The association between neighborhood deprivation and DNA methylation in an autopsy cohort
Aging (Albany NY). 2024 Apr 24;16. doi: 10.18632/aging.205764. Online ahead of print.ABSTRACTPrevious research has found that living in a disadvantaged neighborhood is associated with poor health outcomes. Living in disadvantaged neighborhoods may alter inflammation and immune response in the body, which could be reflected in epigenetic mechanisms such as DNA methylation (DNAm). We used robust linear regression models to conduct an epigenome-wide association study examining the association between neighborhood deprivation (Area Deprivation Index; ADI), and DNAm in brain tissue from 159 donors enrolled in the Emory Goizueta...
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Lindsay Pett Zhenjiang Li Sarina Abrishamcar Kenyaita Hodge Todd Everson Grace Christensen Marla Gearing Michael S Kobor Chaini Konwar Julia L MacIsaac Kristy Dever Aliza P Wingo Allan Levey James J Lah Thomas S Wingo Anke H üls Source Type: research
Comprehensive bioinformatics analysis of NOX4 as a biomarker for pan-cancer prognosis and immune infiltration
CONCLUSIONS: This study imparts valuable insights into the potential applications of NOX4 in cancer research, highlighting its significance as a multifaceted biomarker with diagnostic, prognostic, and immunomodulatory implications across diverse malignancies.PMID:38663913 | DOI:10.18632/aging.205769 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Yuying Liu Hua Huang Xijun Yang Danhe Huang Xiongwei Wang Mingyu Yuan Lianqing Hong Source Type: research
Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data
CONCLUSIONS: METTL5 is a potential diagnostic marker for AS subtypes. Macrophages, SMCs, and ECs, which exhibit METTL5 upregulation, may modulate AS progression by regulating m6A methylation levels.PMID:38663914 | DOI:10.18632/aging.205755 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Jianjin Wu Lei Wang Shuaishuai Xi Chao Ma Fukang Zou Guanyu Fang Fangbing Liu Xiaokai Wang Lefeng Qu Source Type: research
Comprehensive analysis of macrophage-related genes in prostate cancer by integrated analysis of single-cell and bulk RNA sequencing
Aging (Albany NY). 2024 Apr 24;16. doi: 10.18632/aging.205727. Online ahead of print.ABSTRACTMacrophages, as essential components of the tumor immune microenvironment (TIME), could promote growth and invasion in many cancers. However, the role of macrophages in tumor microenvironment (TME) and immunotherapy in PCa is largely unexplored at present. Here, we investigated the roles of macrophage-related genes in molecular stratification, prognosis, TME, and immunotherapeutic response in PCa. Public databases provided single-cell RNA sequencing (scRNA-seq) and bulk RNAseq data. Using the Seurat R package, scRNA-seq data was pr...
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Jili Zhang Zhihao Li Zhenlin Chen Wenzhen Shi Yue Xu Zhangcheng Huang Zequn Lin Ruiling Dou Shaoshan Lin Xin Jiang Mengqiang Li Shaoqin Jiang Source Type: research
Identification and validation of an anoikis-related genes signature for prognostic implication in papillary thyroid cancer
This study explored the impact of anoikis on PTC prognosis. Analyzing data from GEO, TCGA, and GeneCards, we identified a prognostic signature consisting of six anoikis-related genes (ARGs): EZH2, PRKCQ, CD36, INHBB, TDGF1, and MMP9. This signature independently predicted patient outcomes, with high-risk scores associated with worse prognoses. A robust predictive ability was confirmed via ROC analysis, and a nomogram achieved a C-index of 0.712. Differences in immune infiltration levels were observed between high- and low-risk groups. Importantly, the high-risk group displayed reduced drug sensitivity and poor responses to...
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Runyu Zhao Yingying Lu Zhihan Wan Peipei Qiao Liyun Yang Yi Zhang Shuixian Huang Xiaoping Chen Source Type: research
An exploration of causal relationships between nine neurological diseases and the risk of breast cancer: a Mendelian randomization study
CONCLUSIONS: This study found the trends towards a decreased risk of ER+ breast cancer in patients with Alzheimer's disease and an increased risk in patients with multiple sclerosis. However, due to the limitations of Mendelian randomization, we cannot determine whether there are definite causal relationships between neurological diseases and breast cancer risk. For conclusive evidences, more prospective randomized controlled trials will be needed in the future.PMID:38663930 | DOI:10.18632/aging.205745 (Source: Aging)
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Fei Ren Chenxuan Yang Kexin Feng Qingyao Shang Jiaxiang Liu Xiyu Kang Xin Wang Xiang Wang Source Type: research
New insights from bidirectional Mendelian randomization: causal relationships between telomere length and mitochondrial DNA copy number in aging biomarkers
Aging (Albany NY). 2024 Apr 24;16. doi: 10.18632/aging.205765. Online ahead of print.ABSTRACTMitochondrial DNA (mtDNA) copy number and telomere length (TL) are dynamic factors that have been linked to the aging process in organisms. However, the causal relationship between these variables remains uncertain. In this research, instrumental variables (IVs) related to mtDNA copy number and TL were obtained from publicly available genome-wide association studies (GWAS). Through bidirectional Mendelian randomization (MR) analysis, we examined the potential causal relationship between these factors. The forward analysis, with mtD...
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Xinyu Yan Peixuan Yang Yani Li Ting Liu Yawen Zha Ting Wang Jingjing Zhang Zhijun Feng Minying Li Source Type: research
Identification of protein methyltransferases 5 associated with ferroptosis and immune cell infiltration of head and neck squamous cell carcinoma
Aging (Albany NY). 2024 Apr 25;16. doi: 10.18632/aging.205768. Online ahead of print.ABSTRACTHead and neck tumors are malignant tumors that appear in the head and neck. Although much progress has been made in the treatment of head and neck tumors, many challenges remain. The prognosis of some advanced cases remains poor and survival and quality of life after treatment face certain limitations. Therefore, further research into the pathogenesis and treatment options for head and neck tumors is important in order to improve the prognosis and quality of life of patients. The Protein Arginine Methyltransferase (PRMT) family is ...
Source: Aging - April 25, 2024 Category: Biomedical Science Authors: Xiaoyue Zhang Qiang Liu Lujuan Wang Qiu Peng Source Type: research
Associations among NMR-measured inflammatory and metabolic biomarkers and accelerated aging in cardiac catheterization patients
Aging (Albany NY). 2024 Apr 23;16. doi: 10.18632/aging.205758. Online ahead of print.ABSTRACTResearch into aging has grown substantially with the creation of molecular biomarkers of biological age that can be used to determine age acceleration. Concurrently, nuclear magnetic resonance (NMR) assessment of biomarkers of inflammation and metabolism provides researchers with new ways to examine intermediate risk factors for chronic disease. We used data from a cardiac catheterization cohort to examine associations between biomarkers of cardiometabolic health and accelerated aging assessed using both gene expression (Transcript...
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Henry Raab Elizabeth R Hauser Lydia Coulter Kwee Svati H Shah William E Kraus Cavin K Ward-Caviness Source Type: research
Keratin 6A (KRT6A) promotes radioresistance, invasion, and metastasis in lung cancer via p53 signaling pathway
CONCLUSIONS: Our research concluded that KRT6A may take part in the radioresistance and progression of lung cancer and can be a potential biomarker for lung cancer patients.PMID:38656878 | DOI:10.18632/aging.205742 (Source: Aging)
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Qiang Xu Ziyang Yu Qiteng Mei Kejun Shi Jiaofeng Shen Guangyu Gao Songtao Liu Ming Li Source Type: research
A novel prognostic signature based on cancer stemness and metabolism-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma
CONCLUSION: The current investigation indicated that a 3-gene signature based on stemness-related metabolic and 4 hub genes with differential expression between high and low-risk score subgroups may serve as valuable prognostic markers and potential therapeutic targets in CESC.PMID:38656879 | DOI:10.18632/aging.205757 (Source: Aging)
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Yaokai Wang Yuanyuan Han Liangzi Jin Lulu Ji Yanxiang Liu Min Lin Sitong Zhou Ronghua Yang Source Type: research
Hepatocyte-specific METTL3 ablation by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and postnatal lethality
In this study, we explored the potential reasons why hepatocyte-specific METTL3 homozygous disruption by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and then postnatal lethality.MAIN METHODS: Mice with hepatocyte-specific METTL3 knockout were generated by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT; Strain No. T003814) purchased from the GemPharmatech Co., Ltd., (Nanjing, China) or with Alb-Cre mice (JAX; Strain No. 003574) obtained from The Jackson Laboratory, followed by combined-phenotype analysis. The publicly available RNA-sequencing data deposited in ...
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Shihao Huang Yingchun Li Bingjie Wang Zhihao Zhou Yonglong Li Lingjun Shen Jinge Cong Liuxin Han Xudong Xiang Jiawei Xia Danhua He Zhanlin Zhao Ying Zhou Qiwen Li Guanqi Dai Hanzhang Shen Taoyan Lin Aibing Wu Junshuang Jia Dong Xiao Jing Li Wentao Zhao Xi Source Type: research
USP15 facilitates the progression of bladder cancer by amplifying the activation of the NF- κB signaling pathway
Aging (Albany NY). 2024 Mar 28;16. doi: 10.18632/aging.205696. Online ahead of print.ABSTRACTUSP15, a pivotal member of the deubiquitinase family, plays a crucial role in orchestrating numerous vital biological processes, including the regulation of NF-κB signaling pathway and deubiquitination of proto-oncogenes. In various cancers, USP15 has been validated to exhibit up-regulated expression, impacting the initiation and progression of cancer. However, its precise mechanism in bladder cancer remains elusive. Our study shed light on the significant overexpression of USP15 in bladder cancer cells compared to normal bladder ...
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Yun Li Chenghang Jiang Quanqi Liu Pengfei Zhou Daxue Tian Ying Zeng Mingfeng Xiang Source Type: research
Integrated multi-omics analysis and machine learning identify hub genes and potential mechanisms of resistance to immunotherapy in gastric cancer
CONCLUSIONS: The results unveil an association between CDH6, EGFLAM, and RASGRF2 and the immunotherapeutic response in gastric cancer. These genes hold potential as predictive biomarkers for gastric cancer immunotherapy resistance and prognostic assessment.PMID:38656888 | DOI:10.18632/aging.205760 (Source: Aging)
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Jinsong Wang Jia Feng Xinyi Chen Yiming Weng Tong Wang Jiayan Wei Yujie Zhan Min Peng Source Type: research
Heart failure potentially affects the cortical structure of the brain
CONCLUSIONS: HF was potentially associated with changes in cortical thickness and in the surface area of the caudal middle frontal lobule, insula lobule, precuneus lobule and superior parietal lobule.PMID:38656892 | DOI:10.18632/aging.205762 (Source: Aging)
Source: Aging - April 24, 2024 Category: Biomedical Science Authors: Yinqin Hu Tianyun Shi Zhaohui Xu Meng Zhang Jiahui Yang Zhirui Liu Qiqi Wan Yongming Liu Source Type: research
