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Geraniol attenuates oxidative stress and neuroinflammation mediated cognitive impairment in D galactose induced mouse-aging model
Aging (Albany NY). 2024 Mar 20;16. doi: 10.18632/aging.205677. Online ahead of print.ABSTRACTD-galactose (D-gal) administration was proven to induce cognitive impairment and aging in rodents' models. Geraniol (GNL) belongs to the acyclic isoprenoid monoterpenes. GNL reduces inflammation by changing important signaling pathways and cytokines, and thus it is plausible to be used as a medicine for treating disorders linked to inflammation. Herein, we examined the therapeutic effects of GNL on D-gal-induced oxidative stress and neuroinflammation-mediated memory loss in mice. The study was conducted using six groups of mice (6 ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Peramaiyan Rajendran Fatma J Al-Saeedi Rebai Ben Ammar Basem M Abdallah Enas M Ali Najla Khaled Al Abdulsalam Sujatha Tejavat Duaa Althumairy Vishnu Priya Veeraraghavan Sarah Abdulaziz Alamer Gamal M Bekhet Emad A Ahmed Source Type: research

Omilancor mitigates the senescence of nucleus pulposus cells induced by DDP through targeting MAP2K6
CONCLUSIONS: Omilancor shows promise as a treatment for IDD by targeting MAP2K6-mediated cellular senescence.PMID:38517363 | DOI:10.18632/aging.205588 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Fang Yafeng Shi Xinpeng Wei Rong Cui Guofeng Source Type: research

Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress
Aging (Albany NY). 2024 Mar 19;15. doi: 10.18632/aging.205468. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is a severe pathophysiological syndrome resulting in heart failure, which is found to be induced by pulmonary vascular remodeling mediated by oxidative stress (OS) and inflammation. Phoenixin-20 (PNX-20) is a reproductive peptide first discovered in mice with potential suppressive properties against OS and inflammatory response. Our study will explore the possible therapeutic functions of PHN-20 against PAH for future clinical application. Rats were treated with normal saline, PHN-20 (100 ng/g ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Yaqin Chai Xing Gu HongJun Zhang Xinting Xu Lizhan Chen Source Type: research

Identification and validation of ferroptosis-related gene SLC2A1 as a novel prognostic biomarker in AKI
CONCLUSIONS: In summary, our study not only identifies SLC2A1 as diagnostic biomarker for AKI, but also sheds light on the role of it in AKI progression, providing novel insights for the clinical diagnosis and treatment of AKI.PMID:38517368 | DOI:10.18632/aging.205669 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Huaying Wang Yuanyuan Li Xinran Liu Yonggui Wu Source Type: research

CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN
CONCLUSIONS: CRIF1 plays a protective role against DOX-caused mitochondrial dysfunction and myocardial senescence partly through downregulating PXDN.PMID:38517371 | DOI:10.18632/aging.205664 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Lina Zhou Guilan Zhai Ge Tian Source Type: research

Single cell RNA-seq identifies a FOS/JUN-related monocyte signature associated with clinical response of heart failure patients with mesenchymal stem cell therapy
In this study, we collected samples from 4 HF patients before and after MSC therapy and performed scRNA-seq. After the MSC therapy, the proportion of CD14+ monocytes decreased significantly in both the treatment response and non-response groups, with a more pronounced decrease in the treatment response group. The therapy-response and non-response group were clearly separated in the UMAP plot, while the CD14+ monocytes in the therapy-response group before and after MSC therapy were very similar, but there were significant differences in the non-response group. By further performing NMF analysis, we identified 11 subsets of ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Hui Yuan Pengfei Zhang Yuanfeng Xin Zhongmin Liu Bingren Gao Source Type: research

A pyrimidine metabolism-related signature for prognostic and immunotherapeutic response prediction in hepatocellular carcinoma by integrating analyses
CONCLUSIONS: Our pyrimidine metabolism-centered prognostic signature accurately predicts overall survival, immune status, and treatment response in hepatocellular carcinoma (HCC) patients, offering innovative insights for precise diagnosis, personalized treatment, and improved prognosis.PMID:38517376 | DOI:10.18632/aging.205663 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Shihang Zhang Ouyang Qin Shu Wu Huanming Xu Wei Huang Song Hailiang Source Type: research

Cinobufotalin regulates the USP36/c-Myc axis to suppress malignant phenotypes of colon cancer cells in vitro and in vivo 
In conclusion, CBF may be a promising therapeutic agent for colon cancer due to its regulation of the USP36/c-Myc axis.PMID:38517383 | DOI:10.18632/aging.205661 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Yongjun Hu Ming Luo Source Type: research

Identification and validation of a novel signature based on macrophage marker genes for predicting prognosis and drug response in kidney renal clear cell carcinoma by integrated analysis of single cell and bulk RNA sequencing
In this study, we initiated a thorough examination of single-cell RNA sequencing (scRNA-seq) data for KIRC retrieved from the Gene Expression Omnibus (GEO) database and determined 244 macrophage marker genes (MMGs). Univariate analysis, LASSO regression, and multivariate regression analysis were performed to develop a five-gene prognostic signature in The Cancer Genome Atlas (TCGA) database, which could divide KIRC patients into low-risk (L-R) and high-risk (H-R) groups. Then, a nomogram was constructed to predict the survival rate of KIRC patients at 1, 3, and 5 years, which was well assessed by receiver operating charact...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Xiaoxu Chen Zheyu Zhang Zheng Qin Xiao Zhu Kaibin Wang Lijuan Kang Changying Li Haitao Wang Source Type: research

Evaluation of the clinical significance of long non-coding RNA MALAT1 genetic variants in human lung adenocarcinoma
In conclusion, our results showed that MALAT1 rs3200401 polymorphisms dramatically raised the probability of LUAD development.PMID:38517388 | DOI:10.18632/aging.205675 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Shu-Hui Lin Jeng-Wei Lu Wang-Ting Hsieh Ying-Erh Chou Tzu-Cheng Su Tun-Jen Tsai Yun-Jung Tsai Po-Jen Yang Shun-Fa Yang Source Type: research

Structural insights into human EMC and its interaction with VDAC
Aging (Albany NY). 2024 Mar 15;16. doi: 10.18632/aging.205660. Online ahead of print.ABSTRACTThe endoplasmic reticulum (ER) membrane protein complex (EMC) is a conserved, multi-subunit complex acting as an insertase at the ER membrane. Growing evidence shows that the EMC is also involved in stabilizing and trafficking membrane proteins. However, the structural basis and regulation of its multifunctionality remain elusive. Here, we report cryo-electron microscopy structures of human EMC in apo- and voltage-dependent anion channel (VDAC)-bound states at resolutions of 3.47 Å and 3.32 Å, respectively. We discovered a specif...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Mingyue Li Chunli Zhang Yuntao Xu Shaobai Li Chenhui Huang Jian Wu Ming Lei Source Type: research

Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway
In this study, we report that CEP improved dysfunction in neurological behavior in a middle cerebral artery occlusion (MCAO) mouse model. Importantly, CEP suppressed blood-brain barrier (BBB) hyperpermeability by increasing the expression of ZO-1. Notably, we found that CEP inhibited the expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor 2 (VEGFR2) in the cortex of MCAO mice. Additionally, the results of in vitro experiments demonstrate that treatment with CEP ameliorated cytotoxicity of human bEnd.3 brain microvascular endothelial cells against hypoxia/reperfusion (H/R)...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Yunfang Yang Changjiang Li Sijin Yang Zhuo Zhang Xue Bai Hongmei Tang Jiang Huang Source Type: research

Cordyceps sinensis extract protects against acute kidney injury by inhibiting perforin expression in NK cells via the STING/IRF3 pathway
This study is the first to demonstrate how NK cells promote AKI by releasing perforin, interferon-gamma (IFN-γ) and other inflammatory factors in vivo and in vitro. Differential gene expression between AKI and normal tissues was assessed using bioinformatic analyses. Quantitative real-time PCR, western blotting, and immunohistochemical staining were used to detect target protein mRNA and protein expression. Levels of inflammatory factors were measured using enzyme-linked immunosorbent assay. We found the high doses of the 2'-deoxyadenosine treatment significantly alleviated FA-induced renal damage in vivo, and alleviated ...
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Shuang Li Wei Pang Yuzhu Wang Yiting Zhang Source Type: research

CMS121: a novel approach to mitigate aging-related obesity and metabolic dysfunction
CONCLUSIONS: The diminished de novo lipogenesis, which is associated with increased acetyl-CoA, acylcarnitine, and butyrate metabolite levels, could contribute to safeguarding not only the peripheral system but also the aging brain. By mimicking the effects of ketogenic diets, CMS121 holds promise for metabolic diseases such as obesity and diabetes, since these diets are hard to follow over the long term.PMID:38517358 | DOI:10.18632/aging.205673 (Source: Aging)
Source: Aging - March 22, 2024 Category: Biomedical Science Authors: Alcir L Dafre Saadia Zahid Jessica Jorge Probst Antonio Currais Jingting Yu David Schubert Pamela Maher Source Type: research