Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition
Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 13, 2024 Category: Research Authors: Gilar Gorji-Bahri, B. Madhu Krishna, Catharina Hagerling, Akira Orimo, Karin Jirstr öm, Konstantinos S. Papadakos and Anna M. Blom Tags: Research Source Type: research
Immersed in a reservoir of potential: amniotic fluid-derived extracellular vesicles
This review aims to encapsulate the current knowledge in extracellular vesicles extracted from amniotic fluid and amniotic fluid derived stem/stromal cells. Amniotic fluid (AF) bathes the developing fetus, pro... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 12, 2024 Category: Research Authors: Ishara Atukorala, Natalie Hannan and Lisa Hui Tags: Review Source Type: research
Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology
Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy of multiple tumor-associated antigens in hepatocellular ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 12, 2024 Category: Research Authors: Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu & hellip; Tags: Research Source Type: research
Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson ’s disease
In this study, we aimed to explore the potential biomarkers and underlying molecular pathways of nicotine for the treatment of olfactory dys... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 12, 2024 Category: Research Authors: Qinglong Guo, Yi Wang, Liangchen Yu, Liao Guan, Xuefei Ji, Xiaohui Li, Gang Pang, Zhenhua Ren, Lei Ye and Hongwei Cheng Tags: Research Source Type: research
The integration of single-cell and bulk RNA-seq atlas reveals ERS-mediated acinar cell damage in acute pancreatitis
Acute pancreatitis (AP) is a clinically common acute abdominal disease, whose pathogenesis remains unclear. The severe patients usually have multiple complications and lack specific drugs, leading to a high mo... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 11, 2024 Category: Research Authors: Kaige Yang, Rongli Xie, Guohui Xiao, Zhifeng Zhao, Min Ding, Tingyu Lin, Yiu Sing Tsang, Ying Chen, Dan Xu and Jian Fei Tags: Research Source Type: research
THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma
THOC7-AS1 and FSTL1 expression are frequently upregulated in cutaneous squamous cell carcinoma (cSCC). However, their molecular biological mechanisms remain elusive and their potential as therapeutic targets n... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 11, 2024 Category: Research Authors: Site Yu, Xu Cui, Situo Zhou, Yun Li, Wenjie Feng, Xiangjun Zhang, Yuhui Zhong and Pihong Zhang Tags: Research Source Type: research
Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study
Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID. Howeve... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 10, 2024 Category: Research Authors: Joan Carles Domingo, Federica Battistini, Bego ña Cordobilla, Maria Cleofé Zaragozá, Ramón Sanmartin-Sentañes, Jose Alegre-Martin, Trinitat Cambras and Jesus Castro-Marrero Tags: Research Source Type: research
Lack of shared neoantigens in prevalent mutations in cancer
Tumors are mostly characterized by genetic instability, as result of mutations in surveillance mechanisms, such as DNA damage checkpoint, DNA repair machinery and mitotic checkpoint. Defect in one or more of t... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 10, 2024 Category: Research Authors: Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Tagliamonte and Luigi Buonaguro Tags: Research Source Type: research
Increased risk of psychiatric disorder in patients with hearing loss: a nationwide population-based cohort study
Hearing loss has been shown to be a risk factor for psychiatric disorders. In addition, long-term hearing loss is associated with increased hospitalization and mortality rates; however, the increased risk and ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 10, 2024 Category: Research Authors: Qun-Yi Nian, Chun-An Cheng, Li-Hsiang Cheng, Yuan-Yung Lin, Chin-Hung Wang, Wu-Chien Chien, Yueng-Hsiang Chu, Cheng-Ping Shih, Chao-Yin Kuo, Hsin-Chien Chen, Jih-Chin Lee, Chi-Hsiang Chung, Wei-Chuan Shangkuan and Hung-Che Lin Tags: Research Source Type: research
SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights
SIRPB1 expression is upregulated in various tumor types, including gliomas, and is known to contribute to tumor progression; nevertheless, its function in the immune milieu of gliomas is still mainly unknown. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 9, 2024 Category: Research Authors: Ren Geng, Yao Zhao, Wanzhen Xu, Xiaoshan Ma, Yining Jiang, Xuefei Han, Liyan Zhao and Yunqian Li Tags: Research Source Type: research
Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field
One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies and current applications are moving on antigen, DNA and RNA-based vaccines to overcome the limita... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 9, 2024 Category: Research Authors: Domenico Riccardi, Lucia Baldino and Ernesto Reverchon Tags: Review Source Type: research
Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma
Lung adenocarcinoma (LUAD), the most common and lethal subtype of lung cancer, continues to be a major health concern worldwide. Despite advances in targeted and immune therapies, only a minority of patients d... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 9, 2024 Category: Research Authors: Zizhen Li, Wenhua Lu, Feng Yin, Peiting Zeng, Heping Li and Amin Huang Tags: Research Source Type: research
In situ chemoimmunotherapy hydrogel elicits immunogenic cell death and evokes efficient antitumor immune response
Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity of chemotherapy and tumor immunosuppressive micr... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 9, 2024 Category: Research Authors: Qin Liu, Rui Xu, Jingwen Shen, Yaping Tao, Jingyi Shao, Yaohua Ke and Baorui Liu Tags: Research Source Type: research
Longitudinal study of the impact of the COVID-19 pandemic on diet and physical activity among Latinos of Mexican ancestry
The COVID-19 pandemic caused societal disruption in the United States and most of the world, affecting many aspects of life, including healthcare and health-related behaviors such as diet, food security, and p... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 9, 2024 Category: Research Authors: Giovanna Muscogiuri, Lindsay Kohler, Oscar Parra, Lisa Soltani, Douglas Spegman, Dawn Coletta and Lawrence J. Mandarino Tags: Research Source Type: research
CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle
This study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) cancer and its effects on stemness and metastasis. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 8, 2024 Category: Research Authors: Yafeng Liu, Tao Han, Zhi Xu, Jing Wu, Jiawei Zhou, Jianqiang Guo, Rui Miao, Yingru Xing, Deyong Ge, Ying Bai and Dong Hu Tags: Research Source Type: research
