Mixed-Grade Urothelial Carcinoma: Insights Into Clinical Behavior and Prognostic Implications Compared to Pure Low-Grade and High-Grade Urothelial Carcinomas
CONCLUSIONS.—: MGUC showed a prognosis closer to LGUC. Our study supports the current recommendation to classify tumors with <5% high-grade component as MGUC, as these tumors display clinical characteristics and outcomes close to that of pure LGUC.PMID:38432312 | DOI:10.5858/arpa.2023-0367-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 3, 2024 Category: Laboratory Medicine Authors: Fateme Khalatbari Miremad Moafi-Madani Ali Amin Source Type: research

Circulating Nucleated Red Blood Cells: An Updated Reference Interval
CONCLUSIONS.—: Based on statistical analysis of our results, we concluded that the upper limit of the RI could be updated from 0.01 × 106/μL to 0.10 × 106/μL. Increasing the upper limit of normal for the nRBC RI should decrease patient consternation from an abnormal laboratory value and significantly decrease costs through reducing unnecessary follow up care, and without causing patient harm.PMID:38432308 | DOI:10.5858/arpa.2023-0328-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 3, 2024 Category: Laboratory Medicine Authors: Amy A Meredith Neil R Meredith Lynelle Smith Julie Rosser Source Type: research

Mixed-Grade Urothelial Carcinoma: Insights Into Clinical Behavior and Prognostic Implications Compared to Pure Low-Grade and High-Grade Urothelial Carcinomas
CONCLUSIONS.—: MGUC showed a prognosis closer to LGUC. Our study supports the current recommendation to classify tumors with <5% high-grade component as MGUC, as these tumors display clinical characteristics and outcomes close to that of pure LGUC.PMID:38432312 | DOI:10.5858/arpa.2023-0367-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 3, 2024 Category: Laboratory Medicine Authors: Fateme Khalatbari Miremad Moafi-Madani Ali Amin Source Type: research

Blast Phase of Myeloproliferative Neoplasm Resembles Acute Myeloid Leukemia, Myelodysplasia-Related, in Clinical Presentation, Cytogenetic Pattern, and Genomic Profile, and Often Undergoes Reversion to Second Chronic Phase Status After Induction Chemotherapy
CONCLUSIONS.—: MPN-blast phase resembles acute myeloid leukemia, myelodysplasia-related, in cytogenetic pattern, mutation profile, and clinical outcome. Two patterns of clonal evolution are inferred by dynamic analysis of mutation profiles: linear and parallel evolutions. Although overall survival was dismal, 62.5% of our cases achieved second chronic phase, and they showed better survival than those without second chronic phase.PMID:38426696 | DOI:10.5858/arpa.2023-0363-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 1, 2024 Category: Laboratory Medicine Authors: Yue Zhao Imran Siddiqi Tyler J Wildes Derald Charles Kristen Deak Endi Wang Source Type: research

Blast Phase of Myeloproliferative Neoplasm Resembles Acute Myeloid Leukemia, Myelodysplasia-Related, in Clinical Presentation, Cytogenetic Pattern, and Genomic Profile, and Often Undergoes Reversion to Second Chronic Phase Status After Induction Chemotherapy
CONCLUSIONS.—: MPN-blast phase resembles acute myeloid leukemia, myelodysplasia-related, in cytogenetic pattern, mutation profile, and clinical outcome. Two patterns of clonal evolution are inferred by dynamic analysis of mutation profiles: linear and parallel evolutions. Although overall survival was dismal, 62.5% of our cases achieved second chronic phase, and they showed better survival than those without second chronic phase.PMID:38426696 | DOI:10.5858/arpa.2023-0363-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 1, 2024 Category: Laboratory Medicine Authors: Yue Zhao Imran Siddiqi Tyler J Wildes Derald Charles Kristen Deak Endi Wang Source Type: research

Blast Phase of Myeloproliferative Neoplasm Resembles Acute Myeloid Leukemia, Myelodysplasia-Related, in Clinical Presentation, Cytogenetic Pattern, and Genomic Profile, and Often Undergoes Reversion to Second Chronic Phase Status After Induction Chemotherapy
CONCLUSIONS.—: MPN-blast phase resembles acute myeloid leukemia, myelodysplasia-related, in cytogenetic pattern, mutation profile, and clinical outcome. Two patterns of clonal evolution are inferred by dynamic analysis of mutation profiles: linear and parallel evolutions. Although overall survival was dismal, 62.5% of our cases achieved second chronic phase, and they showed better survival than those without second chronic phase.PMID:38426696 | DOI:10.5858/arpa.2023-0363-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 1, 2024 Category: Laboratory Medicine Authors: Yue Zhao Imran Siddiqi Tyler J Wildes Derald Charles Kristen Deak Endi Wang Source Type: research

Rapid Examination of Nonprocessed Renal Cell Carcinoma Using Nonlinear Microscopy
CONCLUSIONS.—: The results of this study demonstrated that NLM had a high degree of correspondence with H&E staining for the classical variants of renal cell carcinoma. NLM offers several clinical benefits, such as facilitating rapid renal cell carcinoma diagnosis, assessment of targeted kidney biopsies for both tumor and medical kidney diseases, and collection of fresh renal cell carcinoma tissue for molecular studies.PMID:38411182 | DOI:10.5858/arpa.2023-0320-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 27, 2024 Category: Laboratory Medicine Authors: Yaileen D Guzm án-Arocho Timothy D Weber Taylor St Jacques James G Fujimoto Seymour Rosen Yue Sun Source Type: research

The Pathologist Pipeline: A Brief Look at the "Other End"
Arch Pathol Lab Med. 2024 Feb 27. doi: 10.5858/arpa.2023-0572-ED. Online ahead of print.NO ABSTRACTPMID:38411264 | DOI:10.5858/arpa.2023-0572-ED (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 27, 2024 Category: Laboratory Medicine Authors: Edward J Gutmann Source Type: research

Rapid Examination of Nonprocessed Renal Cell Carcinoma Using Nonlinear Microscopy
CONCLUSIONS.—: The results of this study demonstrated that NLM had a high degree of correspondence with H&E staining for the classical variants of renal cell carcinoma. NLM offers several clinical benefits, such as facilitating rapid renal cell carcinoma diagnosis, assessment of targeted kidney biopsies for both tumor and medical kidney diseases, and collection of fresh renal cell carcinoma tissue for molecular studies.PMID:38411182 | DOI:10.5858/arpa.2023-0320-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 27, 2024 Category: Laboratory Medicine Authors: Yaileen D Guzm án-Arocho Timothy D Weber Taylor St Jacques James G Fujimoto Seymour Rosen Yue Sun Source Type: research

The Pathologist Pipeline: A Brief Look at the "Other End"
Arch Pathol Lab Med. 2024 Feb 27. doi: 10.5858/arpa.2023-0572-ED. Online ahead of print.NO ABSTRACTPMID:38411264 | DOI:10.5858/arpa.2023-0572-ED (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 27, 2024 Category: Laboratory Medicine Authors: Edward J Gutmann Source Type: research

Rapid Examination of Nonprocessed Renal Cell Carcinoma Using Nonlinear Microscopy
CONCLUSIONS.—: The results of this study demonstrated that NLM had a high degree of correspondence with H&E staining for the classical variants of renal cell carcinoma. NLM offers several clinical benefits, such as facilitating rapid renal cell carcinoma diagnosis, assessment of targeted kidney biopsies for both tumor and medical kidney diseases, and collection of fresh renal cell carcinoma tissue for molecular studies.PMID:38411182 | DOI:10.5858/arpa.2023-0320-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 27, 2024 Category: Laboratory Medicine Authors: Yaileen D Guzm án-Arocho Timothy D Weber Taylor St Jacques James G Fujimoto Seymour Rosen Yue Sun Source Type: research

The Pathologist Pipeline: A Brief Look at the "Other End"
Arch Pathol Lab Med. 2024 Feb 27. doi: 10.5858/arpa.2023-0572-ED. Online ahead of print.NO ABSTRACTPMID:38411264 | DOI:10.5858/arpa.2023-0572-ED (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 27, 2024 Category: Laboratory Medicine Authors: Edward J Gutmann Source Type: research

The Chemistry in Immunohistochemistry: A Reply From UK NEQAS
Arch Pathol Lab Med. 2024 Mar 1;148(3):265-266. doi: 10.5858/arpa.2023-0389-LE.NO ABSTRACTPMID:38408029 | DOI:10.5858/arpa.2023-0389-LE (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 26, 2024 Category: Laboratory Medicine Authors: Andrew Dodson Suzanne Parry Source Type: research

Male Invasive Lobular Breast Cancer: Clinicopathologic Features Including Recurrence Score Results From a Population-Based Database
Arch Pathol Lab Med. 2024 Mar 1;148(3):263-264. doi: 10.5858/arpa.2023-0364-LE.NO ABSTRACTPMID:38408030 | DOI:10.5858/arpa.2023-0364-LE (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 26, 2024 Category: Laboratory Medicine Authors: Michael Balatico Ana L Ruano Allison S Cleary Lesley Lomo H Evin Gulbahce Source Type: research

Fumarate Hydratase-Deficient Renal Cell Carcinoma With Predominant Tubulocystic Features Mimics Tubulocystic Renal Cell Carcinoma
CONCLUSIONS.—: We emphasized multiple sectioning to identify a nontubulocystic architecture to exclude tubulocystic RCC. Moreover, tumor size, FH/2SC staining, and the Ki-67 index can differentiate tubulocystic FH-deficient RCC from tubulocystic RCC. The diagnosis of tubulocystic RCC was not recommended in renal mass biopsy because of the limited tissues sampled.PMID:38390749 | DOI:10.5858/arpa.2023-0330-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 23, 2024 Category: Laboratory Medicine Authors: Xiaoqun Yang Yang Liu Huafeng Wang Yunze Xu Huizhi Zhang Ming Zhao Xiaoqing Luo Hongtao Jin Ji Xiong Lili Tao Jiankun Xu Luting Zhou Xiangyun Li Haimin Xu Lei Dong Chaofu Wang Source Type: research