lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1
CONCLUSIONS: Our research suggests that linc00907 functions as a competitive endogenous RNA (ceRNA) by sequestering miRNA-942-5p, thus increasing the expression of TAOK1 and encouraging lipid accumulation in hepatocytes, leading to the aggravation of NASH development. Targeting the linc00907/miRNA-942-5p/TAOK1 axis may hold therapeutic potential for the treatment of NASH.PMID:38613803 | DOI:10.18632/aging.205730 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Gang Du Zhaochen Jiang Tong Xia Mingkun Liu Zeyang Liu Huaxin Zhou Hao Zhang Xiangyu Zhai Bin Jin Source Type: research
The mechanism of USP43 in the development of tumor: a literature review
Aging (Albany NY). 2024 Apr 8;16. doi: 10.18632/aging.205731. Online ahead of print.ABSTRACTUbiquitination of the proteins is crucial for governing protein degradation and regulating fundamental cellular processes. Deubiquitinases (DUBs) have emerged as significant regulators of multiple pathways associated with cancer and other diseases, owing to their capacity to remove ubiquitin from target substrates and modulate signaling. Consequently, they represent potential therapeutic targets for cancer and other life-threatening conditions. USP43 belongs to the DUBs family involved in cancer development and progression. This rev...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Ziqi Zhao Meichen Liu Zhikun Lin Mengru Zhu Linlin Lv Xinqing Zhu Rui Fan Abdullah Al-Danakh Hui He Guang Tan Source Type: research
Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine γ-lyase expression in a rat model of intracerebral hemorrhage
CONCLUSIONS: This study thereby emphasizes the crucial role of ATF6 in secondary brain injury in response to ICH, indicating that ATF6 upregulation may potentially ameliorate ICH-induced secondary brain injury. Consequently, ATF6 could serve as a promising therapeutic target to alleviate clinical ICH-induced secondary brain injuries.PMID:38613810 | DOI:10.18632/aging.205737 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Tianyu Liang Sen Xu Renyang Liu Xiaoping Xia Source Type: research
The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats
This study determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior in the TgF344-AD rat model of AD. At 6 months-old, TgF344-AD and wild-type (WT) littermates were placed on a control (CD), KD, or IKD (morning CD and afternoon KD) provided as two meals per day for 2 or 6 months. Cognitive and motor behavior and circulating β-hydroxybutyrate (BHB), AD biomarkers and blood lipids were assessed. Animals on a KD diet had elevated circulating BHB, with IKD levels intermediate to CD and KD. TgF344-AD rats displayed impaired spatial learning memory in the Barnes maze at 8 and 12 months of age and imp...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Jennifer M Rutkowsky Zabrisky Roland Anthony Valenzuela An B Nguyen Heui Hye Park Natalie Six Ilknur Dursun Kyoungmi Kim Pamela J Lein Jon J Ramsey Source Type: research
The coupling between healthspan and lifespan in < em > Caenorhabditis < /em > depends on complex interactions between compound intervention and genetic background
In this study, thermotolerance, but not oxidative stress or swimming ability, correlates with lifespan. Notably, some compounds exert strong impact on some health measures without an equally strong impact on lifespan. Our results demonstrate the importance of assessing health and lifespan across genetic backgrounds in the effort to identify reproducible anti-aging interventions, with data underscoring how personalized treatments might be required to optimize health benefits.PMID:38613792 | DOI:10.18632/aging.205743 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Stephen A Banse E Grace Jackson Christine A Sedore Brian Onken David Hall Anna Coleman-Hulbert Phu Huynh Theo Garrett Erik Johnson Girish Harinath Delaney Inman Suzhen Guo Mackenzie Morshead Jian Xue Ron Falkowski Esteban Chen Christopher Herrera Allie J Source Type: research
NXPH4 can be used as a biomarker for pan-cancer and promotes colon cancer progression
Aging (Albany NY). 2024 Apr 12;16. doi: 10.18632/aging.205648. Online ahead of print.ABSTRACTNXPH4 promotes cancer proliferation and invasion. However, its specific role and mechanism in cancer remain unclear. Transcriptome and clinical data for pan-cancer were derived from the TCGA database. K-M survival curve and univariate Cox were used for prognostic analysis. CIBERSORT and TIMER algorithms were employed to calculate immune cell infiltration. Gene set enrichment analysis (GSEA) was employed for investigating the function of NXPH4. Western blot verified differential expression of NXPH4 in colon cancer. Functional assays...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Zhipeng Zhang Pengfei Wang Siwen Chen Dezhi Xiang Jinzhen Chen Wanchang Huang Xiao Liu Tongwen Yi Dawei Wang Yunfei Pu Longfu He Hao Zhang Source Type: research
Machine learning for identifying tumor stemness genes and developing prognostic model in gastric cancer
Aging (Albany NY). 2024 Apr 12;16. doi: 10.18632/aging.205715. Online ahead of print.ABSTRACTGastric cancer presents a formidable challenge, marked by its debilitating nature and often dire prognosis. Emerging evidence underscores the pivotal role of tumor stem cells in exacerbating treatment resistance and fueling disease recurrence in gastric cancer. Thus, the identification of genes contributing to tumor stemness assumes paramount importance. Employing a comprehensive approach encompassing ssGSEA, WGCNA, and various machine learning algorithms, this study endeavors to delineate tumor stemness key genes (TSKGs). Subseque...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Guo-Xing Li Yun-Peng Chen You-Yang Hu Wen-Jing Zhao Yun-Yan Lu Fu-Jian Wan Zhi-Jun Wu Xiang-Qian Wang Qi-Ying Yu Source Type: research
Garlic oil supplementation blocks inflammatory pyroptosis-related acute lung injury by suppressing the NF- κB/NLRP3 signaling pathway via H < sub > 2 < /sub > S generation
This study aimed to investigate the protective effects of garlic oil (GO) supplementation on lipopolysaccharide (LPS)-induced ALI models. Hematoxylin and eosin staining, pathology scores, lung myeloperoxidase (MPO) activity measurement, lung wet/dry (W/D) ratio detection, and bronchoalveolar lavage fluid (BALF) analysis were performed to investigate ALI histopathology. Real-time polymerase chain reaction, western blotting, and enzyme-linked immunosorbent assay were conducted to evaluate the expression levels of inflammatory factors, nuclear factor-κB (NF-κB), NLRP3, pyroptosis-related proteins, and H2S-producing enzymes....
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Tursunay Dilxat Qiang Shi Xiaofan Chen Xuxin Liu Source Type: research
Age and aging process alter the gut microbes
CONCLUSIONS: The individuals in different ages have characteristic gut microbes. The changes in community structure of gut microbes may be related to age-induced diseases.PMID:38613799 | DOI:10.18632/aging.205728 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Qu Zhanbo Zhuang Jing Han Shugao Wu Yinhang Chu Jian Yu Xiang Zhao Feimin Liu Jian Wu Xinyue Wu Wei Han Shuwen Source Type: research
PROS1 is a crucial gene in the macrophage efferocytosis of diabetic foot ulcers: a concerted analytical approach through the prisms of computer analysis
CONCLUSIONS: PROS1 was identified and validated as a biomarker for DFU. This finding has the potential to provide a target for macrophage clearance of DFU.PMID:38613800 | DOI:10.18632/aging.205732 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Hongshuo Shi Zhicheng Zhang Xin Yuan Guobin Liu Weijing Fan Wenbo Wang Source Type: research
Compound sophora decoction alleviates ulcerative colitis by regulating macrophage polarization through cGAS inhibition: network pharmacology and experimental validation
CONCLUSION: We concluded that CSD alleviated DSS-induced UC by inhibiting cGAS, thus regulating macrophage polarization.PMID:38613801 | DOI:10.18632/aging.205734 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Fei Gao Shuangjiao Deng Yujin Liu Pengcheng Wu Lifen Huang Feng Zhu Chunzhu Wei Yuyi Yuan Yang Gui Yushi Tian Heng Fan Hui Wu Source Type: research
Identification of a robust biomarker LAPTM4A for glioma based on comprehensive computational biology and experimental verification
CONCLUSIONS: In conclusion, our study identifies LATPM4A as a promising biomarker for prognosis and immune characteristics in glioma.PMID:38613802 | DOI:10.18632/aging.205736 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Yongqi Ding Yike Jiang Hong Zeng Minqin Zhou Xuanrui Zhou Zichuan Yu Jingying Pan Xitong Geng Yanting Zhu Hao Zheng Shuhan Huang Yiyang Gong Huabin Huang Chengfeng Xiong Da Huang Source Type: research
lincRNA00907 promotes NASH progression by targeting miRNA-942-5p/TAOK1
CONCLUSIONS: Our research suggests that linc00907 functions as a competitive endogenous RNA (ceRNA) by sequestering miRNA-942-5p, thus increasing the expression of TAOK1 and encouraging lipid accumulation in hepatocytes, leading to the aggravation of NASH development. Targeting the linc00907/miRNA-942-5p/TAOK1 axis may hold therapeutic potential for the treatment of NASH.PMID:38613803 | DOI:10.18632/aging.205730 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Gang Du Zhaochen Jiang Tong Xia Mingkun Liu Zeyang Liu Huaxin Zhou Hao Zhang Xiangyu Zhai Bin Jin Source Type: research
The mechanism of USP43 in the development of tumor: a literature review
Aging (Albany NY). 2024 Apr 8;16. doi: 10.18632/aging.205731. Online ahead of print.ABSTRACTUbiquitination of the proteins is crucial for governing protein degradation and regulating fundamental cellular processes. Deubiquitinases (DUBs) have emerged as significant regulators of multiple pathways associated with cancer and other diseases, owing to their capacity to remove ubiquitin from target substrates and modulate signaling. Consequently, they represent potential therapeutic targets for cancer and other life-threatening conditions. USP43 belongs to the DUBs family involved in cancer development and progression. This rev...
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Ziqi Zhao Meichen Liu Zhikun Lin Mengru Zhu Linlin Lv Xinqing Zhu Rui Fan Abdullah Al-Danakh Hui He Guang Tan Source Type: research
Activating transcription factor 6 alleviates secondary brain injury by increasing cystathionine γ-lyase expression in a rat model of intracerebral hemorrhage
CONCLUSIONS: This study thereby emphasizes the crucial role of ATF6 in secondary brain injury in response to ICH, indicating that ATF6 upregulation may potentially ameliorate ICH-induced secondary brain injury. Consequently, ATF6 could serve as a promising therapeutic target to alleviate clinical ICH-induced secondary brain injuries.PMID:38613810 | DOI:10.18632/aging.205737 (Source: Aging)
Source: Aging - April 13, 2024 Category: Biomedical Science Authors: Tianyu Liang Sen Xu Renyang Liu Xiaoping Xia Source Type: research
