Knockdown of Peroxiredoxin V increased the cytotoxicity of non-thermal plasma-treated culture medium to A549 cells
Aging (Albany NY). 2022 May 11;14(undefined). doi: 10.18632/aging.204063. Online ahead of print.ABSTRACTAdministration of non-thermal plasma therapy via the use of plasma-activated medium (PAM) might be a novel strategy for cancer treatment, as it induces apoptosis by increasing reactive oxygen species (ROS) levels. Peroxiredoxin V (PRDX5) scavenges ROS and reactive nitrogen species and is known to regulate several physiological and pathological reactions. However, its role in lung cancer cells exposed to PAM is unknown. Here, we investigated the effect of PRDX5 in PAM-treated A549 lung cancer cells and determined the mech...
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Hu-Nan Sun Xiao-Yu Guo Dan-Ping Xie Xiao-Ming Wang Chen-Xi Ren Ying-Hao Han Nan-Nan Yu Yu-Lan Huang Taeho Kwon Source Type: research

Ferroptosis-related long non-coding RNA signature predicts the prognosis of hepatocellular carcinoma
CONCLUSIONS: The risk model based on seventeen-ferroptosis-related lncRNA has significant prognostic value for HCC and may be therapeutic targets associated with ferroptosis in clinical ways.PMID:35550563 | DOI:10.18632/aging.204073 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Xin Yang Minhui Mei Jingze Yang Jinlu Guo Fan Du Shi Liu Source Type: research

CCL19 has potential to be a potential prognostic biomarker and a modulator of tumor immune microenvironment (TIME) of breast cancer: a comprehensive analysis based on TCGA database
In conclusion, CCL19 functioned as a potential prognostic biomarker and a modulator of TIME in BC through communicating with various TICs.PMID:35550569 | DOI:10.18632/aging.204081 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Jinyan Wang Dongmei Qin Lingling Ye Li Wan Fen Wang Yan Yang Yajun Ma Hui Yang Zhaohui Yang Meili Chen Wen Jiang Quan'an Zhang Source Type: research

RecQ mediated genome instability 2 ( < em > RMI2 < /em > ): a potential prognostic and immunological biomarker for pan-cancers
CONCLUSIONS: RMI2 may serve as a potential biological target and probably assume a crucial part in tumorigenesis and progression.PMID:35552266 | DOI:10.18632/aging.204076 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Wei Wei Xiaomei Ying Liang Chen Qingmei Sun Xiaohuan Lu Yang Xia Rubin Xu Zhechen Zhu Dong Zhang Qikai Tang Li Li Jiaheng Xie Hongzhu Yu Source Type: research

Knockdown of Peroxiredoxin V increased the cytotoxicity of non-thermal plasma-treated culture medium to A549 cells
Aging (Albany NY). 2022 May 11;14(undefined). doi: 10.18632/aging.204063. Online ahead of print.ABSTRACTAdministration of non-thermal plasma therapy via the use of plasma-activated medium (PAM) might be a novel strategy for cancer treatment, as it induces apoptosis by increasing reactive oxygen species (ROS) levels. Peroxiredoxin V (PRDX5) scavenges ROS and reactive nitrogen species and is known to regulate several physiological and pathological reactions. However, its role in lung cancer cells exposed to PAM is unknown. Here, we investigated the effect of PRDX5 in PAM-treated A549 lung cancer cells and determined the mech...
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Hu-Nan Sun Xiao-Yu Guo Dan-Ping Xie Xiao-Ming Wang Chen-Xi Ren Ying-Hao Han Nan-Nan Yu Yu-Lan Huang Taeho Kwon Source Type: research

Ferroptosis-related long non-coding RNA signature predicts the prognosis of hepatocellular carcinoma
CONCLUSIONS: The risk model based on seventeen-ferroptosis-related lncRNA has significant prognostic value for HCC and may be therapeutic targets associated with ferroptosis in clinical ways.PMID:35550563 | DOI:10.18632/aging.204073 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Xin Yang Minhui Mei Jingze Yang Jinlu Guo Fan Du Shi Liu Source Type: research

CCL19 has potential to be a potential prognostic biomarker and a modulator of tumor immune microenvironment (TIME) of breast cancer: a comprehensive analysis based on TCGA database
In conclusion, CCL19 functioned as a potential prognostic biomarker and a modulator of TIME in BC through communicating with various TICs.PMID:35550569 | DOI:10.18632/aging.204081 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Jinyan Wang Dongmei Qin Lingling Ye Li Wan Fen Wang Yan Yang Yajun Ma Hui Yang Zhaohui Yang Meili Chen Wen Jiang Quan'an Zhang Source Type: research

RecQ mediated genome instability 2 ( < em > RMI2 < /em > ): a potential prognostic and immunological biomarker for pan-cancers
CONCLUSIONS: RMI2 may serve as a potential biological target and probably assume a crucial part in tumorigenesis and progression.PMID:35552266 | DOI:10.18632/aging.204076 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Wei Wei Xiaomei Ying Liang Chen Qingmei Sun Xiaohuan Lu Yang Xia Rubin Xu Zhechen Zhu Dong Zhang Qikai Tang Li Li Jiaheng Xie Hongzhu Yu Source Type: research

Knockdown of Peroxiredoxin V increased the cytotoxicity of non-thermal plasma-treated culture medium to A549 cells
Aging (Albany NY). 2022 May 11;14(undefined). doi: 10.18632/aging.204063. Online ahead of print.ABSTRACTAdministration of non-thermal plasma therapy via the use of plasma-activated medium (PAM) might be a novel strategy for cancer treatment, as it induces apoptosis by increasing reactive oxygen species (ROS) levels. Peroxiredoxin V (PRDX5) scavenges ROS and reactive nitrogen species and is known to regulate several physiological and pathological reactions. However, its role in lung cancer cells exposed to PAM is unknown. Here, we investigated the effect of PRDX5 in PAM-treated A549 lung cancer cells and determined the mech...
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Hu-Nan Sun Xiao-Yu Guo Dan-Ping Xie Xiao-Ming Wang Chen-Xi Ren Ying-Hao Han Nan-Nan Yu Yu-Lan Huang Taeho Kwon Source Type: research

Ferroptosis-related long non-coding RNA signature predicts the prognosis of hepatocellular carcinoma
CONCLUSIONS: The risk model based on seventeen-ferroptosis-related lncRNA has significant prognostic value for HCC and may be therapeutic targets associated with ferroptosis in clinical ways.PMID:35550563 | DOI:10.18632/aging.204073 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Xin Yang Minhui Mei Jingze Yang Jinlu Guo Fan Du Shi Liu Source Type: research

CCL19 has potential to be a potential prognostic biomarker and a modulator of tumor immune microenvironment (TIME) of breast cancer: a comprehensive analysis based on TCGA database
In conclusion, CCL19 functioned as a potential prognostic biomarker and a modulator of TIME in BC through communicating with various TICs.PMID:35550569 | DOI:10.18632/aging.204081 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Jinyan Wang Dongmei Qin Lingling Ye Li Wan Fen Wang Yan Yang Yajun Ma Hui Yang Zhaohui Yang Meili Chen Wen Jiang Quan'an Zhang Source Type: research

RecQ mediated genome instability 2 ( < em > RMI2 < /em > ): a potential prognostic and immunological biomarker for pan-cancers
CONCLUSIONS: RMI2 may serve as a potential biological target and probably assume a crucial part in tumorigenesis and progression.PMID:35552266 | DOI:10.18632/aging.204076 (Source: Aging)
Source: Aging - May 13, 2022 Category: Biomedical Science Authors: Wei Wei Xiaomei Ying Liang Chen Qingmei Sun Xiaohuan Lu Yang Xia Rubin Xu Zhechen Zhu Dong Zhang Qikai Tang Li Li Jiaheng Xie Hongzhu Yu Source Type: research

Comprehensive analysis of histone deacetylases genes in the prognosis and immune infiltration of glioma patients
Aging (Albany NY). 2022 May 11;14(undefined). doi: 10.18632/aging.204071. Online ahead of print.ABSTRACTThe occurrence and development of tumors are closely related to histone deacetylases (HDACs). However, their relationship with the overall biology and prognosis of glioma is still unknown. In the present study, we developed and validated a prognostic model for glioma based on HDAC genes. Glioma patients can be divided into two subclasses based on eleven HDAC genes, and patients from the two subclasses had markedly different survival outcomes. Then, using six HDAC genes (HDAC1, HDAC3, HDAC4, HDAC5, HDAC7, and HDAC9), we e...
Source: Aging - May 12, 2022 Category: Biomedical Science Authors: Lin Shen Yanyan Li Na Li Liangfang Shen Zhanzhan Li Source Type: research

Comprehensive analysis of histone deacetylases genes in the prognosis and immune infiltration of glioma patients
Aging (Albany NY). 2022 May 11;14(undefined). doi: 10.18632/aging.204071. Online ahead of print.ABSTRACTThe occurrence and development of tumors are closely related to histone deacetylases (HDACs). However, their relationship with the overall biology and prognosis of glioma is still unknown. In the present study, we developed and validated a prognostic model for glioma based on HDAC genes. Glioma patients can be divided into two subclasses based on eleven HDAC genes, and patients from the two subclasses had markedly different survival outcomes. Then, using six HDAC genes (HDAC1, HDAC3, HDAC4, HDAC5, HDAC7, and HDAC9), we e...
Source: Aging - May 12, 2022 Category: Biomedical Science Authors: Lin Shen Yanyan Li Na Li Liangfang Shen Zhanzhan Li Source Type: research

Elucidating the anti-aging mechanism of Si Jun Zi Tang by integrating network pharmacology and experimental validation < em > in vivo < /em >
In conclusion, the anti-aging effect of SJZT was associated with the inhibition of the PI3K-AKT and P38 MAPK signalling pathways, and these findings were consistent with the network pharmacology prediction.PMID:35537009 | DOI:10.18632/aging.204055 (Source: Aging)
Source: Aging - May 10, 2022 Category: Biomedical Science Authors: Yang Yuan Yanghuan Zhang Runzi Zheng Hongjun Yuan Ruoyu Zhou Shuting Jia Jing Liu Source Type: research