: research

Animal to human translation: a systematic scoping review of reported concordance rates
Drug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-c... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 15, 2019 Category: Research Authors: Cathalijn H. C. Leenaars, Carien Kouwenaar, Frans R. Stafleu, Andr é Bleich, Merel Ritskes-Hoitinga, Rob B. M. De Vries and Franck L. B. Meijboom Tags: Review Source Type: research

Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone
Adrenocorticotrophic hormone (ACTH)-treatment rat model has been utilized as a widely accepted model of treatment-resistant depression. Metabolomic signatures represent the pathophysiological phenotype of dise... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 15, 2019 Category: Research Authors: Jing Song, Weini Ma, Xinyi Gu, Le Zhao, Jiaye Jiang, Ying Xu, Lei Zhang, Mingmei Zhou and Li Yang Tags: Research Source Type: research

Smoking and microbiome in oral, airway, gut and some systemic diseases
The human microbiome harbors a diverse array of microbes which establishes a mutually beneficial relation with the host in healthy conditions, however, the dynamic homeostasis is influenced by both host and en... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - July 15, 2019 Category: Research Authors: Chunrong Huang and Guochao Shi Tags: Review Source Type: research