Uncommon Tumors of the Lung: Recently Described and Rediscovered Tumors
CONCLUSIONS.—: The 3 entities represent uncommon tumors occurring primarily in the lung and a diagnostic challenge not only in biopsy specimens but also often in surgically resected specimens. The use of immunohistochemical stains and in some cases of molecular diagnostics is of aid in arriving at final interpretation.PMID:38484776 | DOI:10.5858/arpa.2023-0414-RA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 14, 2024 Category: Laboratory Medicine Authors: Cesar A Moran Source Type: research

A Large Postmortem Database of COVID-19 Patients Can Inform Disease Research and Public Policy Decision Making
CONCLUSIONS.—: Changes in hospitalization and disease likely stem from longer lifespans after COVID-19 diagnosis and alteration in treatment approaches. Although Omicron variants preferentially replicate in the upper airways, autopsied patients who died of COVID-19 in that time period showed the same lung damage as earlier decedents. Most importantly, findings suggest that there are still unelucidated risk factors for death from COVID-19 including possibly genetic susceptibility.PMID:38452801 | DOI:10.5858/arpa.2023-0380-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Jody E Hooper Harry Sanchez Silvio Litovsky Zhen Arthur Lu Edward W Gabrielson Robert F Padera Thora Steffensen Isaac H Solomon Andrea Gilbert Kirsten J Threlkeld Amy V Rapkiewicz Holly Harper Meghan E Kapp Mary K Schwerdt Sharon Mount Yiwen Wang Rong Lu Source Type: research

Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma
CONCLUSIONS.—: PDACs with different mutant KRAS alleles are associated with distinct morphologies and clinical outcomes, with KRAS G12R allele associated with P+LD morphology and longer OS when compared with G12D using Kaplan-Meier studies.PMID:38452805 | DOI:10.5858/arpa.2023-0005-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Timothy Chao Zi-Xuan Wang Wilbur B Bowne Clifford J Yudkoff Ava Torjani Vishal Swaminathan Taylor R Kavanagh Austin Roadarmel Cyrus J Sholevar Shawnna Cannaday Geoffrey Krampitz Tingting Zhan Eliyahu Gorgov Avinoam Nevler Harish Lavu Charles J Yeo Stephen Source Type: research

A Large Postmortem Database of COVID-19 Patients Can Inform Disease Research and Public Policy Decision Making
CONCLUSIONS.—: Changes in hospitalization and disease likely stem from longer lifespans after COVID-19 diagnosis and alteration in treatment approaches. Although Omicron variants preferentially replicate in the upper airways, autopsied patients who died of COVID-19 in that time period showed the same lung damage as earlier decedents. Most importantly, findings suggest that there are still unelucidated risk factors for death from COVID-19 including possibly genetic susceptibility.PMID:38452801 | DOI:10.5858/arpa.2023-0380-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Jody E Hooper Harry Sanchez Silvio Litovsky Zhen Arthur Lu Edward W Gabrielson Robert F Padera Thora Steffensen Isaac H Solomon Andrea Gilbert Kirsten J Threlkeld Amy V Rapkiewicz Holly Harper Meghan E Kapp Mary K Schwerdt Sharon Mount Yiwen Wang Rong Lu Source Type: research

Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma
CONCLUSIONS.—: PDACs with different mutant KRAS alleles are associated with distinct morphologies and clinical outcomes, with KRAS G12R allele associated with P+LD morphology and longer OS when compared with G12D using Kaplan-Meier studies.PMID:38452805 | DOI:10.5858/arpa.2023-0005-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Timothy Chao Zi-Xuan Wang Wilbur B Bowne Clifford J Yudkoff Ava Torjani Vishal Swaminathan Taylor R Kavanagh Austin Roadarmel Cyrus J Sholevar Shawnna Cannaday Geoffrey Krampitz Tingting Zhan Eliyahu Gorgov Avinoam Nevler Harish Lavu Charles J Yeo Stephen Source Type: research

A Large Postmortem Database of COVID-19 Patients Can Inform Disease Research and Public Policy Decision Making
CONCLUSIONS.—: Changes in hospitalization and disease likely stem from longer lifespans after COVID-19 diagnosis and alteration in treatment approaches. Although Omicron variants preferentially replicate in the upper airways, autopsied patients who died of COVID-19 in that time period showed the same lung damage as earlier decedents. Most importantly, findings suggest that there are still unelucidated risk factors for death from COVID-19 including possibly genetic susceptibility.PMID:38452801 | DOI:10.5858/arpa.2023-0380-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Jody E Hooper Harry Sanchez Silvio Litovsky Zhen Arthur Lu Edward W Gabrielson Robert F Padera Thora Steffensen Isaac H Solomon Andrea Gilbert Kirsten J Threlkeld Amy V Rapkiewicz Holly Harper Meghan E Kapp Mary K Schwerdt Sharon Mount Yiwen Wang Rong Lu Source Type: research

Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma
CONCLUSIONS.—: PDACs with different mutant KRAS alleles are associated with distinct morphologies and clinical outcomes, with KRAS G12R allele associated with P+LD morphology and longer OS when compared with G12D using Kaplan-Meier studies.PMID:38452805 | DOI:10.5858/arpa.2023-0005-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Timothy Chao Zi-Xuan Wang Wilbur B Bowne Clifford J Yudkoff Ava Torjani Vishal Swaminathan Taylor R Kavanagh Austin Roadarmel Cyrus J Sholevar Shawnna Cannaday Geoffrey Krampitz Tingting Zhan Eliyahu Gorgov Avinoam Nevler Harish Lavu Charles J Yeo Stephen Source Type: research

A Large Postmortem Database of COVID-19 Patients Can Inform Disease Research and Public Policy Decision Making
CONCLUSIONS.—: Changes in hospitalization and disease likely stem from longer lifespans after COVID-19 diagnosis and alteration in treatment approaches. Although Omicron variants preferentially replicate in the upper airways, autopsied patients who died of COVID-19 in that time period showed the same lung damage as earlier decedents. Most importantly, findings suggest that there are still unelucidated risk factors for death from COVID-19 including possibly genetic susceptibility.PMID:38452801 | DOI:10.5858/arpa.2023-0380-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Jody E Hooper Harry Sanchez Silvio Litovsky Zhen Arthur Lu Edward W Gabrielson Robert F Padera Thora Steffensen Isaac H Solomon Andrea Gilbert Kirsten J Threlkeld Amy V Rapkiewicz Holly Harper Meghan E Kapp Mary K Schwerdt Sharon Mount Yiwen Wang Rong Lu Source Type: research

Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma
CONCLUSIONS.—: PDACs with different mutant KRAS alleles are associated with distinct morphologies and clinical outcomes, with KRAS G12R allele associated with P+LD morphology and longer OS when compared with G12D using Kaplan-Meier studies.PMID:38452805 | DOI:10.5858/arpa.2023-0005-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Timothy Chao Zi-Xuan Wang Wilbur B Bowne Clifford J Yudkoff Ava Torjani Vishal Swaminathan Taylor R Kavanagh Austin Roadarmel Cyrus J Sholevar Shawnna Cannaday Geoffrey Krampitz Tingting Zhan Eliyahu Gorgov Avinoam Nevler Harish Lavu Charles J Yeo Stephen Source Type: research

A Large Postmortem Database of COVID-19 Patients Can Inform Disease Research and Public Policy Decision Making
CONCLUSIONS.—: Changes in hospitalization and disease likely stem from longer lifespans after COVID-19 diagnosis and alteration in treatment approaches. Although Omicron variants preferentially replicate in the upper airways, autopsied patients who died of COVID-19 in that time period showed the same lung damage as earlier decedents. Most importantly, findings suggest that there are still unelucidated risk factors for death from COVID-19 including possibly genetic susceptibility.PMID:38452801 | DOI:10.5858/arpa.2023-0380-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Jody E Hooper Harry Sanchez Silvio Litovsky Zhen Arthur Lu Edward W Gabrielson Robert F Padera Thora Steffensen Isaac H Solomon Andrea Gilbert Kirsten J Threlkeld Amy V Rapkiewicz Holly Harper Meghan E Kapp Mary K Schwerdt Sharon Mount Yiwen Wang Rong Lu Source Type: research

Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma
CONCLUSIONS.—: PDACs with different mutant KRAS alleles are associated with distinct morphologies and clinical outcomes, with KRAS G12R allele associated with P+LD morphology and longer OS when compared with G12D using Kaplan-Meier studies.PMID:38452805 | DOI:10.5858/arpa.2023-0005-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Timothy Chao Zi-Xuan Wang Wilbur B Bowne Clifford J Yudkoff Ava Torjani Vishal Swaminathan Taylor R Kavanagh Austin Roadarmel Cyrus J Sholevar Shawnna Cannaday Geoffrey Krampitz Tingting Zhan Eliyahu Gorgov Avinoam Nevler Harish Lavu Charles J Yeo Stephen Source Type: research

A Large Postmortem Database of COVID-19 Patients Can Inform Disease Research and Public Policy Decision Making
CONCLUSIONS.—: Changes in hospitalization and disease likely stem from longer lifespans after COVID-19 diagnosis and alteration in treatment approaches. Although Omicron variants preferentially replicate in the upper airways, autopsied patients who died of COVID-19 in that time period showed the same lung damage as earlier decedents. Most importantly, findings suggest that there are still unelucidated risk factors for death from COVID-19 including possibly genetic susceptibility.PMID:38452801 | DOI:10.5858/arpa.2023-0380-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Jody E Hooper Harry Sanchez Silvio Litovsky Zhen Arthur Lu Edward W Gabrielson Robert F Padera Thora Steffensen Isaac H Solomon Andrea Gilbert Kirsten J Threlkeld Amy V Rapkiewicz Holly Harper Meghan E Kapp Mary K Schwerdt Sharon Mount Yiwen Wang Rong Lu Source Type: research

Association of Mutant KRAS Alleles With Morphology and Clinical Outcomes in Pancreatic Ductal Adenocarcinoma
CONCLUSIONS.—: PDACs with different mutant KRAS alleles are associated with distinct morphologies and clinical outcomes, with KRAS G12R allele associated with P+LD morphology and longer OS when compared with G12D using Kaplan-Meier studies.PMID:38452805 | DOI:10.5858/arpa.2023-0005-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 7, 2024 Category: Laboratory Medicine Authors: Timothy Chao Zi-Xuan Wang Wilbur B Bowne Clifford J Yudkoff Ava Torjani Vishal Swaminathan Taylor R Kavanagh Austin Roadarmel Cyrus J Sholevar Shawnna Cannaday Geoffrey Krampitz Tingting Zhan Eliyahu Gorgov Avinoam Nevler Harish Lavu Charles J Yeo Stephen Source Type: research

Circulating Nucleated Red Blood Cells: An Updated Reference Interval
CONCLUSIONS.—: Based on statistical analysis of our results, we concluded that the upper limit of the RI could be updated from 0.01 × 106/μL to 0.10 × 106/μL. Increasing the upper limit of normal for the nRBC RI should decrease patient consternation from an abnormal laboratory value and significantly decrease costs through reducing unnecessary follow up care, and without causing patient harm.PMID:38432308 | DOI:10.5858/arpa.2023-0328-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 3, 2024 Category: Laboratory Medicine Authors: Amy A Meredith Neil R Meredith Lynelle Smith Julie Rosser Source Type: research

Mixed-Grade Urothelial Carcinoma: Insights Into Clinical Behavior and Prognostic Implications Compared to Pure Low-Grade and High-Grade Urothelial Carcinomas
CONCLUSIONS.—: MGUC showed a prognosis closer to LGUC. Our study supports the current recommendation to classify tumors with <5% high-grade component as MGUC, as these tumors display clinical characteristics and outcomes close to that of pure LGUC.PMID:38432312 | DOI:10.5858/arpa.2023-0367-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 3, 2024 Category: Laboratory Medicine Authors: Fateme Khalatbari Miremad Moafi-Madani Ali Amin Source Type: research