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Therapeutic Drug Monitoring of 6 New-Generation Antiseizure Medications Using a Mass Spectrometry Method: Analysis of 2-Year Experience in a Large Cohort of Korean Epilepsy Patients
CONCLUSIONS.—: A simple and rapid LC-MS/MS method for TDM of 6 ASMs was developed and successfully applied to clinical practice. This large-scale TDM data could help establish an effective monitoring strategy for these drugs.PMID:38576184 | DOI:10.5858/arpa.2023-0386-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Sang-Mi Kim Won Young Heo Hyeonju Oh Eun Yeon Joo Young-Min Shon Seung Bong Hong Soo-Youn Lee Dae-Won Seo Source Type: research

Is Fragmentation of Prostate Core Biopsies Inevitable? A Quality Improvement Initiative
CONCLUSIONS.—: Submission of >1 biopsy core per jar and use of Telfa for mounting are associated with increased fragmentation. We recommend limiting submission to 1 core per jar and avoid mounting on Telfa pads.PMID:38576208 | DOI:10.5858/arpa.2023-0492-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Krithika Shenoy Richard J Cote Gayathri Kini Mary Anthes-Bartlow Vijayalakshmi Padmanabhan Source Type: research

Clinically Undiagnosed Diseases in Autopsies: Frequency and Risk Factors
CONCLUSIONS.—: Autopsy is a useful investigation for the detection of clinically undiagnosed entities. In our cohort, cardiac amyloidosis showed the highest number of underlying risk factors, but was clinically underdiagnosed. Our findings underline the necessity of improved clinical detection of cardiac amyloidosis, especially in light of emerging therapeutic options. Moreover, we characterize the most common entities prone to clinical underdiagnosis.PMID:38576236 | DOI:10.5858/arpa.2023-0429-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Umberto Maccio Christoph Andreas Meier Michael Reinehr Frank Ruschitzka Reto Sch üpbach Holger Moch Zsuzsanna Varga Source Type: research

High-Grade Transformation and Carcinosarcoma
CONCLUSIONS.—: High-grade transformation occurs rarely but has a significant impact on prognosis and management. By microscopy, the high-grade area is usually a distinct nodule and shows solid and nested architecture, cellular atypia, high mitotic count, and necrosis. The molecular features are not well established. Carcinosarcoma almost always arises in a pleomorphic adenoma and likely follows an adenoma-carcinoma-sarcoma pathway.PMID:38569599 | DOI:10.5858/arpa.2023-0534-RA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 3, 2024 Category: Laboratory Medicine Authors: Anuj Verma Raja R Seethala He Wang Source Type: research

Clinicopathologic and Molecular Characterization of High-Risk Human Papillomavirus-Positive Carcinomas of the Urinary Tract
CONCLUSIONS.—: HPV+ UTCs show distinct clinical, morphologic, and molecular characteristics, suggesting important roles for HPV in UTC.PMID:38555943 | DOI:10.5858/arpa.2023-0285-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 31, 2024 Category: Laboratory Medicine Authors: Neslihan Kayraklioglu Bradley A Stohr Emily Chan Source Type: research

Perivascular Epithelioid Cell-Family Tumors in Children, Adolescents and Young Adults:Clinicopathologic Features in 70 Cases
CONCLUSIONS.—: Compared to the general population, TSC was more prevalent in our cohort; PEComas-NOS showed more frequent TFE3 rearrangements and possible association with LFS. This series expands the spectrum of PEComas in young patients and demonstrates molecular features and germline contexts that set them apart from older patients.PMID:38547914 | DOI:10.5858/arpa.2023-0552-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 28, 2024 Category: Laboratory Medicine Authors: Phoebe M Hammer Angus Toland Muhammad Shaheen Archana Shenoy Ashwini Esnakula M John Hicks Mikako Warran Alyaa Al-Ibraheemi Jessica L Davis Serena Y Tan Source Type: research