Metabolic score for insulin resistance predicts major adverse cardiovascular event in premature coronary artery disease
CONCLUSIONS: METS-IR serves as a reliable prognostic predictor of MACE in patients with premature CAD. Therefore, METS-IR may be considered a novel, cost-effective, and dependable indicator for risk stratification and early intervention in premature CAD.PMID:38568104 | DOI:10.18632/aging.205710 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Dachuan Guo Chong Zhang Mingyan Zhang Zhenguo Wu Xiaoyu Liu Yerui Zhang Li Liu Meili Sun Jianmin Yang Source Type: research
CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma
CONCLUSIONS: CCNA2 and KIF23 exhibit high expression levels in ACC, suggesting their potential role as molecular targets for this malignancy.PMID:38568110 | DOI:10.18632/aging.205703 (Source: Aging)
Source: Aging - April 3, 2024 Category: Biomedical Science Authors: Yongbin Di Haolei Zhang Bohao Zhang Tianke Li Dan Li Source Type: research
A retrospective study on the effect of Chinese patent medicine combined with conventional treatment on the survival outcomes of 313 patients with stage II-III NSCLC
CONCLUSION: The medium and long-term use of CPM/HSOS was positively associated with higher survival rate in NSCLC patients. Patients with high-level preoperative FIB level and those without surgery might have a poor prognosis in the following years.PMID:38555532 | DOI:10.18632/aging.205697 (Source: Aging)
Source: Aging - March 31, 2024 Category: Biomedical Science Authors: Kegang Jia Chenxu Zhang Fang Li Bin He Shenglong Xie Jun Du Gang Feng Source Type: research
Inflammatory risk of albumin combined with C-reactive protein predicts long-term cardiovascular risk in patients with diabetes
CONCLUSIONS: The inflammatory risk as defined by the GPS was closely related to the increased risk of cardiovascular and all-cause death in patients with diabetes. It may be a convenient and efficient clinical practical risk assessment tool for patients with diabetes.PMID:38555533 | DOI:10.18632/aging.205709 (Source: Aging)
Source: Aging - March 31, 2024 Category: Biomedical Science Authors: Xiaoqun Xu Houyong Zhu Hanxin Wang Xinyu Zhu Libin Liu Fengwei Zhang Hongjuan Zhou Mingzhi Zhu Lingshan Dai Long Cai Source Type: research
A retrospective study on the effect of Chinese patent medicine combined with conventional treatment on the survival outcomes of 313 patients with stage II-III NSCLC
CONCLUSION: The medium and long-term use of CPM/HSOS was positively associated with higher survival rate in NSCLC patients. Patients with high-level preoperative FIB level and those without surgery might have a poor prognosis in the following years.PMID:38555532 | DOI:10.18632/aging.205697 (Source: Aging)
Source: Aging - March 31, 2024 Category: Biomedical Science Authors: Kegang Jia Chenxu Zhang Fang Li Bin He Shenglong Xie Jun Du Gang Feng Source Type: research
Inflammatory risk of albumin combined with C-reactive protein predicts long-term cardiovascular risk in patients with diabetes
CONCLUSIONS: The inflammatory risk as defined by the GPS was closely related to the increased risk of cardiovascular and all-cause death in patients with diabetes. It may be a convenient and efficient clinical practical risk assessment tool for patients with diabetes.PMID:38555533 | DOI:10.18632/aging.205709 (Source: Aging)
Source: Aging - March 31, 2024 Category: Biomedical Science Authors: Xiaoqun Xu Houyong Zhu Hanxin Wang Xinyu Zhu Libin Liu Fengwei Zhang Hongjuan Zhou Mingzhi Zhu Lingshan Dai Long Cai Source Type: research
A retrospective study on the effect of Chinese patent medicine combined with conventional treatment on the survival outcomes of 313 patients with stage II-III NSCLC
CONCLUSION: The medium and long-term use of CPM/HSOS was positively associated with higher survival rate in NSCLC patients. Patients with high-level preoperative FIB level and those without surgery might have a poor prognosis in the following years.PMID:38555532 | DOI:10.18632/aging.205697 (Source: Aging)
Source: Aging - March 31, 2024 Category: Biomedical Science Authors: Kegang Jia Chenxu Zhang Fang Li Bin He Shenglong Xie Jun Du Gang Feng Source Type: research
Inflammatory risk of albumin combined with C-reactive protein predicts long-term cardiovascular risk in patients with diabetes
CONCLUSIONS: The inflammatory risk as defined by the GPS was closely related to the increased risk of cardiovascular and all-cause death in patients with diabetes. It may be a convenient and efficient clinical practical risk assessment tool for patients with diabetes.PMID:38555533 | DOI:10.18632/aging.205709 (Source: Aging)
Source: Aging - March 31, 2024 Category: Biomedical Science Authors: Xiaoqun Xu Houyong Zhu Hanxin Wang Xinyu Zhu Libin Liu Fengwei Zhang Hongjuan Zhou Mingzhi Zhu Lingshan Dai Long Cai Source Type: research
Potential value of expression of receptor accessory protein 4 for evaluating the prognosis of lower-grade glioma patients
CONCLUSIONS: In brief, this study is the first to introduce REEP4 in malignant tumors, which can be used as an independent risk factor that participates in the malignant process of LGG. More importantly, REEP4 has the potential to become a new star in the field of anti-tumor treatment.PMID:38552216 | DOI:10.18632/aging.205695 (Source: Aging)
Source: Aging - March 29, 2024 Category: Biomedical Science Authors: Shuping Luo Zhendong Liu Haigang Chang Xingbo Cheng Rongjun Qian Yanzheng Gao Chaofeng Hou Source Type: research
KIF3C: an emerging biomarker with prognostic and immune implications across pan-cancer types and its experiment validation in gastric cancer
Aging (Albany NY). 2024 Mar 28;16. doi: 10.18632/aging.205694. Online ahead of print.ABSTRACTKinesin Family Member 3C (KIF3C) assumes a crucial role in various biological processes of specific human cancers. Nevertheless, there exists a paucity of systematic assessments pertaining to the contribution of KIF3C in human malignancies. We conducted an extensive analysis of KIF3C, covering its expression profile, prognostic relevance, molecular function, tumor immunity, and drug sensitivity. Functional enrichment analysis was also carried out. In addition, we conducted in vitro experiments to substantiate the role of KIF3C in g...
Source: Aging - March 29, 2024 Category: Biomedical Science Authors: Qiangqiang Zhong Wenbo Hong Lina Xiong Source Type: research
Role of CCR1/5/7 in hepatocellular carcinoma: a study on prognostic evaluation, molecular subtyping, and association with immune infiltration
This study aims to assess the prognostic value of the C-C motif chemokine receptor (CCR) gene family in hepatocellular carcinoma (HCC) and its relationship with immune infiltration and molecular subtypes of HCC. The evaluation of the GSE14520 dataset and TCGA database confirmed the prognostic significance of CCR. Building upon the correlation between CCR1, CCR5, and CCR7 and favorable prognosis, we further validated the prognostic importance of CCR1, CCR5, and CCR7 in ICGC database and an independent cohort from Guangxi autonomous region. Then, we constructed a risk prognosis model. Additionally, we observed significant po...
Source: Aging - March 29, 2024 Category: Biomedical Science Authors: Huasheng Huang Chenlu Lan Yongguang Wei Jusen Nong Xiwen Liao Xinping Ye Ganlu Deng Tao Peng Xin Zhou Source Type: research
Potential value of expression of receptor accessory protein 4 for evaluating the prognosis of lower-grade glioma patients
CONCLUSIONS: In brief, this study is the first to introduce REEP4 in malignant tumors, which can be used as an independent risk factor that participates in the malignant process of LGG. More importantly, REEP4 has the potential to become a new star in the field of anti-tumor treatment.PMID:38552216 | DOI:10.18632/aging.205695 (Source: Aging)
Source: Aging - March 29, 2024 Category: Biomedical Science Authors: Shuping Luo Zhendong Liu Haigang Chang Xingbo Cheng Rongjun Qian Yanzheng Gao Chaofeng Hou Source Type: research
KIF3C: an emerging biomarker with prognostic and immune implications across pan-cancer types and its experiment validation in gastric cancer
Aging (Albany NY). 2024 Mar 28;16. doi: 10.18632/aging.205694. Online ahead of print.ABSTRACTKinesin Family Member 3C (KIF3C) assumes a crucial role in various biological processes of specific human cancers. Nevertheless, there exists a paucity of systematic assessments pertaining to the contribution of KIF3C in human malignancies. We conducted an extensive analysis of KIF3C, covering its expression profile, prognostic relevance, molecular function, tumor immunity, and drug sensitivity. Functional enrichment analysis was also carried out. In addition, we conducted in vitro experiments to substantiate the role of KIF3C in g...
Source: Aging - March 29, 2024 Category: Biomedical Science Authors: Qiangqiang Zhong Wenbo Hong Lina Xiong Source Type: research
Role of CCR1/5/7 in hepatocellular carcinoma: a study on prognostic evaluation, molecular subtyping, and association with immune infiltration
This study aims to assess the prognostic value of the C-C motif chemokine receptor (CCR) gene family in hepatocellular carcinoma (HCC) and its relationship with immune infiltration and molecular subtypes of HCC. The evaluation of the GSE14520 dataset and TCGA database confirmed the prognostic significance of CCR. Building upon the correlation between CCR1, CCR5, and CCR7 and favorable prognosis, we further validated the prognostic importance of CCR1, CCR5, and CCR7 in ICGC database and an independent cohort from Guangxi autonomous region. Then, we constructed a risk prognosis model. Additionally, we observed significant po...
Source: Aging - March 29, 2024 Category: Biomedical Science Authors: Huasheng Huang Chenlu Lan Yongguang Wei Jusen Nong Xiwen Liao Xinping Ye Ganlu Deng Tao Peng Xin Zhou Source Type: research
The protective effects of Arctiin in asthma by attenuating airway inflammation and inhibiting p38/NF- κB signaling
In this study, an asthma model was established in mice by stimulation with ovalbumin (OVA). Bronchoalveolar lavage (BALF) was collected from OVA-challenged mice and the cells were counted. Lung tissue was harvested for hematoxylin-eosin (HE) staining and measurement of Wet/Dry weight ratios. The expressions of proteins were detected using enzyme-linked immunosorbent assay (ELISA) and Western blots. The superoxide dismutase (SOD) activity in lung tissue was measured using a commercial kit. We found that Arctiin had beneficial effects on asthma treatment. Firstly, it attenuated OVA-challenged lung pathological alterations. S...
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Lang Yuan Chao Sun Source Type: research
