Optimization of the Mainzelliste software for fast privacy-preserving record linkage
Data analysis for biomedical research often requires a record linkage step to identify records from multiple data sources referring to the same person. Due to the lack of unique personal identifiers across the... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 15, 2021 Category: Research Authors: Florens Rohde, Martin Franke, Ziad Sehili, Martin Lablans and Erhard Rahm Tags: Methodology Source Type: research

Alteration of transthyretin and thyroxine-binding globulin in major depressive disorder: multiple reaction monitoring-based proteomic analysis
The objective of this study was to perform proteomic analysis to identify proteins with changed exp... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 15, 2021 Category: Research Authors: Hye In Woo, Jisook Park, Shinn-Won Lim, Doh Kwan Kim and Soo-Youn Lee Tags: Research Source Type: research

Immune landscape and prognostic immune-related genes in KRAS-mutant colorectal cancer patients
KRAS gene is the most common type of mutation reported in colorectal cancer (CRC). KRAS mutation-mediated regulation of immunophenotype and immune pathways in CRC remains to be elucidated. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 7, 2021 Category: Research Authors: Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang and Weizhong Tang Tags: Research Source Type: research

Systematic review and meta-analysis of the prognostic significance of microRNAs related to metastatic and EMT process among prostate cancer patients
The ability of tumor cells to spread from their origin place and form secondary tumor foci is determined by the epithelial –mesenchymal transition process. In epithelial tumors such as prostate cancer (PCa), th... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 7, 2021 Category: Research Authors: Martyna Parol, Arkadiusz Gzil, Magdalena Bodnar and Dariusz Grzanka Tags: Review Source Type: research

CT radiomics facilitates more accurate diagnosis of COVID-19 pneumonia: compared with CO-RADS
This study aimed to investigate the value of chest CT radiomics for diagnosing COVID-19 pneumonia ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 7, 2021 Category: Research Authors: Huanhuan Liu, Hua Ren, Zengbin Wu, He Xu, Shuhai Zhang, Jinning Li, Liang Hou, Runmin Chi, Hui Zheng, Yanhong Chen, Shaofeng Duan, Huimin Li, Zongyu Xie and Dengbin Wang Tags: Research Source Type: research

Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients
COVID-19 has caused a global pandemic and the death toll is increasing. However, there is no definitive information regarding the type of clinical specimens that is the best for SARS-CoV-2 detection, the antib... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 7, 2021 Category: Research Authors: Ling Li, Chianru Tan, Jia Zeng, Chen Luo, Shi Hu, Yanke Peng, Wenjuan Li, Zhixiong Xie, Yueming Ling, Xuejun Zhang, E. Deng, Haixia Xu, Jue Wang, Yudi Xie, Yaling Zhou, Wei Zhang & hellip; Tags: Research Source Type: research

Transcriptomic analysis identifies organ-specific metastasis genes and pathways across different primary sites
Metastasis is the most devastating stage of cancer progression and often shows a preference for specific organs. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 7, 2021 Category: Research Authors: Lin Zhang, Ming Fan, Francesco Napolitano, Xin Gao, Ying Xu and Lihua Li Tags: Research Source Type: research

Hemolysis at low blood flow rates: in-vitro and in-silico evaluation of a centrifugal blood pump
Treating severe forms of the acute respiratory distress syndrome and cardiac failure, extracorporeal membrane oxygenation (ECMO) has become an established therapeutic option. Neonatal or pediatric patients rec... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 5, 2021 Category: Research Authors: Malte Sch öps, Sascha H. Groß-Hardt, Thomas Schmitz-Rode, Ulrich Steinseifer, Daniel Brodie, Johanna C. Clauser and Christian Karagiannidis Tags: Research Source Type: research

The evidence base for physiotherapy in myalgic encephalomyelitis/chronic fatigue syndrome when considering post-exertional malaise: a systematic review and narrative synthesis
Due to the inconsistent use of diagnostic criteria in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), it is unsure whether physiotherapeutic management regarded effective in ME/CFS is appropriate ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - January 4, 2021 Category: Research Authors: Marjon E. A. Wormgoor and Sanne C. Rodenburg Tags: Review Source Type: research

Design of a companion bioinformatic tool to detect the emergence and geographical distribution of SARS-CoV-2 Spike protein genetic variants
Tracking the genetic variability of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) is a crucial challenge. Mainly to identify target sequences in order to generate robust vaccines and neutralizin... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 30, 2020 Category: Research Authors: Alice Massacci, Eleonora Sperandio, Lorenzo D ’Ambrosio, Mariano Maffei, Fabio Palombo, Luigi Aurisicchio, Gennaro Ciliberto and Matteo Pallocca Tags: Research Source Type: research

Parkinson ’s disease following COVID-19: causal link or chance occurrence?
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 29, 2020 Category: Research Authors: Wei-Shan Li, Ling-Ling Chan, Yin-Xia Chao and Eng-King Tan Tags: Letter to the Editor Source Type: research

Correction to: Systematic review of randomized controlled trials for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 23, 2020 Category: Research Authors: Do-Young Kim, Jin-Seok Lee, Samuel-Young Park, Soo-Jin Kim and Chang-Gue Son Tags: Correction Source Type: research

May the analysis of 1918 influenza pandemic give hints to imagine the possible magnitude of Corona Virus Disease-2019 (COVID-19)?
In 1918 an unknown infectious agent spread around the world infecting over one-third of the general population and killing almost 50 million people. Many countries were at war, the First World War. Since Spain... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 22, 2020 Category: Research Authors: Raffaele Scarpa, Francesco Caso, Luisa Costa, Saverio Passavanti, Maria Grazia Vitale, Claudia Trojaniello, Antonio Del Puente and Paolo A. Ascierto Tags: Review Source Type: research

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 22, 2020 Category: Research Authors: Abu Saleh Md Moin, Thozhukat Sathyapalan, Stephen L. Atkin and Alexandra E. Butler Tags: Letter to the Editor Source Type: research

Correction to: The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 22, 2020 Category: Research Authors: Junfeng Sun, Chaohui Ding, Zhen Yang, Tao Liu, Xiefu Zhang, Chunlin Zhao and Jiaxiang Wang Tags: Correction Source Type: research

Evaluation of the diagnostic accuracy of a new point-of-care rapid test for SARS-CoV-2 virus detection
The easy access to a quick diagnosis of coronavirus disease 2019 (COVID-19) is a key point to improve the management of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and to contain its spread. U... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 21, 2020 Category: Research Authors: Leonardo Miscio, Antonio Olivieri, Francesco Labonia, Gianfranco De Feo, Paolo Chiodini, Giuseppe Portella, Luigi Atripaldi, Roberto Parrella, Rodolfo Conenna, Franco Maria Buonaguro, Ernesta Cavalcanti, Paolo Ascierto, Gerardo Botti and Attilio Bianchi Tags: Research Source Type: research

Donor-intrinsic variables determine mobilization efficiency: analyses from a cohort of sixty twice-mobilized stem cell donors
Healthy volunteer registry donors have become the backbone of stem cell transplantation programs. While most registrants will never become actual donors, a small minority are called upon twice, most commonly f... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 18, 2020 Category: Research Authors: Soo-Zin Kim-Wanner, Seo-Youn Lee, Erhard Seifried and Halvard Bonig Tags: Research Source Type: research

The effectiveness of pediatric obesity prevention policies: a comprehensive systematic review and dose –response meta-analysis of controlled clinical trials
Childhood obesity persists as a serious public health problem. In the current meta-analysis, we summarized the results of controlled trials that evaluated the effect of obesity prevention policies in children ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 14, 2020 Category: Research Authors: Shahnaz Taghizadeh and Mahdieh Abbasalizad Farhangi Tags: Review Source Type: research

Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres
Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase (IDH)-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells.... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 14, 2020 Category: Research Authors: Seon-Jin Yoon, Hye Young Son, Jin-Kyoung Shim, Ju Hyung Moon, Eui-Hyun Kim, Jong Hee Chang, Wan Yee Teo, Se Hoon Kim, Sahng Wook Park, Yong-Min Huh and Seok-Gu Kang Tags: Research Source Type: research

Potential causal factors of CFS/ME: a concise and systematic scoping review of factors researched
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is understood as a complex condition, likely triggered and sustained by an interplay of biological, psychological, and social factors. Little oversig... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 14, 2020 Category: Research Authors: Ashley Elizabeth Muller, Kari Tveito, Inger Johanne Bakken, Signe A. Flottorp, Siri Mjaaland and Lillebeth Larun Tags: Review Source Type: research

Viruses belonging to Anelloviridae or Circoviridae as a possible cause of chronic fatigue
Chronic fatigue often starts with an acute viral infection —as witnessed in the case of SARS-CoV-2—but indirect consequences of these infections are presumably the actual cause of the condition. As recently rev... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 14, 2020 Category: Research Authors: Bj ørn Grinde Tags: Commentary Source Type: research

Survival differences by ethnicity among patients diagnosed with bladder cancer
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 14, 2020 Category: Research Authors: Boda Guo and Ming Liu Tags: Letter to the Editor Source Type: research

PD-L1 expression in liver metastasis: its clinical significance and discordance with primary tumor in colorectal cancer
This study wa... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 11, 2020 Category: Research Authors: Xiao-Li Wei, Xuan Luo, Hui Sheng, Yun Wang, Dong-Liang Chen, Jia-Ning Li, Feng-Hua Wang and Rui-Hua Xu Tags: Research Source Type: research

Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data
Nonalcoholic fatty liver disease (NAFLD) is primarily characterized by the hepatic cholesterol accumulation. Circular RNA (circRNA), one of noncoding RNA, involves in many liver diseases progression. However, ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 11, 2020 Category: Research Authors: Xinlu Yuan, Jianjun Diao, Anqing Du, Song Wen, Ligang Zhou and Yangbin Pan Tags: Research Source Type: research

Exogenous interleukin-33 promotes hepatocellular carcinoma growth by remodelling the tumour microenvironment
Interleukin-33 (IL-33) is an effective inducer of pro-inflammatory cytokines regulating innate and adaptive immunity. Inflammation could be a double-edged sword, promoting or inhibiting tumour growth. To date,... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 11, 2020 Category: Research Authors: Wenxiu Wang, Jun Wu, Mei Ji and Changping Wu Tags: Research Source Type: research

Plasma levels and tissue expression of soluble TGF βrIII receptor in women with early-stage breast cancer and in healthy women: a prospective observational study
Mammary carcinogenesis is partly regulated by the transforming growth factor beta (TGF β) signaling pathway. Its function in cancer progression and metastasis is highly dependent on disease stage, and it is lik... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 11, 2020 Category: Research Authors: Lovorka Grgurevic, Ruder Novak, Vladimir Trkulja, Stela Hrkac, Grgur Salai, Josko Bilandzic, Lejla Ferhatovic Hamzic, Ivan Milas, Tiha Vucemilo, Melita Peric Balja and Karmen Bilic Tags: Research Source Type: research

The roles of osteocytes in alveolar bone destruction in periodontitis
Periodontitis, a bacterium-induced inflammatory disease that is characterized by alveolar bone loss, is highly prevalent worldwide. Elucidating the underlying mechanisms of alveolar bone loss in periodontitis ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 11, 2020 Category: Research Authors: Xiaofei Huang, Mengru Xie, Yanling Xie, Feng Mei, Xiaofeng Lu, Xiaoshuang Li and Lili Chen Tags: Review Source Type: research

Cellular analysis of bronchoalveolar lavage fluid to narrow differential diagnosis of checkpoint inhibitor-related pneumonitis in metastatic melanoma
The diagnosis of check-point inhibitor-related pneumonitis (CIP) relies on radiological and clinical patterns which are not specific and can mimic other conditions (cancer progression, infectious diseases or i... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 10, 2020 Category: Research Authors: Sabino Strippoli, Livia Fucci, Antonio Negri, Daniela Putignano, Marco Luigi Cisternino, Gaetano Napoli, Ruggiero Filannino, Ivana De Risi, Angela Monica Sciacovelli and Michele Guida Tags: Research Source Type: research

Hypoxic exosomes orchestrate tumorigenesis: molecular mechanisms and therapeutic implications
The solid tumor microenvironment possesses a hypoxic condition, which promotes aggressiveness and resistance to therapies. Hypoxic tumor cells undergo broadly metabolic and molecular adaptations and communicat... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 10, 2020 Category: Research Authors: Reza Jafari, Reza Rahbarghazi, Mahdi Ahmadi, Mehdi Hassanpour and Jafar Rezaie Tags: Review Source Type: research

Comparing COVID-19-linked neurological complications with other viral infections
(Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 9, 2020 Category: Research Authors: Xiao Deng, Yew-Long Lo and Eng -King Tan Tags: Letter to the Editor Source Type: research

Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes
In pre-clinical research, systematic reviews have the potential to mitigate translational challenges by facilitating understanding of how pre-clinical studies can inform future clinical research. Yet their con... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 9, 2020 Category: Research Authors: Nicola L. Harman, Adri án Sanz-Moreno, Stamatia Papoutsopoulou, Katie A. Lloyd, Kamar E. Ameen-Ali, Malcolm Macleod and Paula R. Williamson Tags: Research Source Type: research

Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy
Cardiomyopathy is a common side effect of doxorubicin (DOX) chemotherapy. Despite intensive research efforts in the field, there is still no evidence available for routine cardioprotective prophylaxis to preve... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 9, 2020 Category: Research Authors: M ária Lódi, Viktor Bánhegyi, Beáta Bódi, Alexandra Gyöngyösi, Árpád Kovács, Anita Árokszállási, Nazha Hamdani, Miklós Fagyas, István Édes, Zoltán Csanádi, István Czuriga, Zoltán Kisvárday, István Lekli, Péter Bai, Attila Tóth, Zol Tags: Research Source Type: research

Non-invasive biomarkers for monitoring the immunotherapeutic response to cancer
Immunotherapy is an efficient way to cure cancer by modulating the patient ’s immune response. However, the immunotherapy response is heterogeneous and varies between individual patients and cancer subtypes, re... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 9, 2020 Category: Research Authors: Sabah Nisar, Ajaz A. Bhat, Sheema Hashem, Santosh K. Yadav, Arshi Rizwan, Mayank Singh, Puneet Bagga, Muzafar A. Macha, Michael P. Frenneaux, Ravinder Reddy and Mohammad Haris Tags: Review Source Type: research

Precision medicine in the era of artificial intelligence: implications in chronic disease management
Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to health and leading to diminished life expectancy. A dysregulated metabolism induces the secretion of several mo... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 9, 2020 Category: Research Authors: Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre, Sabri Boughorbel, Jingxuan Shan, Khaled B. Letaief, Nelly Pitteloud and Lotfi Chouchane Tags: Review Source Type: research

Risk factors for severe COVID-19 in middle-aged patients without comorbidities: a multicentre retrospective study
Information regarding characteristics and risk factors of COVID-19 amongst middle-aged (40 –59 years) patients without comorbidities is scarce. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 7, 2020 Category: Research Authors: Peng Wang, Jing Sha, Mei Meng, Cuiyan Wang, Qingchun Yao, Zhongfa Zhang, Wenqing Sun, Xingguang Wang, Guoqiang Qie, Xue Bai, Keke Liu and Yufeng Chu Tags: Research Source Type: research

Predicting 30-days mortality for MIMIC-III patients with sepsis-3: a machine learning approach using XGboost
Sepsis is a significant cause of mortality in-hospital, especially in ICU patients. Early prediction of sepsis is essential, as prompt and appropriate treatment can improve survival outcomes. Machine learning ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 7, 2020 Category: Research Authors: Nianzong Hou, Mingzhe Li, Lu He, Bing Xie, Lin Wang, Rumin Zhang, Yong Yu, Xiaodong Sun, Zhengsheng Pan and Kai Wang Tags: Research Source Type: research

Exploration of predictive and prognostic alternative splicing signatures in lung adenocarcinoma using machine learning methods
Alternative splicing (AS) plays critical roles in generating protein diversity and complexity. Dysregulation of AS underlies the initiation and progression of tumors. Machine learning approaches have emerged a... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 7, 2020 Category: Research Authors: Qidong Cai, Boxue He, Pengfei Zhang, Zhenyu Zhao, Xiong Peng, Yuqian Zhang, Hui Xie and Xiang Wang Tags: Research Source Type: research

Respiratory microbiome profiles differ by recent hospitalization and nursing home residence in patients on mechanical ventilation
Healthcare-associated pneumonia (HCAP) is a heterogeneous disease. We redefined nursing-home- and hospital-associated infections (NHAI) group by revising existing HCAP risk factors. The NHAI group comprised nu... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 7, 2020 Category: Research Authors: Min-gyung Baek, Seong Ji Woo, Nam Eun Kim, Chaeyun Baek, Sungho Won, Youngmi Kim, Jae Jun Lee, Hana Yi and Ji Young Hong Tags: Research Source Type: research

The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
Although immune modulation is a promising therapeutic avenue in coronavirus disease 2019 (COVID-19), the most relevant targets remain to be found. COVID-19 has peculiar characteristics and outcomes, suggesting... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 3, 2020 Category: Research Authors: Mathieu Blot, Jean-Baptiste Bour, Jean Pierre Quenot, Abderrahmane Bourredjem, Maxime Nguyen, Julien Guy, Serge Monier, Marjolaine Georges, Audrey Large, Auguste Dargent, Alexandre Guilhem, Suzanne Mouries-Martin, Jeremy Barben, Belaid Bouhemad, Pierre-Em Tags: Research Source Type: research

Intra-erythrocytes magnesium deficiency could reflect cognitive impairment status due to vascular disease: a pilot study
Magnesium is a fundamental cation that regulates neuronal transmission, protein synthesis, energy metabolism. Magnesium deficiency mostly affects nervous and cardiovascular systems determining weakness, tremor... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 3, 2020 Category: Research Authors: Clementina Sitzia, Michele Sterlicchio, Calogero Crapanzano, Elena Dozio, Elena Vianello and Massimiliano Marco Corsi Romanelli Tags: Research Source Type: research

Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858
Exosome-derived microRNAs (exo-miRs) as messengers play important roles, in the cross-talk between genetic [ATP-sensitive potassium channels (KATP) genetic variant rs1799858] and environmental [elevated serum low... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 3, 2020 Category: Research Authors: Cheng Liu, Yanxian Lai, Songsong Ying, Junfang Zhan and Yan Shen Tags: Research Source Type: research

Association of carbamylated high-density lipoprotein with coronary artery disease in type 2 diabetes mellitus: carbamylated high-density lipoprotein of patients promotes monocyte adhesion
Increasing evidence showed that carbamylated lipoprotein accelerated atherosclerosis. However, whether such modification of high-density lipoprotein (HDL) particles alters in type 2 diabetes mellitus (T2DM) pa... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 3, 2020 Category: Research Authors: Zhongli Chen, Song Ding, Yan Ping Wang, Liang Chen, Jing Yan Mao, Ying Yang, Jia Teng Sun and Ke Yang Tags: Research Source Type: research

Regulatory T cells mediated immunomodulation during asthma: a therapeutic standpoint
Asthma is an inflammatory disease of the lung airway network, which is initiated and perpetuated by allergen-specific CD4+ T cells, IgE antibodies, and a massive release of Th2 cytokines. The most common clinical... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - December 2, 2020 Category: Research Authors: Mohammad Afzal Khan Tags: Review Source Type: research

Logistics of an advanced therapy medicinal product during COVID-19 pandemic in Italy: successful delivery of mesenchymal stromal cells in dry ice
During the coronavirus disease-2019 (COVID-19) pandemic, Italian hospitals faced the most daunting challenges of their recent history, and only essential therapeutic interventions were feasible. From March to ... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - November 30, 2020 Category: Research Authors: Giuseppe Astori, Martina Bernardi, Angela Bozza, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Monica Santimaria, Roberto Barbazza, Giuseppe Amodeo, Rachele Ciccocioppo, Francesca Elice and Marco Ruggeri Tags: Research Source Type: research

LMWF5A suppresses cytokine release by modulating select inflammatory transcription factor activity in stimulated PBMC
Dysregulation of transcription and cytokine expression has been implicated in the pathogenesis of a variety inflammatory diseases. The resulting imbalance between inflammatory and resolving transcriptional pro... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - November 30, 2020 Category: Research Authors: Gregory Thomas, Elizabeth Frederick, Lisa Thompson, Raphael Bar-Or, Yetti Mulugeta, Melissa Hausburg, Michael Roshon, Charles Mains and David Bar-Or Tags: Research Source Type: research

Heparanase and the hallmarks of cancer
Heparanase is the only mammalian enzyme that cleaves heparan sulphate, an important component of the extracellular matrix. This leads to the remodelling of the extracellular matrix, whilst liberating growth fa... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - November 30, 2020 Category: Research Authors: Krishnath M. Jayatilleke and Mark D. Hulett Tags: Review Source Type: research

A machine learning-based clinical tool for diagnosing myopathy using multi-cohort microarray expression profiles
Myopathies are a heterogenous collection of disorders characterized by dysfunction of skeletal muscle. In practice, myopathies are frequently encountered by physicians and precise diagnosis remains a challenge... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - November 30, 2020 Category: Research Authors: Andrew Tran, Chris J. Walsh, Jane Batt, Claudia C. dos Santos and Pingzhao Hu Tags: Research Source Type: research

Positive association of Parkinson ’s disease with ankylosing spondylitis: a nationwide population-based study
Ankylosing spondylitis (AS) is characterized by excessive production of inflammatory cytokines. Recent evidence suggests that inflammation underlies the neurodegenerative process of Parkinson ’s disease (PD). W... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - November 30, 2020 Category: Research Authors: Fu-Chiang Yeh, Hsiang-Cheng Chen, Yu-Ching Chou, Cheng-Li Lin, Chia-Hung Kao, Hsin-Yi Lo, Feng-Cheng Liu and Tse-Yen Yang Tags: Research Source Type: research

Correction to: LTBP1 plays a potential bridge between depressive disorder and glioblastoma
An amendment to this paper has been published and can be accessed via the original article. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - November 27, 2020 Category: Research Authors: Xiaojun Fu, Pei Zhang, Hongwang Song, Chenxing Wu, Shengzhen Li, Shouwei Li and Changxiang Yan Tags: Correction Source Type: research

Mesenchymal stem cell derived-exosomes: a modern approach in translational medicine
Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for over a few decades by virtue of their differentiation capacity, potent immunomodulatory properties, and their ability to... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - November 27, 2020 Category: Research Authors: Sepideh Nikfarjam, Jafar Rezaie, Naime Majidi Zolbanin and Reza Jafari Tags: Review Source Type: research