A prognostic signature established based on genes related to tumor microenvironment for patients with hepatocellular carcinoma
CONCLUSION: This study provided TRGs to help classify patients with HCC and predict their prognoses, contributing to personalized treatments for patients with HCC.PMID:38579170 | DOI:10.18632/aging.205722 (Source: Aging)
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Zhongfeng Cui Ge Li Yanbin Shi Xiaoli Zhao Juan Wang Shanlei Hu Chunguang Chen Guangming Li Source Type: research
Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer
CONCLUSIONS: Taken together, these findings implicate TCF19 as a promising therapeutic target in aggressive thyroid malignancies and designate rs2073724 as a causal biomarker warranting further investigation in thyroid cancer.PMID:38579171 | DOI:10.18632/aging.205718 (Source: Aging)
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Xianhui Ruan Yu Liu Shuping Wu Guiming Fu Mei Tao Yue Huang Dapeng Li Songfeng Wei Ming Gao Shicheng Guo Junya Ning Xiangqian Zheng Source Type: research
Pan-cancer analysis of Sushi domain-containing protein 4 (SUSD4) and validated in colorectal cancer
In conclusion, SUSD4 is a valuable prognostic indicator for diverse types of cancer, and it has the potential to be a target for cancer therapy.PMID:38579174 | DOI:10.18632/aging.205712 (Source: Aging)
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Yuchen Zhong Chaojing Zheng Weiyuan Zhang Hongyu Wu Qian Zhang Dechuan Li Haixing Ju Haiyang Feng Yinbo Chen Yongtian Fan Weiping Chen Meng Wang Guiyu Wang Source Type: research
Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF- β1/Smad2 and IL-17A signaling pathways
In this study, we evaluated the effects of stigmasterol on inflammatory cytokines and the TGF-β1/Smad2 and IL-17A signaling pathway in an ovalbumin (OVA)-induced asthma mouse model. Stigmasterol treatment improved airway remodeling. In addition, it significantly attenuated the symptoms of asthma attacks, reduced the number of macrophages, lymphocytes, neutrophils, and eosinophils in BALF and inflammatory cytokines, including IL-1β, IL-5, IL-6, and IL-13. It further decreased the level of IL-17A in BALF, serum and spleen. Spleen single-cell suspension analysis via flow cytometry showed that IL-17A level was consistent wit...
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Sihong Huang Rong Zhou Yuyun Yuan Yiyun Shen Source Type: research
Correction for: KIFC1 promotes proliferation and pseudo-bipolar division of ESCC through the transportation of Aurora B kinase
Aging (Albany NY). 2024 Mar 31;16(6):5795. doi: 10.18632/aging.205719. Epub 2024 Mar 31.NO ABSTRACTPMID:38578656 | DOI:10.18632/aging.205719 (Source: Aging)
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Bin Du Lingyu Wei Jia Wang Yanyan Li Jing Huo Jinsheng Wang Pu Wang Source Type: research
Correction for: Apremilast ameliorates IL-1 α-induced dysfunction in epidermal stem cells
Aging (Albany NY). 2024 Mar 31;16(6):5792-5794. doi: 10.18632/aging.205318. Epub 2024 Mar 31.NO ABSTRACTPMID:38578657 | DOI:10.18632/aging.205318 (Source: Aging)
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Yuxi Jia Xiangru Chen Jing Sun Source Type: research
has-miR-134-5p inhibits the proliferation and migration of glioma cells by regulating the BDNF/ERK signaling pathway
Aging (Albany NY). 2024 Apr 4;16. doi: 10.18632/aging.205720. Online ahead of print.ABSTRACTOur research investigated the effects of hsa-miR-134-5p on glioma progression, focusing on its interaction with the BDNF/ERK signaling pathway. U251 and U87 cell lines were analyzed post-transfection with hsa-miR-134-5p mimics and inhibitors, confirming the miRNA's binding to BDNF using dual luciferase assays. Q-PCR was employed to measure expression changes, revealing that hsa-miR-134-5p markedly inhibited glioma cell proliferation, migration, and invasion, as evidenced by CCK8, monoclonal formation, and Transwell assays. Scratch t...
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Zeshang Guo Pingxv An Xinyu Hong Source Type: research
A prognostic signature established based on genes related to tumor microenvironment for patients with hepatocellular carcinoma
CONCLUSION: This study provided TRGs to help classify patients with HCC and predict their prognoses, contributing to personalized treatments for patients with HCC.PMID:38579170 | DOI:10.18632/aging.205722 (Source: Aging)
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Zhongfeng Cui Ge Li Yanbin Shi Xiaoli Zhao Juan Wang Shanlei Hu Chunguang Chen Guangming Li Source Type: research
Multidimensional data analysis revealed thyroiditis-associated TCF19 SNP rs2073724 as a highly ranked protective variant in thyroid cancer
CONCLUSIONS: Taken together, these findings implicate TCF19 as a promising therapeutic target in aggressive thyroid malignancies and designate rs2073724 as a causal biomarker warranting further investigation in thyroid cancer.PMID:38579171 | DOI:10.18632/aging.205718 (Source: Aging)
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Xianhui Ruan Yu Liu Shuping Wu Guiming Fu Mei Tao Yue Huang Dapeng Li Songfeng Wei Ming Gao Shicheng Guo Junya Ning Xiangqian Zheng Source Type: research
Pan-cancer analysis of Sushi domain-containing protein 4 (SUSD4) and validated in colorectal cancer
In conclusion, SUSD4 is a valuable prognostic indicator for diverse types of cancer, and it has the potential to be a target for cancer therapy.PMID:38579174 | DOI:10.18632/aging.205712 (Source: Aging)
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Yuchen Zhong Chaojing Zheng Weiyuan Zhang Hongyu Wu Qian Zhang Dechuan Li Haixing Ju Haiyang Feng Yinbo Chen Yongtian Fan Weiping Chen Meng Wang Guiyu Wang Source Type: research
Stigmasterol alleviates airway inflammation in OVA-induced asthmatic mice via inhibiting the TGF- β1/Smad2 and IL-17A signaling pathways
In this study, we evaluated the effects of stigmasterol on inflammatory cytokines and the TGF-β1/Smad2 and IL-17A signaling pathway in an ovalbumin (OVA)-induced asthma mouse model. Stigmasterol treatment improved airway remodeling. In addition, it significantly attenuated the symptoms of asthma attacks, reduced the number of macrophages, lymphocytes, neutrophils, and eosinophils in BALF and inflammatory cytokines, including IL-1β, IL-5, IL-6, and IL-13. It further decreased the level of IL-17A in BALF, serum and spleen. Spleen single-cell suspension analysis via flow cytometry showed that IL-17A level was consistent wit...
Source: Aging - April 5, 2024 Category: Biomedical Science Authors: Sihong Huang Rong Zhou Yuyun Yuan Yiyun Shen Source Type: research
Machine learning identifies novel coagulation genes as diagnostic and immunological biomarkers in ischemic stroke
CONCLUSIONS: The current study identified ACTN1, F5 and JMJD1C as novel coagulation-related biomarkers associated with IS immune microenvironment, which enriches our knowledge of coagulation-mediated pathogenesis of IS and sheds light on next-step in vivo and in vitro experiments to elucidate the relevant molecular mechanisms.PMID:38575196 | DOI:10.18632/aging.205706 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Jinzhi Liu Zhihua Si Ju Liu Xu Zhang Cong Xie Wei Zhao Aihua Wang Zhangyong Xia Source Type: research
Identifying an immunogenic cell death-related gene signature contributes to predicting prognosis, immunotherapy efficacy, and tumor microenvironment of lung adenocarcinoma
CONCLUSIONS: The molecular subtypes and a risk model based on ICDGs proposed in our study are both promising prognostic classifications in LUAD, which may provide novel insights for developing accurate targeted cancer therapies.PMID:38575204 | DOI:10.18632/aging.205705 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Xue Li Dengfeng Zhang Pengfei Guo Shaowei Ma Shaolin Gao Shujun Li Yadong Yuan Source Type: research
Lactobacillus plantarum 45 activates SHP2 through inhibition of oxidative stress to regulate osteoblast and osteoclast differentiation
CONCLUSION: LP45 can exert its antioxidant effect by inhibiting the production of oxidative stress to activate the SHP2 signaling pathway, thus promoting osteoblast differentiation and repressing osteoclast formation to maintain bone homeostasis and improve bone metabolism.PMID:38575308 | DOI:10.18632/aging.205708 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Yaming Yang Zheng Yan Qi Xie Yong Wang Zhiying Liu Min Lei Source Type: research
Risk assessment of extra-uterine involvement and prognosis in young type I endometrial carcinoma with high or moderate differentiation and less than 1/2 myometrial invasion
CONCLUSIONS: Surgery with adnexal preservation and without systematic lymphadenectomy could be employed for the patients who are high differentiation with less than 1/2 myometrial invasion or moderate differentiation without myometrial invasion, but not recommended to the patients with moderate differentiation and superficial myometrial invasion.PMID:38575312 | DOI:10.18632/aging.205714 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Yi Sun Pin Han Yuanpei Wang Xiaoran Cheng Weijia Wu Qianwen Liu Fang Ren Source Type: research
