Fine-Needle Aspiration Cytology of Cellular Basaloid Neoplasms of the Salivary Gland.
CONCLUSIONS.—: Some basaloid neoplasms, in particular pleomorphic adenomas and adenoid cystic carcinomas, may have characteristic findings on fine-needle aspiration that allow for definitive diagnosis. In other cases, however, fine-needle aspiration can confirm a neoplastic basaloid process, but specific classification of a benign or malignant neoplasm cannot be rendered. The Milan System for Reporting Salivary Gland Cytopathology acknowledges this difficulty, and recommends benign or malignant classification only when definitive diagnostic features of a specific neoplasm are present. For indeterminate cases, the sub...
Source: Archives of Pathology and Laboratory Medicine - September 11, 2019 Category: Laboratory Medicine Authors: Cantley RL Tags: Arch Pathol Lab Med Source Type: research

A Clinicopathologic and Molecular Update of Pancreatic Neuroendocrine Neoplasms With a Focus on the New World Health Organization Classification.
CONCLUSIONS.—: The evolving clinical, histopathologic, immunohistochemical, and molecular features of PanNENs are reviewed. Important differential diagnoses with other neoplasms of the pancreas are discussed. PMID: 31509453 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 11, 2019 Category: Laboratory Medicine Authors: Fang JM, Shi J Tags: Arch Pathol Lab Med Source Type: research

Histologic Evaluation of Malignant Polyps and Low-Stage Colorectal Carcinoma.
CONCLUSIONS.—: Poor prognostic factors for malignant polyps include high tumor grade, presence of lymphovascular invasion, tumor less than 1 mm from resection margin, submucosal invasion deeper than 1 mm, and high tumor budding. These features should be assessed by the pathologist and communicated to the clinical team in order to allow proper management. PMID: 31509454 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 11, 2019 Category: Laboratory Medicine Authors: Hagen CE, Farooq A Tags: Arch Pathol Lab Med Source Type: research

Evaluation of the Anyplex II HPV28 Assay in the Detection of Human Papillomavirus in Archival Samples of Oropharyngeal Carcinomas.
CONCLUSIONS.—: Anyplex II HPV28 showed a higher HPV detection rate and HPV-associated fraction than the other methods used. This assay is suitable for HPV detection in archival OPSCC tissues. PMID: 31509455 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 11, 2019 Category: Laboratory Medicine Authors: Rollo F, Donà MG, Pichi B, Pellini R, Covello R, Benevolo M Tags: Arch Pathol Lab Med Source Type: research

Correlation of ROS1 Immunohistochemistry With ROS1 Fusion Status Determined by Fluorescence In Situ Hybridization.
CONCLUSIONS.—: Herein, we present a standardized staining protocol for ROS1 (SP384) and data that support the high correlation between ROS1 status and ROS1 (SP384) antibody. PMID: 31509456 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - September 11, 2019 Category: Laboratory Medicine Authors: Huang RSP, Smith D, Le CH, Liu WW, Ordinario E, Manohar C, Lee M, Rajamani J, Truong H, Li J, Choi C, Li J, Pati A, Bubendorf L, Buettner R, Kerr KM, Lopez-Rios F, Marchetti A, Marondel I, Nicholson AG, Öz AB, Pauwels P, Penault-Llorca F, Rossi G, Thun Tags: Arch Pathol Lab Med Source Type: research

Comparative Performance of High-Risk Human Papillomavirus RNA and DNA In Situ Hybridization on College of American Pathologists Proficiency Tests.
Abstract CONTEXT.—: Detection of high-risk human papillomavirus (HR-HPV) in squamous cell carcinoma is important for classification and prognostication. In situ hybridization (ISH) is a commonly used HR-HPV-specific test that targets viral RNA or DNA. The College of American Pathologists (CAP) provides proficiency testing for laboratories performing HR-HPV ISH. OBJECTIVE.—: To compare the analytical performance of RNA- and DNA-based ISH methods on CAP HR-HPV proficiency tests. DESIGN.—: Data from the 2016-2018 CAP HPV ISH proficiency testing surveys were reviewed. These surveys consist ...
Source: Archives of Pathology and Laboratory Medicine - September 4, 2019 Category: Laboratory Medicine Authors: Keung ES, Souers RJ, Bridge JA, Faquin WC, Graham RP, Hameed MR, Lewis JS, Merker JD, Vasalos P, Moncur JT Tags: Arch Pathol Lab Med Source Type: research

Use of Programmed Death Ligand-1 (PD-L1) Staining to Separate Sarcomatoid Malignant Mesotheliomas From Benign Mesothelial Reactions.
Abstract CONTEXT.—: The separation of benign from malignant mesothelial proliferations is a difficult morphologic problem. Some mesotheliomas stain for programmed death ligand-1 (PD-L1). OBJECTIVE.—: To determine whether PD-L1 staining can separate mesotheliomas from reactive mesothelial proliferations (RMPs). DESIGN.—: We stained 2 tissue microarrays containing in toto 62 malignant mesotheliomas and 88 RMPs, using anti-PD-L1 antibody 22C3. Staining was graded by using an immunoreactive score encompassing intensity/distribution and was divided into negative, weak, moderate, and strong. ...
Source: Archives of Pathology and Laboratory Medicine - September 4, 2019 Category: Laboratory Medicine Authors: Derakhshan F, Ionescu D, Cheung S, Churg A Tags: Arch Pathol Lab Med Source Type: research

Abstracts and Case Studies From the College of American Pathologists 2019 Annual Meeting (CAP19).
Authors: Abstract and case study poster sessions will be conducted during the 2019 College of American Pathologists Annual Meeting (CAP19), which is scheduled for September 21 to 25, 2019. The meeting will take place at the Gaylord Palms Resort & Convention Center, Kissimmee, Florida. The poster sessions will occur in the CAP19 Exhibit Hall. Specific dates and times for each poster session are listed below; "poster focus" times are dedicated poster-viewing periods. Also shown before each poster session are the subject areas that will be presented. PMID: 31465693 [PubMed - in process] (Source: A...
Source: Archives of Pathology and Laboratory Medicine - August 31, 2019 Category: Laboratory Medicine Tags: Arch Pathol Lab Med Source Type: research

Abstract/Case Study Review Committee for the College of American Pathologists 2019 Annual Meeting (CAP19).
Authors: Abstract The Archives of Pathology & Laboratory Medicine acknowledges the following individuals for volunteering to review abstract and case study submissions for the CAP19 meeting. PMID: 31465694 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 31, 2019 Category: Laboratory Medicine Tags: Arch Pathol Lab Med Source Type: research

The Evolution of Decedent Ownership.
PMID: 31453728 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 30, 2019 Category: Laboratory Medicine Authors: Allen TC Tags: Arch Pathol Lab Med Source Type: research

Clinical Governance Should Be a Priority When Care Delivery Systems Are Disrupted.
PMID: 31453729 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 30, 2019 Category: Laboratory Medicine Authors: Birindelli S, Panteghini M Tags: Arch Pathol Lab Med Source Type: research

The History of the American Association of Pathologists' Assistants and of a Profession Built the Hard Way.
PMID: 31453730 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 30, 2019 Category: Laboratory Medicine Authors: Reilly TL, Eckman J Tags: Arch Pathol Lab Med Source Type: research

In Reply.
PMID: 31453731 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 30, 2019 Category: Laboratory Medicine Authors: Rogers BB Tags: Arch Pathol Lab Med Source Type: research

In Reply.
PMID: 31453732 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 30, 2019 Category: Laboratory Medicine Authors: Schifman RB, Perrotta PL, Blond BJ Tags: Arch Pathol Lab Med Source Type: research

Reflex Testing of Free Prostate-Specific Antigen as Effective Health Care Policy.
PMID: 31453733 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 30, 2019 Category: Laboratory Medicine Authors: Ferraro S, Caruso S, Panteghini M Tags: Arch Pathol Lab Med Source Type: research

Trends in Mortality From Human Immunodeficiency Virus Infection, 1984-2016: An Autopsy-Based Study.
Abstract CONTEXT.—: With increasing use and efficacy of antiretroviral therapy for human immunodeficiency virus (HIV) infection, deaths from acquired immunodeficiency syndrome (AIDS)-defining conditions have decreased. OBJECTIVE.—: To examine trends in the cause of death of HIV-infected patients who underwent autopsy at a major New York City hospital from 1984 to 2016, a period including the major epochs of the AIDS epidemic. DESIGN.—: Retrospective review of autopsy records and charts with modeling of trends by logistic regression using polynomial models. RESULTS.—: We ident...
Source: Archives of Pathology and Laboratory Medicine - August 28, 2019 Category: Laboratory Medicine Authors: Nizami S, Morales C, Hu K, Holzman R, Rapkiewicz A Tags: Arch Pathol Lab Med Source Type: research

The Patient-Pathologist Consultation Program: A Mixed-Methods Study of Interest and Motivations in Cancer Patients.
CONCLUSIONS.—: In a select group of cancer patients, there is a very high level of interest in a patient-pathologist consultation program. Pathologists, clinicians, and hospital leadership should work together to pilot these programs in diverse settings. Additional quantitative work to scale interventions for the interested population and qualitative work to design effective, patient-centered consultation programs and to assess value are needed. PMID: 31429605 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 20, 2019 Category: Laboratory Medicine Authors: Lapedis CJ, Horowitz JK, Brown L, Tolle BE, Smith LB, Owens SR Tags: Arch Pathol Lab Med Source Type: research

Pathologic Features of Down Syndrome Myelodysplastic Syndrome and Acute Myeloid Leukemia: A Report From the Children's Oncology Group Protocol AAML0431.
CONCLUSIONS.—: Myelodysplastic syndrome and acute myeloid leukemia in Down syndrome display features that allow discrimination from standard cases of disease. These distinctions are important for treatment decisions, and for understanding disease pathogenesis. We propose specific diagnostic criteria for Down syndrome-related subtypes of acute myeloid leukemia and myelodysplastic syndrome. PMID: 31429606 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 20, 2019 Category: Laboratory Medicine Authors: Mast KJ, Taub JW, Alonzo TA, Gamis AS, Mosse CA, Mathew P, Berman JN, Wang YC, Jones HM, Campana D, Coustan-Smith E, Raimondi SC, Hirsch B, Hitzler JK, Head DR Tags: Arch Pathol Lab Med Source Type: research

Eosinophilic Kidney Tumors: Old and New.
CONCLUSIONS.—: Eosinophilic cytoplasm is a feature shared by many kidney tumors. Understanding the morphologic differences and the role of ancillary studies is key when encountering such a tumor. PMID: 31403331 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 12, 2019 Category: Laboratory Medicine Authors: Iczkowski KA, Czaja RC Tags: Arch Pathol Lab Med Source Type: research

Lost in Transportation: Calcium Oxalate Crystals in Kidney Biopsy Specimens Fixed in Michel Medium May Disappear.
Abstract CONTEXT.—: Calcium oxalate (CaOx) deposits in a kidney biopsy specimen can be seen in acute or chronic kidney injury and in oxalate nephropathy. Although no established cutoff criteria to diagnose oxalate nephropathy versus incidental CaOx deposition in the kidney exist, these conditions require different treatment. We noticed a significant decrease in the number of CaOx deposits in the kidney biopsy cores that were fixed in Michel transport medium (MTM) as compared to their counterparts fixed in formalin. OBJECTIVE.—: To investigate the impact of different fixatives on the number of CaOx...
Source: Archives of Pathology and Laboratory Medicine - August 12, 2019 Category: Laboratory Medicine Authors: Cassol CA, Braga JR, Hartage R, Satoskar AA, Nadasdy T, Brodsky SV Tags: Arch Pathol Lab Med Source Type: research

What the Oncologist Needs From the Pathologist for Immune Therapies.
PMID: 31403333 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 12, 2019 Category: Laboratory Medicine Authors: Bernicker EH Tags: Arch Pathol Lab Med Source Type: research

Bethesda System for Reporting Thyroid Cytopathology in Pediatric Thyroid Nodules: Experience of a Tertiary Care Referral Center.
CONCLUSIONS.—: TBSRTC is effective for appropriate categorization of pediatric thyroid nodules. Risk of malignancy in thyroid nodules is higher for the pediatric than adult population. Understanding the difference in TBSRTC categorization between children and adults may aid in achieving more appropriate evaluation and management of pediatric thyroid nodules. PMID: 31403334 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 12, 2019 Category: Laboratory Medicine Authors: Heider A, Arnold S, Jing X Tags: Arch Pathol Lab Med Source Type: research

Clinicopathologic Diagnostic Approach to Aggressive Variant Prostate Cancer.
CONCLUSIONS.—: The current review summarizes the pathologic features of AVPCa, describes how it has been defined clinically, and discusses how biomarkers may inform treatment strategies in the future. PMID: 31403335 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 12, 2019 Category: Laboratory Medicine Authors: Manucha V, Henegan J Tags: Arch Pathol Lab Med Source Type: research

Differential Diagnosis of Epithelioid Malignant Mesothelioma With Lung and Breast Pleural Metastasis: A Systematic Review Compared With a Standardized Panel of Antibodies-A New Proposal That May Influence Pathologic Practice.
CONCLUSIONS.—: Highlighted by their relevance in the large cohort reported, we recommend 2 useful panels to the differential diagnosis at 10% cutoff. PMID: 31389715 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 7, 2019 Category: Laboratory Medicine Authors: Le Stang N, Burke L, Blaizot G, Gibbs AR, Lebailly P, Clin B, Girard N, Galateau-Sallé F, MESOPATH and EURACAN networks Tags: Arch Pathol Lab Med Source Type: research

Chondroblastoma-like Osteosarcoma.
CONCLUSIONS.—: Although exceedingly rare, chondroblastoma-like osteosarcoma should be considered in the differential diagnosis of chondroblastoma, especially in the presence of radiologic findings suggestive of an aggressive lesion. PMID: 31389716 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 7, 2019 Category: Laboratory Medicine Authors: Hmada YA, Bernieh A, Morris RW, Lewin J, Allen T Tags: Arch Pathol Lab Med Source Type: research

Practical Application of Lineage-Specific Immunohistochemistry Markers: Transcription Factors (Sometimes) Behaving Badly.
CONCLUSIONS.—: The application of TF diagnostic immunohistochemistry has enabled pathologists to better assess the lineage/origin of primary and metastatic tumors. However, the awareness of potential pitfalls is essential to avoid misdiagnosis. PMID: 31385722 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 6, 2019 Category: Laboratory Medicine Authors: Lou SKS, Adeyi OA Tags: Arch Pathol Lab Med Source Type: research

Practical Molecular Testing in a Clinical Genitourinary Service.
CONCLUSIONS.—: Understanding of the molecular oncology of genitourinary neoplasms is rapidly advancing, and the pathologist must be aware of the practical implications of molecular testing. While many genomic abnormalities are not yet clinically relevant, there is an increasing library of ancillary tests that may guide diagnosis, prognosis, and/or treatment of many neoplasms. Recurrent genomic abnormalities have been identified in many types of renal cell carcinoma, and some types of renal cell carcinoma are specifically defined by the molecular abnormality. Two major routes of developing urothelial carcinoma have be...
Source: Archives of Pathology and Laboratory Medicine - August 2, 2019 Category: Laboratory Medicine Authors: Magers MJ, Cheng L Tags: Arch Pathol Lab Med Source Type: research

Breast Cancer Biomarkers: Challenges in Routine Estrogen Receptor, Progesterone Receptor, and HER2/neu Evaluation.
CONCLUSIONS.—: Attention must be given to specimen handling to ensure accurate ER, PR, and HER2 biomarker assessment and appropriate management of breast cancer patients. PMID: 31373514 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - August 2, 2019 Category: Laboratory Medicine Authors: Jorns JM Tags: Arch Pathol Lab Med Source Type: research

Do Synoptic Reports Add Value in Prostate Needle Biopsies?
PMID: 31339751 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 26, 2019 Category: Laboratory Medicine Authors: Renshaw AA, Gould EW Tags: Arch Pathol Lab Med Source Type: research

How to Validate Predictive Immunohistochemistry Testing in Pathology?
PMID: 31339752 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 26, 2019 Category: Laboratory Medicine Authors: Torlakovic EE Tags: Arch Pathol Lab Med Source Type: research

Emerging From the Basement: The Visible Pathologist.
PMID: 31339753 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 26, 2019 Category: Laboratory Medicine Authors: Harrold IM, Bean SM, Williams NC Tags: Arch Pathol Lab Med Source Type: research

In Reply to "Malignant Mesothelioma and Its Nonasbestos Causes".
In Reply to "Malignant Mesothelioma and Its Nonasbestos Causes". Arch Pathol Lab Med. 2019 Aug;143(8):911-914 Authors: Attanoos RL, Churg A, Galateau-Salle F, Gibbs AR, Roggli VL PMID: 31339754 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 26, 2019 Category: Laboratory Medicine Authors: Attanoos RL, Churg A, Galateau-Salle F, Gibbs AR, Roggli VL Tags: Arch Pathol Lab Med Source Type: research

In Reply.
PMID: 31339755 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 26, 2019 Category: Laboratory Medicine Authors: Thunnissen E Tags: Arch Pathol Lab Med Source Type: research

External Quality Assurance of Platelet Function Assays: Results of the College of American Pathologists Proficiency Testing Program.
PMID: 31339756 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 26, 2019 Category: Laboratory Medicine Authors: Hartmann J Tags: Arch Pathol Lab Med Source Type: research

Predictive Markers Require Thorough Analytic Validation.
PMID: 31339757 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 26, 2019 Category: Laboratory Medicine Authors: Troxell ML, Fulton RS, Swanson PE, Bellizzi AM, Fitzgibbons PL, Ambaye AB, Haas TS, Goldsmith JD, Loykasek PA, Miller DV, O'Malley D, Qiu J, Salama ME, Schaberg KB, Schwartz RA, Shia J, Summers TA, Wu Y Tags: Arch Pathol Lab Med Source Type: research

A Systematic Approach to the Cutaneous Lymphoid Infiltrates: A Clinical, Morphologic, and Immunophenotypic Evaluation.
CONCLUSIONS.—: A diagnosis of cutaneous lymphoid infiltrates can be adequately approached using a systematic scheme following the proposed ABCDE system. Overall, cutaneous T- and B-cell lymphomas are rare and "reactive" infiltrates are more common. Evaluation of lymphoid proliferations should start with a good sense of knowledge of the clinical presentation of the lesions, the clinical differential considerations, and a conscientious and appropriate use of immunohistochemistry and molecular tools. PMID: 31339758 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 26, 2019 Category: Laboratory Medicine Authors: Gru AA, McHargue C, Salavaggione AL Tags: Arch Pathol Lab Med Source Type: research

Adequacy of Cytologic Samples by Ultrasound-Guided Percutaneous Transthoracic Fine-Needle Aspiration Cytology of Peripheral Pulmonary Nodules for Morphologic Diagnosis and Molecular Evaluations: Comparison With Computed Tomography-Guided Percutaneous Transthoracic Fine-Needle Aspiration Cytology.
CONCLUSIONS.—: Our experience showed an elevated clinical applicability and diagnostic utility of US-guided transthoracic FNAC in selected pulmonary nodules. PMID: 31329477 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 22, 2019 Category: Laboratory Medicine Authors: Cozzolino I, Ronchi A, Messina G, Montella M, Morgillo F, Vicidomini G, Tirino V, Grimaldi A, Marino FZ, Santini M, Cappabianca S, Franco R Tags: Arch Pathol Lab Med Source Type: research

Preanalytics and Precision Pathology: Pathology Practices to Ensure Molecular Integrity of Cancer Patient Biospecimens for Precision Medicine.
Abstract Biospecimens acquired during routine medical practice are the primary sources of molecular information about patients and their diseases that underlies precision medicine and translational research. In cancer care, molecular analysis of biospecimens is especially common because it often determines treatment choices and may be used to monitor therapy in real time. However, patient specimens are collected, handled, and processed according to routine clinical procedures during which they are subjected to factors that may alter their molecular quality and composition. Such artefactual alteration may skew data...
Source: Archives of Pathology and Laboratory Medicine - July 22, 2019 Category: Laboratory Medicine Authors: Compton CC, Robb JA, Anderson MW, Berry AB, Birdsong GG, Bloom KJ, Branton PA, Crothers JW, Cushman-Vokoun AM, Hicks DG, Khoury JD, Laser J, Marshall CB, Misialek MJ, Natale KE, Nowak JA, Olson D, Pfeifer JD, Schade A, Vance GH, Walk EE, Yohe SL Tags: Arch Pathol Lab Med Source Type: research

Laboratory Staff Turnover.
CONCLUSIONS.—: Laboratory staff turnover rates among institutions varied widely. Two human resource practices were associated with lower laboratory staff turnover rates. PMID: 31313958 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 17, 2019 Category: Laboratory Medicine Authors: Novis DA, Nelson S, Blond BJ, Guidi AJ, Talbert ML, Mix P, Perrotta PL Tags: Arch Pathol Lab Med Source Type: research

An Examination of Advocacy Education in Residency Training.
CONCLUSIONS.—: Teaching advocacy in training is important and part of the Accreditation Council for Graduate Medical Education core requirements as well as a level 5 Milestone. Education may require a balance of internal and external resources, since different programs may offer different opportunities. Shadowing during real advocacy events was the most impressionable experience. PMID: 31313959 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 17, 2019 Category: Laboratory Medicine Authors: Black CC, Motta A Tags: Arch Pathol Lab Med Source Type: research

Interpretation and Utility of Drug of Abuse Screening Immunoassays: Insights From Laboratory Drug Testing Proficiency Surveys.
CONCLUSIONS.—: Survey results indicate strong clinical interest in urine drug testing and some adoption of new assays. However, urine drug testing availability does not parallel prevailing patterns of drug prescribing and abuse patterns. In particular, specific immunoassays for synthetic opioids and a lower positive cutoff for opiate immunoassays may be underused, whereas immunoassays for barbiturates, methadone, propoxyphene, and phencyclidine may be overused. Laboratories are encouraged to review their test menu, cutoffs, and assay performance and adjust their test offerings based on clinical needs and technical ca...
Source: Archives of Pathology and Laboratory Medicine - July 17, 2019 Category: Laboratory Medicine Authors: Krasowski MD, McMillin GA, Melanson SEF, Dizon A, Magnani B, Snozek CLH Tags: Arch Pathol Lab Med Source Type: research

Diversion Principle Reduces Skin Flora Contamination Rates in a Community Hospital.
Abstract CONTEXT.—: Blood culture contamination is a common problem faced by medical centers and leads to significant cost. A possible method to reduce contamination is to discard the initial aliquot of blood, which contains skin and bacteria. OBJECTIVE.—: To determine whether the rate of contaminant blood cultures could be reduced by changing the order of draw to divert the first 7 mL to a gold- or green-top tube. DESIGN.—: A preintervention and postintervention study was conducted. During the 18-month intervention phase (September 2015-February 2017), all nurses in the emergency depar...
Source: Archives of Pathology and Laboratory Medicine - July 11, 2019 Category: Laboratory Medicine Authors: Syed S, Liss DT, Costas CO, Atkinson JM Tags: Arch Pathol Lab Med Source Type: research

Complete Digital Pathology for Routine Histopathology Diagnosis in a Multicenter Hospital Network.
CONCLUSIONS.—: Digital pathology is an adequate medium for primary histopathology diagnosis. Successful digitization relies on existing sample tracking and integration of the information technology infrastructure. Rapid and reliable scanning at ×40 equivalent was key to the transition to a fully digital workflow. Digital pathology resulted in efficiency gains in the preanalytical and analytical phases, and created the basis for computational pathology: the use of computer-assisted tools to aid diagnosis. PMID: 31295015 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 11, 2019 Category: Laboratory Medicine Authors: Retamero JA, Aneiros-Fernandez J, Del Moral RG Tags: Arch Pathol Lab Med Source Type: research

Ex Vivo Microscopy: A Promising Next-Generation Digital Microscopy Tool for Surgical Pathology Practice.
CONCLUSIONS.—: Ex vivo imaging of tissues can be performed by using various types of optical imaging techniques. These next-generation digital microscopy tools have a promising potential for utilization in surgical pathology practice. PMID: 31295016 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 11, 2019 Category: Laboratory Medicine Authors: Krishnamurthy S, Brown JQ, Iftimia N, Levenson RM, Rajadhyaksha M Tags: Arch Pathol Lab Med Source Type: research

Practice Patterns in Urinary Cytopathology Prior to the Paris System for Reporting Urinary Cytology.
CONCLUSIONS.—: Most laboratories use the ThinPrep method followed by the Cytospin technique; therefore, the criteria published in The Paris System for Reporting Urinary Cytology, based mostly on ThinPrep and SurePath, should be validated for Cytospin, and relevant information should be included in the revised edition of The Paris System for Reporting Urinary Cytology. PMID: 31295017 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 11, 2019 Category: Laboratory Medicine Authors: Barkan GA, Tabatabai ZL, Kurtycz DFI, Padmanabhan V, Souers RJ, Nayar R, Sturgis CD Tags: Arch Pathol Lab Med Source Type: research

Regulating Artificial Intelligence for a Successful Pathology Future.
PMID: 31268373 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - July 3, 2019 Category: Laboratory Medicine Authors: Allen TC Tags: Arch Pathol Lab Med Source Type: research

Pearls and Updates in Dermatopathology for the General Surgical Pathologist: Experts Weigh In on What You Need to Know.
PMID: 31225990 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 22, 2019 Category: Laboratory Medicine Authors: Shalin SC, Gardner JM, Kaley JR Tags: Arch Pathol Lab Med Source Type: research

In Response to "Cost Effectiveness of Intraoperative Gross Examination in Colorectal Resections".
In Response to "Cost Effectiveness of Intraoperative Gross Examination in Colorectal Resections". Arch Pathol Lab Med. 2019 Jul;143(7):785 Authors: Frankel KA PMID: 31225991 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 22, 2019 Category: Laboratory Medicine Authors: Frankel KA Tags: Arch Pathol Lab Med Source Type: research

In Reply.
PMID: 31225992 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 22, 2019 Category: Laboratory Medicine Authors: Schnadig VJ Tags: Arch Pathol Lab Med Source Type: research

In Response to "Overdiagnosis of Thyroid Cancer: Is This Not an Ethical Issue for Pathologists As Well As Radiologists and Clinicians?"
In Response to "Overdiagnosis of Thyroid Cancer: Is This Not an Ethical Issue for Pathologists As Well As Radiologists and Clinicians?" Arch Pathol Lab Med. 2019 Jul;143(7):782-783 Authors: Renshaw AA, Gould EW PMID: 31225993 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 22, 2019 Category: Laboratory Medicine Authors: Renshaw AA, Gould EW Tags: Arch Pathol Lab Med Source Type: research