5-Hydroxytryptophan acts as a gap junction inhibitor to limit the spread of chemotherapy-induced cardiomyocyte injury and mitochondrial dysfunction
Aging (Albany NY). 2024 Mar 10;16. doi: 10.18632/aging.205641. Online ahead of print.ABSTRACTAnthracycline chemotherapeutics like doxorubicin (DOX) are widely used against various cancers but are accompanied by severe cardiotoxic effects that can lead to heart failure. Through whole transcriptome sequencing and pathological tissue analysis in a murine model, our study has revealed that DOX impairs collagen expression in the early phase, causing extracellular matrix anomalies that weaken the mechanical integrity of the heart. This results in ventricular wall thinning and dilation, exacerbating cardiac dysfunction. In this w...
Source: Aging - March 11, 2024 Category: Biomedical Science Authors: Wenshe Sun Qi Lu Yukun Zhang Dongming Xing Source Type: research
Development and validation of a novel biomarker panel for Crohn's disease and rheumatoid arthritis diagnosis and treatment
CONCLUSION: Our study revealed some core genes shared between CD and RA and established a novel biomarker panel with potential implications for the diagnosis and treatment of these diseases.PMID:38462694 | DOI:10.18632/aging.205644 (Source: Aging)
Source: Aging - March 11, 2024 Category: Biomedical Science Authors: Hao Zhang Wenhao Qiao Ran Liu Zuoxiu Shi Jie Sun Shuxiao Dong Source Type: research
BMSCs-derived exosomes inhibit macrophage/microglia pyroptosis by increasing autophagy through the miR-21a-5p/PELI1 axis in spinal cord injury
Aging (Albany NY). 2024 Mar 11;16. doi: 10.18632/aging.205638. Epub 2024 Mar 11.ABSTRACTSpinal cord injury (SCI) results in a diverse range of disabilities and lacks effective treatment options. In recent years, exosomes derived from bone mesenchymal stem cells (BMSCs) have emerged as a promising cell-free therapeutic approach for treating ischemic brain injury and other inflammatory conditions. Macrophage/microglial pyroptosis has been identified as a contributing factor to neuroinflammation following SCI. The therapeutic potential of BMSC-derived exosomes in macrophage/microglia pyroptosis-induced neuroinflammation, howe...
Source: Aging - March 11, 2024 Category: Biomedical Science Authors: Jun Gu Jingyi Wu Chunming Wang Zhenwei Xu Zhengshuai Jin Donghua Yan Sheng Chen Source Type: research
COP9 signalosome complex is a prognostic biomarker and corresponds with immune infiltration in hepatocellular carcinoma
Aging (Albany NY). 2024 Mar 11;16. doi: 10.18632/aging.205646. Epub 2024 Mar 11.ABSTRACTHepatocellular carcinoma (HCC) is among the most common deadly tumors but still lacks specific biomarkers for diagnosis, prognosis, and treatment guidance. The COP9 signalosome (COPS) is an essential regulator of the ubiquitin conjugation pathway upregulated in various cancers. We evaluated the contributions of COPS subunits to HCC tumorigenesis and their utility for prognosis. We comprehensively evaluated the tumor expression pattern and tumorigenic functions of COPS subunits using The Cancer Genome Atlas (TCGA), The Human Protein Atla...
Source: Aging - March 11, 2024 Category: Biomedical Science Authors: Jiahui Liu Dexing Han Junfeng Xuan Jinye Xie Weijia Wang Quan Zhou Kang Chen Source Type: research
Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice
This study explored the role of miR-31-5p and AMPK in UC through a bioinformatics investigation. It investigated the potential of miR-31-5p antagomir to shift macrophages from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype and enhance the intestinal mucosal barrier in DSS-induced UC mice. Additionally, RAW264.7 cells stimulated with LPS were employed to confirm the reversal of miR-31-5p antagomir's therapeutic effect under AMPK inhibition. The findings demonstrated that miR-31-5p antagomir penetrated colonic tissues and ameliorated DSS-induced experimental colitis. Transformation of spleen and mesenteric l...
Source: Aging - March 11, 2024 Category: Biomedical Science Authors: Yuyi Yuan Shuangjiao Deng Jia Yang Zhexing Shou Chunzhu Wei Lijuan Zhang Feng Zhu Fei Gao Xingxing Liu Yujin Liu Qianyun Chen Heng Fan Source Type: research
