The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer.
CONCLUSIONS.—: Percent Gleason pattern 4 (%GP4) is as follows: (1) report %GP4 in needle biopsy with Grade Groups (GrGp) 2 and 3, and in needle biopsy on other parts (jars) of lower grade in cases with at least 1 part showing Gleason score (GS) 4 + 4 = 8; and (2) report %GP4: less than 5% or less than 10% and 10% increments thereafter. Tertiary grade patterns are as follows: (1) replace "tertiary grade pattern" in radical prostatectomy (RP) with "minor tertiary pattern 5 (TP5)," and only use in RP with GrGp 2 or 3 with less than 5% Gleason pattern 5; and (2) minor TP5 is noted along with the GS, w...
Source: Archives of Pathology and Laboratory Medicine - June 26, 2020 Category: Laboratory Medicine Authors: Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA, Jimenez RE, Khani F, Tags: Arch Pathol Lab Med Source Type: research

Utility of Immunohistochemistry for MUC4 and GATA3 to Aid in the Distinction of Pleural Sarcomatoid Mesothelioma From Pulmonary Sarcomatoid Carcinoma.
CONCLUSIONS.—: Diffuse GATA3 expression favors sarcomatoid mesothelioma over sarcomatoid carcinoma, which rarely shows diffuse expression (sensitivity and specificity of diffuse staining 66% and 94%, respectively). Focal and patchy GATA3 expression is observed in both tumor types, and therefore is not helpful in this distinction. Sensitivity of MUC4 for sarcomatoid carcinoma was low in our cohort, positive in only 38% with frequent patchy staining, but it was quite specific. PMID: 32589069 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 26, 2020 Category: Laboratory Medicine Authors: Terra SBSP, Roden AC, Aubry MC, Yi ESJ, Boland JM Tags: Arch Pathol Lab Med Source Type: research

Postmortem swabs in the Sars-CoV-2 Pandemic: Report on 12 complete clinical autopsy cases.
Conclusions A thorough knowledge of the eventual persistence of pathogens in deaths related to infectious diseases is fundamental for the safety of the operators during the autopsy practice, especially when referring to emergent pathogens like Sars-Cov-2. Our study highlights the importance in performing multiple swabs in the postmortem, since Sars-CoV-2 swab positivity can be limited to only a single swab. PMID: 32589448 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 26, 2020 Category: Laboratory Medicine Authors: Dell'Aquila M, Cattani P, Fantoni M, Marchetti S, Aquila I, Stigliano E, Carbone A, Oliva A, Arena V Tags: Arch Pathol Lab Med Source Type: research

Adrenal Vascular Changes in COVID-19 Autopsies.
PMID: 32579380 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 24, 2020 Category: Laboratory Medicine Authors: Iuga AC, Marboe CC, Yilmaz MM, Lefkowitch JH, Gauran C, Lagana SM Tags: Arch Pathol Lab Med Source Type: research

Protecting the Pathology Commons in the Digital Era.
PMID: 32579394 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 24, 2020 Category: Laboratory Medicine Authors: Mazer BL, Paulson N, Sinard JH Tags: Arch Pathol Lab Med Source Type: research

Point-of-Care Drug of Abuse Testing in the Opioid Epidemic.
CONCLUSIONS.—: The opioid epidemic provides unprecedented opportunities for POC drug testing, with significant clinical needs. Compared with gold standard tests, limitations for commercially available opioid POC testing include lower analytical sensitivity, lower specificity, and cross-reactivity. In response to unmet clinical needs, novel methods have emerged in research literature, such as microfluidics and miniature mass spectrometry. Future prospects include the development of quantitative POC devices and smarter and real-time drug testing. PMID: 32579399 [PubMed - as supplied by publisher] (Source: Archives...
Source: Archives of Pathology and Laboratory Medicine - June 24, 2020 Category: Laboratory Medicine Authors: Li Z, Wang P Tags: Arch Pathol Lab Med Source Type: research

Workflow Mapping: A Q-Probes Study of Preanalytic Testing Processes.
CONCLUSIONS.—: Aggregate specimen processing times may be shortened by reducing the number of steps involving sample waiting and computer entry activities. Rapid centrifugation is likely to reduce overall average institutional SPTs. PMID: 32579404 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 24, 2020 Category: Laboratory Medicine Authors: Perrotta P, Novis DA, Nelson S, Blond B, Stankovic A, Talbert M Tags: Arch Pathol Lab Med Source Type: research

Coagulation dysfunction: A hallmark in COVID-19.
Conclusions: COVID-19-associated coagulopathy ranges from mild laboratory alterations to disseminated intravascular coagulation (DIC) with a predominant phenotype of thrombotic/multiple organ failure. Characteristically, high D-dimer levels on admission and/or continuously increasing concentrations of D-dimer is associated with disease progression and poor overall survival. SARS-CoV-2 infection triggers the immune-hemostatic response. Drastic inflammatory responses including, but not limited to, cytokine storm, vasculopathy, and NETosis may contribute to an overwhelming activation of coagulation. Hypercoagulability and sys...
Source: Archives of Pathology and Laboratory Medicine - June 18, 2020 Category: Laboratory Medicine Authors: Fei Y, Tang N, Liu H, Cao W Tags: Arch Pathol Lab Med Source Type: research

Rapid Validation of Telepathology by an Academic Neuropathology Practice During the COVID-19 Pandemic.
CONCLUSIONS: Our study demonstrates that accuracy of neuropathological diagnoses and interpretation of ancillary preparations via WSI are not inferior to those generated via traditional microscopy. This study provides a framework for rapid subspecialty validation and deployment of WSI for diagnostic purposes during a pandemic event. PMID: 32551815 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 18, 2020 Category: Laboratory Medicine Authors: Henriksen J, Kolognizak T, Houghton T, Cherne S, Zhen D, Cimino PJ, Latimer CS, Scherpelz KP, Yoda RA, Alpers CE, Chhieng DF, Dirk Keene C, Gonzalez-Cuyar LF Tags: Arch Pathol Lab Med Source Type: research

Paraffin Immunofluorescence Increases Light-Chain Detection in Extra-Renal Light Chain Amyloidosis and Other Light-Chain-Associated Diseases.
CONCLUSIONS.—: We therefore view paraffin immunofluorescence as a significant addition to the routine workflow for detection of light-chain-related diseases. PMID: 32539437 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 15, 2020 Category: Laboratory Medicine Authors: Gibier JB, Perbet R, Lopez B, Colombat M, Dubois R, Humez S, Terriou L, Copin MC, Gnemmi V Tags: Arch Pathol Lab Med Source Type: research

Risk of COVID-19 Transmission During Autopsy.
PMID: 32520589 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 10, 2020 Category: Laboratory Medicine Authors: Davis GG, Williamson AK Tags: Arch Pathol Lab Med Source Type: research

COVID-19 Autopsies and Personal Protective Equipment.
PMID: 32520590 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 10, 2020 Category: Laboratory Medicine Authors: Han B, Bhalla R, da Silva Lameira F, Stuart Vander Heide R, Lee Love G Tags: Arch Pathol Lab Med Source Type: research

Analysis of COVID-19 transmission: Low risk of presymptomatic spread?
PMID: 32501120 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 5, 2020 Category: Laboratory Medicine Authors: Slifka MK, Messer WB, Amanna IJ Tags: Arch Pathol Lab Med Source Type: research

Pathology Laboratory Policies and Procedures for Releasing Diagnostic Tissue for Cancer Research.
CONCLUSIONS.—: This project indicated a general willingness of pathology laboratories to participate in research by sharing FFPE tissue. Given the variability of research policies across laboratories, it is critical for each SEER registry to work with laboratories in their catchment area to understand such policies and state legislation regulating tissue retention and guardianship. PMID: 32496836 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 4, 2020 Category: Laboratory Medicine Authors: Yuan Y, Van Dyke AL, Petkov VI, Hussey S, Moravec R, Altekruse SF, Sandoval M, Cress RD, Mueller LM, Mogi A, Hernandez BY, Selk FR, Lynch CF, Tucker TC, Lynch MA, Lefante C, Wu XC, Sweeney C, Doherty JA, Penberthy LS Tags: Arch Pathol Lab Med Source Type: research

Improving Malignancy Detection Rates in Body Fluids Submitted to the Hematology Laboratory for Nucleated Cell Count and Differential: A Quality Improvement Study.
CONCLUSIONS.—: We demonstrate the comparatively lower malignancy detection rate for body fluid specimens processed in our hematology laboratory, particularly for carcinomas. Hematology technologist education/training improved the malignancy detection rate, an important quality improvement given the large proportion of body fluids undergoing hematology evaluation without concurrent cytology reviews. PMID: 32491945 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 3, 2020 Category: Laboratory Medicine Authors: Zhang ML, Maglantay RJ, Cunningham VL, Goodwin MT, Feeney MW, Keefe J, Tambouret RH, Sohani AR Tags: Arch Pathol Lab Med Source Type: research

Multinational Retrospective Central Pathology Review of Neuroblastoma: Lessons Learned to Establish a Regional Pathology Referral Center in Resource-Limited Settings.
CONCLUSIONS.—: This retrospective CPR highlights the need for a CPR program to serve this region, to ensure correct diagnosis and subclassification of NB, and to provide manual MYCN IHC-with reflexing to fluorescence in situ hybridization, if questionable. This approach can further regional collaboration, enhance test utilization, and ultimately improve patients' outcomes. PMID: 32491946 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - June 3, 2020 Category: Laboratory Medicine Authors: Santiago T, Polanco AC, Fuentes-Alabi S, Hayes C, Orellana E, Gomero B, González MT, Ruiz E, Durán ME, Rodriguez-Galindo C, Metzger M Tags: Arch Pathol Lab Med Source Type: research

The Effect of Direct Oral Anticoagulants on Antithrombin Activity Testing Is Abolished by DOAC-Stop in Venous Thromboembolism Patients.
s A Abstract CONTEXT.—: Direct oral anticoagulants (DOACs) may cause falsely negative results of antithrombin (AT) deficiency screening. OBJECTIVE.—: To evaluate the impact of DOAC-Stop, an agent reversing in vitro effects of DOACs, on AT testing in anticoagulated patients. DESIGN.—: We assessed 130 venous thromboembolism patients aged 46.7 ± 13.5 years. Blood samples were collected 2 to 27 hours after DOAC intake from 49 patients on rivaroxaban, 54 on apixaban, and 27 on dabigatran. Antithrombin activity was assessed using the activated factor X (FXa)-based and the activa...
Source: Archives of Pathology and Laboratory Medicine - June 3, 2020 Category: Laboratory Medicine Authors: Ząbczyk M, Natorska J, Kopytek M, Malinowski KP, Undas A Tags: Arch Pathol Lab Med Source Type: research

A Department-Sponsored, Hospital-Based Pathology Education Symposium Is a Cost-Effective Method to Provide Laboratory Staff With Highly Rated Continuing Education Experiences.
Abstract CONTEXT.—: Continuing education improves the quality of medical care and is a required part of most health care professions. Although a variety of educational modules are available online or at external conferences, completion of these activities can be expensive and time-consuming. In addition, externally produced modules may have limited applicability to a local practice. OBJECTIVE.—: To assess the ability of an economically efficient, locally produced, department-wide pathology educational seminar to efficiently meet education requirements for a large number of employees in a large hea...
Source: Archives of Pathology and Laboratory Medicine - June 3, 2020 Category: Laboratory Medicine Authors: Blagg LN, Hruban RH, Gehrie EA Tags: Arch Pathol Lab Med Source Type: research

In Reply.
PMID: 32459530 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 30, 2020 Category: Laboratory Medicine Authors: Hagen CE, Farooq A Tags: Arch Pathol Lab Med Source Type: research

Diverging Ways of Determining Depth of Invasion in Pedunculated pT1 Colon Carcinomas.
PMID: 32459531 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 30, 2020 Category: Laboratory Medicine Authors: de Freitas Pinheiro N, da Silva NDF Tags: Arch Pathol Lab Med Source Type: research

Developing Pathology Measures for the Quality Payment Program-Part II: Overcoming Challenges With Data Capture to Maximize Reimbursement.
CONCLUSIONS.—: Development of quality measures is a necessary and ongoing effort within the College of American Pathologists. Increased awareness about pathology-specific issues in measure development and reporting is essential to ensuring pathology's ability to demonstrate value and meaningfully participate in the QPP. PMID: 32459532 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 30, 2020 Category: Laboratory Medicine Authors: Kelley J, Patil P, Kennedy A, Singh L, Peditto S, Cardona DM Tags: Arch Pathol Lab Med Source Type: research

Developing Pathology Measures for the Quality Payment Program-Part I: A Quest for Meaningful Measures.
CONCLUSIONS.—: Because the implications of reporting on these pathology-specific metrics are significant, these measures and the process by which they were designed are presented here in peer-reviewed fashion. The measures described in this article (part 1) represent recent efforts by the CAP to develop meaningful measures that reflect rigorous clinical evidence and highlight areas with opportunities for performance improvement. PMID: 32459533 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 30, 2020 Category: Laboratory Medicine Authors: Bocsi GT, Kang J, Kennedy A, Singh L, Peditto S, Cardona DM Tags: Arch Pathol Lab Med Source Type: research

Updates to Medicare's Quality Payment Program That May Impact You.
CONCLUSIONS.—: By staying up to date with the ever-evolving Merit-based Incentive Payment System requirements, pathologists will be better equipped to successfully comply with this relatively new payment system, reduce the burden of participating, understand the reporting differences of the various performance categories, and thereby be able to maximize their scoring and incentive potential. PMID: 32459534 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 30, 2020 Category: Laboratory Medicine Authors: Cardona DM, Peditto S, Singh L, Black-Schaffer S Tags: Arch Pathol Lab Med Source Type: research

Medicare's Quality Payment Program Continues to Evolve: What Pathologists Need to Know to Succeed.
PMID: 32459535 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 30, 2020 Category: Laboratory Medicine Authors: Cardona DM Tags: Arch Pathol Lab Med Source Type: research

Microscope? No, Thanks: User Experience With Complete Digital Pathology for Routine Diagnosis.
PMID: 32459536 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 30, 2020 Category: Laboratory Medicine Authors: Retamero JA, Aneiros-Fernandez J, Del Moral RG Tags: Arch Pathol Lab Med Source Type: research

Creation and benefits of the "COVID Autopsy Listserve".
Creation and benefits of the "COVID Autopsy Listserve". Arch Pathol Lab Med. 2020 May 18;: Authors: Williamson AK PMID: 32422064 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 18, 2020 Category: Laboratory Medicine Authors: Williamson AK Tags: Arch Pathol Lab Med Source Type: research

Effects of SARS-CoV-2 infection on pregnant women and their infants: A retrospective study in Wuhan, China.
Conclusions: No major complication were reported among the studied cohort, though one serious case and one perinatal infection were observed. Much effort should be done to reduce the pathogenic effect of COVID-19 infection in pregnancies. PMID: 32422078 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 18, 2020 Category: Laboratory Medicine Authors: Yang H, Hu B, Zhan S, Yang LY, Xiong G Tags: Arch Pathol Lab Med Source Type: research

Autopsy Report with Clinical Pathological Correlation.
We present a clinical-pathological correlation report of a previously healthy Hispanic woman with laboratory-confirmed COVID-19 who had typical features of acute respiratory distress syndrome (ARDS), and also showed cardiac abnormalities thought to represent fulminant viral myocarditis. Congruent with the ARDS clinical impression, autopsy findings were remarkable for extensive and markedly severe acute lung injury consistent with viral pneumonia, characterized by diffuse alveolar damage, pulmonary infarction, severe pulmonary edema, desquamation of pneumocytes with intraalveolar aggregation, and pneumocyte morphological al...
Source: Archives of Pathology and Laboratory Medicine - May 18, 2020 Category: Laboratory Medicine Authors: Yan L, Mir M, Sanchez P, Beg M, Peters J, Enriquez O, Gilbert A Tags: Arch Pathol Lab Med Source Type: research

Variability in the Laboratory Measurement of Cytokines: A Longitudinal Summary of a College of American Pathologists Proficiency Testing Survey.
CONCLUSIONS.—: This retrospective analysis of College of American Pathologists proficiency testing data for cytokine measurement is the largest method comparison to date, and this study provides a description of the variation of cytokine measurement across methods, across laboratories, and within laboratories. Serial monitoring of cytokines should preferentially be performed by the same method within the same laboratory. PMID: 32401053 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 13, 2020 Category: Laboratory Medicine Authors: Knight V, Long T, Meng QH, Linden MA, Rhoads DD Tags: Arch Pathol Lab Med Source Type: research

Collection and Handling of Thoracic Small Biopsy and Cytology Specimens for Ancillary Studies: Guideline From the College of American Pathologists in Collaboration With the American College of Chest Physicians, Association for Molecular Pathology, American Society of Cytopathology, American Thoracic Society, Pulmonary Pathology Society, Papanicolaou Society of Cytopathology, Society of Interventional Radiology, and Society of Thoracic Radiology.
CONCLUSIONS.—: Based on the systematic review and expert panel consensus, thoracic small specimens can be handled and processed to perform downstream testing (eg, molecular markers, immunohistochemical biomarkers), core needle and fine-needle techniques can provide appropriate cytologic and histologic specimens for ancillary studies, and rapid on-site cytologic evaluation remains helpful in appropriate triage, handling, and processing of specimens. PMID: 32401054 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 13, 2020 Category: Laboratory Medicine Authors: Roy-Chowdhuri S, Dacic S, Ghofrani M, Illei PB, Layfield LJ, Lee C, Michael CW, Miller RA, Mitchell JW, Nikolic B, Nowak JA, Pastis NJ, Rauch CA, Sharma A, Souter L, Billman BL, Thomas NE, VanderLaan PA, Voss JS, Wahidi MM, Yarmus LB, Gilbert CR Tags: Arch Pathol Lab Med Source Type: research

E-Cigarette or Vaping Product Use-Associated Lung Injury: A Review for Pathologists.
CONCLUSIONS.—: Most cases of vaping-associated lung injury have been linked to vaping products containing tetrahydrocannabinol or other cannabinoids. Lung biopsies show a spectrum of nonspecific acute lung injury patterns (organizing pneumonia, diffuse alveolar damage, acute fibrinous, and organizing pneumonia, or combinations of the above), accompanied by prominent, foamy macrophage accumulation. Injury is usually accentuated around small airways. Lipid-laden macrophages can be identified in bronchioloalveolar lavage fluid in most patients and these can be highlighted using lipid stains, such as oil red O, but the c...
Source: Archives of Pathology and Laboratory Medicine - May 13, 2020 Category: Laboratory Medicine Authors: Cecchini MJ, Mukhopadhyay S, Arrossi AV, Beasley MB, Butt YM, Jones KD, Pambuccian S, Mehrad M, Monaco SE, Saqi A, Smith ML, Tazelaar HD, Larsen BT Tags: Arch Pathol Lab Med Source Type: research

SARS-CoV-2 Pandemic: Review of the Literature and Proposal for Safe Autopsy Practice.
Discussion: Throughout the history of medicine, the role of autopsy has been fundamental to the understanding of multiple pathogenic processes that are investigated postmortem through autopsy. The purpose of the study is to propose an operating protocol that can be useful for all clinical and forensic autopsies with particular reference to the correct methods to be applied to the examination of positive or suspected COVID-19 cases regarding both the autopsy procedure and the collection and analysis of biological samples. PMID: 32383963 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 8, 2020 Category: Laboratory Medicine Authors: Aquila I, Sacco MA, Abenavoli L, Malara N, Arena V, Grassi S, Ausania F, Boccuto L, Ricci C, Gratteri S, Oliva A, Ricci P Tags: Arch Pathol Lab Med Source Type: research

Overview of Pathologic Findings of Vaping in the Context of an Autopsy Patient With Chronic Injury.
CONCLUSIONS.—: Vaping-induced lung injury has emerged as a public health issue, and this case represents a rare opportunity to evaluate this issue at autopsy. Most commonly, the injury has been attributed to tetrahydrocannabinol product use as opposed to nicotine. This case demonstrates that as today's young and relatively healthy vapers grow older and develop the comorbidities that come with advanced age, there is serious risk of chronic lung damage from vaping that could result in death. Further observations and studies, particularly autopsy evidence, are clearly important to understand the possible outcomes. ...
Source: Archives of Pathology and Laboratory Medicine - May 8, 2020 Category: Laboratory Medicine Authors: Priemer DS, Gravenmier C, Batouli A, Hooper JE Tags: Arch Pathol Lab Med Source Type: research

Primary Amyloidosis of the Genitourinary Tract.
CONCLUSIONS.—: Primary localized amyloidosis within the urogenital tract can present as a neoplastic process and may be clinically and radiologically considered as a mass. Awareness of primary amyloidosis by pathologists and clinicians is required for accurate diagnosis and proper patient management. PMID: 32383975 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 8, 2020 Category: Laboratory Medicine Authors: Al-Obaidy KI, Grignon DJ Tags: Arch Pathol Lab Med Source Type: research

Recent Advances in Anatomic and Clinical Pathology Board Examination Pass Rates.
PMID: 32383976 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - May 8, 2020 Category: Laboratory Medicine Authors: Adkins BD Tags: Arch Pathol Lab Med Source Type: research

Leveraging Technology for Remote Learning in the Era of COVID-19 and Social Distancing: Tips and Resources for Pathology Educators and Trainees.
Abstract The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has rapidly disrupted traditional modes of operation in healthcare and education. In March 2020, institutions in the United States began to implement a range of policies to discourage direct contact and encourage social distancing. These measures have placed us in an unprecedented position where education can no longer occur at close quarters - most notably, around a multi-headed microscope - but must instead continue at a distance. This guide is intended to be a resource for pathologists and pathologists-in-training who wish to leverage t...
Source: Archives of Pathology and Laboratory Medicine - May 4, 2020 Category: Laboratory Medicine Authors: Mukhopadhyay S, Booth AL, Calkins SM, Doxtader EE, Fine SW, Gardner JM, Gonzalez RS, Mirza KM, Jiang XS Tags: Arch Pathol Lab Med Source Type: research

Gharpure's Papers (1927-1951) on Autopsies at Grant Medical College and Sir J. J. Hospital, Mumbai.
PMID: 32330097 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 25, 2020 Category: Laboratory Medicine Authors: Pandya SS, Pai SA, Pandya SK Tags: Arch Pathol Lab Med Source Type: research

In Reply.
PMID: 32330098 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 25, 2020 Category: Laboratory Medicine Authors: Lanjewar DN, Sheth NS, Lanjewar SD, Wagholikar UL Tags: Arch Pathol Lab Med Source Type: research

Transbronchial Cryobiopsy in the Diagnosis of Fibrotic Interstitial Lung Disease.
CONCLUSIONS.—: While the diagnostic yield of transbronchial cryobiopsy is slightly lower than surgical lung biopsy, a growing literature suggests that with a multidisciplinary approach cryobiopsy provides diagnostic and prognostic information approaching that of surgical lung biopsy with lower morbidity and mortality. PMID: 32320274 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 22, 2020 Category: Laboratory Medicine Authors: Mehrad M, Colby TV, Rossi G, Cavazza A Tags: Arch Pathol Lab Med Source Type: research

Select Epstein-Barr Virus-Associated Digestive Tract Lesions for the Practicing Pathologist.
CONCLUSIONS.—: This article highlights the importance of recognizing the discussed lesions because they influence the direct clinical management or work as a potential predictive marker for therapy. PMID: 32320275 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 22, 2020 Category: Laboratory Medicine Authors: Alruwaii ZI, Montgomery EA Tags: Arch Pathol Lab Med Source Type: research

COVID-19 Associated Hepatitis Complicating Recent Living Donor Liver Transplantation.
We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On post-operative day (POD) 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function tests increased approximately 5-fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocyt...
Source: Archives of Pathology and Laboratory Medicine - April 17, 2020 Category: Laboratory Medicine Authors: Lagana SM, De Michele S, Lee MJ, Emond JC, Griesemer AD, Tulin-Silver SA, Verna EC, Martinez M, Lefkowitch JH Tags: Arch Pathol Lab Med Source Type: research

Resurrecting the Hospital Autopsy: Impact of an Office of Decedent Affairs on Consent Rates, Providers, and Next-of-Kin.
Abstract CONTEXT.—: Autopsy rates have decreased dramatically despite providing important clinical information to medical practices and social benefits to decedents' families. OBJECTIVE.—: To assess the impact of an institutional Office of Decedent Affairs (ODA), a direct communication link between pathology and decedents' families, on hospital autopsy consent rates, autopsy-related communication, practitioner views, and next-of-kin experiences. DESIGN.—: A before and after study involving all hospital decedents whose deaths did not fall within the jurisdiction of the medical examiner's...
Source: Archives of Pathology and Laboratory Medicine - April 16, 2020 Category: Laboratory Medicine Authors: Juskewitch JE, Griffin JM, Maleszewski JJ, Asiedu GB, Paolini MA, Regnier AK, Yrjo ML, Kendall ML, Comfere NI, Cheville AL, Carey EC, Amirahmadi F, Rabatin JT, Moynihan TJ, Reichard RR, Aubry MC Tags: Arch Pathol Lab Med Source Type: research

Viral transportation in covid-19 pandemic: inactivated virus transportation should be implemented for safe transportation and handling at diagnostics laboratories.
VIRAL TRANSPORTATION IN COVID-19 PANDEMIC: INACTIVATED VIRUS TRANSPORTATION SHOULD BE IMPLEMENTED FOR SAFE TRANSPORTATION AND HANDLING AT DIAGNOSTICS LABORATORIES. Arch Pathol Lab Med. 2020 Apr 16;: Authors: Dewar R, Baunoch D, Wojno K, Parkash V, Khosravi-Far R PMID: 32298137 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 16, 2020 Category: Laboratory Medicine Authors: Dewar R, Baunoch D, Wojno K, Parkash V, Khosravi-Far R Tags: Arch Pathol Lab Med Source Type: research

Pancreatic Neuroendocrine Neoplasms: Landscape and Horizon.
CONCLUSIONS.—: Evolving experience and knowledge have established subtypes of pancreatic neuroendocrine neoplasms, based on their genotype and phenotype. Accurate pathologic interpretation of the specific neoplasm has significant implications for therapy and prognosis. PMID: 32298138 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 16, 2020 Category: Laboratory Medicine Authors: Tang LH Tags: Arch Pathol Lab Med Source Type: research

Geospatial Hotspots Need Point-of-Care Strategies to Stop Highly Infectious Outbreaks: Ebola and Coronavirus.
Conclusions POCT can interrupt spirals of dysfunction and delay by enhancing disease detection, decision making, contagion containment, and safe spacing, thereby softening outbreak surges and diminishing risk before human, economic, and cultural losses mount. Point-of-care tests results identify where infected individuals spread COVID-19, when delays cause death, and how to deploy resources. Results in national cloud databases help optimize outbreak control, mitigation, emergency response, and community resilience. The COVID-19 pandemic demonstrates unequivocally that governments must support POCT and multidisciplinary hea...
Source: Archives of Pathology and Laboratory Medicine - April 16, 2020 Category: Laboratory Medicine Authors: Kost GJ Tags: Arch Pathol Lab Med Source Type: research

Defining Normal Healthy Term Newborn Automated Hematologic Reference Intervals at 24 Hours of Life.
CONCLUSIONS.—: This prospective study has defined hematologic RIs for this newborn population, including new advanced clinical parameters from the Sysmex XN-1000 Automated Hematology Analyzer. These RIs are proposed as the new standard and can serve as a strong foundation for continued research to further explore their value in diagnosing and managing morbidities such as sepsis, anemia, and thrombocytopenia. PMID: 32298140 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 16, 2020 Category: Laboratory Medicine Authors: Ianni B, McDaniel H, Savilo E, Wade C, Micetic B, Johnson S, Gerkin R Tags: Arch Pathol Lab Med Source Type: research

Squamous Neoplasia in the Esophagus.
CONCLUSIONS.—: Accurate diagnosis of squamous neoplasia requires adherence to established diagnostic criteria, attention to subtle histologic features, and correlation with clinical and imaging findings. In difficult cases, multiple biopsies may be necessary to reach a definitive diagnosis. PMID: 32271610 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 9, 2020 Category: Laboratory Medicine Authors: Savant D, Zhang Q, Yang Z Tags: Arch Pathol Lab Med Source Type: research

SMARCA4/BRG1-Deficient Non-Small Cell Lung Carcinomas: A Case Series and Review of the Literature.
CONCLUSIONS.—: BRG1 loss occurs in a subset of TTF-1/p40-negative poorly differentiated NSCLCs. Identification and follow-up will clarify the prognosis, diagnostic criteria, and potential for therapeutic personalization. PMID: 32271611 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 9, 2020 Category: Laboratory Medicine Authors: Nambirajan A, Singh V, Bhardwaj N, Mittal S, Kumar S, Jain D Tags: Arch Pathol Lab Med Source Type: research

From Undergraduate Medical School Student to Visible Pathologist.
PMID: 32233991 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 1, 2020 Category: Laboratory Medicine Authors: Montironi R, Cimadamore A, Scarpelli M Tags: Arch Pathol Lab Med Source Type: research

Root Cause Analysis of Amendments in Tumor Summaries.
PMID: 32233992 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 1, 2020 Category: Laboratory Medicine Authors: Renshaw AA, Gould EW Tags: Arch Pathol Lab Med Source Type: research