Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study
CONCLUSIONS: Our study provided novel insights into protein targets affecting COVID-19, healthspan and lifespan, with implications for developing new treatment and drug repurposing.PMID:38575325 | DOI:10.18632/aging.205711 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Jie V Zhao Minhao Yao Zhonghua Liu Source Type: research
Machine learning identifies novel coagulation genes as diagnostic and immunological biomarkers in ischemic stroke
CONCLUSIONS: The current study identified ACTN1, F5 and JMJD1C as novel coagulation-related biomarkers associated with IS immune microenvironment, which enriches our knowledge of coagulation-mediated pathogenesis of IS and sheds light on next-step in vivo and in vitro experiments to elucidate the relevant molecular mechanisms.PMID:38575196 | DOI:10.18632/aging.205706 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Jinzhi Liu Zhihua Si Ju Liu Xu Zhang Cong Xie Wei Zhao Aihua Wang Zhangyong Xia Source Type: research
Identifying an immunogenic cell death-related gene signature contributes to predicting prognosis, immunotherapy efficacy, and tumor microenvironment of lung adenocarcinoma
CONCLUSIONS: The molecular subtypes and a risk model based on ICDGs proposed in our study are both promising prognostic classifications in LUAD, which may provide novel insights for developing accurate targeted cancer therapies.PMID:38575204 | DOI:10.18632/aging.205705 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Xue Li Dengfeng Zhang Pengfei Guo Shaowei Ma Shaolin Gao Shujun Li Yadong Yuan Source Type: research
Lactobacillus plantarum 45 activates SHP2 through inhibition of oxidative stress to regulate osteoblast and osteoclast differentiation
CONCLUSION: LP45 can exert its antioxidant effect by inhibiting the production of oxidative stress to activate the SHP2 signaling pathway, thus promoting osteoblast differentiation and repressing osteoclast formation to maintain bone homeostasis and improve bone metabolism.PMID:38575308 | DOI:10.18632/aging.205708 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Yaming Yang Zheng Yan Qi Xie Yong Wang Zhiying Liu Min Lei Source Type: research
Risk assessment of extra-uterine involvement and prognosis in young type I endometrial carcinoma with high or moderate differentiation and less than 1/2 myometrial invasion
CONCLUSIONS: Surgery with adnexal preservation and without systematic lymphadenectomy could be employed for the patients who are high differentiation with less than 1/2 myometrial invasion or moderate differentiation without myometrial invasion, but not recommended to the patients with moderate differentiation and superficial myometrial invasion.PMID:38575312 | DOI:10.18632/aging.205714 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Yi Sun Pin Han Yuanpei Wang Xiaoran Cheng Weijia Wu Qianwen Liu Fang Ren Source Type: research
Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study
CONCLUSIONS: Our study provided novel insights into protein targets affecting COVID-19, healthspan and lifespan, with implications for developing new treatment and drug repurposing.PMID:38575325 | DOI:10.18632/aging.205711 (Source: Aging)
Source: Aging - April 4, 2024 Category: Biomedical Science Authors: Jie V Zhao Minhao Yao Zhonghua Liu Source Type: research
Establishment and verification of a prognostic model based on coagulation and fibrinolysis-related genes in hepatocellular carcinoma
CONCLUSIONS: We screened CFR related genes to design a RiskScore model, which could accurately evaluate the prognosis and survival status of HCC patients, providing certain value for optimizing the clinical treatment of cancer in the future.PMID:38568089 | DOI:10.18632/aging.205699 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Meng Fan Le Lu Hao Shang Yuxuan Lu Yi Yang Xiuyan Wang Hongwei Lu Source Type: research
Human umbilical cord-derived mesenchymal stem cells and auto-crosslinked hyaluronic acid gel complex for treatment of intrauterine adhesion
CONCLUSIONS: The findings of this study suggest that both HA-gel, hUC-MSCs, and hUC-MSCs/HA-gel complexes have the potential for partial repair of IUA and fertility restoration caused by endometrium mechanical injury. Nonetheless, the transplantation of the hUC-MSCs/HA-gel complex displayed exceptional dual healing effects, combining effective anti-adhesive properties with endometrial regeneration stimuli.PMID:38568100 | DOI:10.18632/aging.205704 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Jiaying Fan Jingying Xie Yunsheng Liao Baoyu Lai Guixin Zhou Wenqin Lian Jian Xiong Source Type: research
Metabolic score for insulin resistance predicts major adverse cardiovascular event in premature coronary artery disease
CONCLUSIONS: METS-IR serves as a reliable prognostic predictor of MACE in patients with premature CAD. Therefore, METS-IR may be considered a novel, cost-effective, and dependable indicator for risk stratification and early intervention in premature CAD.PMID:38568104 | DOI:10.18632/aging.205710 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Dachuan Guo Chong Zhang Mingyan Zhang Zhenguo Wu Xiaoyu Liu Yerui Zhang Li Liu Meili Sun Jianmin Yang Source Type: research
CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma
CONCLUSIONS: CCNA2 and KIF23 exhibit high expression levels in ACC, suggesting their potential role as molecular targets for this malignancy.PMID:38568110 | DOI:10.18632/aging.205703 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Yongbin Di Haolei Zhang Bohao Zhang Tianke Li Dan Li Source Type: research
Establishment and verification of a prognostic model based on coagulation and fibrinolysis-related genes in hepatocellular carcinoma
CONCLUSIONS: We screened CFR related genes to design a RiskScore model, which could accurately evaluate the prognosis and survival status of HCC patients, providing certain value for optimizing the clinical treatment of cancer in the future.PMID:38568089 | DOI:10.18632/aging.205699 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Meng Fan Le Lu Hao Shang Yuxuan Lu Yi Yang Xiuyan Wang Hongwei Lu Source Type: research
Human umbilical cord-derived mesenchymal stem cells and auto-crosslinked hyaluronic acid gel complex for treatment of intrauterine adhesion
CONCLUSIONS: The findings of this study suggest that both HA-gel, hUC-MSCs, and hUC-MSCs/HA-gel complexes have the potential for partial repair of IUA and fertility restoration caused by endometrium mechanical injury. Nonetheless, the transplantation of the hUC-MSCs/HA-gel complex displayed exceptional dual healing effects, combining effective anti-adhesive properties with endometrial regeneration stimuli.PMID:38568100 | DOI:10.18632/aging.205704 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Jiaying Fan Jingying Xie Yunsheng Liao Baoyu Lai Guixin Zhou Wenqin Lian Jian Xiong Source Type: research
Metabolic score for insulin resistance predicts major adverse cardiovascular event in premature coronary artery disease
CONCLUSIONS: METS-IR serves as a reliable prognostic predictor of MACE in patients with premature CAD. Therefore, METS-IR may be considered a novel, cost-effective, and dependable indicator for risk stratification and early intervention in premature CAD.PMID:38568104 | DOI:10.18632/aging.205710 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Dachuan Guo Chong Zhang Mingyan Zhang Zhenguo Wu Xiaoyu Liu Yerui Zhang Li Liu Meili Sun Jianmin Yang Source Type: research
CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma
CONCLUSIONS: CCNA2 and KIF23 exhibit high expression levels in ACC, suggesting their potential role as molecular targets for this malignancy.PMID:38568110 | DOI:10.18632/aging.205703 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Yongbin Di Haolei Zhang Bohao Zhang Tianke Li Dan Li Source Type: research
A retrospective study on the effect of Chinese patent medicine combined with conventional treatment on the survival outcomes of 313 patients with stage II-III NSCLC
CONCLUSION: The medium and long-term use of CPM/HSOS was positively associated with higher survival rate in NSCLC patients. Patients with high-level preoperative FIB level and those without surgery might have a poor prognosis in the following years.PMID:38555532 | DOI:10.18632/aging.205697 (Source: Aging)
Source: Aging - March 31, 2024 Category: Biomedical Science Authors: Kegang Jia Chenxu Zhang Fang Li Bin He Shenglong Xie Jun Du Gang Feng Source Type: research
